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Pressure chamber

Viraj Vasavada, Samaresh Srivastava, Shail A Vasavada, Aditya Sudhalkar, Abhay R Vasavada, Vaishali A Vasavada
PURPOSE: To evaluate the outcomes of a new posterior chamber phakic intraocular lens (IPCL; Care Group, Baroda, India) to correct myopia. METHODS: This prospective, observational case series included 30 eyes undergoing implantation of the IPCL for high myopia (> -8.00 diopters [D]). Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, vault, endothelial cell loss, and adverse events were evaluated 3 years after implantation of the IPCL for high myopia...
December 1, 2018: Journal of Refractive Surgery
Neelam Singh, Giriraj T Kulkarni, Yatendra Kumar
AIM AND BACKGROUND: The rationale of this study is that, treatment of asthmatic Guinea pig with combined administration of Montelukast sodium and green tea extract (GTE) as a single capsule will mitigate the inflammatory injury in the airways and weaken the asthmatic response. Recent patents for the treatment of asthma researched a polyphenolic alternatives for antiasthmatic combination therapy, especially for those patients who remains unresponsive or poorly responsive for current asthma therapy (US7232585B2)...
December 11, 2018: Recent Patents on Drug Delivery & Formulation
Fabrizio Giansanti, Ruggero Tartaro, Tomaso Caporossi, Vittoria Murro, Alfonso Savastano, Francesco Barca, Daniela Bacherini, Tito Fiore, Carlo Cagini, Stanislao Rizzo
Objective: Intraocular lens (IOL) repositioning using a closed-eye approach could be carried out in some selected cases. Our study focuses on the efficacy and safety of a IOL closed-eye repositioning technique using scleral suture, which is performed using a trocar as an intrastromal limbal guide. Methods and analysis: Thirty-one eyes of 31 patients with late IOL dislocation operated on between January 2015 and May 2017 were included in this retrospective non-comparative consecutive case series study...
2018: BMJ Open Ophthalmology
Eriko Seo, Yoshiteru Seo
In order to analyse the roles of Keber's valve for foot manipulation in the clam Nodularia douglasiae , the anatomy and hemolymph flow in the cardiovascular system were detected by magnetic resonance imaging. The superficial layer of the foot was covered by a dense muscle layer, which extended to the dorsal side and connected with the shell. This closed space, the foot chamber, had an inlet (anterior aorta) and an outlet (Keber's valve). At rest, in the beginning of the systolic phase, flows in the anterior aorta and the pedal artery increased, followed by the pedal and visceral sinuses...
December 10, 2018: Biology Open
Wenjuan Wan, Lei Shi, Can Li
BACKGROUND: This study aims to compare the safety and effectiveness of two closed-chamber techniques for repairing iridodialysis. METHODS: Seventy five patients with iridodialysis undergoing surgery from February 2008 to October 2017 were included in this study. Patients were divided into two Groups, Group A (32 eyes) and Group B (35 eyes), with Group A using a 26-gauge hypodermic needle guided 10-0 nylon suture, and Group B using a double-armed polypropylene suture...
December 7, 2018: BMC Ophthalmology
Roya Ostovar, Martin Hartrumpf, Ralf-Uwe Kuehnel, Filip Schroeter, Magdalena Laux, Michael Erb, Thomas Claus, Johannes Maximilian Albes
OBJECTIVES: The invention of new surgical procedures requires testing at different stages including animal models. To facilitate this process, we have developed a computer-controlled extracorporeal circulation system for testing of an explanted porcine heart simulating a variety of physiological parameters. Mitral valve function can be assessed before and after induced valve insufficiency and after valve repair. Accordingly, techniques and instruments can be modified at early stages of prototype development...
December 4, 2018: Interactive Cardiovascular and Thoracic Surgery
Sota Nishisako, Dai Aoki, Chiaki Sasaki, Kazunari Higa, Jun Shimazaki
Purpose: To optimize methods of preparing donor cornea tissue for Descemet's stripping automated endothelial keratoplasty (DSAEK), we compared five experimental conditions with different internal pressures and cutting systems. Methods: The artificial anterior chamber internal pressure (IP) was set at 100 or 200 mm Hg. The microkeratome cut was performed with or without an artificial chamber pressurizer (ACP), using a CBm turbine (CBm) or one use-plus automated (OUP-A)...
