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Myriam V Thoma, Simon Forstmeier, Roger Schmid, Oliver Kellner, Franziskos Xepapadakos, Ursula Schreiter Gasser, Andreas Blessing, Axel Ropohl, Gabriela Bieri-Brüning, Dries Debeer, Andreas Maercker
BACKGROUND: Motivational abilities (MA), that describe skills in relation to goal-oriented behavior, have recently been found to be associated with neuropathological aging. Here we examine the impact of MA on the long-term course of mild cognitive impairment (MCI). METHODS: We followed-up N = 64 individuals diagnosed with MCI (Mage  = 73 years, 44% female) for 3 years. MA were assessed by long-term informants of the participants using two scales: motivation and decision regulation [Volitional Components Questionnaires, VCQ, (Kuhl and Fuhrmann, Decomposing self-regulation and self-control: the volitional components inventory, 1998)]...
August 13, 2018: BMC Geriatrics
Annabella Osei-Tutu, Vivian Afi Dzokoto, Glenn Adams, Katja Hanke, Charlotte Kwakye-Nuako, Francis Adu-Mensa, Rita Appiah-Danquah
The purpose of the study was to explore the extent to which contemporary social, economic, and religious developments inform social constructions of success in Ghana. Participants, consisting of 21 females and 39 males, aged between 20 and 70, from different educational and occupational backgrounds were interviewed about what they consider as success. Participants belonged to either Traditionally Western Mission Churches or Charismatic Christian denominations and were selected from three regions of Ghana. Thematic analysis revealed four dimensions of success: (1) Social (including marriage, children, social recognition, and social contribution to society); (2) Material (comprising meeting basic needs; economic independence; material wealth); (3) Educational; and (4) Religious (e...
July 2018: Heliyon
Chidiebere C Eluke, Blessing C Eluke, Ndidiamaka I Okereke, Chukwugozie Okwuosa, Silas Ufelle
Ahaptoglobinaemia have been indicated in blacks from West Africa. Owing to the clinical and biologicimportance of haptoglobin (hpt), this work explores the situation in a Nigerian cohort since there are no published values ofhaptoglobin levels of individuals in this locality. The study was aimed at determining the amount of haptoglobin in the bloodof normal healthy Nigerians. Haptoglobin was quantitatively estimated in one hundred and fifty-two apparently healthyindividuals using highly sensitive immunoassay technology...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
Ying Yang, Haiyan Zhao, Ma Aidi, Yu Kou
BACKGROUND: Studies have found lower well-being among prisoners than in the general population. Positive psychological interventions provide fruitful ways of enhancing people's well-being, but little is known about whether these contribute to prisoners' well-being. AIMS: To test the effects of two typical positive psychological interventions - kindness and gratitude - on Chinese prisoners' well-being. METHODS: One hundred and forty-four participants were randomly assigned to three conditions: kindness or gratitude groups in addition to 'treatment as usual' and a control condition of treatment as usual alone, with 48 men in each condition...
July 27, 2018: Criminal Behaviour and Mental Health: CBMH
Alanna C Green, Victoria Rudolph-Stringer, Lenny Straszkowski, Gavin Tjin, Blessing Crimeen-Irwin, Mannu Walia, T John Martin, Natalie A Sims, Louise E Purton
Retinoic acid receptor (RAR) signaling regulates bone structure and hematopoiesis through intrinsic and extrinsic mechanisms. This study aimed to establish how early in the osteoblast lineage loss of RARγ (Rarg) disrupts the bone marrow microenvironment. Bone structure was analyzed by micro-computed tomography (μCT) in Rarg-/- mice and mice with Rarg conditional deletion in Osterix-Cre-targeted osteoblast progenitors or Prrx1-Cre-targeted mesenchymal stem cells. Rarg-/- tibias exhibited less trabecular and cortical bone and impaired longitudinal and radial growth...
