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https://www.readbyqxmd.com/read/30054280/a-biologic-signature-for-breast-ductal-carcinoma-in-situ-to-predict-radiation-therapy-rt-benefit-and-assess-recurrence-risk
#1
Troy Bremer, Pat Whitworth, Rakesh Patel, Jess Savala, Todd Barry, Stephen Lyle, Glen Leesman, Steven P Linke, Karin Jirstrom, Wenjing Zhou, Rose-Marie Amini, Fredrik Wärnberg
PURPOSE: DCIS patients and their physicians currently face challenging treatment decisions with limited information about the individual's subsequent breast cancer risk or treatment benefit. The DCISionRT biologic signature developed in this study provides recurrence risk and predicts radiation therapy (RT) benefit for DCIS patients following breast conserving surgery (BCS). EXPERIMENTAL DESIGN: A biologic signature that calculates an individualized Decision Score (DS) was developed and cross-validated in 526 DCIS patients treated with BCS ±RT...
July 27, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30039324/an-update-on-immunotherapy-for-solid-tumors-a-review
#2
REVIEW
Toan Pham, Sara Roth, Joseph Kong, Glen Guerra, Vignesh Narasimhan, Lloyd Pereira, Jayesh Desai, Alexander Heriot, Robert Ramsay
In recent years, it has been demonstrated that immunotherapy is an effective strategy for the management of solid tumors. The origins of immunotherapy can be traced back to the work of William Coley, who elicited an immune response against sarcoma by injecting patients with a mixture of dead bacteria. Significant progress has been made since, with immune markers within the tumor now being used as predictors of cancer prognosis and manipulated to improve patient survival. While surgery remains central to the management of most patients with solid malignancies, it is important that surgeons consider the different immunotherapy strategies that can be employed to manage disease...
July 23, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30019933/the-endocrine-disruptor-bisphenol-a-is-implicated-in-urinary-voiding-dysfunction-in-male-mice
#3
Tristan M Nicholson, Jalissa L Nguyen, Glen E Leverson, Julia A Taylor, Frederik S Vom Saal, Ronald W Wood, William A Ricke
Estrogens, acting synergistically with androgens, are known from animal experiments to be important in lower urinary tract symptoms (LUTS) and benign prostate enlargement. Human exposure to environmental estrogens occurs throughout the lifespan, but the urologic health risks in men are largely unknown. Bisphenol-A (BPA) is an endocrine disruptor implicated in male urogenital malformations. Given the role of estrogens in male LUTS, we studied the effects of BPA administered in combination with testosterone (T) on the urinary voiding behavior of adult male mice...
July 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/30017301/pelvic-mri-staging-of-endometriosis-at-3-t-without-patient-preparation-or-anti-peristaltic-diagnostic-performance-outcomes
#4
Shaun Zheng Liang Yap, Sebastian Leathersich, Joy Lu, Laura Fender, Glen Lo
PURPOSE: Endometriosis is a disease of significant burden among pre-menopausal women characterised by the appearance of functional endometrial tissue in locations outside the uterus. Deep infiltrating endometriosis (DIE) is an invasion of the endometriotic lesion that exceeds 5 mm in depth into the peritoneum. In most cases, pelvic MRI is the imaging modality of choice for the pre-operative workup for DIE to guide surgery. The recommended standard for pelvic MRI images is at 1.5 T with patient preparations in the form of laxatives, anti-spasmodics and/or rectal contrast...
August 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30003452/the-impact-of-hospital-neoadjuvant-therapy-utilization-on-survival-outcomes-for-pancreatic-cancer
#5
Alexander V Fisher, Daniel E Abbott, Manasa Venkatesh, Glen E Leverson, Stephanie A Campbell-Flohr, Sean M Ronnekleiv-Kelly, Caprice C Greenberg, Emily R Winslow, Sharon M Weber
BACKGROUND: Many surgeons advocate the use of neoadjuvant treatment for resectable pancreatic cancer, however little is known about variation in the utilization of neoadjuvant therapy (NAT) at the hospital level. METHODS: The National Cancer Data Base was used to identify patients undergoing resection for pancreatic cancer between 2006 and 2014 at high-volume centers. Hospitals were grouped by NAT utilization using standard deviations (SD) from the mean as follows: high neoadjuvant utilizers (> 2 SDs above the mean, > 40% of patients receiving NAT); medium-high (1-2 SDs, 27-40%), medium (0-1 SD, 14-26%); or low (- 1...
