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Protein creatinine ratio

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https://www.readbyqxmd.com/read/29769504/dipstick-method-versus-spot-urinary-protein-creatinine-ratio-for-evaluation-of-massive-proteinuria-in-childhood-nephrotic-syndrome
#1
M N Sultana, B Majumder, M J Rahman, A M Moniruzzaman, A M Suja, M E Ali, Z H Sarker, S N Nabi, M A Mostakim
Measurement of massive proteinuria is vital for diagnosis of childhood Nephrotic syndrome. Quantification of 24 hours urinary protein is the gold standard test. Dipstick method of urinary protein measurement gives instant result for massive proteinuria. Spot urinary protein creatinine ratio measurement is variable. This was a hospital based prospective cross sectional study done at Department of Paediatric Nephrology, Rangpur Medical College Hospital from January 2014 to December 2015 to evaluate accuracy of dipstick method versus spot urinary protein-creatinine ratio in estimation of massive proteinuria in childhood nephrotic syndrome...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29768353/correlation-of-increased-th17-treg-cell-ratio-with-endoplasmic-reticulum-stress-in-chronic-kidney-disease
#2
Xiaojing Zhu, Shuiqin Li, Qiaona Zhang, Dan Zhu, Yang Xu, Pengqian Zhang, Jin Han, Zhaoyang Duan, Jie Gao, Yan Ou
To investigate the relationship between the regulatory immune network and endoplasmic reticulum stress (ERS) in patients with different stages of chronic kidney disease (CKD).A total of 91 patients diagnosed with CKD were divided into different groups according to the stage of disease and treatment with hemodialysis (HD) or peritoneal dialysis (PD). Routine blood and biochemical tests were performed in patients in the different CKD groups and in healthy controls (n = 20). The frequencies of T helper type 17 (Th17) and regulatory T (Treg) cells in the overall T cell population were measured by flow cytometric analysis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767729/a-comparative-study-on-the-excretion-of-urinary-metabolites-in-goats-and-sheep-to-evaluate-spot-sampling-applied-to-protein-nutrition-trials
#3
A C S Dos Santos, S A Santos, G G P Carvalho, L D S Mariz, M S L Tosto, S C Valadares Filho, J A G Azevedo
The main objective of this study was to establish a protocol to validate urine spot samples to estimate N excretion and microbial synthesis in goat and sheep; and to study factors that affect daily creatinine and purine derivatives urinary excretion. Also a performance trial was carried out to compare goat and sheep slaughtered after different feedlot periods. Twelve Boer goats (20.6 kg±3.4 initial BW) and twelve Dorper sheep (18.4 kg±2.3 initial BW), all 4-month-old, males, were used. Eight animals (four goats and four sheep) were randomly allocated to be slaughtered at 28, 56 and 84 days in feedlot...
May 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29761227/outcome-of-flexible-ureteroscopy-for-renal-stone-with-overnight-ureteral-catheterization-a-propensity-score-matching-analysis
#4
Mitsuru Komeya, Kimitsugu Usui, Takuo Asai, Takehiko Ogawa, Masataka Taguri, Koshi Kataoka, Masahiro Yao, Junichi Matsuzaki
PURPOSE: To evaluate the influence of overnight ureteral catheterization and determine if routine long-term post-stenting can be avoided in flexible ureterorenoscopy (fURS) procedure for kidney stone. METHODS: Three hundred ninety-three patients who underwent single fURS for kidney stone between January 2013 and June 2016 at a single institute were retrospectively analyzed. The stone-free (SF) and perioperative complication rates in patients with routine long-term post-stenting after fURS (long-term stent group) were compared with those of patients with overnight ureteral catheterization (short-term stent group)...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29761105/prevalence-of-proteinuria-and-albuminuria-in-an-obese-population-and-associated-risk-factors
#5
Jordan L Rosenstock, Max Pommier, Guillaume Stoffels, Satyam Patel, Michael F Michelis
Obesity has been increasingly recognized as a risk factor for kidney disease and both proteinuria and microalbuminuria have been associated with obesity. The actual prevalence of microalbuminuria and proteinuria in obese patients in the United States (US) has not been clearly described in the literature. Furthermore, obesity is associated with risk factors of kidney disease, such as diabetes and hypertension (HTN), and the prevalence of proteinuria and albuminuria excluding these risk factors is uncertain. In this study, we collected urine albumin/creatinine and urine protein/creatinine ratios on obese patients undergoing bariatric surgery to determine the prevalence of albuminuria and proteinuria in obese patients with and without associated diabetes and HTN...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29757588/association-of-regulatory-t-cells-with-diabetes-type-1-and-its-renal-and-vascular-complications-based-on-the-expression-of-forkhead-box-protein-p3-foxp3-helios-and-neurophilin-1
#6
Tahereh Khamechian, Behnaz Irandoust, Hanieh Mohammadi, Hassan Nikoueinejad, Hossein Akbari
In recent years, it has been recognized that regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. Moreover, the expression of two markers named Helios and neurophilin-1 (NRP-1) has been highlighted in such cells. Helios, an intracellular transcription marker, largely differentiates twomost operative sub group of Tregs, namely naturally occurring (nTreg) and induced (iTreg) Tregs, and NRP-1 is reckoned as a membranous activity marker of Tregs. We aimed to count peripheral mononuclear cells expressing such markers in a group of type 1 diabetes patients to elucidate the possible role of Tregs in the pathogenesis of such disease and its complications...
