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https://www.readbyqxmd.com/read/30098492/high-body-mass-index-is-associated-with-an-expansion-of-endometrial-t-regulatory-cell-and-macrophage-populations
#1
Magdalena Palacz, Kelton Tremellen
Obesity is associated with implantation failure, miscarriage, low-grade inflammation and a reduction in peripheral immune-suppressive T regulatory (Treg) cells. Therefore, we postulated that this reduction may also extend to the endometrium and cause embryonic loss. In a cohort of 40 infertile women, without implantation failure or recurrent miscarriage, we examined the density of Treg cells, macrophages and natural killer (NK) cells in mid-luteal endometrial biopsies. Significant positive correlations were observed between BMI and endometrial Treg cells and macrophages, but no relationship with NK cells...
August 4, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/30098440/pro-angiogenic-near-infrared-responsive-hydrogels-for-deliberate-transgene-expression
#2
Francisco Martín-Saavedra, Clara Escudero-Duch, Martín Prieto, Silvia Sánchez-Casanova, Daniel López, Manuel Arruebo, Richard Voellmy, Jesús Santamaría, Nuria Vilaboa
CuS nanoparticles (CuSNP) are degradable, readily prepared, inexpensive to produce and efficiently cleared from the body. In this work, we explored the feasibility of CuSNP to function as degradable near infrared (NIR) nanotransducers within fibrin-based cellular scaffolds. To prepare NIR-responsive CuSNP hydrogels, fibrinogen was dissolved in cell culture medium and supplemented with aqueous dispersions of CuSNP. Fibrinogen polymerization was catalyzed by the addition of thrombin. In some experiments, HUVEC, C3H/10T1/2 or C3H/10T1/2-fLuc cells, that harbor a heat-activated and rapamycin-dependent gene switch for regulating the expression of firefly luciferase transgene expression, were incorporated to the sol phase of the hydrogel...
August 8, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30098385/early-diagnosis-of-radio-insensitive-human-nasopharyngeal-carcinoma-xenograft-models-by-diffusion-kurtosis-imaging
#3
Xiang Zheng, Yunbin Chen, Youping Xiao, Dechun Zheng, Weibo Chen
OBJECTIVE: To investigate the feasibility of DKI in early detection of radio-insensitive nasopharyngeal carcinoma (NPC) xenografts in nude mice. MATERIALS AND METHODS: Seventy-two nude mice were implanted with CNE-1 (low radio-sensitive) and CNE-2 (high radio-sensitive) NPC cell lines, and their respective xenografts were obtained. Then, the NPC-bearing nude mice were exposed to different doses of fraction irradiation, which are divided into non-irradiated group (G0), 10Gy group (G1), 20Gy group (G2), 30Gy group (G3), 3rd (G4) and 5th (G5) days after the entire dose (30y) of irradiation...
August 8, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/30098234/-unknown-title
#4
K Zaoui, P K Plinkert, P A Federspil
OBJECTIVE: The treatment strategy of squamous cell carcinoma of the nasal vestibule (SCCNV) is controversial. The objective of this study is to investigate the role of surgery, which is the preferred treatment option at our institution. DESIGN: This was a monocentric prospective study of patients that were diagnosed with SCCNV between 2005 and 2013. MATERIAL AND METHODS: Twenty-six patients were included. Tumors were staged using the UICC (7th edition) TNM classification of nasal cavity cancer and the classification proposed by Wang...