July 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29953883/long-term-natural-history-of-lower-urinary-tract-symptoms-following-radical-retropubic-prostatectomy-a-prospective-15-year-longitudinal-study
#6
Alex J Xu, Glen B Taksler, Elton Llukani, Herbert Lepor
OBJECTIVE: To provide insights into the long-term impact of radical retro-pubic prostatectomy (ORRP) on LUTS which are age and prostate dependent and adversely impact quality of life. METHODS: 1,995 men undergoing ORRP enrolled in a prospective longitudinal outcomes study. The American Urological Association symptom index (AUASI) was self-administered before ORRP and at pre-determined time-points after surgery. A multivariate generalized linear model was used to evaluate the association of time since ORRP with AUASS...
June 25, 2018: Urology
https://www.readbyqxmd.com/read/29932208/treating-melanoma-in-situ-and-lentigo-maligna-with-mohs-micrographic-surgery-in-australia
#7
Glen C Foxton, Timothy G Elliott, Kelly A Litterick
BACKGROUND/OBJECTIVES: There is a paucity of Australian data on the use of Mohs micrographic surgery for treating melanoma in situ and lentigo maligna. We share an Australian centre's experience with the technique. METHODS: A total of 62 patients with 62 lesions of melanoma in situ and lentigo maligna referred for treatment between 2015 and 2017 comprised the study group. All melanomas were excised with Mohs micrographic surgery utilising melanoma-associated antigen recognised by T-cells (MART-1) immunostaining...
June 22, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29923226/yonsei-nomogram-a-predictive-model-of-new-onset-chronic-kidney-disease-after-on-clamp-partial-nephrectomy-in-patients-with-t1-renal-tumors
#8
Ali Abdel Raheem, Tae Young Shin, Ki Don Chang, Glen Denmer R Santok, Mohamed Jayed Alenzi, Young Eun Yoon, Won Sik Ham, Woong Kyu Han, Young Deuk Choi, Koon Ho Rha
OBJECTIVES: To develop a predictive nomogram for chronic kidney disease-free survival probability in the long term after partial nephrectomy. METHODS: A retrospective analysis was carried out of 698 patients with T1 renal tumors undergoing partial nephrectomy at a tertiary academic institution. A multivariable Cox regression analysis was carried out based on parameters proven to have an impact on postoperative renal function. Patients with incomplete data, <12 months follow up and preoperative chronic kidney disease stage III or greater were excluded...
July 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29914521/the-prognostic-value-of-pain-catastrophizing-in-health-related-quality-of-life-judgments-after-total-knee-arthroplasty
#9
Esther Yakobov, William Stanish, Michael Tanzer, Michael Dunbar, Glen Richardson, Michael J L Sullivan
BACKGROUND: Total knee arthroplasty (TKA) is a highly effective procedure that yields reductions in pain and disability associated with end stage osteoarthritis (OA) of the knee. Quality of life instruments are frequently used to gauge the outcomes of total knee arthroplasty (TKA). However, research suggests that post-TKA reductions in symptom severity may not be the sole predictors of quality of life post-TKA. The primary objective of the present study was to examine the prognostic value of catastrophic thinking in health-related quality of life (HRQoL) judgments in patients with severe OA after TKA...
