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Pd-l1 Recycling

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https://www.readbyqxmd.com/read/28864496/a-recycling-program-that-keeps-pd-l1-out-of-the-cancer-cell-s-junkyard
#1
Gabriel K Griffin
CMTM6 limits antitumor immunity by ensuring efficient recycling of endocytosed PD-L1 protein.
September 1, 2017: Science Immunology
https://www.readbyqxmd.com/read/28813417/cmtm6-maintains-the-expression-of-pd-l1-and-regulates-anti-tumour-immunity
#2
Marian L Burr, Christina E Sparbier, Yih-Chih Chan, James C Williamson, Katherine Woods, Paul A Beavis, Enid Y N Lam, Melissa A Henderson, Charles C Bell, Sabine Stolzenburg, Omer Gilan, Stuart Bloor, Tahereh Noori, David W Morgens, Michael C Bassik, Paul J Neeson, Andreas Behren, Phillip K Darcy, Sarah-Jane Dawson, Ilia Voskoboinik, Joseph A Trapani, Jonathan Cebon, Paul J Lehner, Mark A Dawson
Cancer cells exploit the expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) to subvert T-cell-mediated immunosurveillance. The success of therapies that disrupt PD-L1-mediated tumour tolerance has highlighted the need to understand the molecular regulation of PD-L1 expression. Here we identify the uncharacterized protein CMTM6 as a critical regulator of PD-L1 in a broad range of cancer cells, by using a genome-wide CRISPR-Cas9 screen. CMTM6 is a ubiquitously expressed protein that binds PD-L1 and maintains its cell surface expression...
September 7, 2017: Nature
https://www.readbyqxmd.com/read/28367063/understanding-the-role-of-pd-l1-pd1-pathway-blockade-and-autophagy-in-cancer-therapy
#3
REVIEW
Marianela Robainas, Rafael Otano, Stephen Bueno, Sihem Ait-Oudhia
Autophagy is a vital, physiological catabolic process for cell survival by which cells clear damaged organelles and recycle nutrients when homeostasis is maintained. Cancer is a complex disease with uncontrolled growth of cancer cells. Recent studies have suggested the role of autophagy in cancer. A complex relationship exists between autophagy and cancer, since autophagy can contribute to the survival or the destruction of malignant cells depending on the stage of tumor development. In this review, we describe in detail the mechanism underlying autophagy in cancer cells and the intricate involvement of the programmed cell death-1 (PD1) receptor with its ligand (PD-L1)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27764774/correlation-between-anti-pd-l1-tumor-concentrations-and-tumor-specific-and-nonspecific-biomarkers-in-a-melanoma-mouse-model
#4
Ana M Contreras-Sandoval, María Merino, Marcos Vasquez, Iñaki F Trocóniz, Pedro Berraondo, María J Garrido
Blockade of PD-L1 with specific monoclonal antibodies (anti-PD-L1) represents a therapeutic strategy to increase the capability of the immune system to modulate the tumor immune-resistance. The relationship between anti-PD-L1 tumor exposition and anti-tumor effect represents a challenge that has been addressed in this work through the identification of certain biomarkers implicated in the antibody's mechanism of action, using a syngeneic melanoma mouse model. The development of an in-vitro/in-vivo platform has allowed us to investigate the PD-L1 behavior after its blockage with anti-PD-L1 at cellular level and in animals...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/26771202/urea-functionalized-self-assembled-molecular-prism-for-heterogeneous-catalysis-in-water
#5
Prodip Howlader, Paramita Das, Ennio Zangrando, Partha Sarathi Mukherjee
Reaction of a ditopic urea "strut" (L1) with cis-(tmen)Pd(NO3)2 yielded a [3+3] self-assembled molecular triangle (T) [L1 = 1,4-di(4-pyridylureido)benzene; tmen = N,N,N',N'-tetramethylethane-1,2-diamine]. Replacing cis-(tmen)Pd(NO3)2 in the above reaction with an equimolar mixture of Pd(NO3)2 and a clip-type donor (L2) yielded a template-free multicomponent 3D trigonal prism (P) decorated with multiple urea moieties [L2 = 3,3'-(1H-1,2,4-triazole-3,5-diyl)dipyridine]. This prism (P) was characterized by NMR spectroscopy, and the structure was confirmed by X-ray crystallography...
February 10, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/22374173/didocosyl-selenide-stabilized-recyclable-pd-0-nanoparticles-and-coordinated-palladium-ii-as-efficient-catalysts-for-suzuki-miyaura-coupling
#6
Gyandshwar Kumar Rao, Arun Kumar, Bharat Kumar, Ajai K Singh
First selenium ligand stabilized Pd(0) nanoparticles (∼3-5 nm) catalyze Suzuki-Miyaura C-C coupling in short time and are recyclable (up to 94% yield after 5 reuses). The air stable compound [PdCl(2)(L1)(2)] shows high catalytic efficiency for this coupling as its 3 × 10(-5) mol% is sufficient for activated ArBr.
April 21, 2012: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/20967343/pd2l2-metallacycles-as-molecular-containers-for-small-molecules
#7
Qian Zhang, Lisi He, Jun-Min Liu, Wei Wang, Jianyong Zhang, Cheng-Yong Su
M(2)L(2) type metallacyclic complexes, [Pd(2)(L1)(2)Cl(4)]·1.5CH(2)Cl(2) (1), [Pd(2)(L1)(2)Cl(4)]·2CHCl(3) (2), [Pd(2)(L2)(2)Cl(4)]·2CH(2)Cl(2)·2CH(3)CN (3), [Pd(2)(L2)(2)Cl(4)]·2CHCl(3)·2CH(3)CN (4) and [Pd(2)(L3)(2)Cl(4)]·CH(2)Cl(2)·2CH(3)CN (5), have been prepared from three semi-rigid benzimidazol or benzotriazol ligands, 1,4-bis(benzimidazol-1-ylmethyl)-2,3,5,6-tetramethylbenzene (L1), 1,4-bis(5,6-dimethylbenzimidazol-1-ylmethyl)-2,3,5,6-tetramethylbenzene (L2) and 1,4-bis(benzotriazol-1-ylmethyl)-2,3,5,6-tetramethylbenzene (L3)...
December 14, 2010: Dalton Transactions: An International Journal of Inorganic Chemistry
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