July 24, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Lena Vogel, Dwi Seno Kuncoro Sihono, Christel Weiss, Frank Lohr, Florian Stieler, Hansjörg Wertz, Sandra von Swietochowski, Anna Simeonova-Chergou, Frederik Wenz, Manuel Blessing, Judit Boda-Heggemann
BACKGROUND AND PURPOSE: Craniocaudal motion during image-guided abdominal SBRT can be reduced by computer-controlled deep-inspiratory-breath-hold (DIBH). However, a residual motion can occur in the DIBH-phases which can only be detected with intrafractional real-time-monitoring. We assessed the intra-breath-hold residual motion of DIBH and compared residual motion of target structures during DIBH detected by ultrasound (US). US data were compared with residual motion of the diaphragm-dome (DD) detected in the DIBH-CBCT-projections...
July 19, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Anna Bruk, Sabine G Scholl, Herbert Bless
Confessing romantic feelings, asking for help, or taking responsibility for a mistake constitute just a few examples of situations that require showing one's vulnerability. Out of fear, many individuals decide against it. To explore whether these fears are reflected in the evaluation of others, we investigate self-other differences in evaluation of showing vulnerability. Drawing on construal level theory, we hypothesize that the mental representations of individuals who find themselves in a vulnerable situation are rather concrete, shifting the focus on the negative aspects of making oneself vulnerable and resulting in a relatively negative evaluation of showing vulnerability...
August 2018: Journal of Personality and Social Psychology
Temidayo Olutayo Omóbòwálé, Ademola Adetokunbo Oyagbemi, Blessing Seun Ogunpolu, Olufunke Eunice Ola-Davies, Johnny Olufemi Olukunle, Ebunoluwa Racheal Asenuga, Temitayo Olabisi Ajibade, Olumuyiwa Abiola Adejumobi, Jeremiah Moyinoluwa Afolabi, Olufunke Olubunmi Falayi, Anofi Ashafa, Adeolu Alex Adedapo, Momoh Audu Yakubu
No abstract text is available yet for this article.
July 18, 2018: Drug Research
Yuhui Lin
Damage accumulation is widely accepted as the central dogma of ageing, and it has been a long-standing belief that tobacco smokers must experience a faster rate of ageing than non-smokers. It is therefore puzzling as to why proportional hazard model is a popular choice in longitudinal studies given that its assumption assumes a constant hazard with increasing time. If the rate of ageing is accelerated, the hazard gradient of smokers d(log(μ(x)))/dx obtained from frailty parametric fit has to be steeper than non-smokers...
July 17, 2018: Scientific Reports
Melissa R Mazan
The airways are the first part of the pathway in the oxygen transport chain that is critical to excellent athletic performance, and the lower airways are considered the final gatekeeper before oxygen enters the blood and carbon dioxide exits. Horses are blessed with large airways and lungs that allow them to be superb athletes, but the down side of this largesse on the part of evolution is that unless they are truly elite athletes they may withstand noninfectious disease of the lower respiratory tract for months to years before the owner or trainer notices...
August 2018: Veterinary Clinics of North America. Equine Practice
Cheng Luo, Blessing Gwekwe, Phares Choto, Wenhua Miao, Meiling Chen, Changfeng Xue, Yunsheng Xu, Xiaolong Yin, Glory Magawa, Di Wu, Jamal S Akida, Likui Wang, Qingqing Li, Shanggui Deng
The large yellow croakers (Larimichthys crocea) are mainly present in the Chinese coast and near seas with high economic importance, but vulnerable to many diseases, especially in the breeding and aquaculture. The purpose of this research was to boost the innate immune system of the large yellow croaker by administering bitter peptides into their peritoneal cavity. Total 120 Juvenile of large yellow croakers in very even weight of 60 g were divided into 4 different groups in 200/300 L of water tank, respectively...
July 10, 2018: Fish & Shellfish Immunology
Sarah Svege, Blessings Kaunda, Bjarne Robberstad, Thandile Nkosi-Gondwe, Kamija S Phiri, Siri Lange
BACKGROUND: In malaria endemic countries of sub-Saharan Africa, many children develop severe anaemia due to previous and current malaria infections. After blood transfusions and antimalarial treatment at the hospital they are usually discharged without any follow-up. In the post-discharge period, these children may contract new malaria infections and develop rebound severe anaemia. A randomised placebo-controlled trial in Malawi showed 31% reduction in malaria- and anaemia-related deaths or hospital readmissions among children under 5 years of age given antimalarial drugs for 3 months post-discharge...
