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https://www.readbyqxmd.com/read/30334234/hiv-treatment-cascade-by-housing-status-at-enrollment-results-from-a-retention-in-care-cohort
#1
Mary Hawk, Catherine Maulsby, Blessing Enobun, Suzanne Kinsky
Though housing instability is linked to poor HIV health outcomes, studies that assess the HIV treatment cascade by housing status are limited. Using data from a multi-site Retention in Care initiative we constructed HIV treatment cascades for participants (n = 463) of five grantee sites. We found no significant differences in viral suppression at follow-up among participants who were unstably housed at enrollment (49%) as compared to those who were stably housed at enrollment (54%). Among participants with available data at 6- or 12-month follow-up, 94% were engaged in care, 90% were retained in, 94% were on ART, and 71% had suppressed viral load...
October 17, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/30332564/genomic-analysis-of-lassa-virus-during-an-increase-in-cases-in-nigeria-in-2018
#2
Katherine J Siddle, Philomena Eromon, Kayla G Barnes, Samar Mehta, Judith U Oguzie, Ikponmwosa Odia, Stephen F Schaffner, Sarah M Winnicki, Rickey R Shah, James Qu, Shirlee Wohl, Patrick Brehio, Christopher Iruolagbe, John Aiyepada, Eghosa Uyigue, Patience Akhilomen, Grace Okonofua, Simon Ye, Tolulope Kayode, Fehintola Ajogbasile, Jessica Uwanibe, Amy Gaye, Mambu Momoh, Bridget Chak, Dylan Kotliar, Amber Carter, Adrianne Gladden-Young, Catherine A Freije, Omigie Omoregie, Blessing Osiemi, Ekene B Muoebonam, Michael Airende, Rachael Enigbe, Benevolence Ebo, Iguosadolo Nosamiefan, Paul Oluniyi, Mahan Nekoui, Ephraim Ogbaini-Emovon, Robert F Garry, Kristian G Andersen, Daniel J Park, Nathan L Yozwiak, George Akpede, Chikwe Ihekweazu, Oyewale Tomori, Sylvanus Okogbenin, Onikepe A Folarin, Peter O Okokhere, Bronwyn L MacInnis, Pardis C Sabeti, Christian T Happi
During 2018, an unusual increase in Lassa fever cases occurred in Nigeria, raising concern among national and international public health agencies. We analyzed 220 Lassa virus genomes from infected patients, including 129 from the 2017-2018 transmission season, to understand the viral populations underpinning the increase. A total of 14 initial genomes from 2018 samples were generated at Redeemer's University in Nigeria, and the findings were shared with the Nigerian Center for Disease Control in real time...
October 17, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30311068/the-characteristics-of-all-terrain-vehicle-atv-related-deaths-a-forensic-autopsy-data-based-study
#3
Peter T Lin, Melissa M Blessing
Using forensic autopsy-based data from a regional medical examiner office in the midwestern U.S. with a mixed small urban-rural population, we describe the characteristics of all-terrain vehicle (ATV)-related deaths occurring between 2000 and 2018. During this period, there were 25 ATV-related deaths. There was a strong male predominance with 22 male and 3 female decedents. The average age at death was 35 years, with a range from 10 to 82 years, and a bimodal age distribution with one peak at 10-19 years old, and a second peak at 60-69 years old...
October 11, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/30309886/the-central-region-of-cnot1-and-cnot9-stimulate-deadenylation-by-the-ccr4-not-nuclease-module
#4
Lorenzo Pavanello, Benjamin Hall, Blessing Airhihen, Gerlof Sebastiaan Winkler
Regulated degradation of cytoplasmic mRNA is important for the accurate execution of gene expression programmes in eukaryotic cells. A key step in this process is the shortening and removal of the mRNA poly(A) tail, which can be achieved by the recruitment of the multi-subunit Ccr4-Not nuclease complex via sequence-specific RNA binding proteins or the microRNA machinery. The Ccr4-Not complex contains several modules that are attached to its large subunit CNOT1. Modules include the nuclease module, which associates with the MIF4G domain of CNOT1 and contains the catalytic subunits Caf1 and Ccr4, as well as the module containing the non-catalytic CNOT9 subunit, which binds to the DUF3819 domain of CNOT1...
