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Tovia Jacobs, Sean R Jacobson, Juan Fortea, Jeffrey S Berger, Alok Vedvyas, Karyn Marsh, Tianshe He, Eugenio Gutierrez-Jimenez, Nathanael R Fillmore, Omonigho M Bubu, Moses Gonzalez, Luisa Figueredo, Naomi L Gaggi, Chelsea Reichert Plaska, Nunzio Pomara, Esther Blessing, Rebecca Betensky, Henry Rusinek, Henrik Zetterberg, Kaj Blennow, Lidia Glodzik, Thomas M Wisniewski, Mony J Leon, Ricardo S Osorio, Jaime Ramos-Cejudo
BACKGROUND: An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or a result of underlying comorbidities. Herein, we explored the relationship between the NLR and AD biomarkers in the cerebrospinal fluid (CSF) of cognitively unimpaired (CU) subjects...
March 14, 2024: Research Square
#22
JOURNAL ARTICLE
Asger Kirkeby-Hinrup
Understanding consciousness is central to understanding human nature. We have competing theories of consciousness. In interdisciplinary consciousness studies most believe that consciousness can be naturalized (i.e., consciousness depends in some substantial way on processes in - or states of - the brain). For roughly two decades, proponents of almost every theory have focused on collecting empirical support for their preferred theory, on the tacit assumption that empirical evidence will resolve the debates...
2024: Frontiers in Psychology
#23
JOURNAL ARTICLE
Zachary J Kastenberg, Scott S Short, Kimberly J Riehle, Alan Utria, Timothy B Lautz, Katherine C Ott, Andrew J Murphy, Sara Mansfield, Dave R Lal, Brian Hallis, Joseph T Murphy, Jonathan P Roach, Stephanie F Polites, Catherine Beckhorn, Elisabeth T Tracy, Elizabeth A Fialkowski, Natashia M Seemann, Andreana M Bütter, Barrie S Rich, Richard D Glick, Alex J Bondoc, Blessing S Ofori-Atta, Angela P Presson, Stephanie Y Chen, Abigail K Zamora, Eugene S Kim, Sanjeev Vasudevan, Hannah N Rinehardt, Marcus M Malek, Eveline Lapidus-Krol, Juan Putra, Riccardo A Superina, Max R Langham, Rebecka L Meyers, Greg Tiao, Roshni Dasgupta, Reto Baertschiger
BACKGROUND: Undifferentiated embryonal sarcoma of the liver (UESL) is a rare tumor for which there are few evidence-based guidelines. The aim of this study was to define current management strategies and outcomes for these patients using a multi-institutional dataset curated by the Pediatric Surgical Oncology Research Collaborative. METHODS: Data were collected retrospectively for patients with UESL treated across 17 children's hospitals in North America from 1989 to 2019...
March 31, 2024: Pediatric Blood & Cancer
#24
JOURNAL ARTICLE
Tope Michael Ipinnimo, Olanrewaju Kassim Olasehinde, Taofeek Adedayo Sanni, Ayodeji Andrew Omotoso, Rita Omobosola Alabi, Paul Oladapo Ajayi, Kayode Rasaq Adewoye, John Olujide Ojo, Olayinka Oloruntoba, Ademuyiwa Adetona, Mojoyinola Oyindamola Adeosun, Temitope Moronkeji Olanrewaju, Oluseyi Adedeji Aderinwale, Blessing Omobolanle Osho, Adewumi Rufus Fajugbagbe, Precious Aderinsola Adeyeye, Ayotomiwa Fiyinfoluwa Ajayi
BACKGROUND: Much previous research on exclusive breastfeeding has focused on urban and semi-urban communities, while there is still a paucity of data from rural areas. We assessed the attitude and practice of exclusive breastfeeding and its predictors among mothers attending the under-five welfare clinics in a rural community. METHODS: A cross-sectional study was conducted among consecutively recruited 217 mothers attending the three health facilities under-five welfare clinics in Ido-Ekiti, Southwest, Nigeria...
