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https://www.readbyqxmd.com/read/30336303/diarylheptanoid-a-constituent-isolated-from-methanol-extract-of-alpinia-officinarum-attenuates-tnf-%C3%AE-level-in-freund-s-complete-adjuvant-induced-arthritis-in-rats
#1
Varsha S Honmore, Amit Kandhare, Parag P Kadam, Vijay M Khedkar, Arun D Natu, Supada R Rojatkar, Subhash L Bodhankar
ETHNOPHARMACOLOGICAL RELEVANCE: Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease that affects the worldwide population. Alpinia officinarum Hance (Zingiberaceae), rhizomes are widely used ethnobotanically as an anti-inflammatory, analgesic, and antioxidant agent in traditional medicine. AIM: To investigate the efficacy and possible mechanism of isolated phytoconstituent from the methanol extract of A. officinarum (MEAO) rhizomes against Freund's complete adjuvant (FCA)-induced arthritis in rats...
October 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30336301/ivermectin-does-not-interfere-with-seminal-and-hormonal-parameters-in-male-rabbits
#2
N Moreira, M A Torres, P E Navas-Suárez, V Gonçalves, P C F Raspantini, L E R Raspantini, A T Gotardo, A F C Andrade, H S Spinosa
Ivermectin (IVM) is a macrocyclic lactone used as a broad spectrum antiparasitic agent against nematodes and arthropods. It is mainly used in the control of parasitic infections of domestic animals, and recently has been used in humans to treat onchocerciasis, scabies, and pediculosis. In mammals, evidence has indicated that macrocyclic lactones interact with gamma-aminobutyric acid (GABA)-mediated chloride channels. The GABAergic system is known to be involved in the manifestation of sexual behavior, and previous studies have shown that IVM impaired sexual behavior in both male and female rats...
September 27, 2018: Theriogenology
https://www.readbyqxmd.com/read/30336292/spontaneous-spinal-epidural-hematoma-correlation-of-timing-of-surgical-decompression-and-mri-findings-with-functional-neurological-outcome
#3
Saleh Baeesa, Peter Jarzem, Mohammed Mansi, Rakan Bokhari, Mahdi Bassi
OBJECTIVE: Spontaneous spinal epidural hematomas (SSEH) are a rare and morbid entity whose prognosis is affected by delayed diagnosis and surgical intervention. Correlation with the time of intervention and neurological recovery is not clearly described in the literature. We present a retrospective study of SSEH, to determine the correlation between the timing of surgical intervention and changes in the spinal cord signal on MRI with the neurological outcome. METHODS: The records of 14 patients who underwent surgical decompression of SSEH over 10-year duration were reviewed...
October 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30336216/pretransplant-angiotensin-ii-type-1-receptor-antibodies-point-to-an-increase-in-renal-graft-sub-intimal-fibrosis-in-living-donor-kidney-transplant-recipients
#4
Alberto González-Almada, José M Arreola-Guerra, José Argenis López-Sánchez, Eric Cuevas, Mario Vilatoba, Alan G Contreras, Luis E Morales-Buenrostro, Josefina Alberu, Norma O Uribe-Uribe
The association between anti-AT1Rabs and microvascular injury observed in antibody-mediated rejection has been described in kidney graft Biopsies (KGBx). METHODS: We herein describe the histopathologic findings of KGBx performed during the first year of transplantation (Tx) in 134 patients tested for pre-Tx anti-AT1Rabs in cryopreserved sera (04/2009 to 09/2013). Protocol KGBx before implantation (time-zero), 1 year after Tx and for cause KGBx were included. 21/134 Tx patients were anti-AT1Rab positive (≥17 U/mL); 7/21 experienced acute rejection...
October 15, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/30336143/voluntary-exercise-improves-muscle-function-and-does-not-exacerbate-muscle-and-heart-pathology-in-aged-duchenne-muscular-dystrophy-mice
#5
Bauke Kogelman, Kayleigh Putker, Margriet Hulsker, Christa Tanganyika-de Winter, Louise van der Weerd, Annemieke Aartsma-Rus, Maaike van Putten
Duchenne muscular dystrophy is a severe muscle wasting disease, characterized by a severely reduced lifespan in which cardiomyopathy is one of the leading causes of death. Multiple therapies aiming at dystrophin restoration have been approved. It is anticipated that these therapies will maintain muscle function for longer and extend the ambulatory period, which in turn will increase the cardiac workload which could be detrimental for cardiac function. We investigated the effects of voluntary running exercise in combination with low dystrophin levels on function and pathology of skeletal muscle and heart...