November 2018: Translational Vision Science & Technology
You-Yi Wang, Zhen-Yu Wang, Wei Peng, Ji-Yu Xu, Shi-Rong Chen, Bin Ye, Chun-Yan Wu
We report the fabrication of KCu7 S₄/Cu x O/Au devices with interfacial Cu x O layers of different thicknesses through the spontaneous oxidation of Cu film during deposition. Deposition was conducted with an electron-beam evaporation system under the deposition rate and the chamber pressure of 0.1 Å s-1 and 9.8×10-3 Pa, respectively. X-ray diffraction and X-ray photoelectron spectroscopy characterizations reveal that the interfacial Cu x O layers mostly comprise Cu₂O and CuO. Electrical characterization reveals that the devices exhibit remarkably thickness-dependent resistive switching behavior...
May 1, 2019: Journal of Nanoscience and Nanotechnology
T J Clark, V Vadakkumbatt, F Souris, H Ramp, J P Davis
A wide variety of applications of microwave cavities, such as measurement and control of superconducting qubits, magnonic resonators, and phase noise filters, would be well served by having a highly tunable microwave resonance. Often this tunability is desired in situ at low temperatures, where one can take advantage of superconducting cavities. To date, such cryogenic tuning while maintaining a high quality factor has been limited to ∼500 MHz. Here we demonstrate a three-dimensional superconducting microwave cavity that shares one wall with a pressurized volume of helium...
November 2018: Review of Scientific Instruments
X J Yu, C Z Diao, T Venkatesan, M B H Breese, A Rusydi
A new beamline and a six-circle UHV diffractometer have been constructed at the Singapore Synchrotron Light Source with a broad energy coverage from 3.5 to 1500 eV. The beamline is optimized for ultraviolet-vacuum-ultraviolet optical reflectivity and resonant soft X-ray scattering with medium energy resolution over a broad energy range, achieved by using a self-focusing monochromator consisting of a plane mirror and three variable line spacing gratings. The unique character of the diffractometer comprises 4-circles in the vertical plane and 2-circles in the horizontal plane...
November 2018: Review of Scientific Instruments
C M Heyl, S B Schoun, G Porat, H Green, J Ye
We present the development of a gas nozzle providing high-density gas at elevated temperatures inside a vacuum environment. Fused silica is used as the nozzle material to allow the placement of the nozzle tip in close proximity to an intense, high-power laser beam, while minimizing the risk of sputtering nozzle tip material into the vacuum chamber. Elevating the gas temperature increases the gas-jet forward velocity, allowing us to replenish the gas volume in the laser-gas interaction region between consecutive laser shots...
November 2018: Review of Scientific Instruments
S Yu Petrov, A V Volzhanin
The XEN-45 drainage implant is a hypotensive device made of hydrophilic gelatin and stabilized by glutaraldehyde. The implant is designed for modern Microinvasive Glaucoma Surgery (MIGS). Being installed ab interno, the stent drains aqueous fluid from the anterior chamber into the subconjunctival space. According to indications, XEN-45 can be used in treatment of primary open angle glaucoma, pseudoexfoliation or pigment glaucoma with uncompensated intraocular pressure amid maximum tolerated hypotensive therapy, and refractory glaucoma including cases with history of unsuccessful surgery...
2018: Vestnik Oftalmologii
M V Budzinskaya, I A Bubnova, A G Kurguzova, E I Fettser
Numerous studies have demonstrated the efficacy of anti-VEGF medications for exudative (wet) age-related macular degeneration (AMD). Significant IOP elevation is one of the side effects of anti-VEGF intravitreal injection. PURPOSE: To study the changes in the parameters of anterior segment of the eyeball against acute IOP elevation after repeated intravitreal injections (IVI) of anti-VEGF medication. MATERIAL AND METHODS: The study was conducted on a random sample of 45 patients (45 eyes) diagnosed with exudative (wet) form of AMD...
2018: Vestnik Oftalmologii
Darin Sakiyalak, Yuwared Chattagoon
Purpose: The aim of this study was to investigate the incidence of and risk factors for secondary ocular hypertension (OHT) in patients with moderate to severe infectious ulcerative keratitis and to evaluate the long-term outcome of patients with secondary OHT. Patients and methods: A retrospective chart review of 346 patients with moderate to severe infectious keratitis admitted to Siriraj Hospital during the period from 1 January 2005 to 31 May 2008 was conducted...
2018: Clinical Ophthalmology
Debashis Dutta
The resolving power of free-flow electrophoretic assays is often limited by the broadening of analyte streams as they migrate through the separation chamber. While molecular diffusion and flow hydrodynamics inherently contribute to such dispersion, non-idealities such as Joule heating and unwanted pressure-driven cross-flows among others can also significantly modify these contributions. In this chapter, we describe a theoretical approach to estimating stream broadening in free-flow electrophoretic systems under steady-state conditions based on the method-of-moments formulation...