2024: PloS One
#25
REVIEW
Sibusiso Alven, Blessing Atim Aderibigbe
Bacterial infections are major problems in wound care due to their impact on the retarded process of wound healing, leading to chronic wounds. Most of the presently utilized wound dressing products exhibit poor antimicrobial properties. Wound dressings formulated from chitosan have been reported to be effective for treating infected wounds, resulting from the antibacterial properties of chitosan. The antibacterial properties of chitosan-based wound dressings can be further enhanced by incorporating metallic nanoparticles into them, such as silver, zinc, titanium, etc...
February 26, 2024: Pharmaceutics
#26
JOURNAL ARTICLE
Blessing O Adeleke, John M Kinuthia, Jonathan Oti, Duncan Pirrie, Matthew Power
The effective use of waste materials is one of the key drivers in ensuring sustainability within the construction industry. This paper investigates the viability and efficacy of sustainably incorporating a polylactic acid-type plastic (WP) as a 10 mm natural coarse aggregate (NA) replacement in geopolymer concrete. Two types of concrete (ordinary Portland cement-OPC and geopolymer) were produced for completeness using a concrete formulation ratio of 1:2:3. The ordinary concrete binder control was prepared using 100% OPC at a water/binder ratio of 0...
March 14, 2024: Materials
#27
JOURNAL ARTICLE
Egemen Savaskan, Dan Georgescu, Stefanie Becker, Brigitte Benkert, Andreas Blessing, Markus Bürge, Ansgar Felbecker, Martin Hatzinger, Ulrich Michael Hemmeter, Therese Hirsbrunner, Stefan Klöppel, Gabriela Latour Erlinger, Finn Jacob Lornsen, Theofanis Ngamsri, Jessica Peter, Mathias Schlögl, Marc Sollberger, Henk Verloo, Samuel Vögeli, Franziska Zúñiga
The «Recommendations for the Diagnosis and Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD)» were developed in parallel with the Swiss National Dementia Strategy 2014-2019 under the auspices of the Swiss Society for Geriatric Psychiatry and Psychotherapy (SGAP) and mark the beginning of a series of recommendations for geriatric psychiatric disorders. They depict the evidence-based state of knowledge about diagnostics and therapy, based on the clinical experience of the experts, and are designed for interprofessional and interdisciplinary use...
February 2024: Praxis
#28
Ana-Alicia Beltran-Bless, Mark Clemons, Lisa Vandermeer, Khaled El Emam, Terry L Ng, Sharon McGee, Arif Ali Awan, Gregory Pond, Julie Renaud, Gwen Barton, Brian Hutton, Marie-France Savard
Patients, families, healthcare providers and funders face multiple comparable treatment options without knowing which provides the best quality of care. As a step towards improving this, the REthinking Clinical Trials (REaCT) pragmatic trials program started in 2014 to break down many of the traditional barriers to performing clinical trials. However, until other innovative methodologies become widely used, the impact of this program will remain limited. These innovations include the incorporation of near equivalence analyses and the incorporation of artificial intelligence (AI) into clinical trial design...
March 6, 2024: Current Oncology
#29
JOURNAL ARTICLE
Arif Ali Awan, Deanna Saunders, Gregory Pond, Caroline Hamm, Nadia Califaretti, Mihaela Mates, Vikaash Kumar, Mohammed F K Ibrahim, Ana-Alicia Beltran-Bless, Lisa Vandermeer, John Hilton, Mark Clemons
For early-stage hormone receptor (HR)-positive and HER2-negative breast cancer, tools to estimate treatment benefit include free and publicly available algorithms (e.g., PREDICT 2.1) and expensive molecular assays (e.g., Oncotype DX). There remains a need to identify patients who de-rive the most benefit from molecular assays and where this test may be of poor value. In this multicenter prospective cohort study, we evaluated whether use of PREDICT 2.1 would impact physician decision making. For the first 6 months of the study, data on physician use of both PREDICT 2...