August 11, 2018: Rhinology
https://www.readbyqxmd.com/read/30098207/acidic-extracellular-environment-affects-mirna-expression-in-tumors-in-vitro-and-in-vivo
#5
Anne Riemann, Sarah Reime, Oliver Thews
Hypoxia can control the expression of miRNAs in tumors which play an important role for the control of the malignant behavior. The aim of the study was to analyze whether extracellular acidosis, a common feature of tumors, also has an impact on the miRNA expression in isolated cells as well as in solid tumors. MiRNA expression was analyzed in two rat tumor cell lines (AT1 prostate and Walker-256 mammary carcinomas) by NGS and qPCR. In vivo the same cell lines were implanted subcutaneously and the tumor pH was modulated by inspiratory hypoxia and inhibition of the respiratory chain...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30097997/therapeutic-implications-of-how-tnf-links-apoe-p-tau-%C3%AE-synuclein-%C3%AE-amyloid-and-insulin-resistance-in-neurodegenerative-diseases
#6
REVIEW
I A Clark, B Vissel
While cytokines such as tumour necrosis factor (TNF) are long recognised as essential to normal cerebral physiology, the implications of their chronic excessive production within the brain are now also increasingly appreciated. Syndromes as diverse malaria and lead poisoning, as well as the non-infectious neurodegenerative diseases illustrate this. These cytokines also orchestrate changes in tau, α-synuclein, β-amyloid levels and degree of insulin resistance in most neurodegenerative states. New data on the effects of salbutamol, an anti-TNF agent, on α-synuclein and Parkinson's disease, APOE4 and tau add considerably to the rationale of the anti-TNF approach to understanding, and treating, these diseases...
August 10, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/30096889/treatment-of-periodontal-ligament-stem-cells-with-mor-and-cbd-promotes-cell-survival-and-neuronal-differentiation-via-the-pi3k-akt-mtor-pathway
#7
Veronica Lanza Cariccio, Domenico Scionti, Antonio Raffa, Renato Iori, Federica Pollastro, Francesca Diomede, Placido Bramanti, Oriana Trubiani, Emanuela Mazzon
Periodontal ligament mesenchymal stem cells (hPDLSCs), as well as all mesenchymal stem cells, show self-renewal, clonogenicity, and multi-tissue differentiation proprieties and can represent a valid support for regenerative medicine. We treated hPDLSCs with a combination of Moringin (MOR) and Cannabidiol (CBD), in order to understand if treatment could improve their survival and their in vitro differentiation capacity. Stem cells survival is fundamental to achieve a successful therapy outcome in the re-implanted tissue of patients...
August 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30096888/an-innovative-approach-to-manganese-substituted-hydroxyapatite-coating-on-zinc-oxide%C3%A2-coated-316l-ss-for-implant-application
#8
Karuppasamy Prem Ananth, Jinxing Sun, Jiaming Bai
In this paper, the synthesis of porous manganese substituted hydroxyapatite (Mn-HAp) coating on zinc oxide (ZnO) coated stainless steel (316L SS) using the electrodeposition technique is reported. The structural, functional, morphological, and elemental analyses are characterized by various analytical techniques including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS)...
August 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30096095/new-insights-into-breast-implant-associated-anaplastic-large-cell-lymphoma
#9
Camille Laurent, Corinne Haioun, Pierre Brousset, Philippe Gaulard
PURPOSE OF REVIEW: Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare form of lymphoma arising adjacent to a breast implant. We aim to review the pathogenesis and clinico-biological features of BI-ALCL. RECENT FINDINGS: BI-ALCL is a new provisional entity in the 2017 updated WHO classification. Among several hypotheses, BI-ALCL development seems to be determined by the interaction of immune response related to implant products and additional genetic events...
September 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/30095195/effect-of-culture-duration-on-chondrogenic-preconditioning-of-equine-bone-marrow-mesenchymal-stem-cells-in-self-assembling-peptide-hydrogel
#10
John D Kisiday, Aimee C Colbath, Suwimol Tangtrongsup
Ex vivo induction of chondrogenesis is a promising approach to improve upon the use of bone marrow mesenchymal stem cells (MSCs) for cartilage tissue engineering. This study evaluated the potential to induce chondrogenesis with days of culture in chondrogenic medium for MSCs encapsulated in self-assembling peptide hydrogel. To simulate the transition from preconditioning culture to implantation, MSCs were isolated from self-assembling peptide hydrogel into an individual cell suspension. Commitment to chondrogenesis was evaluated by seeding preconditioned MSCs into agarose and culturing in the absence of the chondrogenic cytokine transforming growth factor beta (TGFβ)...
