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Hui Yu, Daniel J Caldwell, Rominder P Suri
Exposure to mixtures of endocrine disrupting compounds (EDCs) has been hypothesized to produce potential synergistic or antagonistic effects that can cause undesired effects that are not reflected by the individual compounds. In this study, the estrogenic activities of 11 EDCs of global environmental concern were systematically investigated using the yeast estrogen screen (YES). The contribution of the individual chemical to the total endocrine activity of environmentally relevant mixtures was evaluated. Compared to 17β-estradiol (E2) as a standard, estrone (E1), estriol (E3), ethinyl estradiol (EE2), bisphenol-A (BPA), and genistein (GEN) showed estrogenic effects, while dibutyl phthalate (DBP), n-butyl benzyl phthalate (BBP), Bis(2-ethylhexyl) phthalate (DEHP), nonyl phenol (NP) and 4-tert-octyl phenol (OP) showed anti-estrogenic effects...
October 11, 2018: Chemosphere
Yusen Qiao, Eric J Schelter
The use of earth-abundant, cheap, potent, and readily available lanthanide photocatalysts provides an opportunity to complement or even replace rare and precious metal photosensitizers. Moreover, lanthanide photosensitizers have been demonstrated for the generation of a variety of reactive species, including aryl radicals, alkyl radicals, and others, by single-electron-transfer (SET) and hydrogen atom transfer (HAT) pathways under mild reaction conditions. Some lanthanide photocatalysts have unprecedented reducing power from their photoexcited states, achieving the activation of challenging organic substrates that have not otherwise been activated by reported organic or transition-metal photosensitizers...
October 18, 2018: Accounts of Chemical Research
Konstantina Pringouri, Muhammad U Anwar, Liz Mansour, Nathan Doupnik, Yassine Beldjoudi, Emma L Gavey, Melanie Pilkington, Jeremy M Rawson
Reaction of 2,6-dicyanopyridine with 2 equiv. of 2-(propylthio)benzenamine in the presence of lithium bis(trimethylsilyl)amide, followed by ring-closing oxidation with N-chlorosuccinimide affords the novel tridentate ligand, 2,6-bis-(1',2',4'-benzothiadiazinyl)pyridine (LH2). Electrochemical studies on the free ligand LH2 reveal a single well-defined 2e- oxidation process with E1/2 = +0.90 V. EPR studies of the in situ chemical oxidation of LH2 reveal the generation of a benzotriazinyl radical. Reactions of ligand LH2 with a range of divalent transition metal salts in either MeOH or MeCN in a 2 : 1 ratio at ambient temperatures afforded mononuclear complexes with general formula [M(LH2)2][X]2 (M = Mn, X = CF3SO3 (1); Fe, X = CF3SO3 (2); Fe, X = BF4 (3); Co, X = Cl (4); Ni, X = Cl (5); Zn, X = CF3SO3 (6)) and the 1 : 1 complex [Cu(LH2)(NO3)2] (7)...
October 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Juan Fernando Cadavid-Vargas, Pablo Maximiliano Arnal, Ruth Dary Mojica Sepúlveda, Andrea Rizzo, Delia Beatriz Soria, Ana Laura Di Virgilio
Ideal drugs to cure cancer leave normal cells unharmed while selectively turning tumor cells unviable. Several copper complexes have been able to selectively slow down tumor proliferation. We hypothesized that Cu(smz)2 (bipy)·H2 O (1)-a copper-complex that has two ligands capable of interacting with DNA-would outperform Cu(smz)2 (OH2 )·2H2 O (2), and also that supporting 1 on mesoporous silica spheres would decrease even further tumor cell viability in vitro. After exposing osteosarcoma cells (MG-63) and normal phenotype cells of bone origin (MC3T3-E1) to either complex, we studied their toxic effect and mechanisms of action...
October 17, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Aran Son, Namju Kang, Ki Woo Kim, Yu-Mi Yang, Dong Min Shin
Mechanical stress plays an important role in the regulation of bone turnover. However, the mechanism underlying hypo-osmotic stress-induced cellular response in osteoblasts remains poorly understood. In this study, we investigated the effect of hypotonic stress on the expression of bone remodeling factors, including the receptor activator of nuclear factor-kappa B ligand (RANKL) and the nuclear factor of activated T cells type c1 (NFATc1) in primary mouse osteoblasts and MC3T3-E1 cells. Hypo-osmotic stress induced significant increases in RANKL mRNA expression and intracellular Ca2+ concentration ([Ca2+]i) from the extracellular space...