February 27, 2024: Current Oncology
#30
JOURNAL ARTICLE
Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova
Cellular debris resulting from large trauma might overwhelm the scavenger mechanisms and lead to autoimmune reactions. We analysed whether a major well-defined trauma in humans induces laboratory signs of transient autoimmunity in the months after the insult. We included 50 patients with pertrochanteric femur fracture undergoing intramedullary nail osteosynthesis in a prospective cohort study and followed them at 3-4 days, 6 weeks, 12 weeks and 12 months postoperatively. By standard techniques, we assessed levels of total immunoglobulins, anti-nuclear antibodies (ANA), anti-cardiolipin antibodies, anti-dsDNA antibodies and anti-C1q antibodies, as well as antibodies against cytomegalovirus (CMV) as a control...
March 25, 2024: Scandinavian Journal of Immunology
#31
EDITORIAL
Lorenzo Patrone, Edoardo Pasqui, Michael S Conte, Alik Farber, Roberto Ferraresi, Matthew Menard, Joseph L Mills, John Rundback, Peter Schneider, August Ysa, Kumar Abhishek, George L Adams, Naseer Ahmad, Irfan Ahmed, Vlad A Alexandrescu, Max Amor, David Alper, Martin Andrassy, Christopher Attinger, Andy Baadh, Hashem Barakat, Lukla Biasi, Theodosios Bisdas, Zagum Bhatti, Erwin Blessing, Marc P Bonaca, Stefano Bonvini, Michel Bosiers, Andrew W Bradbury, Robert Beasley, Christian-Alexander Behrendt, Marianne Brodmann, Gonzalo Cabral, Roberto Cancellieri, Andrea Casini, Venita Chandra, Emiliano Chisci, Omar Chohan, Edward T C Choke, Patrick F S Chong, Giacomo Clerici, Raphael Coscas, Mary Costantino, Luca Dalla Paola, Sabeen Dand, Robert S M Davies, Mario D'Oria, Athanasios Diamantopoulos, Sebastian Debus, Koen Deloose, Costantino Del Giudice, Gianmarco de Donato, Brian De Rubertis, Jean Paul De Vries, Nuno V Dias, Larry Diaz-Sandoval, Florian Dick, Konstantinos Donas, Anahita Dua, Fabrizio Fanelli, Stefano Fazzini, Mazin Foteh, Roberto Gandini, Mauro Gargiulo, Luca Garriboli, Elizabeth A Genovese, Edward Gifford, Yann Goueffic, Peter Goverde, Prem Chand Gupta, Robert Hinchliffe, Andrew Holden, Kim C Houlind, Dominic Pj Howard, Bella Huasen, Giacomo Isernia, Konstantinos Katsanos, Barry Katzen, Philippe Kolh, Igor Koncar, Grigorios Korosoglou, Prakash Krishnan, Thomas Kroencke, Miltiadis Krokidis, Arun Kumarasamy, Paul Hayes, Osamu Iida, Enrique Alejandre Lafont, Ralf Langhoff, Alexandre Lecis, Mark Lessne, Hady Lichaa, Michael Lichtenberg, Marta Lobato, Alice Lopes, Giorgio Loreni, Pierleone Lucatelli, Sreekumar Madassery, Lieven Maene, Marco Manzi, Martin Maresch, Jay Santhosh Mathews, James McCaslin, Antonio Micari, Stefano Michelagnoli, Bruno Migliara, Robert Morgan, Luis Morelli, Daniele Morosetti, Nicolas Mouawad, Paul Moxey, Stefan Müller-Hülsbeck, Jihad Mustapha, Tatsuya Nakama, Bahaa Nasr, Zola N'dandu, Richard Neville, Elias Noory, Joakim Nordanstig, Katariina Noronen, Luis Mariano Palena, Gianbattista Parlani, Ashish S Patel, Parag Patel, Rafiuddin Patel, Sanjay Patel, Costantino Pena, Drazen Perkov, Mark Portou, Giovanni Pratesi, Christos Rammos, Jim Reekers, Vicente Riambau, Trisha Roy, Kenneth Rosenfield, Maria Antonella Ruffino, Fadi Saab, Athanasios Saratzis, Paolo Sbarzaglia, Andrej Schmidt, Eric Secemsky, Michael Siah, Henrik Sillesen, Gioele Simonte, Marc Sirvent, Jill