October 15, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/30335918/ultrasound-image-of-malignant-bone-tumors-in-children-an-analysis-of-nine-patients-diagnosed-in-2011-2016
#6
Tomasz Madej, Joanna Flak-Nurzyńska, Ewa Dutkiewicz, Anna Ciechomska, Jerzy Kowalczyk, Andrzej Paweł Wieczorek
INTRODUCTION: The diagnostic process of bone tumors, including malignant ones, is based on conventional radiological methods, such as radiography and computed tomography, and with precise assessment of local advancement in magnetic resonance imaging. Ultrasonography is not included in the diagnostic algorithms as a tool suitable to detect this type of pathology. More and more frequent usage of musculoskeletal ultrasound in children as the first imaging method or, in some cases, as the only diagnostic method, makes it necessary to be familiar with sonographic presentation of bone tumors to suggest this diagnosis early enough and, after its verification, start treatment without a significant delay...
2018: Journal of Ultrasonography
https://www.readbyqxmd.com/read/30335903/microrna-206-is-required-for-osteoarthritis-development-through-its-effect-on-apoptosis-and-autophagy-of-articular-chondrocytes-via-modulating-the-phosphoinositide-3-kinase-protein-kinase-b-mtor-pathway-by-targeting-insulin-like-growth-factor-1
#7
Qian Yu, Bei Zhao, Qi He, Yuan Zhang, Xian-Bo Peng
microRNA (miR) has been shown to be involved in the treatment of diseases such as osteoarthritis (OA). This study aims to investigate the role of miR-206 in regulating insulin-like growth factor-1 (IGF-1) in chondrocyte autophagy and apoptosis in an OA rat model via the phosphoinositide 3-kinase (P13K)/protein kinase B (AKT)-mechanistic target of rapamycin (mTOR) signaling pathway. Wistar rats were used to establish the OA rat model, followed by the observation of histopathological changes, Mankin score, and the detection of IGF-1-positive expression and tissue apoptosis...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335567/a-conservative-approach-for-localized-spongiotic-gingivitis-hyperplasia-using-photodynamic-therapy-a-case-report-and-review-of-the-literature
#8
Danielle Leal Vieira, André Ferreira Leite, Paulo Tadeu de Souza Figueiredo, Leonora Maciel Vianna, Carla Ruffeil Moreira-Mesquita, Nilce Santos de Melo
OBJECTIVE: To describe a clinical case of successful conservative management of Localized Juvenile Spongiotic Gingivitis Hyperplasia (LJSGH) using photodynamic therapy (PDT) and reviews the current literature on this pathology. BACKGROUND DATA: LJSGH is a recently described rare disease with controversial treatment results. As of today, 13 publications report surgical treatment approaches. The use of CO2 laser and cryotherapy was reported only in one study. The use of PDT was not previously reported...
October 18, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/30335535/immunohistochemical-and-immunocytochemical-analyses-in-patients-with-vitreoretinal-lymphoma
#9
Satoru Kase, Kenichi Namba, Hiromi Kanno-Okada, Masahiro Onozawa, Daisuke Hidaka, Daiju Iwata, Kazuomi Mizuuchi, Takako Fukuhara, Junichi Fukuhara, Nobuyoshi Kitaichi, Yoshihiro Matsuno, Susumu Ishida
PURPOSE: The aim of this study was to analyze immunohistochemical and immunocytological findings by examining enucleated eyes and vitreous cell block (CB) in patients with vitreoretinal lymphoma (VRL). METHODS: Histological specimens were obtained from two enucleated eyes with VRL associated with neovascular glaucoma. CB specimens were prepared in 18 patients from diluted waste fluids containing shredded vitreous. Histological and cytological specimens were submitted for hematoxylin-eosin staining and immunopathological analyses...
