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https://www.readbyqxmd.com/read/28435196/hemato-biochemical-alterations-and-urinalysis-in-dogs-suffering-from-benign-prostatic-hyperplasia
#1
M R Das, R C Patra, R K Das, P K Rath, B P Mishra
AIM: The study was designed to evaluate the hemato-biochemical alterations, urinalysis along with histomorphological and histological changes of prostate glands in dogs affected with benign prostatic hyperplasia (BPH) in and around Bhubaneswar, Odisha, India. MATERIALS AND METHODS: In toto, 445 dogs presented to the Teaching Veterinary Clinical Complex of the College of Veterinary Sciences and Animal Husbandry, one Government Veterinary Hospital and two pet clinics in and around Bhubaneswar screened for the presence of BPH...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28433070/effects-of-nicorandil-on-renal-function-and-histopathology-in-rats-with-partial-unilateral-ureteral-obstruction
#2
Hayrettin Ozturk, Tulin Firat, Buket Kin Tekce, Fahri Yilmaz, Hulya Ozturk
To evaluate the effects of nicorandil in a rat kidney model of partial unilateral ureteral obstruction (PUUO). Thirty male rats were randomly divided into three groups as follows: (1) Group 1 (Sham-control), ureters of the rats were manipulated but not ligated; (2) Group 2 (PUUO-untreated), PUUO was performed with two-thirds of the left ureter embedded in the psoas muscle; and (3) Group 3 (PUUO-nicorandil treated). After PUUO was established, nicorandil (15 mg/kg/day) was administered by gastric lavage for 21 days to determine its effects on PUUO-induced histopathological-, functional-, and oxidative stress-induced changes...
May 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28431808/a-practical-standardized-composite-nutrition-score-based-on-lean-tissue-index-application-in-nutrition-screening-and-prediction-of-outcome-in-hemodialysis-population
#3
Huan-Sheng Chen, Chun-Ting Cheng, Chun-Cheng Hou, Hung-Hsiang Liou, Cheng-Tsung Chang, Chun-Ju Lin, Tsai-Kun Wu, Chang-Hsu Chen, Paik-Seong Lim
OBJECTIVE: Rapid screening and monitoring of nutritional status is mandatory in hemodialysis population because of the increasingly encountered nutritional problems. Considering the limitations of previous composite nutrition scores applied in this population, we tried to develop a standardized composite nutrition score (SCNS) using low lean tissue index as a marker of protein wasting to facilitate clinical screening and monitoring and to predict outcome. DESIGN AND METHODS: This retrospective cohort used 2 databases of dialysis populations from Taiwan between 2011 and 2014...
April 18, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28431528/diagnostic-performance-of-the-urinary-canine-calgranulins-in-dogs-with-lower-urinary-or-urogenital-tract-carcinoma
#4
Romy M Heilmann, Elizabeth A McNiel, Niels Grützner, David J Lanerie, Jan S Suchodolski, Jörg M Steiner
BACKGROUND: Onset of canine transitional cell carcinoma (TCC) and prostatic carcinoma (PCA) is usually insidious with dogs presenting at an advanced stage of the disease. A biomarker that can facilitate early detection of TCC/PCA and improve patient survival would be useful. S100A8/A9 (calgranulin A/B or calprotectin) and S100A12 (calgranulin C) are expressed by cells of the innate immune system and are associated with several inflammatory disorders. S100A8/A9 is also expressed by epithelial cells after malignant transformation and is involved in the regulation of cell proliferation and metastasis...