April 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29752172/social-determinants-of-health-are-associated-with-markers-of-renal-injury-in-adolescents-with-type-1-diabetes
#7
Laura A M Cummings, Antoine Clarke, Etienne Sochett, Denis Daneman, David Z Cherney, Heather N Reich, James W Scholey, David B Dunger, Farid H Mahmud
OBJECTIVE: To examine the relationship between the social determinants of health and markers of early renal injury in adolescent patients with type 1 diabetes (T1D). STUDY DESIGN: Renal outcomes included estimated glomerular filtration rate (eGFR) and albumin-creatinine excretion ratio (ACR). Differences in urinary and serum inflammatory markers also were assessed in relation to social determinants of health. Regression analysis was used to evaluate the association between the Ontario Marginalization Index (ON-Marg) as a measure of the social determinants of health, patient characteristics, ACR, eGFR, and renal filtration status (hyperfiltration vs normofiltration)...
May 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29739389/effect-of-increased-enteral-protein-intake-on-plasma-and-urinary-urea-concentrations-in-preterm-infants-born-at-32-weeks-gestation-and-1500-g-birth-weight-enrolled-in-a-randomized-controlled-trial-a-secondary-analysis
#8
Michaela Mathes, Christoph Maas, Christine Bleeker, Julia Vek, Wolfgang Bernhard, Andreas Peter, Christian F Poets, Axel R Franz
BACKGROUND: Feeding breast milk is associated with reduced morbidity and mortality, as well as improved neurodevelopmental outcome but does not meet the high nutritional requirements of preterm infants. Both plasma and urinary urea concentrations represent amino acid oxidation and low concentrations may indicate insufficient protein supply. This study assesses the effect of different levels of enteral protein on plasma and urinary urea concentrations and determines if the urinary urea-creatinine ratio provides reliable information about the protein status of preterm infants...
May 8, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29728855/influence-of-moringa-oleifera-extract-vitamin-c-and-sodium-bicarbonate-on-heat-stress-induced-hsp70-expression-and-cellular-immune-response-in-rabbits
#9
Mahmoud Abdel-Latif, Thabet Sakran, Yasser K Badawi, Doaa S Abdel-Hady
The current study aimed to test the effect of Moringa oleifera extract (MOE), vitamin (Vit) C, and sodium bicarbonate (NaHCO3 ) on heat stress (HS)-induced alterations in rabbits. Five groups of rabbits were designed as control, HS, HS + MOE, HS + Vit C, and HS + NaHCO3 . HS groups were exposed to high temperatures, while treatments were given in drinking water for 6 weeks. Levels of blood cortisol, leptin, IFN-γ, TNF-α, and IL-10 were assayed using ELISA, while adrenaline was assayed calorimetrically...
May 4, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29722110/biochemical-comparison-of-8-hour-haemodialysis-and-4-hour-haemodiafiltration-and-two-dialysis-membranes-in-a-randomised-cross-over-trial
#10
Shi Z Choo, Kevan R Polkinghorne, Peter G Kerr
AIM: Extended-hours haemodialysis has long been regarded as the optimal form of dialysis for solute clearance. With emerging benefits of haemodiafiltration, we wanted to compare these two head-to-head. METHODS: In this randomised cross-over trial, we recruited existing nocturnal haemodialysis patients, who had not been hospitalised in the prior three months. After a baseline 8-hour haemodialysis session, subjects were randomised to either 2 weeks of 8-hour haemodialysis or 4-hour haemodiafiltration with cross-over to the alternative treatment after a 2-week washout period...