June 18, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29907226/paravertebral-block-associated-with-decreased-opioid-use-and-less-nausea-and-vomiting-after-reduction-mammaplasty
#10
David D Rivedal, Harry S Nayar, Jacqueline S Israel, Glen Leverson, Andrew J Schulz, Tamara Chambers, Ahmed M Afifi, Jocelyn M Blake, Samuel O Poore
BACKGROUND: In light of data finding that postoperative pain, nausea, and vomiting worsen outcomes, a renewed emphasis has been placed on optimizing the perioperative period. Use of preoperative paravertebral block (PVB) has been shown to reduce opioid administration and postoperative nausea and vomiting (PONV) in many surgical populations, though its role in reduction mammaplasty remains undefined. Therefore, we seek to evaluate PVB as an adjunct to general anesthesia (GA) for reduction mammaplasty...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29847610/rate-of-recurrence-of-lentigo-maligna-treated-with-off-label-neoadjuvant-topical-imiquimod-5-cream-prior-to-conservatively-staged-excision
#11
Jessica M Donigan, Mark A Hyde, David E Goldgar, Michael L Hadley, Marianne Bowling, Glen M Bowen
Importance: Staged excision of lentigo maligna (LM) often requires multiple stages and can result in significant cosmetic morbidity. Imiquimod cream has been used off-label as monotherapy in the treatment of LM and may be used in the neoadjuvant setting prior to staged excision as a strategy to reduce the size of the surgical margins required to confirm negative histologic margins. Objective: To examine the rate of recurrence of LM in patients treated with neoadjuvant topical imiquimod, 5%, cream prior to conservatively staged excisions...
May 30, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29710208/comparison-between-patient-perceived-voice-changes-and-quantitative-voice-measures-in-the-first-postoperative-year-after-thyroidectomy-a-secondary-analysis-of-a-randomized-clinical-trial
#12
Heidi Kletzien, Cameron L Macdonald, Jason Orne, David O Francis, Glen Leverson, Elizabeth Wendt, Rebecca S Sippel, Nadine P Connor
Importance: Voice changes after thyroidectomy are typically attributed to recurrent laryngeal nerve injury. However, most postoperative voice changes occur in the absence of clinically evident vocal fold paralysis. To date, no study has compared the prevalence, duration, and consequences of voice-related disability from the patient perspective with use of quantitative vocal measures. Objectives: To assess the quality-of-life consequences of postthyroidectomy voice change from the perspective of patients with thyroid cancer and to compare patient-perceived voice changes with changes in quantitative vocal variables at 5 time points in the first postoperative year...
April 18, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29610456/potential-of-quantitative-sept9-and-shox2-methylation-in-plasmatic-circulating-cell-free-dna-as-auxiliary-staging-parameter-in-colorectal-cancer-a-prospective-observational-cohort-study
#13
Julia Bergheim, Alexander Semaan, Heidrun Gevensleben, Susanne Groening, Andreas Knoblich, Jörn Dietrich, Julia Weber, Jörg C Kalff, Friedrich Bootz, Glen Kristiansen, Dimo Dietrich
BACKGROUND: Septin 9 (SEPT9) and short stature homeobox 2 (SHOX2) methylation in circulating cell-free DNA (ccfDNA) are powerful biomarkers for colorectal cancer (CRC) screening, as well as head and neck squamous cell carcinoma staging and monitoring. In the present study, we investigated SEPT9 and SHOX2 ccfDNA methylation as auxiliary pre and post-therapeutic staging parameters in CRC patients. METHODS: ccfDNA methylation was quantified in 184 prospectively enrolled patients prior to and 3-10 days after surgery, and biomarker levels were associated with clinico-pathological parameters...