October 18, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/30335473/abdominal-organ-perfusion-and-inflammation-in-experimental-sepsis-a-magnetic-resonance-imaging-study
#10
Silvia Marchesi, Fracisco Ortiz Nieto, Kerstin Magdalena Ahlgren, Agneta Roneus, Ricardo Feinstein, Miklos Lipcsey, Anders Larsson, Håkan Ahlström, Goran Hedenstierna
Diffusion-weighted magnetic resonance imaging (DW-MRI) uses water as contrast and enables the study of perfusion in many organs simultaneously in situ. We used DW-MRI in a sepsis model, comparing abdominal organs perfusion with global hemodynamic measurements and inflammation. Sixteen anesthetized piglets were randomized into 3 groups: HighMAP (mean arterial pressure, MAP > 65 mmHg), LowMAP (MAP between 50 and 60 mmHg) and Healthy Controls (HC). Sepsis was obtained with endotoxin and the desired MAP maintained with noradrenaline...
October 18, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/30335234/disseminated-histoplasmosis-as-a-first-clinical-manifestation-in-a-patient-with-small-lymphocytic-lymphoma-a-case-report
#11
Nhora Silva, Natalia Calvache, Elizabeth Arrieta, Juan Carlos Bravo, Camilo Salazar, Joaquín Rosales, Francisco Jaramillo, Juan Guillermo Restrepo
The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis. A female 82-year-old patient was admitted due to an intermittent dry cough, asthenia, and adynamia that had persisted for one month...
September 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/30335212/malignancy-rate-of-atypia-of-undetermined-significance-follicular-lesion-of-undetermined-significance-in-thyroid-nodules-undergoing-fna-in-a-suburban-endocrinology-practice-a-retrospective-cohort-analysis
#12
Maighan A Seagrove-Guffey, Haris Hatic, Haoran Peng, Kimberly C Bates, A Ola Odugbesan
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was created to establish a standard terminology regarding thyroid nodules that can be shared between endocrinologists, pathologists, radiologists, and surgeons. Since its inception and use in 2009, multiple large hospitals and academic institutions have performed retrospective studies to compare their classification rates, specifically those of atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS), with the recommended rates created by the National Cancer Institute...
October 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/30335178/frequent-diagnostic-under-grading-in-isocitrate-dehydrogenase-wild-type-gliomas-due-to-small-pathological-tissue-samples
#13
Marielena Gutt-Will, Michael Murek, Christa Schwarz, Ekkehard Hewer, Sonja Vulcu, Jürgen Beck, Andreas Raabe, Philippe Schucht
BACKGROUND: In contrast to isocitrate dehydrogenase (IDH) mutation analysis, which is homogenous within a given tumor, diagnostic errors in histological analysis following the 2016 World Health Organization (WHO) classification could be due to small samples because of histological heterogeneity. OBJECTIVE: To assess whether the sample size sent to histopathology influences the tumor grading in IDH wild-type gliomas. METHODS: Histologically diagnosed WHO grade, sample volume, and preoperative tumor volume data of 111 patients aged who received resection of IDHwt gliomas between January 2007 and December 2015 at our hospital were evaluated...