April 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28422372/effect-of-urine-creatinine-level-during-pregnancy-on-dipstick-test
#5
Yosuke Baba, Itsuko Furuta, Tianyue Zhai, Akihide Ohkuchi, Takahiro Yamada, Kayo Takahashi, Shigeki Matsubara, Hisanori Minakami
AIM: Dipstick results for proteinuria are affected by urine concentration, and thus urine creatinine concentration ([Cr]). This study was performed to determine whether spot urine [Cr] changes significantly during pregnancy, leading to a significantly different false-negative rate (FNR) on dipstick test between trimester. METHODS: The [Cr] and protein concentrations ([P]) were analyzed in 631 spot urine samples with negative/equivocal dipstick from 425 pregnant women...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28412995/development-and-validation-of-prediction-models-for-risks-of-complications-in-early-onset-pre-eclampsia-prep-a-prospective-cohort-study
#6
Shakila Thangaratinam, John Allotey, Nadine Marlin, Ben W Mol, Peter Von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Asif Ahmed, Jane Daniels, Jon Deeks, Khaled Ismail, Ann Marie Barnard, Julie Dodds, Sally Kerry, Carl Moons, Richard D Riley, Khalid S Khan
BACKGROUND: The prognosis of early-onset pre-eclampsia (before 34 weeks' gestation) is variable. Accurate prediction of complications is required to plan appropriate management in high-risk women. OBJECTIVE: To develop and validate prediction models for outcomes in early-onset pre-eclampsia. DESIGN: Prospective cohort for model development, with validation in two external data sets. SETTING: Model development: 53 obstetric units in the UK...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28400421/kidney-outcomes-and-risk-factors-for-nephritis-flare-de-novo-in-a-multiethnic-cohort-of-pregnant-patients-with-lupus
#7
Jill P Buyon, Mimi Y Kim, Marta M Guerra, Sifan Lu, Emily Reeves, Michelle Petri, Carl A Laskin, Michael D Lockshin, Lisa R Sammaritano, D Ware Branch, T Flint Porter, Allen Sawitzke, Joan T Merrill, Mary D Stephenson, Elisabeth Cohn, Jane E Salmon
BACKGROUND AND OBJECTIVES: Kidney disease is a critical concern in counseling patients with lupus considering pregnancy. This study sought to assess the risk of renal flares during pregnancy in women with previous lupus nephritis in partial or complete remission, particularly in those with antidouble-stranded DNA antibodies and low complement levels, and the risk of new-onset nephritis in patients with stable/mildly active SLE. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We assessed active nephritis (renal flares and de novo kidney disease) and associated predictors during pregnancy in patients with lupus with urine protein ≤1000 mg and serum creatinine <1...
April 11, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28397719/toll-like-receptor-4-signaling-pathway-in-the-protective-effect-of-pioglitazone-on-experimental-immunoglobulin-a-nephropathy
#8
Jia-Nan Zou, Jing Xiao, Sha-Sha Hu, Chen-Sheng Fu, Xiao-Li Zhang, Zhen-Xing Zhang, Yi-Jun Lu, Wei-Jun Chen, Zhi-Bin Ye
BACKGROUND: In vitro experiments have revealed that toll-like receptor 4 (TLR4) pathway is involved in the progression of immunoglobulin A nephropathy (IgAN) by induction of proinflammatory cytokines. Evidence showed that, in other disease models, peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists have been shown to exert anti-inflammatory effects through suppression of the expression and activity of TLR4. However, the interaction between PPAR-γ and TLR4 in IgAN has not been fully studied both in vitro and in vivo...
April 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28395289/urinary-angiotensinogen-and-renin-excretion-are-associated-with-chronic-kidney-disease
#9
Annett Juretzko, Antje Steinbach, Anke Hannemann, Karlhans Endlich, Nicole Endlich, Nele Friedrich, Uwe Lendeckel, Sylvia Stracke, Rainer Rettig
BACKGROUND/AIMS: Several studies sought to identify new biomarkers for chronic kidney disease (CKD). As the renal renin-angiotensin system is activated in CKD, urinary angiotensinogen or renin excretion may be suitable candidates. We tested whether urinary angiotensinogen or renin excretion is elevated in CKD and whether these parameters are associated with estimated glomerular filtration rate (eGFR). We further tested whether urinary angiotensinogen or renin excretion may convey additional information beyond that provided by albuminuria...
April 11, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28392997/fatty-liver-associated-with-metabolic-derangement-in-patients-with-chronic-kidney-disease-a-controlled-attenuation-parameter-study
#10
Chang-Yun Yoon, Misol Lee, Seung Up Kim, Hyunsun Lim, Tae Ik Chang, Youn Kyung Kee, Seung Gyu Han, In Mee Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, Jung Tak Park, Seung Hyeok Han, Sang Hoon Ahn, Shin-Wook Kang, Tae-Hyun Yoo
BACKGROUND: Hepatic steatosis measured with controlled attenuation parameter (CAP) using transient elastography predicts metabolic syndrome in the general population. We investigated whether CAP predicted metabolic syndrome in chronic kidney disease patients. METHODS: CAP was measured with transient elastography in 465 predialysis chronic kidney disease patients (mean age, 57.5 years). RESULTS: The median CAP value was 239 (202-274) dB/m. In 195 (41...
