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https://www.readbyqxmd.com/read/30511604/survey-of-multinational-surgical-management-practices-in-tetralogy-of-fallot
#1
Sara Hussain, Osman Al-Radi, Tae-Jin Yun, Zhongdong Hua, Budi Rahmat, Suresh Rao, An Qi, Charles Fraser, Yves d'Udekem, Quazi Ibrahim, Ingrid Copland, Richard Whitlock, Glen Van Arsdell
BACKGROUND: A wide variety of surgical strategies are used in tetralogy of Fallot repair. We sought to describe the international contemporary practice patterns for surgical management of tetralogy of Fallot. METHODS: Surgeons from 18 international paediatric cardiac surgery centres (representing over 1800 tetralogy of Fallot cases/year) completed a Research Electronic Data Capture-based survey. Participating countries include: China (4), India (2), Nepal (1), Korea (1), Indonesia (1), Saudi Arabia (3), Japan (1), Turkey (1), Australia (1), United States of America (2), and Canada (1)...
December 4, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/30511131/timed-stair-climbing-as-a-surrogate-marker-for-sarcopenia-measurements-in-predicting-surgical-outcomes
#2
Samantha Baker, Mary Glen Waldrop, Joshua Swords, Thomas Wang, Martin Heslin, Carlo Contreras, Sushanth Reddy
BACKGROUND: Estimating sarcopenia by measuring psoas muscle density (PMD) has been advocated as a method to accurately predict post-operative morbidity. The aim of the present study was to determine whether the Timed Stair Climb (TSC) could be used to replace PMD measurements in predicting morbidity. METHODS: Patients were prospectively enrolled from March 2014-2015 and were eligible if they were undergoing an abdominal operation. PMD was measured using pre-operative CT scans obtained within 90 days of surgery...
December 3, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/30468997/analysis-of-the-drivers-of-cost-of-management-when-patients-with-brain-metastases-are-treated-with-upfront-radiosurgery
#3
Rachel F Shenker, Emory R McTyre, Glen B Taksler, Ralph B D'Agostino, Christina K Cramer, Jimmy Ruiz, Natalie K Alphonse-Sullivan, Michael Farris, Kounosuke Watabe, Fei Xing, Adrian W Laxton, Stephen B Tatter, Michael D Chan
OBJECTIVES: We aimed to assess the driving factors for increased cost of brain metastasis management when using upfront stereotactic radiosurgery (SRS). PATIENT AND METHODS: 737 patients treated with upfront SRS without whole brain radiotherapy (WBRT). Patients were evaluated for use of craniotomy, length of hospital stay, need for rehabilitation or facility placement, and use of salvage SRS or salvage WBRT. Costs of care of these interventions were estimated based on 2013 Medicare reimbursements...
November 13, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/30462279/continued-vs-interrupted-direct-oral-anticoagulants-at-the-time-of-device-surgery-in-patients-with-moderate-to-high-risk-of-arterial-thrombo-embolic-events-bruise-control-2
#4
David H Birnie, Jeff S Healey, George A Wells, Felix Ayala-Paredes, Benoit Coutu, Glen L Sumner, Giuliano Becker, Atul Verma, François Philippon, Eli Kalfon, John Eikelboom, Roopinder K Sandhu, Pablo B Nery, Nicholas Lellouche, Stuart J Connolly, John Sapp, Vidal Essebag
Aims: Guidelines recommend warfarin continuation rather than heparin bridging for pacemaker and defibrillator surgery, after the BRUISE CONTROL trial demonstrated an 80% reduction in device pocket haematoma with this approach. However, direct oral anticoagulants (DOACs) are now used to treat the majority of patients with atrial fibrillation. We sought to understand the best strategy to manage the DOACs at the time of device surgery and specifically hypothesized that performing device surgery without DOAC interruption would result in a reduced haematoma rate...
November 21, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30268174/gunshot-injuries-to-the-extremity-is-immediate-general-surgery-presence-needed
#5
Brian G Harbrecht, Keith R Miller, Amirreza T Motameni, Matthew V Benns, Matthew C Bozeman, Nicholas A Nash, Glen A Franklin, Jason W Smith
Gunshot wounds (GSW) are becoming increasingly prevalent in urban settings. GSW to the trunk mandate full trauma activation and immediate surgeon response because of the high likelihood of operative intervention. Extremity GSW proximal to the knee/elbow also require full trauma activation based on American College of Surgeons Committee on trauma standards. However, whether isolated extremity GSW require frequent operative intervention is unclear. We evaluated GSW at our Level I trauma center from January 2012 to December 2016...