May 2, 2018: Nephrology
https://www.readbyqxmd.com/read/29706289/urinary-antimicrobial-peptides-potential-novel-biomarkers-of-obstructive-uropathy
#11
S Gupta, A R Jackson, D G DaJusta, D J McLeod, S A Alpert, V R Jayanthi, K McHugh, A R Schwaderer, B Becknell, C B Ching
INTRODUCTION: Antimicrobial peptides (AMPs) have historically been evaluated for their role in protecting against uropathogens. However, there is mounting evidence to support their expression in noninfectious injury, with unclear meaning as to their function. It is possible that AMPs represent urothelial injury. Urinary tract obstruction is known to alter the urothelium; however, AMPs have not been evaluated for expression in this noninfectious injury. OBJECTIVE: A pilot study to compare urinary AMP expression in children undergoing surgical intervention for ureteropelvic junction obstruction (UPJO) with nonobstructed controls...
March 29, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29702139/renal-health-after-long-term-exposure-to-tenofovir-disoproxil-fumarate-tdf-in-hiv-hbv-positive-adults-in-ghana
#12
G Villa, R O Phillips, C Smith, A J Stockdale, A Beloukas, L T Appiah, D Chadwick, A Ruggiero, F S Sarfo, F Post, A M Geretti
OBJECTIVES: The study assessed markers of renal health in HIV/HBV co-infected patients receiving TDF-containing antiretroviral therapy in Ghana. METHODS: Urinary protein-to-creatinine ratio (uPCR) and albumin-to-protein ratio (uAPR) were measured cross-sectionally after a median of four years of TDF. At this time, alongside extensive laboratory testing, patients underwent evaluation of liver stiffness and blood pressure. The estimated glomerular filtration rate (eGFR) was measured longitudinally before and during TDF therapy...
April 24, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29694445/survival-predictors-in-anuric-patients-on-peritoneal-dialysis-a-prospective-multicenter-propensity-score-matched-cohort-study
#13
Ja-Yong Park, Jang-Hee Cho, Hye Min Jang, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim
Prevalent anuric peritoneal dialysis (PD) patients usually have higher mortality than PD patients with residual urine volume. We aimed to evaluate the predictors of survival in anuric PD patients. Anuric PD patients (n = 505, <100 mL of daily urine) enrolled in Korean nationwide prospective cohort were analyzed. Survived and non-survived anuric PD patients were compared by propensity score matching analysis with a ratio of two to one. The propensity method was used to adjust for patient age, dialysis duration, and presence of diabetes...
2018: PloS One
https://www.readbyqxmd.com/read/29693328/american-college-of-rheumatology-provisional-criteria-for-global-flares-in-childhood-onset-systemic-lupus-erythematosus
#14
Hermine I Brunner, Michael Holland, Michael W Beresford, Stacy P Ardoin, Simone Appenzeller, Clovis A Silva, Francisco Flores, Beatrice Goilav, Scott E Wenderfer, Deborah M Levy, Angelo Ravelli, Raju Khunchandani, Tadej Avcin, Marisa S Klein-Gitelman, Brian M Feldman, Nicolino Ruperto, Jun Ying
OBJECTIVE: To validate the preliminary criteria of global flare for childhood-onset SLE (cSLE). METHODS: Pediatricians experienced in cSLE care (n = 268) rated unique patient profiles; results of standard cSLE laboratory testing and information about the cSLE flare descriptors were presented as follows: global assessment of patient well-being, physician global assessment of disease activity (MD-global), Disease Activity Index score, protein/creatinine ratio (PCR), and erythrocyte sedimentation rate (ESR)...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29688781/effect-of-blood-contamination-on-results-of-dipstick-evaluation-and-urine-protein-to-urine-creatinine-ratio-for-urine-samples-from-dogs-and-cats
#15
Aida I Vientós-Plotts, Ellen N Behrend, Elizabeth G Welles, Dennis J Chew, Philippe R Gaillard, Jessica N Busler, Hollie P Lee
OBJECTIVE To evaluate effects of blood contamination on dipstick results, specific gravity (SG), and urine protein-to-urine creatinine ratio (UPCR) for urine samples from dogs and cats. SAMPLE Urine samples collected from 279 dogs and 120 cats. PROCEDURES Urine pools were made for each species (dogs [n = 60] and cats [30]). Blood was added to an aliquot of a pool, and serial dilutions were prepared with the remaining urine. Color and dipstick variables were recorded, and SG and UPCR were measured. For cats, 1 set of pools was used; for dogs, 2 sets were used...