March 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28392738/the-role-of-laboratory-testing-in-detection-and-classification-of-chronic-kidney-disease-national-recommendations
#11
REVIEW
Vanja Radišić Biljak, Lorena Honović, Jasminka Matica, Branka Krešić, Sanela Šimić Vojak
Chronic kidney disease (CKD) is a common clinical condition with significant adverse consequences for the patient and it is recognized as a significant public health problem. The role of laboratory medicine in diagnosis and management of CKD is of great importance: the diagnosis and staging are based on estimation of glomerular filtration rate (eGFR) and assessment of albuminuria (or proteinuria). Therefore, the joint working group of the Croatian society of medical biochemistry and laboratory medicine and Croatian chamber of medical biochemists for laboratory diagnostics in CKD issued this national recommendation regarding laboratory diagnostics of CKD...
February 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28392272/a-new-preprocedure-risk-score-for-predicting-contrast-induced-acute-kidney-injury
#12
Chongyang Duan, Yingshu Cao, Yong Liu, Lizhi Zhou, Kaike Ping, Ming T Tan, Ning Tan, Jiyan Chen, Pingyan Chen
BACKGROUND: Most of the risk models for predicting contrast-induced acute kidney injury (CI-AKI) are available for only postcontrast exposure prediction; however, prediction before the procedure is more valuable in practice. This study aimed to develop a risk scoring system based on preprocedural characteristics for early prediction of CI-AKI in patients after coronary angiography or percutaneous coronary intervention (PCI). METHODS: We prospectively recruited 1777 consecutive patients who were randomized in an approximate 3:2 ratio to create a development data set (n = 1076) and a validation data set (n = 701)...
January 28, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28391339/mycophenolate-mofetil-therapy-in-immunoglobulin-a-nephropathy-histological-changes-after-treatment
#13
Hannah Beckwith, Nick Medjeral-Thomas, Jack Galliford, Megan Griffith, Jeremy Levy, Liz Lightstone, Andrew Palmer, Candice Roufosse, Charles Pusey, H Terence Cook, Tom Cairns
Background: Endocapillary hypercellularity independently predicts renal outcome in immunoglobulin A nephropathy (IgAN). Mycophenolate mofetil (MMF) treatment is offered to patients presenting to the Imperial College Renal and Transplant Centre with IgAN and histological evidence of endocapillary hypercellularity. Clinical trials of MMF in IgAN have been inconclusive and have been limited by a lack of specific histological inclusion and exclusion criteria when recruiting patients. Evidence of histological improvement following MMF treatment would support its therapeutic use...
January 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28387019/plasma-n-terminal-probrain-natriuretic-peptide-vascular-endothelial-growth-factor-and-cardiac-troponin-i-as-novel-biomarkers-of-hypertensive-disease-and-target-organ-damage-in-cats
#14
E S Bijsmans, R E Jepson, C Wheeler, H M Syme, J Elliott
BACKGROUND: In the absence of ocular target organ damage (ocular-TOD), diagnosis of hypertension is challenging in cats. Biomarkers would provide additional support for the diagnosis of hypertension. HYPOTHESIS: Vascular endothelial growth factor (VEGF), N-terminal probrain natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), and urine protein-to-creatinine ratio (UPC) are predictors of systemic hypertension, will be increased in cats with hypertension with or without ocular-TOD, and will decrease with antihypertensive treatment...
April 7, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28381801/association-of-single-nucleotide-polymorphisms-in-stat3-abcb1-and-abcg2-with-stomatitis-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-sunitinib-a-retrospective-analysis-in-japanese-patients
#15
Aimi Watanabe, Kazuhiro Yamamoto, Takeshi Ioroi, Sachi Hirata, Kenichi Harada, Hideaki Miyake, Masato Fujisawa, Tsutomu Nakagawa, Ikuko Yano, Midori Hirai
Signal transducer and activator of transcription (STAT) 3 is a key factor in homeostasis of the oral mucosa by regulating the production of inflammatory cytokines. Sunitinib is a substrate of P-glycoprotein (multidrug resistance (MDR)-1/ABCB1) and breast-cancer resistance protein (BCRP/ABCG2). In this retrospective study, we evaluated the association between sunitinib-induced stomatitis and STAT3, ABCB1, and ABCG2 polymorphisms in patients with metastatic renal cell carcinoma (mRCC). Fifty-two Japanese patients with RCC treated with sunitinib were retrospectively genotyped to elucidate a potential association between STAT3, ABCB1, and ABCG2 polymorphisms and stomatitis development...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28373588/vascular-stiffness-in-children-with-chronic-kidney-disease
#16
Jonathan D Savant, Aisha Betoko, Kevin E C Meyers, Mark Mitsnefes, Joseph T Flynn, Raymond R Townsend, Larry A Greenbaum, Allison Dart, Bradley Warady, Susan L Furth
Carotid-femoral pulse wave velocity (cfPWV) is a measure of arterial stiffness associated with cardiovascular events in the general population and in adults with chronic kidney disease. However, few data exist regarding cfPWV in children with chronic kidney disease. We compared observed cfPWV assessed via applanation tonometry in children enrolled in the CKiD cohort study (Chronic Kidney Disease in Children) to normative data in healthy children and examined risk factors associated with elevated cfPWV. cfPWV Z score for height/gender and age/gender was calculated from and compared with published pediatric norms...
