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Aliasgar V Moiyadi, Prakash Shetty, Robin John
Purpose: Non-enhancing diffuse gliomas are a challenging surgical proposition. Delineation of tumour extent on preoperative imaging and intraoperative visualization are often difficult. Methods: We retrospectively analyzed all cases of non-enhancing gliomas that were operated on using navigated 3-dimensional ultrasonography (US). Tumour delineation (good, moderate, or poor) on preoperative magnetic resonance imaging (MRI) and intraoperative US was compared. Post-resection US findings with respect to residual tumour status were compared to the postoperative imaging findings...
July 29, 2018: Ultrasonography
Atsushi Hamabe, Takayuki Ogino, Tsukasa Tanida, Shingo Noura, Shunji Morita, Keizo Dono
BACKGROUND: Currently, we lack tools that can reliably guide laparoscopic surgeons to a target anatomical destination for dissection. We aimed to develop and evaluate a fluorescent destination marker (FDM), composed of a resected omental appendix injected with indocyanine green (ICG), for real-time navigation in laparoscopic surgery for colorectal cancer in this pilot study. METHODS: This study included ten patients diagnosed with colorectal cancer. To prepare FDMs, we laparoscopically harvested omental appendices attached to the colon we planned to resect...
October 19, 2018: Surgical Endoscopy
Darren J Burgess
No abstract text is available yet for this article.
October 19, 2018: Nature Reviews. Genetics
Muyinatu A Lediju Bell, Joshua Shubert
In intraoperative settings, the presence of acoustic clutter and reflection artifacts from metallic surgical tools often reduces the effectiveness of ultrasound imaging and complicates the localization of surgical tool tips. We propose an alternative approach for tool tracking and navigation in these challenging acoustic environments by augmenting ultrasound systems with a light source (to perform photoacoustic imaging) and a robot (to autonomously and robustly follow a surgical tool regardless of the tissue medium)...
October 19, 2018: Scientific Reports
Olveen Carrasquillo, BreAnne Young, Stuti Dang, Orieta Fontan, Natalie Ferras, Jose G Romano, Chuanhui Dong, Sonjia Kenya
BACKGROUND: Hispanic-Latino populations face a disproportionate stroke burden and are less likely to have sufficient control over stroke risk factors in comparison with other ethnic populations. A promising approach to improving chronic health outcomes has been the use of community health workers (CHWs). OBJECTIVE: The objective of this randomized controlled trial is to evaluate the effectiveness of a CHW intervention among Latino patients at risk of recurrent stroke...
October 19, 2018: JMIR Research Protocols
Anders Klingberg, Lee Alan Wallis, Marie Hasselberg, Po-Yin Yen, Sara Caroline Fritzell
BACKGROUND: The referral process in acute care remains challenging in many areas including burn care. Mobile phone apps designed explicitly for medical referrals and consultations could streamline the referral process by using structured templates and integrating features specific to different specialties. However, as these apps are competing with commercial chat services, usability becomes a crucial factor for successful uptake. OBJECTIVE: The aim of this study was to assess the usability of a mobile phone app for remote consultations and referrals of burn injuries...
October 19, 2018: JMIR MHealth and UHealth
L Corral Gudino, L A Rodríguez Arroyo, L M Zorita-Viota Sánchez
INTRODUCTION: Integrated care is a top priority for most of the National Health Services. In this study, an evaluation is made on the professional's beliefs and expectations regarding integration. MATERIAL AND METHODS: Between March and June 2017, Health Professionals from El Bierzo, León, Spain, were invited to complete 2 questionnaires on health integration process, including an online questionnaire on patient care integration (405 and 211 participants, respectively out of the total 1854 professionals)...
October 16, 2018: Semergen
Flavia Ballocca, Lukas M Meier, Karim Ladha, Joshua Qua Hiansen, Eric M Horlick, Massimiliano Meineri
OBJECTIVE: The use of 3-dimensional (3D) transesophageal echocardiography (TEE) in perioperative evaluation of the mitral valve (MV) is increasing progressively, including the use of 3D MV models for quantitative analysis. However, the use of 3D MV models in clinical practice still is limited by the need for specific training and the long time required for analysis. A new stereoscopic visualization tool (EchoPixel True 3D) allows virtual examination of anatomic structures in the clinical setting, but its accuracy and feasibility for intraoperative use is unknown...
August 11, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Riley Kellermeyer, Leah M Heydman, Grant S Mastick, Thomas Kidd
Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics. Drosophila studies indicate that cells exhibit a low level of continuous caspase protease activation, and that axon guidance cues can activate or suppress caspase activity. We base a model for axon guidance on these observations. By analogy with other systems in which caspase signaling has non-apoptotic functions, we propose that caspase signaling can either reinforce repulsion or negate attraction in response to external guidance cues by cleaving cytoskeletal proteins...
October 18, 2018: Journal of Developmental Biology
Javier Vaquero-Martínez, Manuel Antón, José Pablo Ortiz de Galisteo, Roberto Román, Victoria E Cachorro, David Mateos
Integrated water vapor (IWV) data from Global Navigation Satellite Systems (GNSS) and radiosounding (RS) are compared over four sites (Lindenberg, Ny-Ålesund, Lauder and Sodankylä), which are part of the Global Climate Observing System (GCOS) Reference Upper Air Network (GRUAN). Both datasets show an excellent agreement, with a high degree of correlation (R2 over 0.98). Dependences of GNSS-RS differences on several variables are studied in detail. Mean bias error (MBE) and standard deviation (SD) increase with IWV, but in relative term, these variables decrease as IWV increases...
