Yue Ding, Wei Yu, Rongkai Shen, Xiangqin Zheng, Hui Zheng, Yong Yao, Yuehua Zhang, Chang Du, Huan Yi
Despite the intense progress of photodynamic and chemotherapy, however they cannot prevent solid tumor invasion, metastasis and relapse, along with inferior efficacy and severe side effect. The hypoxia-responsive nanoprodrugs integrating photodynamic functions have been highly sought to address the above-mentioned problems and overcome the tumor hypoxia-reduced efficacy. Herein, a hypoxia-responsive tetrameric supramolecular polypeptide nanoprodrug (SPN-TAPP-PCB4) was constructed from the self-assembly of tetrameric porphyrin-central poly(L-lysine-azobenzene-chlorambucil) (TAPP-(PLL-Azo-CB)4) and an anionic water-soluble [2]biphenyl-extended-pillar[6]arene (AWBpP6) via the synergy of hydrophobic, π-π stacking, and host-guest interactions...
November 4, 2023: Advanced Healthcare Materials