October 11, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/30303948/human-immunodeficiency-virus-serodiscordance-and-dual-contraceptive-method-use-among-human-immunodeficiency-virus-infected-men-and-women-in-lilongwe-malawi
#5
Blessings Gausi, Maganizo B Chagomerana, Jennifer H Tang, Mina C Hosseinipour, Lisa B Haddad, Tweya Hannock, Sam Phiri
BACKGROUND: Some human immunodeficiency virus (HIV) serodiscordant couples are faced with the dual challenge of preventing HIV transmission to the uninfected partner and avoiding unintended pregnancy. Therefore, we hypothesized that serodiscordance is associated with dual method use at last sex. METHODS: We analyzed data from a cross-sectional survey of HIV-infected men and women attending 2 ante-retroviral therapy clinics in Lilongwe, Malawi. We used Fisher exact test and Wilcoxon rank sum to assess for associations between serodiscordance, covariates, and dual method use...
November 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/30303818/recurrent-genomic-alterations-in-soft-tissue-perineuriomas
#6
Jodi M Carter, Yanhong Wu, Melissa M Blessing, Andrew L Folpe, Erik C Thorland, Robert J Spinner, Mark E Jentoft, Chen Wang, Saurabh Baheti, Zhiyv Niu, Michelle L Mauermann, Christopher J Klein
Perineuriomas are rare nerve sheath tumors, divided into intraneural and extraneural (soft tissue) types. Intraneural perineuriomas frequently contain TRAF7 mutations, and rarely, chr22q12 deletions. While chr22q losses can occur in soft tissue perineuriomas, comprehensive high-resolution molecular profiling has not been reported in these tumors and TRAF7 status is unknown. We used whole-exome sequencing and OncoScan single nucleotide polymorphism (SNP) array to evaluate 14 soft tissue perineuriomas. Thirteen cases showed 2 or more chromosomal abnormalities, composed primarily of large deletions...
October 9, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30303551/is-this-the-last-requiem-for-simtuzumab-blessed-is-who-expects-nothing-for-he-shall-never-be-disappointed-alexander-pope
#7
EDITORIAL
Peter Fickert
In modern hepatology we sing the song for the advent of effective antifibrotic drugs for decades recalling the line of a masterpiece song of the late Leonard Cohen "a million candles burning for the help that never came". We realize but hardly accept that most likely such drugs will not work without resolving the causative problem of a liver disease such as in viral hepatitis. In liver diseases with so far unknown etiology as in primary sclerosing cholangitis (PSC), the task of successful antifibrotic treatment will even harder be pursued...
October 10, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30302246/prevalence-of-helicobacter-pylori-in-asymptomatic-patients-at-surgical-outpatient-department-harare-hospitals
#8
Simbarashe Gift Mungazi, Onesai Blessing Chihaka, Godfrey I Muguti
Background: Helicobacter pylori infection is present in more than 50% of the world's population. The estimated life time risk of peptic ulcer disease is 20 percent and of gastric cancer is 1-2 percent. Materials and methods: A cross sectional study was done at two Central hospitals in Harare, Zimbabwe, with the objective being to estimate the prevalence of Helicobacter pylori infection in asymptomatic individuals. Other objectives were to determine the association of the Helicobacter pylori infection with potential risk factors...
November 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30302245/factors-during-training-which-predict-future-use-of-minimally-invasive-thoracic-surgery
#9
Paul E Rothenberg, Byron D Hughes, Farshad Amirkhosravi, Bless P Onaiwu, Ikenna C Okereke
Background: While minimally invasive thoracic surgery (MIS) has increased nationwide over the years, most patients undergoing lung and esophageal resections still undergo an open approach. We performed a national survey to analyze factors associated with a propensity to perform MIS after completing a cardiothoracic training program. Materials and methods: Cardiothoracic surgery trainees in 2 or 3-year programs from 2010 to 2016 were sent an online survey regarding the numbers and types of cases performed during training and current practice patterns as attending surgeons...