July 11, 2018: BMC Health Services Research
Funmilayo I D Afolayan, Blessing Erinwusi, Oyetunde T Oyeyemi
Background: Studies have shown that curcumin from Curcuma longa has a wide range of medicinal and immunomodulatory properties. These activities have, however, been hindered by its low bioavailability. Meanwhile, incorporation of nanoparticles has been shown to increase bioavailability of certain drugs. This study was, therefore, conducted to comparatively evaluate the immunomodulatory activity of free and nanoparticulate curcumin in mice. Methods: Healthy albino mice were sensitized with sheep red blood cells (SRBCs) and thereafter free and nanoparticulate curcumin were administered orally at doses of 5 mg/kg/day and 10 mg/kg/day for 10 days to the mice...
June 2018: Integrative Medicine Research
Takondwa Zuze, Matthew S Painschab, Ryan Seguin, Evarista Kudowa, Bongani Kaimila, Edwards Kasonkanji, Tamiwe Tomoka, Bal Mukunda Dhungel, Maurice Mulenga, Maria Chikasema, Blessings Tewete, Asekanadziwa Ntangwanika, Sarah Chiyoyola, Fred Chimzimu, Coxcilly Kampani, Robert Krysiak, Nathan D Montgomery, Yuri Fedoriw, Satish Gopal
Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26-71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24-79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIV-negative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA...
2018: Infectious Agents and Cancer
Pramesh Raj Ghimire, Kingsley E Agho, Blessing J Akombi, Nidhi Wali, Michael Dibley, Camille Raynes-Greenow, Andre M N Renzaho
BACKGROUND: This study aimed to systematically review observational studies on perinatal mortality in South Asia. METHODS: This review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Five computerized bibliographic databases: MEDLINE, CINAHL, Embase, PsycINFO, and Scopus were searched for published studies which reported factors associated with perinatal mortality in South Asia from 1 January 2000 to 20 March 2018...
July 6, 2018: International Journal of Environmental Research and Public Health
Argonde C van Harten, Michelle M Mielke, Dana M Swenson-Dravis, Clinton E Hagen, Kelly K Edwards, Rosebud O Roberts, Yonas E Geda, David S Knopman, Ronald C Petersen
OBJECTIVE: We investigated different dimensions of subjective cognitive decline (SCD) to determine which was the best prognostic risk factor for incident mild cognitive impairment (MCI) among cognitively unimpaired participants. METHODS: We included 1,167 cognitively unimpaired participants, aged 70 to 95 years, from the Mayo Clinic Study of Aging based on 2 concurrent SCD scales (part of the Blessed memory test and the 39-item Everyday Cognition [ECog] scale, which included a validated 12-item derivative) and a single question assessing worry about cognitive decline...