Sommerset, Sabine Steiner, Ahmed Sakr, Dierk Scheinert, Mehdi Shishebor, Stavros Spiliopoulos, Alessio Spinelli, Konstantinos Stravoulakis, Gergana Taneva, Desarom Teso, Joerg Tessarek, Selva Theivacumar, Anish Thomas, Shannon Thomas, Narayan Thulasidasan, Giovanni Torsello, Ramesh Tripathi, Nicola Troisi, Srini Tummala, Venkat Tummala, Christopher Twine, Raman Uberoi, Alessandro Ucci, Domenico Valenti, Jos van den Berg, Daniel van den Heuvel, Isabelle Van Herzeele, Ramon Varcoe, Melina Vega de Ceniga, Frank J Veith, Maarit Venermo, Badri Vijaynagar, Sanjiv Virdee, Conrad Von Stempel, Michiel T Voûte, Kak Khee Yeung, Thomas Zeller, Hany Zayed, Miguel Montero Baker
No abstract text is available yet for this article.
March 25, 2024: Journal of Endovascular Therapy
#32
JOURNAL ARTICLE
Richard E Brown
In the study of transgenic mouse models of neurodevelopmental and neurodegenerative disorders, we use batteries of tests to measure deficits in behaviour and from the results of these tests, we make inferences about the mental states of the mice that we interpret as deficits in "learning", "memory", "anxiety", "depression", etc. This paper discusses the problems of determining whether a particular transgenic mouse is a valid mouse model of disease X, the problem of background strains, and the question of whether our behavioural tests are measuring what we say they are...
March 21, 2024: Journal of Neuroscience Methods
#33
REVIEW
Andrew Nosakhare Amenaghawon, Joshua Efosa Ayere, Ubani Oluwaseun Amune, Ifechukwude Christopher Otuya, Emmanuel Christopher Abuga, Chinedu Lewis Anyalewechi, Oseweuba Valentine Okoro, Jude A Okolie, Peter Kayode Oyefolu, Steve Oshiokhai Eshiemogie, Blessing Esohe Osahon, Melissa Omede, Stanley Aimhanesi Eshiemogie, Shedrach Igemhokhai, Maxwell Ogaga Okedi, Heri Septya Kusuma, Obiora Ebuka Muojama, Amin Shavandi, Handoko Darmokoesoemo
Organic acids are important compounds with numerous applications in different industries. This work presents a comprehensive review of the biological synthesis of oxalic acid, an important organic acid with many industrial applications. Due to its important applications in pharmaceuticals, textiles, metal recovery, and chemical and metallurgical industries, the global demand for oxalic acid has increased. As a result, there is an increasing need to develop more environmentally friendly and economically attractive alternatives to chemical synthesis methods, which has led to an increased focus on microbial fermentation processes...
March 20, 2024: Environmental Research
#34
JOURNAL ARTICLE
Daniel Wm-Bekele, GirmaTilahun, Elias Dadebo, Amare Haileslassie, Zinabu Gebremariam
Currently, pesticide production and use are on the rise globally. This trend is certain to continue in the coming decades with residues posing risks to the environment and human health even at low levels. Although various aspects of pesticides and their possible implications have widely been studied, such studies have mostly been carried out in developed countries leaving the rest of the world with little scientific information. We present here the results of a study on the occurrences, concentrations, and ecological risks of 30 pesticide residues (PRs) in water and sediment samples from a tropical freshwater Lake Hawassa in the Ethiopian Rift Valley...