November 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30300794/dietary-co-exposure-to-methylmercury-and-monosodium-glutamate-disrupts-cellular-and-behavioral-responses-in-the-lobster-cockroach-nauphoeta-cinerea-model
#10
Blessing A Afolabi, Isaac A Adedara, Diogo O Souza, João B T Rocha
The present study aims to investigate the effect of monosodium glutamate (MSG) both separately and combined with a low dose of methylmercury (MeHg) on behavioral and biochemical parameters in Nauphoeta cinerea (lobster cockroach). Cockroaches were fed with the basal diet alone, basal diet + 2% NaCl, basal diet + 2% MSG; basal diet + 0.125 mg/g MeHg, basal diet + 0.125 mg/g MeHg + 2% NaCl; and basal diet + 0.125 mg/g MeHg + 2% MSG for 21 days. Behavioral parameters such as distance traveled, immobility and turn angle were automatically measured using ANY-maze video tracking software (Stoelting, CO, USA)...
September 16, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/30293634/assessing-outpatient-follow-up-care-compliance-complications-and-sequelae-in-children-hospitalized-for-isolated-traumatic-abdominal-injuries
#11
Blessing Ogbemudia, Jodi Raymond, LaRanna S Hatcher, Ashley N Vetor, Thomas Rouse, Aaron E Carroll, Teresa M Bell
BACKGROUND: Currently there is limited knowledge on compliance with follow-up care in pediatric patients after abdominal trauma. The Indiana Network for Patient Care (INPC) is a large regional health information exchange with both structured clinical data (e.g., diagnosis codes) and unstructured data (e.g., provider notes). The objective of this study is to determine if regional health information exchanges can be used to evaluate whether patients receive all follow-up care recommended by providers...
September 21, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30284896/henry-gleitman-1925-2015
#12
Paul Rozin
Presents an obituary of Henry Gleitman (1925-2015). Gleitman was an author of major papers in animal learning, memory, theater, and the psychology of language, including one book with Lila Gleitman ( Phrase and Paraphrase , 1970). Gleitman was among the very best teachers in the history of psychology. He taught introductory psychology about 100 times, engaging the minds of some 30,000 students, each exposed to his enlightening, expansive, and entertaining synthesis of psychology. Gleitman came to the University of Pennsylvania in 1964 as Professor and Chair of Psychology...
October 2018: American Psychologist
https://www.readbyqxmd.com/read/30281781/atrial-fibrillation-possible-influences-of-rate-and-rhythm-control-strategy-on-cognitive-performance
#13
Sarah Damanti, Luca Pasina, Laura Cortesi, Paolo D Rossi, Matteo Cesari
OBJECTIVES: To determine whether rate or rhythm control strategy may affect cognition in older adults with atrial fibrillation (AF). DESIGN: Retrospective analysis of the REgistro POliterapie SIMI database. SETTING: Italian internal medicine and geriatric wards. PARTICIPANTS: Individuals aged 65 and older (N=1,082, mean age 80.6 ± 7; 50% male) with AF before hospital admission (for any cause). MEASUREMENTS: Evaluation of cognitive performance using the Short Blessed Test (SBT) according to rhythm and rate control strategy, anticoagulant and antiplatelet therapy, age, education, and comorbidities...
October 3, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/30281727/elementary-and-lower-secondary-school-students-perceptions-of-the-health-at-school-programme-a-case-study-in-belo-horizonte-brazil
#14
Fernanda Piana Santos Lima de Oliveira, Andrea Maria Duarte Vargas, Zulmira Hartz, Sônia Dias, Efigênia Ferreira E Ferreira
The Health at School Programme is a Brazilian inter-sector policy resulting from a partnership between the Ministries of Health and Education to expand health actions to public school students, with a view to the comprehensive education of primary and lower middle school students. This qualitative study was carried out in 2016 to investigate Brazilian schoolchildren's perceptions of activities under the Health at School Programme. Data were collected from schoolchildren eleven to fourteen years of age using the written report (essay) as the instrument...
September 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/30280986/a-woman-s-status-and-prenatal-care-utilization-in-patrilocal-households-of-post-soviet-countries
#15
Jildyz Urbaeva, Eunju Lee
Women's household autonomy is associated with maternal healthcare utilization in developing countries, but its effects are not consistently positive. In the current study, the researchers test prenatal care utilization in Armenia and Azerbaijan (N = 2,159). After controlling for socioeconomic factors, we find that women's autonomy seems to be a mixed blessing. For instance, participating in daily purchases delays the start of prenatal care, but results in more prenatal care visits. Additionally, a woman's household position as a daughter-in-law has significant negative associations with accessing prenatal care during the first trimester of pregnancy...