August 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30095082/effect-of-nanostructures-on-anchoring-stem-cell-derived-neural-tissue-to-artificial-surfaces
#11
Zsofia Berces, Judit Pomothy, Ágoston Csaba Horváth, Timea Kőhidi, Éva Benyei, Zoltan Fekete, Emília Madarász, Anita Pongrácz
Chronic application of brain implants monitoring or modulating neuronal activity are hindered by the foreign body response of the tissue. Topographical modification of implant surfaces may reduce negative tissue response, by imitating the structure of the extracellular matrix, and therefore affecting the attachment and behavior of neural cells. 
 In our in vitro study, the effect of nanostructuring was investigated on two commercially used neural implant material: silicon and platinum. The adhesion, survival and arrangement of neural stem cells (NE4C) and microglial cells (BV2) were investigated and compared to nanostructured and flat Si and Pt surfaces using cell viability studies and fluorescent microscopy image analysis...
August 10, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/30094977/-electroacupuncture-of-tianshu-st-25-suppresses-visceral-pain-possibly-by-down-regulating-mast-cell-activation-and-tryptase-and-sp-expression-in-rats-with-post-infectious-irritable-bowel-syndrome
#12
Li-Xia Pei, Wei Zhang, Ya-Fang Song, Hao Geng, Lu Chen, Xiao-Liang Wu, Jun-Ling Zhou, Jian-Hua Sun
OBJECTIVE: To observe the effect of electroacupuncture (EA) at "Tianshu" (ST 25) on visceral pain and colonic mast cell (MCs) number and tryptase and SP expression in post-infectious irritable bowel syndrome (PI-IBS) rats, so as to reveal its mechanisms underlying improvement of PI-IBS. METHODS: Forty-five female Wistar rats were randomly divided into control, model and EA groups (15 rats/ group, 3 rats/group used for H. E. staining, and 12 rats/group for immunohistochemistry)...
July 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/30094550/breast-implant-associated-anaplastic-large-cell-lymphoma-immediate-or-delayed-implant-replacement
#13
Julien J Shine, Elie Boghossian, Gabriel Beauchemin, Vasilios W Papanastasiou, Daniel E Borsuk
INTRODUCTION: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare and recently described type of peripheral T-cell lymphoma. Fewer than 550 cases have been reported worldwide. Although BIA-ALCL is usually indolent, early diagnosis and treatment have been shown to improve outcome. CASE DESCRIPTION: This case report describes the management of a 50-year-old healthy Caucasian woman presenting with rapid painful enlargement of the left breast...
August 9, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/30094508/identification-of-reference-genes-suitable-for-rt-qpcr-studies-of-murine-gastrulation-and-patterning
#14
Kristen S Barratt, Koula E M Diamand, Ruth M Arkell
Quantitative reverse transcriptase PCR (RT-qPCR), a powerful and efficient means of rapidly comparing gene expression between experimental conditions, is routinely used as a phenotyping tool in developmental biology. The accurate comparison of gene expression across multiple embryonic stages requires normalisation to reference genes that have stable expression across the time points to be examined. As the embryo and its constituent tissues undergo rapid growth and differentiation during development, reference genes known to be stable across some time points cannot be assumed to be stable across all developmental stages...
August 9, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30094397/bilateral-brightocular-iris-implants-necessitating-explantation-and-subsequent-endothelial-keratoplasty
#15
Zale Mednick, Devin Betsch, Tanguy Boutin, Adi Einan-Lifshitz, Nir Sorkin, Allan Slomovic
Purpose: To demonstrate the dangers associated with the BrightOcular iris implant, a model that had initially been touted as safer than its predecessors. Observations: A 41-year-old male presented with decreased vision in both eyes, approximately two years following bilateral BrightOcular cosmetic iris implantation performed in Mexico. On initial consultation, he was found to have bilateral corneal decompensation with stromal edema and a significantly reduced endothelial cell count (ECC)...