May 2017: Hypertension
https://www.readbyqxmd.com/read/28372541/nephrotoxicity-induced-proteinuria-increases-biomarker-diagnostic-thresholds-in-acute-kidney-injury
#17
Fahim Mohamed, Nicholas A Buckley, John W Pickering, Klintean Wunnapuk, Sandamali Dissanayake, Umesh Chathuranga, Indika Gawarammana, Shaluka Jayamanne, Zoltan H Endre
BACKGROUND: Paraquat ingestion is frequently fatal. While biomarkers of kidney damage increase during paraquat-induced acute kidney injury (AKI), significant concurrent proteinuria may alter diagnostic thresholds for diagnosis and prognosis to an unknown extent. This study evaluated the effect of albuminuria on biomarker cutoffs for diagnosis and outcome prediction. METHODS: This was a multi-centre prospective clinical study of patients following acute paraquat self-poisoning in 5 Sri Lankan hospitals...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28366228/albuminuria-and-posttransplant-chronic-kidney-disease-stage-predict-transplant-outcomes
#18
Ngan N Lam, Marcello Tonelli, Krista L Lentine, Brenda Hemmelgarn, Feng Ye, Kevin Wen, Scott Klarenbach
In 2012, the KDIGO guidelines updated the classification system for chronic kidney disease to include albuminuria. Whether this classification system predicts adverse clinical outcomes among kidney transplant recipients is unclear. To evaluate this, we conducted a retrospective study using linked databases in Alberta, Canada to follow kidney transplant recipients from 2002-2011. We examined the association between an estimated glomerular filtration rate (eGFR of 60 or more, 45-59, 30-44, 15-29 mL/min/1.73 m(2)) and albuminuria (normal, mild, heavy) at one year post-transplant and subsequent mortality and graft loss...
March 30, 2017: Kidney International
https://www.readbyqxmd.com/read/28363480/targeted-release-budesonide-versus-placebo-in-patients-with-iga-nephropathy-nefigan-a-double-blind-randomised-placebo-controlled-phase-2b-trial
#19
Bengt C Fellström, Jonathan Barratt, Heather Cook, Rosanna Coppo, John Feehally, Johan W de Fijter, Jürgen Floege, Gerd Hetzel, Alan G Jardine, Francesco Locatelli, Bart D Maes, Alex Mercer, Fernanda Ortiz, Manuel Praga, Søren S Sørensen, Vladimir Tesar, Lucia Del Vecchio
BACKGROUND: IgA nephropathy is thought to be associated with mucosal immune system dysfunction, which manifests as renal IgA deposition that leads to impairment and end-stage renal disease in 20-40% of patients within 10-20 years. In this trial (NEFIGAN) we aimed to assess safety and efficacy of a novel targeted-release formulation of budesonide (TRF-budesonide), designed to deliver the drug to the distal ileum in patients with IgA nephropathy. METHODS: We did a randomised, double-blind, placebo-controlled phase 2b trial, comprised of 6-month run-in, 9-month treatment, and 3-month follow-up phases at 62 nephrology clinics across ten European countries...
March 28, 2017: Lancet
https://www.readbyqxmd.com/read/28356148/prediction-of-complications-in-early-onset-pre-eclampsia-prep-development-and-external-multinational-validation-of-prognostic-models
#20
Shakila Thangaratinam, John Allotey, Nadine Marlin, Julie Dodds, Fiona Cheong-See, Peter von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Sally Kerry, Ben W Mol, Karl G M Moons, Richard D Riley, Khalid S Khan
BACKGROUND: Unexpected clinical deterioration before 34 weeks gestation is an undesired course in early-onset pre-eclampsia. To safely prolong preterm gestation, accurate and timely prediction of complications is required. METHOD: Women with confirmed early onset pre-eclampsia were recruited from 53 maternity units in the UK to a large prospective cohort study (PREP-946) for development of prognostic models for the overall risk of experiencing a complication using logistic regression (PREP-L), and for predicting the time to adverse maternal outcome using a survival model (PREP-S)...
March 30, 2017: BMC Medicine
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