October 3, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/30279405/polymeric-nanocarriers-for-the-delivery-of-antimalarials
#16
REVIEW
Zandile Mhlwatika, Blessing Atim Aderibigbe
Malaria is an infectious disease caused by a protozoan parasite which is transmitted by female Anopheles mosquitoes around tropical and sub-tropical regions. Half of the world's population is at risk of being infected by malaria. This mainly includes children, pregnant women and people living with chronic diseases. The main factor that has contributed to the spread of this disease is the increase in the number of drug-resistant parasites. To overcome drug resistance, researchers have developed drug delivery systems from biodegradable polymers for the loading of antimalarials...
October 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30275602/-mirror-of-patients-a-reflection-on-the-honor-of-serving-as-a-male-obstetrician-gynecologist
#17
Jonathan D Scrafford
Physicians' work challenges them to learn and grow from their experiences with patients. Male obstetrician-gynecologists are uniquely blessed and challenged by their experiences in women's health care. The following is a reflection by one male obstetrician-gynecologist who considers the role of Saint Joseph in the holy family in contemplating his own role in providing women's health care. Summary: One hundred twenty-five men who underwent therapy trying to change sexual orientation from homosexual to heterosexual were asked about negative and positive experiences...
August 2018: Linacre Quarterly
https://www.readbyqxmd.com/read/30273369/pharmacogenetic-variation-influences-sensory-neuropathy-occurrence-in-southern-africans-treated-with-stavudine-containing-antiretroviral-therapy
#18
Marvin Blessings Moketla, Antonia L Wadley, Peter Kamerman, Debra de Assis Rosa
BACKGROUND: The use of the HIV antiretroviral drug stavudine (d4T), a thymidine analogue, is associated with the development of mitochondrial toxicities such as sensory neuropathy (SN). Genetic variation in genes relating to d4T transport and metabolism, as well as genetic variation in the thymidine synthesis pathway, could influence occurrence of d4T-related toxicity. METHODS: We examined this hypothesis in a cohort of HIV-positive South African adults exposed to d4T, including 143 cases with SN and 120 controls without SN...
2018: PloS One
https://www.readbyqxmd.com/read/30267251/it-s-a-battle-and-a-blessing-the-experience-and-needs-of-custodial-grandparents-of-children-with-autism-spectrum-disorder
#19
Jennifer L Hillman, Connie M Anderson
We know little about custodial grandparents of children with autism spectrum disorder (ASD) who offer a vital social safety net. 117 custodial grandparents of children with ASD from 37 states completed an online survey with open-ended questions about their "greatest challenges and joys" as grandparent. Grounded theory analysis revealed four categories of experience (Issues with Adult Children, Caregiving Burden, Coping, & Wisdom) explained by 15 themes. Grandparents' stressors encompassed custody issues, ASD problem behaviors like tantrums and eloping, insufficient ASD services, financial burden, 24/7 caregiving demands, social isolation, and fears for the future...
September 28, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/30264146/characteristics-of-spontaneous-spinal-cord-infarction-and-proposed-diagnostic-criteria
#20
Nicholas L Zalewski, Alejandro A Rabinstein, Karl N Krecke, Robert D Brown, Eelco F M Wijdicks, Brian G Weinshenker, Timothy J Kaufmann, Jonathan M Morris, Allen J Aksamit, J D Bartleson, Giuseppe Lanzino, Melissa M Blessing, Eoin P Flanagan
Importance: Spinal cord infarction (SCI) is often disabling, and the diagnosis can be challenging without an inciting event (eg, aortic surgery). Patients with a spontaneous SCI are often misdiagnosed as having transverse myelitis. Diagnostic criteria for SCI are lacking, hindering clinical care and research. Objective: To describe the characteristics of spontaneous SCI and propose diagnostic criteria. Design, Setting, and Participants: An institution-based search tool was used to identify patients evaluated at Mayo Clinic, Rochester, Minnesota, from January 1997 to December 2017 with a spontaneous SCI...
September 24, 2018: JAMA Neurology
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