December 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/30094359/the-impact-of-photofunctionalized-gold-nanoparticles-on-osseointegration
#16
Yassir Elkhidir, Renfa Lai, Zhiqiang Feng
Objectives: The aims of this study were to create a new surface topography using simulated body fluids (SBF) and Gold Nanoparticles (GNPs) and then to assess the influence of UV Photofunctionalization (PhF) on the osteogenic capacity of these surfaces. Materials and methods: Titanium plates were divided into six groups All were acid etched with 67% Sulfuric acid, 4 were immersed in SBF and 2 of these were treated with 10 nm GNPs. Half of the TiO2 plates were photofunctionalized to be compared with the non-PhF ones...
July 2018: Heliyon
https://www.readbyqxmd.com/read/30094235/skin-tissue-substitutes-and-biomaterial-risk-assessment-and-testing
#17
REVIEW
Houman Savoji, Brent Godau, Mohsen Sheikh Hassani, Mohsen Akbari
Tremendous progress has been made over the past few decades to develop skin substitutes for the management of acute and chronic wounds. With the advent of tissue engineering and the ability to combine advanced manufacturing technologies with biomaterials and cell culture systems, more biomimetic tissue constructs have been emerged. Synthetic and natural biomaterials are the main constituents of these skin-like constructs, which play a significant role in tissue grafting, the body's immune response, and the healing process...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/30094063/construction-and-evaluation-of-fibrillar-composite-hydrogel-of-collagen-konjac-glucomannan-for-potential-biomedical-applications
#18
Jiayuan Tang, Jinlin Chen, Jing Guo, Qingrong Wei, Hongsong Fan
Konjac glucomannan (KGM) is recognized as a safe material for its health-promoting benefits and thus widely used in various fields including pharmaceutical industry. In recent decades, the combination of collagen and KGM attracts more attentions for biomedical purpose, especially the hybrid films of collagen-KGM or collagen-KGM-polysaccharide. In this study, to further and deeply develop the intrinsic values of both collagen and KGM as biomaterials, a novel kind of composite hydrogel comprising collagen and KGM at a certain ratio was fabricated under mild conditions via fibrillogenesis process of the aqueous blends of collagen and KGM that experienced deacetylation simultaneously...
August 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/30094060/tissue-engineering-using-3d-printed-nano-bioactive-glass-loaded-with-nell1-gene-for-repairing-alveolar-bone-defects
#19
Jing Zhang, Yang Chen, Jing Xu, Jingjing Wang, Chengzhang Li, Liyan Wang
The purposes of this study were to construct a novel tissue engineered bone composed of 3D-printed bioactive glass block/chitosan nanoparticles (BD/CSn) composites loaded with Nel-like Type I molecular-1 DNA (pDNA-NELL1) and/or bone marrow mesenchymal stem cells (BMSCs), and study their osteogenic activities by repairing bone defects in rhesus monkeys. CSn with NELL1 gene plasmid and rhesus monkey BMSCs were composited with a BD scaffold to prepare the tissue-engineered bone. Four adult female rhesus monkeys with 10- to 12-years old and 5-7 kg in weight were used in animal experiments...
August 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/30093864/danhong-injection-enhances-the-therapeutic-efficacy-of-mesenchymal-stem-cells-in-myocardial-infarction-by-promoting-angiogenesis
#20
Jingrui Chen, Jing Wei, Yuting Huang, Yuling Ma, Jingyu Ni, Min Li, Yan Zhu, Xiumei Gao, Guanwei Fan
Stem cell-based therapies have the potential to dramatically transform the treatment and prognosis of myocardial infarction (MI), and mesenchymal stem cells (MSCs) have been suggested as a promising cell population to ameliorate the heart remodeling in post-MI. However, poor implantation and survival in ischemic myocardium restrict its efficacy and application. In this study, we sought to use the unique mode of action of Chinese medicine to improve this situation. Surrounding the myocardial infarct area, we performed a multi-point MSC transplantation and administered in conjunction with Danhong injection, which is mainly used for the treatment of MI...
2018: Frontiers in Physiology
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