September 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/30189006/use-of-gentamicin-impregnated-beads-or-sponges-in-the-treatment-of-early-acute-periprosthetic-joint-infection-a-propensity-score-analysis
#6
Marjan Wouthuyzen-Bakker, Claudia A M Löwik, Bas A S Knobben, Wierd P Zijlstra, Joris J W Ploegmakers, Glen Mithoe, Aziz Al Moujahid, Greetje A Kampinga, Paul C Jutte
Objectives: Early acute periprosthetic joint infections (PJIs) treated with debridement, antibiotics and implant retention (DAIR) have failure rates ranging from 10% to 60%. We determined the efficacy of applying local gentamicin-impregnated beads and/or sponges during debridement in early PJI. Methods: Patients with early acute PJI, defined as less than 21 days of symptoms and treated with DAIR within 90 days after index surgery, were retrospectively evaluated...
September 5, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30054280/a-biological-signature-for-breast-ductal-carcinoma-in-situ-to-predict-radiotherapy-rt-benefit-and-assess-recurrence-risk
#7
Troy Bremer, Pat W Whitworth, Rakesh Patel, Jess Savala, Todd Barry, Stephen Lyle, Glen Leesman, Steven P Linke, Karin Jirström, Wenjing Zhou, Rose-Marie Amini, Fredrik Wärnberg
Purpose: Ductal carcinoma in situ (DCIS) patients and their physicians currently face challenging treatment decisions with limited information about the individual's subsequent breast cancer risk or treatment benefit. The DCISionRT biological signature developed in this study provides recurrence risk and predicts radiotherapy (RT) benefit for DCIS patients following breast-conserving surgery (BCS). Experimental Design: A biological signature that calculates an individualized Decision Score (DS) was developed and cross-validated in 526 DCIS patients treated with BCS ± RT...
July 27, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30039324/an-update-on-immunotherapy-for-solid-tumors-a-review
#8
REVIEW
Toan Pham, Sara Roth, Joseph Kong, Glen Guerra, Vignesh Narasimhan, Lloyd Pereira, Jayesh Desai, Alexander Heriot, Robert Ramsay
In recent years, it has been demonstrated that immunotherapy is an effective strategy for the management of solid tumors. The origins of immunotherapy can be traced back to the work of William Coley, who elicited an immune response against sarcoma by injecting patients with a mixture of dead bacteria. Significant progress has been made since, with immune markers within the tumor now being used as predictors of cancer prognosis and manipulated to improve patient survival. While surgery remains central to the management of most patients with solid malignancies, it is important that surgeons consider the different immunotherapy strategies that can be employed to manage disease...
October 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30019933/the-endocrine-disruptor-bisphenol-a-is-implicated-in-urinary-voiding-dysfunction-in-male-mice
#9
Tristan M Nicholson, Jalissa L Nguyen, Glen E Leverson, Julia A Taylor, Frederik S Vom Saal, Ronald W Wood, William A Ricke
Estrogens, acting synergistically with androgens, are known from animal experiments to be important in lower urinary tract symptoms (LUTS) and benign prostate enlargement. Human exposure to environmental estrogens occurs throughout the lifespan, but the urologic health risks in men are largely unknown. Bisphenol-A (BPA) is an endocrine disruptor implicated in male urogenital malformations. Given the role of estrogens in male LUTS, we studied the effects of BPA administered in combination with testosterone (T) on the urinary voiding behavior of adult male mice...
July 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/30017301/pelvic-mri-staging-of-endometriosis-at-3-t-without-patient-preparation-or-anti-peristaltic-diagnostic-performance-outcomes
#10
Shaun Zheng Liang Yap, Sebastian Leathersich, Joy Lu, Laura Fender, Glen Lo
PURPOSE: Endometriosis is a disease of significant burden among pre-menopausal women characterised by the appearance of functional endometrial tissue in locations outside the uterus. Deep infiltrating endometriosis (DIE) is an invasion of the endometriotic lesion that exceeds 5 mm in depth into the peritoneum. In most cases, pelvic MRI is the imaging modality of choice for the pre-operative workup for DIE to guide surgery. The recommended standard for pelvic MRI images is at 1.5 T with patient preparations in the form of laxatives, anti-spasmodics and/or rectal contrast...