October 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/30335019/choriocarcinoma-with-brain-metastasis-after-term-pregnancy-a-case-report
#14
Liang Song, Qingli Li, Rutie Yin, Danqing Wang
RATIONALE: Although the incidence of postpartum choriocarcinoma is extremely low, careful postpartum placental examination, histopathological examination in patients with abnormalities, and blood β-human chorionic gonadotropin (HCG) monitoring in high-risk pregnant women are necessary for early diagnosis of postpartum choriocarcinoma and improvement in prognosis. PATIENT CONCERNS: A 32-year-old woman presented with the chief complaint of postpartum irregular vaginal bleeding for 45 days and coughing and hemoptysis for 7 days...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334973/osteoblastoma-of-the-frontal-bone-invading-the-orbital-roof-a-case-report
#15
Kun Wang, Feidan Yu, Keng Chen, Huanjiang Niu, Yirong Wang, Shuxu Yang, Xiujun Cai
RATIONALE: Osteoblastoma is an uncommon primary bone tumor that involves any part of the skeleton. But its occurrence in the skull is extremely rare. PATIENTS CONCERNS: A 30-year-old female was admitted to our hospital, because of the mass in the right frontal region with the history of headache for 3 years without nausea or vomiting. DIAGNOSIS: Initial differential diagnoses included hemangiopericytoma, atypical intraosseous meningioma, calvarial osteosarcoma, fibrous dysplasia, and histiocytosis, based on the results of enhanced CT and MRI...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334947/rituximab-for-idiopathic-and-igg4-related-retroperitoneal-fibrosis
#16
Rachel Wallwork, Zachary Wallace, Cory Perugino, Amita Sharma, John H Stone
Retroperitoneal fibrosis (RPF) refers to a fibro-inflammatory lesion in the retroperitoneum, often anterolateral to the aorta. Most cases are due to IgG4-related disease (IgG4-RD) or are idiopathic. RPF can lead to severe morbidity. Treatment strategies remain poorly-defined. We evaluated the efficacy and safety of rituximab (RTX) for idiopathic or IgG4-related RPF.We retrospectively reviewed the records of patients who had RPF treated with RTX. Treatment response was determined by assessing changes in both clinical features, including symptoms and laboratory measurements, as well as in the radiographic dimensions of the lesion...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334874/descemet-membrane-endothelial-keratoplasty-dmek-graft-dislocation-into-the-vitreous-cavity
#17
Alfonso Vasquez-Perez, Nicholas Brennan, Tariq Ayoub, Bruce Allan, Daniel F P Larkin, Lyndon da Cruz
PURPOSE: To present our experience of Descemet stripping endothelial keratoplasty (DMEK) graft luxation into the vitreous cavity in 2 cases. METHODS: DMEK was performed in 2 patients with aphakic bullous keratopathy. The indications for keratoplasty were endothelial failure caused by chronic intermediate uveitis and glaucoma in 1 case and decompensated previous penetrating keratoplasty in the other. Both cases had enlarged pupils and had previously undergone pars plana vitrectomy...
October 16, 2018: Cornea
https://www.readbyqxmd.com/read/30334828/cutaneous-leishmaniasis-contribution-of-routine-histopathology-in-unexpected-encounters
#18
Jerome B Taxy, Harry M Goldin, Sara Dickie, Thomas Cibull
The ulcerated papules of cutaneous leishmaniasis represent an unusual form of granulomatous dermatitis caused by Leishmania species, a protozoan transmitted by sandfly bites. As the disease is not native to North America, clinical suspicion is partially based on a compatible travel history and may result in a biopsy. The key role of standard morphology is the identification of Leishmania organisms, supplemented by Giemsa and/or CD1a immunostaining. Histologically, the organism may be confused with Histoplasma species, which is resolved by staining with methenamine silver or PAS...
October 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30334722/rickettsia-typhi-as-cause-of-fatal-encephalitic-typhus-in-hospitalized-patients-hamburg-germany-1940-1944
#19
Jessica Rauch, Birgit Muntau, Petra Eggert, Dennis Tappe
We evaluated formalin-fixed paraffin-embedded tissue specimens from 7 patients who died with encephalitic typhus in Hamburg, Germany, during World War II. The archived specimens included only central nervous system tissues >70 years old that had been stored at room temperature. We demonstrated successful detection of Rickettsia typhi DNA by a nested qPCR specific to prsA in 2 patients. These results indicate that R. typhi infections contributed to typhus outbreaks during World War II. Immunohistochemical analyses of brain tissue specimens of R...
November 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/30334708/african-histoplasmosis-in-hiv-negative-patients-kimpese-democratic-republic-of-the-congo
#20
Nestor Pakasa, Asaf Biber, Samuel Nsiangana, Désiré Imposo, Ernest Sumaili, Hypolite Muhindo, Maria J Buitrago, Iris Barshack, Eli Schwartz
We describe a case series of histoplasmosis caused by Histoplasma capsulatum var. duboisii during July 2011-January 2014 in Kimpese, Democratic Republic of the Congo. Cases were confirmed by histopathology, immunohistochemistry, and reverse transcription PCR. All patients were HIV negative. Putative sources for the pathogen were cellar bats and guano fertilizer exploitation.
November 2018: Emerging Infectious Diseases
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