May 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29582537/prognostic-value-of-tumour-regression-grade-in-locally-advanced-rectal-cancer-a-systematic-review-and-meta-analysis
#14
REVIEW
J C Kong, G R Guerra, S K Warrier, A Craig Lynch, M Michael, S Y Ngan, W Phillips, G Ramsay, A G Heriot
AIM: The current standard of care for locally advanced rectal cancer involves neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision. There is a spectrum of response to neoadjuvant therapy; however, the prognostic value of tumour regression grade (TRG) in predicting disease-free survival (DFS) or overall survival (OS) is inconsistent in the literature. METHOD: This study was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
July 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29337772/salvage-surgery-for-locoregional-failure-in-anal-squamous-cell-carcinoma
#15
Glen R Guerra, Joseph C Kong, Maria-Pia Bernardi, Robert G Ramsay, Wayne A Phillips, Satish K Warrier, A Craig Lynch, Samuel Y Ngan, Alexander G Heriot
BACKGROUND: Anal squamous cell carcinoma is a rare cancer with a high cure rate, making research into the treatment of locoregional failure difficult. OBJECTIVE: The purpose of this study was to examine factors related to local treatment failure and determine the outcomes of patients undergoing local salvage resection. DESIGN: This was a retrospective cohort study. SETTING: This study was conducted at a quaternary referral center...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29174777/cardiac-surgery-outcomes-in-abdominal-solid-organ-transplant-recipients
#16
Takushi Kohmoto, Satoru Osaki, Dixon B Kaufman, Glen Leverson, Nilto DeOliveira, Shahab A Akhter, Susan Ulschmid, Lucian Lozonschi, Entela B Lushaj
BACKGROUND: Cardiovascular disease is a cause of morbidity and mortality in organ transplant recipients. Cardiac surgery after organ transplantation is not uncommon in this population. We evaluated 30-day outcomes and long-term survival of abdominal transplant recipients undergoing cardiac surgery at our institution. METHODS: In all, 138 patients with previous kidney, kidney-pancreas, and liver transplants underwent cardiac surgery from 2000 to 2016. Propensity score (ratio 1:3) matched 115 abdominal transplant with 345 patients undergoing cardiac surgery without a history of abdominal transplant...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29174166/pre-simulation-orientation-for-medical-trainees-an-approach-to-decrease-anxiety-and-improve-confidence-and-performance
#17
Cassidy Bommer, Sarah Sullivan, Krystle Campbell, Zachary Ahola, Suresh Agarwal, Ann O'Rourke, Hee Soo Jung, Angela Gibson, Glen Leverson, Amy E Liepert
BACKGROUND: We assessed the effect of basic orientation to the simulation environment on anxiety, confidence, and clinical decision making. METHODS: Twenty-four graduating medical students participated in a two-week surgery preparatory curriculum, including three simulations. Baseline anxiety was assessed pre-course. Scenarios were completed on day 2 and day 9. Prior to the first simulation, participants were randomly divided into two groups. Only one group received a pre-simulation orientation...
February 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29171793/preoperative-skin-antisepsis-with-chlorhexidine-gluconate-versus-povidone-iodine-a-prospective-analysis-of-6959-consecutive-spinal-surgery-patients
#18
MULTICENTER STUDY
George M Ghobrial, Michael Y Wang, Barth A Green, Howard B Levene, Glen Manzano, Steven Vanni, Robert M Starke, George Jimsheleishvili, Kenneth M Crandall, Marina Dididze, Allan D Levi
OBJECTIVE The aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery procedures. METHODS Two preoperative surgical skin antiseptic agents-ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol) and Betadine (7.5% povidone-iodine solution)-were prospectively compared across 2 consecutive time periods for all consecutive adult neurosurgical spine patients...
February 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29135417/retzius-sparing-robot-assisted-radical-prostatectomy-is-safe-for-patients-with-prior-transurethral-prostate-surgery
#19
Lawrence H C Kim, Glen Denmer Santok, Ali Abdel Raheem, Kidon Chang, Trenton Lum, Byung Ha Chung, Young Deuk Choi, Koon Ho Rha
No abstract text is available yet for this article.
July 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29132900/experience-from-the-thoracic-surgery-residents-association-traveling-fellowship-adult-and-pediatric-lung-transplantation-in-toronto
#20
EDITORIAL
Taufiek Konrad Rajab, Glen Van Arsdell, Shaf Keshavjee
No abstract text is available yet for this article.
December 2017: Journal of Thoracic and Cardiovascular Surgery
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