August 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30003452/the-impact-of-hospital-neoadjuvant-therapy-utilization-on-survival-outcomes-for-pancreatic-cancer
#11
Alexander V Fisher, Daniel E Abbott, Manasa Venkatesh, Glen E Leverson, Stephanie A Campbell-Flohr, Sean M Ronnekleiv-Kelly, Caprice C Greenberg, Emily R Winslow, Sharon M Weber
BACKGROUND: Many surgeons advocate the use of neoadjuvant treatment for resectable pancreatic cancer, however little is known about variation in the utilization of neoadjuvant therapy (NAT) at the hospital level. METHODS: The National Cancer Data Base was used to identify patients undergoing resection for pancreatic cancer between 2006 and 2014 at high-volume centers. Hospitals were grouped by NAT utilization using standard deviations (SD) from the mean as follows: high neoadjuvant utilizers (> 2 SDs above the mean, > 40% of patients receiving NAT); medium-high (1-2 SDs, 27-40%), medium (0-1 SD, 14-26%); or low (- 1...
September 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29953883/long-term-natural-history-of-lower-urinary-tract-symptoms-following-radical-retropubic-prostatectomy-a-prospective-15-year-longitudinal-study
#12
Alex J Xu, Glen B Taksler, Elton Llukani, Herbert Lepor
OBJECTIVE: To provide insights into the long-term impact of radical retro-pubic prostatectomy (ORRP) on lower urinary tract symptoms (LUTS) which are age and prostate dependent and adversely impact quality of life. METHODS: 1995 men undergoing ORRP enrolled in a prospective longitudinal outcomes study. The American Urological Association Symptom Index was self-administered before ORRP and at predetermined time-points after surgery. A multivariate generalized linear model was used to evaluate the association of time since ORRP with American Urological Association symptom score (AUASS)...
October 2018: Urology
https://www.readbyqxmd.com/read/29932208/treating-melanoma-in-situ-and-lentigo-maligna-with-mohs-micrographic-surgery-in-australia
#13
Glen C Foxton, Timothy G Elliott, Kelly A Litterick
BACKGROUND/OBJECTIVES: There is a paucity of Australian data on the use of Mohs micrographic surgery for treating melanoma in situ and lentigo maligna. We share an Australian centre's experience with the technique. METHODS: A total of 62 patients with 62 lesions of melanoma in situ and lentigo maligna referred for treatment between 2015 and 2017 comprised the study group. All melanomas were excised with Mohs micrographic surgery utilising melanoma-associated antigen recognised by T-cells (MART-1) immunostaining...
June 22, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29923226/yonsei-nomogram-a-predictive-model-of-new-onset-chronic-kidney-disease-after-on-clamp-partial-nephrectomy-in-patients-with-t1-renal-tumors
#14
Ali Abdel Raheem, Tae Young Shin, Ki Don Chang, Glen Denmer R Santok, Mohamed Jayed Alenzi, Young Eun Yoon, Won Sik Ham, Woong Kyu Han, Young Deuk Choi, Koon Ho Rha
OBJECTIVES: To develop a predictive nomogram for chronic kidney disease-free survival probability in the long term after partial nephrectomy. METHODS: A retrospective analysis was carried out of 698 patients with T1 renal tumors undergoing partial nephrectomy at a tertiary academic institution. A multivariable Cox regression analysis was carried out based on parameters proven to have an impact on postoperative renal function. Patients with incomplete data, <12 months follow up and preoperative chronic kidney disease stage III or greater were excluded...
July 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29914521/the-prognostic-value-of-pain-catastrophizing-in-health-related-quality-of-life-judgments-after-total-knee-arthroplasty
#15
Esther Yakobov, William Stanish, Michael Tanzer, Michael Dunbar, Glen Richardson, Michael J L Sullivan
BACKGROUND: Total knee arthroplasty (TKA) is a highly effective procedure that yields reductions in pain and disability associated with end stage osteoarthritis (OA) of the knee. Quality of life instruments are frequently used to gauge the outcomes of total knee arthroplasty (TKA). However, research suggests that post-TKA reductions in symptom severity may not be the sole predictors of quality of life post-TKA. The primary objective of the present study was to examine the prognostic value of catastrophic thinking in health-related quality of life (HRQoL) judgments in patients with severe OA after TKA...