May 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29687557/osteopontin-as-a-marker-of-vasculopathy-in-pediatric-patients-with-type-1-diabetes-mellitus-relation-to-vascular-structure
#16
Mohamed Abo El-Asrar, Eman Abdel Rahman Ismail, Rasha Adel Thabet, Ashraf Sayed Kamel, Sameh NehmedAllah
BACKGROUND: Type 1 diabetes mellitus (T1DM) is associated with serious micro-vascular and macrovascular complications. Osteopontin (OPN) has emerged as a strong predictor of incipient diabetic nephropathy and a first-ever cardiovascular event in adults with T1DM. OPN is linked to coronary atherosclerosis in type 2 diabetes. AIM: To test the hypothesis that OPN could be a potential marker for micro-vascular complications in children and adolescents with T1DM and we assessed its relation to carotid and aortic intima media thickness (CIMT and AIMT) as non-invasive index for subclinical atherosclerosis...
April 23, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29684848/protective-effects-of-ifn-%C3%AE-on-the-kidney-of-type-2-diabetic-kkay-mice
#17
Juan Du, Wenpeng Dong, Huifeng Li, Bo Li, Xiaodan Liu, Qinghui Kong, Wei Sun, Tingli Sun, Peilong Ma, Yan Cui, Ping Kang
BACKGROUND: Development of novel therapeutic strategies that specifically target diabetic kidney disease (DKD) is urgently needed. METHODS: Male KKAy mice were divided randomly into three equal groups - KK, KI, and KF; Male C57BL/6 mice were the control group. All KKAy mice were fed a high-fat diet. From the 16th week, the KI group was given IFN-γ, and the KF group was assigned to be treated with fludarabine. C57BL/6 mice were always fed a normal mouse diet. Every 4 weeks, body weight, random blood sugar, urine albumin and urea of all mice were measured...
December 21, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29683855/a-week-48-randomized-phase-3-trial-of-darunavir-cobicistat-emtricitabine-tenofovir-alafenamide-in-treatment-na%C3%A3-ve-hiv-1-patients
#18
Joseph J Eron, Chloe Orkin, Joel Gallant, Jean-Michel Molina, Eugenia Negredo, Andrea Antinori, Anthony Mills, Jacques Reynes, Erika Van Landuyt, Erkki Lathouwers, Veerle Hufkens, John Jezorwski, Simon Vanveggel, Magda Opsomer
OBJECTIVES: To investigate efficacy and safety of a single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg vs. darunavir/cobicistat plus emtricitabine/tenofovir disoproxyl fumarate (TDF) (control) in antiretroviral-treatment-naïve, HIV-1-infected adults. DESIGN: Phase-3, randomized, active-controlled, double-blind, international, multicenter, noninferiority study (NCT02431247). METHODS: Seven hundred and twenty-five participants were randomized (1 : 1) to D/C/F/TAF (362) or control (363)...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683094/role-of-inflammatory-markers-in-elderly-type-2-diabetic-patients-with-mild-cognitive-impairment
#19
Salwa S Hosny, Ahmed M Bahaaeldin, Mohamed S Khater, Meram M Bekhet, Hayam A Hebah, Ghada A Hasanin
BACKGROUND: Type 2 diabetes (T2DM) is a risk factor for Alzheimer's disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. OBJECTIVES: to determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI)...
April 22, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29677049/urinary-podocyte-associated-molecules-and-albuminuria-in-hypertension
#20
Javier Perez-Hernandez, Maria D Olivares, Elena Solaz, Fernando Martinez, Sergio Martínez-Hervas, Gernot Pichler, Felipe J Chaves, Josep Redon, Raquel Cortes
OBJECTIVE: Hypertension-induced podocyte damage and the relationship with UAE is analyzed in diabetic and nondiabetic participants. PATIENTS AND METHODS: Sixty-four hypertensive patients, 30 diabetics, with glomerular filtration rate (eGFR) greater than 60 ml/min per 1.73 m were included. Urinary albumin excretion was measured in morning urine using a nephelometric immunoassay and expressed as albumin/creatinine ratio. Urinary pellets were obtained from fresh urine and mRNA was assessed by real-time quantitative PCR...
April 19, 2018: Journal of Hypertension
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