Marta R Moksnes, Sarah E Graham, Kuan-Han Wu, Ailin Falkmo Hansen, Sarah A Gagliano Taliun, Wei Zhou, Ketil Thorstensen, Lars G Fritsche, Dipender Gill, Amy Mason, Francesco Cucca, David Schlessinger, Gonçalo R Abecasis, Stephen Burgess, Bjørn Olav Åsvold, Jonas B Nielsen, Kristian Hveem, Cristen J Willer, Ben M Brumpton
Iron is essential for many biological processes, but iron levels must be tightly regulated to avoid harmful effects of both iron deficiency and overload. Here, we perform genome-wide association studies on four iron-related biomarkers (serum iron, serum ferritin, transferrin saturation, total iron-binding capacity) in the Trøndelag Health Study (HUNT), the Michigan Genomics Initiative (MGI), and the SardiNIA study, followed by their meta-analysis with publicly available summary statistics, analyzing up to 257,953 individuals...
June 16, 2022: Communications Biology