January 15, 2019: Science of the Total Environment
Supraja G Varadarajan, Andrew D Huberman
Vision is the sense humans rely on most to navigate the world and survive. A tremendous amount of research has focused on understanding the neural circuits for vision and the developmental mechanisms that establish them. The eye-to-brain, or 'retinofugal' pathway remains a particularly important model in these contexts because it is essential for sight, its overt anatomical features relate to distinct functional attributes and those features develop in a tractable sequence. Much progress has been made in understanding the growth of retinal axons out of the eye, their selection of targets in the brain, the development of laminar and cell type-specific connectivity within those targets, and also dendritic connectivity within the retina itself...
October 16, 2018: Current Opinion in Neurobiology
Judith L M Mccoyd, Shari Munch, Laura Curran
Medically high-risk pregnancy (MHRP) affects 3 to 10% (diagnosis-dependent) of pregnant women in the United States (National Institute of Child Health Development, 2015), threatening maternal and fetal well-being. Although mothers' prenatal distress and mother-infant attachment after birth have been quantitatively researched, little research has examined women's lived experiences of MHRP in the United States. We examined 16 women's experiences of MHRP during hospitalization at an urban, Northeastern U.S. hospital using an interpretive phenomenological approach...
October 19, 2018: Infant Mental Health Journal
Duncan A A MacLaren, Trisha L Ljungberg, Meghan E Griffin, Stewart D Clark
PSP is the most common atypical Parkinsonism. Although Progressive Supranuclear Palsy (PSP) shares some symptomology with Parkinson's Disease (PD), PSP has a different underlying pathology characterized by tau aggregation. Furthermore, PSP sufferers respond poorly to PD medications and there are no effective alternative therapeutics. The development of both palliative and disease altering therapeutics has been hampered by the lack of an animal model that displays relevant PSP-like pathology and behavioral deficits...
October 19, 2018: European Journal of Neuroscience
Julia Lukewich, Samantha Taylor, Marie-Eve Poitras, Ruth Martin-Misener
Family practice nurses (also known as primary care nurses) are registered nurses who practice in primary healthcare and function as generalists who provide a broad range of health services, including preventative screening, health education, chronic disease management, care coordination, and system navigation. This paper reports on the current state of family practice nursing in Canada and findings from an environmental scan of literature focused on family practice nursing competency development internationally...
June 2018: Nursing Leadership
Holly A Taylor, Christian Morales, Liza-Marie Johnson, Benjamin S Wilfond
No abstract text is available yet for this article.
October 2018: American Journal of Bioethics: AJOB
Joseph D Greer, Tania K Morimoto, Allison M Okamura, Elliot W Hawkes
Soft continuum robots exhibit access and manipulation capabilities in constrained and cluttered environments not achievable by traditional robots. However, navigation of these robots can be difficult due to the kinematics of these devices. Here we describe the design, modeling, and control of a soft continuum robot with a tip extension degree of freedom. This design enables extremely simple navigation of the robot through decoupled steering and forward movement. To navigate to a destination, the robot is steered to point at the destination and the extension degree of freedom is used to reach it...
October 19, 2018: Soft Robotics
Efthymios P Papageorgiou, Hui Zhang, Simeon Giverts, Catherine Park, Bernhard E Boser, Mekhail Anwar
Microscopic tumor cell foci left in a patient after surgery significantly increase the chance of cancer recurrence. However, fluorescence microscopes used for intraoperative navigation lack the necessary sensitivity for imaging microscopic disease and are too bulky to maneuver within the resection cavity. We have developed a scalable chip-scale fluorescence contact imager for detecting microscopic cancer in vivo and in real-time. The imager has been characterized under simulated in vivo conditions using ex vivo samples, providing strong evidence that our device can be used in vivo ...
August 1, 2018: Biomedical Optics Express
Gillian Strudwick, Linda McGillis Hall, Lynn Nagle, Patricia Trbovich
Aim: The overall aim of this study is to examine nurses' perceptions of electronic health record use in an acute care hospital setting. Design: This study uses a sequential mixed methods design in two phases. Methods: Phase one consists of a survey of Registered Nurses to understand nurses' perceptions of electronic health record use. Phase two is comprised of focus groups of a subsample from phase one. Data collection occurred from November 2015 - August 2016 and was done in Toronto, Canada...
October 2018: Nursing Open
Andrea Scalabrini, Clara Mucci, Georg Northoff
The concept and the assessment of personality have been extensively discussed in psychoanalysis and in clinical psychology over the years. Nowadays there is large consensus in considering the constructs of the self and relatedness as central criterions to assess the personality and its disturbances. However, the relation between the psychological organization of personality, the construct of the self, and its neuronal correlates remain unclear. Based on the recent empirical data on the neural correlates of the self (and others), on the importance of early relational and attachment experiences, and on the relation with the brain's spontaneous/resting state activity (rest-self overlap/containment), we propose here a multilayered model of the self with: (i) relational alignment; (ii) self-constitution; (iii) self-manifestation; and (iv) self-expansion...
2018: Frontiers in Human Neuroscience
Arthur Rawlings, Jennifer Doty, Amanda Frevert, Jacob Quick
PURPOSE: Nondesignated preliminary residents (N-DPRs) in General Surgery face difficult challenges of overcoming failure to match and quickly reentering the match again with little time to significantly improve their application. Programs with N-DPRs should take seriously their responsibility for helping these residents obtain a successful career path just as they do for their categorical residents. This study evaluates an intervention to improve the matching of N-DPRs into desired positions...
October 15, 2018: Journal of Surgical Education
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