2019: Methods in Molecular Biology
Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara, Akira Narita, Woei-Yuh Saw, Sanghoon Moon, Cassandra N Spracklen, Jin-Fang Chai, Young-Jin Kim, Liang Zhang, Chaolong Wang, Huaixing Li, Honglan Li, Jer-Yuarn Wu, Rajkumar Dorajoo, Jovia L Nierenberg, Ya Xing Wang, Jing He, Derrick A Bennett, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Hiromi Rakugi, Eitaro Nakashima, Masato Isono, Matsuyuki Shirota, Atsushi Hozawa, Sahoko Ichihara, Tatsuaki Matsubara, Ken Yamamoto, Katsuhiko Kohara, Michiya Igase, Sohee Han, Penny Gordon-Larsen, Wei Huang, Nanette R Lee, Linda S Adair, Mi Yeong Hwang, Juyoung Lee, Miao Li Chee, Charumathi Sabanayagam, Wanting Zhao, Jianjun Liu, Dermot F Reilly, Liang Sun, Shaofeng Huo, Todd L Edwards, Jirong Long, Li-Ching Chang, Chien-Hsiun Chen, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Tanika N Kelly, Wen Bin Wei, Liang Xu, Hui Cai, Yong-Bing Xiang, Kuang Lin, Robert Clarke, Robin G Walters, Iona Y Millwood, Liming Li, John C Chambers, Jaspal S Kooner, Paul Elliott, Pim van der Harst, Zhengming Chen, Makoto Sasaki, Xiao-Ou Shu, Jost B Jonas, Jiang He, Chew-Kiat Heng, Yuan-Tsong Chen, Wei Zheng, Xu Lin, Yik-Ying Teo, E-Shyong Tai, Ching-Yu Cheng, Tien Yin Wong, Xueling Sim, Karen L Mohlke, Masayuki Yamamoto, Bong-Jo Kim, Tetsuro Miki, Toru Nabika, Mitsuhiro Yokota, Yoichiro Kamatani, Michiaki Kubo, Norihiro Kato
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups...
November 28, 2018: Nature Communications
Sarah Mancini, Angela M Crotty, Jerald Cook
BACKGROUND: Decompression sickness is a condition that results from an abrupt change from a higher to a lower pressure. It is described most commonly in divers; however, it can occur in aviation incidents, which this case report will discuss. CASE REPORT: Following an acute cabin depressurization incident, 36 patients presented to a small outpatient clinic with multiple symptoms, including fatigue, headache, nausea, vomiting, and dizziness. These patients were evaluated, triaged, and some were able to be successfully treated with supplemental oxygen in clinic...
December 1, 2018: Aerospace Medicine and Human Performance
William Ottestad, Jan Ivar Kåsin, Lars Øivind Høiseth
INTRODUCTION: Clinical accuracy of pulse oximeters (giving Sp o₂) is routinely tested down to an Sa o₂ of 70%, but lower oxygen saturations are often experienced during hypobaric hypoxia. Cerebral (Sc o₂) and peripheral tissue (St o₂) oxygen saturations can be measured using near infra-red spectroscopy. In a project simulating oxygen system failure during high altitude-high opening parachuting (HAHO), Sa o₂, Sp o₂, Sc o₂, and forearm St o₂ were measured. The aim of the present analysis was to explore the agreement between Sa o₂ and the three noninvasive measurements of hypoxemia (Sp o₂, Sc o₂, and St o₂)...
December 1, 2018: Aerospace Medicine and Human Performance
Yu-Zhou Wang, Tian Chen, Hai-Hui Liu, Xue-Chen Wang, Xing-Xiang Zhang
Graphene has attracted a great number of attentions due to the excellent physical and chemical properties. For the convenience of investigations and applications, it is crucial to produce the grapheme with high-quality and high-yield by an easy-obtained method. In this research, a promising method is demonstrated to produce a high-concentration few-layer graphene (FLG) dispersion by direct microfluidization in water/surfactant systems. The effects of surfactant selection, chamber pressure and microfluidization cycles on the graphitic material exfoliation efficiency are systematically studied...
April 1, 2019: Journal of Nanoscience and Nanotechnology
David Kiessling, Hildegard Christ, Caroline Gietzelt, Friederike Schaub, Thomas S Dietlein, Claus Cursiefen, Ludwig M Heindl, Philip Enders
PURPOSE: To analyze the longitudinal change in Bruch's membrane opening minimal rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) after glaucoma surgery via ab-interno trabeculectomy in adult glaucoma patients. METHODS: Retrospective audit of 65 eyes of 65 participants undergoing ab-interno trabeculectomy using electroablation of the trabecular meshwork. In 53 eyes, surgery was combined with phacoemulsification and posterior chamber lens implantation...
November 28, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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