July 24, 2018: Neurology
V M Abazov, B Abbott, B S Acharya, M Adams, T Adams, J P Agnew, G D Alexeev, G Alkhazov, A Alton, A Askew, S Atkins, K Augsten, V Aushev, Y Aushev, C Avila, F Badaud, L Bagby, B Baldin, D V Bandurin, S Banerjee, E Barberis, P Baringer, J F Bartlett, U Bassler, V Bazterra, A Bean, M Begalli, L Bellantoni, S B Beri, G Bernardi, R Bernhard, I Bertram, M Besançon, R Beuselinck, P C Bhat, S Bhatia, V Bhatnagar, G Blazey, S Blessing, K Bloom, A Boehnlein, D Boline, E E Boos, G Borissov, M Borysova, A Brandt, O Brandt, M Brochmann, R Brock, A Bross, D Brown, X B Bu, M Buehler, V Buescher, V Bunichev, S Burdin, C P Buszello, E Camacho-Pérez, B C K Casey, H Castilla-Valdez, S Caughron, S Chakrabarti, K M Chan, A Chandra, E Chapon, G Chen, S W Cho, S Choi, B Choudhary, S Cihangir, D Claes, J Clutter, M Cooke, W E Cooper, M Corcoran, F Couderc, M-C Cousinou, J Cuth, D Cutts, A Das, G Davies, S J de Jong, E De La Cruz-Burelo, F Déliot, R Demina, D Denisov, S P Denisov, S Desai, C Deterre, K DeVaughan, H T Diehl, M Diesburg, P F Ding, A Dominguez, A Drutskoy, A Dubey, L V Dudko, A Duperrin, S Dutt, M Eads, D Edmunds, J Ellison, V D Elvira, Y Enari, H Evans, A Evdokimov, V N Evdokimov, A Fauré, L Feng, T Ferbel, F Fiedler, F Filthaut, W Fisher, H E Fisk, M Fortner, H Fox, J Franc, S Fuess, P H Garbincius, A Garcia-Bellido, J A García-González, V Gavrilov, W Geng, C E Gerber, Y Gershtein, G Ginther, O Gogota, G Golovanov, P D Grannis, S Greder, H Greenlee, G Grenier, Ph Gris, J-F Grivaz, A Grohsjean, S Grünendahl, M W Grünewald, T Guillemin, G Gutierrez, P Gutierrez, J Haley, L Han, K Harder, A Harel, J M Hauptman, J Hays, T Head, T Hebbeker, D Hedin, H Hegab, A P Heinson, U Heintz, C Hensel, I Heredia-De La Cruz, K Herner, G Hesketh, M D Hildreth, R Hirosky, T Hoang, J D Hobbs, B Hoeneisen, J Hogan, M Hohlfeld, J L Holzbauer, I Howley, Z Hubacek, V Hynek, I Iashvili, Y Ilchenko, R Illingworth, A S Ito, S Jabeen, M Jaffré, A Jayasinghe, M S Jeong, R Jesik, P Jiang, K Johns, E Johnson, M Johnson, A Jonckheere, P Jonsson, J Joshi, A W Jung, A Juste, E Kajfasz, D Karmanov, I Katsanos, M Kaur, R Kehoe, S Kermiche, N Khalatyan, A Khanov, A Kharchilava, Y N Kharzheev, I Kiselevich, J M Kohli, A V Kozelov, J Kraus, A Kumar, A Kupco, T Kurča, V A Kuzmin, S Lammers, P Lebrun, H S Lee, S W Lee, W M Lee, X Lei, J Lellouch, D Li, H Li, L Li, Q Z Li, J K Lim, D Lincoln, J Linnemann, V V Lipaev, R Lipton, H Liu, Y Liu, A Lobodenko, M Lokajicek, R Lopes de Sa, R Luna-Garcia, A L Lyon, A K A Maciel, R Madar, R Magaña-Villalba, S Malik, V L Malyshev, J Mansour, J Martínez-Ortega, R McCarthy, C L McGivern, M M Meijer, A Melnitchouk, D Menezes, P G Mercadante, M Merkin, A Meyer, J Meyer, F Miconi, N K Mondal, M Mulhearn, E Nagy, M Narain, R Nayyar, H A Neal, J P Negret, P Neustroev, H T Nguyen, T Nunnemann, J Orduna, N Osman, A Pal, N Parashar, V Parihar, S K Park, R Partridge, N Parua, A Patwa, B Penning, M Perfilov, Y Peters, K Petridis, G Petrillo, P Pétroff, M-A Pleier, V M Podstavkov, A V Popov, M Prewitt, D Price, N Prokopenko, J Qian, A Quadt, B Quinn, P N Ratoff, I Razumov, I Ripp-Baudot, F Rizatdinova, M Rominsky, A Ross, C Royon, P Rubinov, R Ruchti, G Sajot, A Sánchez-Hernández, M P Sanders, A S Santos, G Savage, M Savitskyi, L Sawyer, T Scanlon, R D Schamberger, Y Scheglov, H Schellman, M Schott, C Schwanenberger, R Schwienhorst, J Sekaric, H Severini, E Shabalina, V Shary, S Shaw, A A Shchukin, O Shkola, V Simak, P Skubic, P Slattery, G R Snow, J Snow, S Snyder, S