March 22, 2024: Environmental Science and Pollution Research International
#35
JOURNAL ARTICLE
Kade Wagers, Blessing S Ofori-Atta, William Tucker, Angela P Presson, Devon Nixon
BACKGROUND: Increasing attention is being paid to the costs associated with various orthopaedic surgeries. Here, we studied the factors that influence costs associated with surgically treated acute Achilles tendon tears. METHODS: We retrospectively identified patients with surgically repaired acute Achilles tendon tears, excluding insertional ruptures or chronic tendon issues. Using the Value Driven Outcome (VDO) tool from our institution, we assessed total direct costs as well as facility costs...
January 2024: Foot & ankle orthopaedics
#36
JOURNAL ARTICLE
Sherry-Ann Brown, Rodney Sparapani, Kristen Osinski, Jun Zhang, Jeffrey Blessing, Feixiong Cheng, Abdulaziz Hamid, Mehri Bagheri MohamadiPour, Jessica Castrillon Lal, Anai N Kothari, Pedro Caraballo, Peter Noseworthy, Roger H Johnson, Kathryn Hansen, Louise Y Sun, Bradley Crotty, Yee Chung Cheng, Gift Echefu, Krishna Doshi, Jessica Olson
Interdisciplinary research teams can be extremely beneficial when addressing difficult clinical problems. The incorporation of conceptual and methodological strategies from a variety of research disciplines and health professions yields transformative results. In this setting, the long-term goal of team science is to improve patient care, with emphasis on population health outcomes. However, team principles necessary for effective research teams are rarely taught in health professional schools. To form successful interdisciplinary research teams in cardio-oncology and beyond, guiding principles and organizational recommendations are necessary...
August 2023: American heart journal plus: cardiology research and practice
#37
JOURNAL ARTICLE
Michael Joner, Léa Wild
No abstract text is available yet for this article.
March 18, 2024: EuroIntervention
#38
JOURNAL ARTICLE
Abolade A Oyelade, Odion O Ikhimiukor, Blessing I Nwadike, Obasola E Fagade, Olawale O Adelowo
The role of recreational water use in the acquisition and transmission of antimicrobial resistance (AMR) is under-explored in low- and middle-income countries (LMICs). We used whole genome sequence analysis to provide insights into the resistomes, mobilomes and virulomes of 14 beta-lactams resistant Enterobacterales isolated from water and wet-sand at four recreational beaches in Lagos, Nigeria. Carriage of multiple beta-lactamase genes was detected in all isolates except two, including six isolates carrying blaNDM-1 ...
March 15, 2024: International Journal of Hygiene and Environmental Health
#39
JOURNAL ARTICLE
Xu Zhang, Yaqian Wang, Yuanyuan Chen, Hailing Yang, Xiaorong Luan
AIMS: During the COVID-19 epidemic, nurses played a crucial role in clinical treatment. As a special group, front-line nurses, especially those assigned to support Hubei Province in the fight against COVID-19 between February and April 2020, brought diverse experiences from different provinces in China in taking care of COVID-19 patients and role cognition. Therefore, our purpose is to explore the real coping experience and role cognition of front-line nurses during the novel coronavirus outbreak to provide relevant experience references for society and managers in the face of such major public health emergencies in the future...
2024: Frontiers in Psychology
#40
JOURNAL ARTICLE
Michael Gold, Susan Taylor, Daniel S Mueller, Jeffrey Adelglass, Joely Kaufman-Janette, Sue E Cox, Michael Cecerle, Konstantin Frank, Mark Nestor
BACKGROUND: Botulinum toxin type A (BoNT-A) injections continue to be widely used as a common treatment for both males and females. According to a recent survey conducted by the International Society of Plastic Aesthetic Surgeons, the majority of patients receiving these injections are females between the ages 35 and 50. OBJECTIVES: A post hoc analysis was conducted to examine whether there were variances in the effectiveness and safety of letibotulinumtoxinA for treating vertical glabellar lines between the broader female study population and a particularly defined group of female participants aged 35 to 50...
2024: Aesthetic surgery journal. Open forum
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