June 18, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29907226/paravertebral-block-associated-with-decreased-opioid-use-and-less-nausea-and-vomiting-after-reduction-mammaplasty
#16
David D Rivedal, Harry S Nayar, Jacqueline S Israel, Glen Leverson, Andrew J Schulz, Tamara Chambers, Ahmed M Afifi, Jocelyn M Blake, Samuel O Poore
BACKGROUND: In light of data finding that postoperative pain, nausea, and vomiting worsen outcomes, a renewed emphasis has been placed on optimizing the perioperative period. Use of preoperative paravertebral block (PVB) has been shown to reduce opioid administration and postoperative nausea and vomiting (PONV) in many surgical populations, though its role in reduction mammaplasty remains undefined. Therefore, we seek to evaluate PVB as an adjunct to general anesthesia (GA) for reduction mammaplasty...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29847610/rate-of-recurrence-of-lentigo-maligna-treated-with-off-label-neoadjuvant-topical-imiquimod-5-cream-prior-to-conservatively-staged-excision
#17
Jessica M Donigan, Mark A Hyde, David E Goldgar, Michael L Hadley, Marianne Bowling, Glen M Bowen
Importance: Staged excision of lentigo maligna (LM) often requires multiple stages and can result in significant cosmetic morbidity. Imiquimod cream has been used off-label as monotherapy in the treatment of LM and may be used in the neoadjuvant setting prior to staged excision as a strategy to reduce the size of the surgical margins required to confirm negative histologic margins. Objective: To examine the rate of recurrence of LM in patients treated with neoadjuvant topical imiquimod, 5%, cream prior to conservatively staged excisions...
August 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29710208/comparison-between-patient-perceived-voice-changes-and-quantitative-voice-measures-in-the-first-postoperative-year-after-thyroidectomy-a-secondary-analysis-of-a-randomized-clinical-trial
#18
Heidi Kletzien, Cameron L Macdonald, Jason Orne, David O Francis, Glen Leverson, Elizabeth Wendt, Rebecca S Sippel, Nadine P Connor
Importance: Voice changes after thyroidectomy are typically attributed to recurrent laryngeal nerve injury. However, most postoperative voice changes occur in the absence of clinically evident vocal fold paralysis. To date, no study has compared the prevalence, duration, and consequences of voice-related disability from the patient perspective with use of quantitative vocal measures. Objectives: To assess the quality-of-life consequences of postthyroidectomy voice change from the perspective of patients with thyroid cancer and to compare patient-perceived voice changes with changes in quantitative vocal variables at 5 time points in the first postoperative year...
November 1, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29610456/potential-of-quantitative-sept9-and-shox2-methylation-in-plasmatic-circulating-cell-free-dna-as-auxiliary-staging-parameter-in-colorectal-cancer-a-prospective-observational-cohort-study
#19
Julia Bergheim, Alexander Semaan, Heidrun Gevensleben, Susanne Groening, Andreas Knoblich, Jörn Dietrich, Julia Weber, Jörg C Kalff, Friedrich Bootz, Glen Kristiansen, Dimo Dietrich
BACKGROUND: Septin 9 (SEPT9) and short stature homeobox 2 (SHOX2) methylation in circulating cell-free DNA (ccfDNA) are powerful biomarkers for colorectal cancer (CRC) screening, as well as head and neck squamous cell carcinoma staging and monitoring. In the present study, we investigated SEPT9 and SHOX2 ccfDNA methylation as auxiliary pre and post-therapeutic staging parameters in CRC patients. METHODS: ccfDNA methylation was quantified in 184 prospectively enrolled patients prior to and 3-10 days after surgery, and biomarker levels were associated with clinico-pathological parameters...
May 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29582537/prognostic-value-of-tumour-regression-grade-in-locally-advanced-rectal-cancer-a-systematic-review-and-meta-analysis
#20
REVIEW
J C Kong, G R Guerra, S K Warrier, A Craig Lynch, M Michael, S Y Ngan, W Phillips, G Ramsay, A G Heriot
AIM: The current standard of care for locally advanced rectal cancer involves neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision. There is a spectrum of response to neoadjuvant therapy; however, the prognostic value of tumour regression grade (TRG) in predicting disease-free survival (DFS) or overall survival (OS) is inconsistent in the literature. METHOD: This study was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
July 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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