Söldner-Rembold, L Sonnenschein, K Soustruznik, J Stark, N Stefaniuk, D A Stoyanova, M Strauss, L Suter, P Svoisky, M Titov, V V Tokmenin, Y-T Tsai, D Tsybychev, B Tuchming, C Tully, L Uvarov, S Uvarov, S Uzunyan, R Van Kooten, W M van Leeuwen, N Varelas, E W Varnes, I A Vasilyev, A Y Verkheev, L S Vertogradov, M Verzocchi, M Vesterinen, D Vilanova, P Vokac, H D Wahl, C Wang, M H L S Wang, J Warchol, G Watts, M Wayne, J Weichert, L Welty-Rieger, M R J Williams, G W Wilson, M Wobisch, D R Wood, T R Wyatt, Y Xiang, Y Xie, R Yamada, S Yang, T Yasuda, Y A Yatsunenko, W Ye, Z Ye, H Yin, K Yip, S W Youn, J M Yu, J Zennamo, T G Zhao, B Zhou, J Zhu, M Zielinski, D Zieminska, L Zivkovic
We present a measurement of the effective weak mixing angle parameter sin^{2}θ_{eff}^{ℓ} in pp[over ¯]→Z/γ^{*}→μ^{+}μ^{-} events at a center-of-mass energy of 1.96 TeV, collected by the D0 detector at the Fermilab Tevatron Collider and corresponding to 8.6  fb^{-1} of integrated luminosity. The measured value of sin^{2}θ_{eff}^{ℓ}[μμ]=0.23016±0.00064 is further combined with the result from the D0 measurement in pp[over ¯]→Z/γ^{*}→e^{+}e^{-} events, resulting in sin^{2}θ_{eff}^{ℓ}[comb]=0...
June 15, 2018: Physical Review Letters
Loong Chuen Lee, Choong-Yeun Liong, Abdul Aziz Jemain
Partial least squares-discriminant analysis (PLS-DA) is a versatile algorithm that can be used for predictive and descriptive modelling as well as for discriminative variable selection. However, versatility is both a blessing and a curse and the user needs to optimize a wealth of parameters before reaching reliable and valid outcomes. Over the past two decades, PLS-DA has demonstrated great success in modelling high-dimensional datasets for diverse purposes, e.g. product authentication in food analysis, diseases classification in medical diagnosis, and evidence analysis in forensic science...
July 23, 2018: Analyst
Quefeng Li, Guang Cheng, Jianqing Fan, Yuyan Wang
Factor modeling is an essential tool for exploring intrinsic dependence structures among high-dimensional random variables. Much progress has been made for estimating the covariance matrix from a high-dimensional factor model. However, the blessing of dimensionality has not yet been fully embraced in the literature: much of the available data are often ignored in constructing covariance matrix estimates. If our goal is to accurately estimate a covariance matrix of a set of targeted variables, shall we employ additional data, which are beyond the variables of interest, in the estimation? In this article, we provide sufficient conditions for an affirmative answer, and further quantify its gain in terms of Fisher information and convergence rate...
2018: Journal of the American Statistical Association
Cornelia Putz, Ann- Kathrin Blessing, Sarah Erhard, Katharina Fiethen, Andreas Geisbüsch, Mirjam Niklasch, Leonhard Döderlein, Sebastian Immanuel Wolf, Thomas Dreher
BACKGROUND: Deterioration of gait in adolescent and adult patients with cerebral palsy can be associated with multiple factors. Multilevel surgery (MLS) is one option in adults with cerebral palsy to improve gait function with encouraging short-term results. It is a question whether these improvements are maintained over time. METHODS: In a retrospective consecutive cohort study, adults with bilateral spastic cerebral palsy (BSCP) treated with MLS between 1995 and 2011 were scanned for potential inclusion...
June 20, 2018: International Orthopaedics
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