October 15, 2018: Journal of Molecular Endocrinology
Satyavani Kaliamurthi, Gurudeeban Selvaraj, Aman Chandra Kaushik, Ke-Ren Gu, Dong-Qing Wei
Background and aim: Human papillomavirus (HPV) is an oncogenic agent that causes over 90% of cases of cervical cancer in the world. Currently available prophylactic vaccines are type specific and have less therapeutic efficiency. Therefore, we aimed to predict the potential species-specific and therapeutic epitopes from the protein sequences of HPV45 by using different immunoinformatics tools. Methods: Initially, we determined the antigenic potential of late (L1 and L2) and early (E1, E2, E4, E5, E6, and E7) proteins...
2018: Biologics: Targets & Therapy
María González Hernández, Rosa Ballester Añón, María Isabel Porras Gallo, María José Báguena Cervellera
OBJECTIVE: Brucellosis was one of the most important health problems in post-Civil War Spain and in subsequent years. The objective of the study was to reconstruct the first programs that the WHO set up in this country, to address this problem, between 1951 and 1972 and their main outcomes. METHODS: On the basis of primary sources of diverse origin, especially unpublished reports on Spain from foreign experts, from the WHO Historical Archive, the contents related to the disease were analyzed, contextualizing them within the framework of both the history of Spanish Public Health during the period studied and the international public health strategies for the prevention and control of brucellosis between 1951 and 1972...
October 17, 2018: Revista Española de Salud Pública
Min Jiang, Tianqi Wang, Xueming Yan, Zhuochao Liu, Yufei Yan, Kai Yang, Jin Qi, Hanbing Zhou, Niandong Qian, Qi Zhou, Bo Chen, Xing Xu, Xiaobing Xi, Chunhao Yang, Lianfu Deng
Osteoporosis, an osteolytic disease that affects millions of people worldwide, features a bone remodelling imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Identifying dual target-directed agents that inhibit excessive bone resorption and increase bone formation is considered an efficient strategy for developing new osteoporosis treatments. Rhein, a natural anthraquinone, can be isolated from various Asian herbal medicines. Rhein and its derivatives have been reported to have various beneficial pharmacological effects, especially their bone-targeting ability and anti-osteoclastogenesis activity...
October 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Jannick Prentoe, Jens Bukh
Chronic hepatitis C virus (HCV) infection is the cause of about 400,000 annual liver disease-related deaths. The global spread of this important human pathogen can potentially be prevented through the development of a vaccine, but this challenge has proven difficult, and much remains unknown about the multitude of mechanisms by which this heterogeneous RNA virus evades inactivation by neutralizing antibodies (NAbs). The N-terminal motif of envelope protein 2 (E2), termed hypervariable region 1 (HVR1), changes rapidly in immunoglobulin-competent patients due to antibody-driven antigenic drift...
2018: Frontiers in Immunology
Xueqian Wang, Mengliu Zhang, Dawei Zhang, Xinluan Wang, Huijuan Cao, Qian Zhang, Chunyan Yan
Curculigo orchioides, is a traditional Chinese medicine, is used in strengthening tendons and bones. We evaluated the anti-osteoporosis activity of the crude polysaccharide (CO70) isolated from the rhizomes of C. orchioides in ovariectomized rats. CO70 showed excellent anti-osteoporosis activity comparable to that of 17β-estradiol. To explore the constituents responsible for the anti-osteoporosis activity of CO70, a novel homogeneous heteropolysaccharide, COP70-3, was isolated and purified from CO70. COP70-3 has a main backbone chain of (1→5)-linked α-L-Araf, (1,3→5)-linked α-L-Araf, (1→6)-linked β-D-Galp, (1→4)-linked β-D-Manp, (1,2→5)-linked α-L-Araf, (1→3)-linked β-L-Rhap, (1, 3→6)-linked β-D-Manp, (1→3)-linked α-D-GalpA, (1,3→6)-linked β-D-Galp and (1→6)-linked α-D-Glcp residues...
January 1, 2019: Carbohydrate Polymers
Karnam Shruthi, S Sreenivasa Reddy, P Swathi Chitra, G Bhanuprakash Reddy
The ubiquitin-proteasome system (UPS) has been implicated in the pathogenesis of many neurodegenerative diseases. Endoplasmic reticulum (ER) stress is shown to play a pathological role in the development of diabetes and its complications. Hence, the current study is aimed to investigate the role of UPS and ER stress in the cerebral cortex of diabetic rats and examine the therapeutic effect of 4-phenylbutyric acid (4-PBA), an ER stress inhibitor. Male Sprague-Dawley rats were divided into three groups: control, diabetes, and diabetes plus 4-PBA treatment group...
October 14, 2018: Journal of Cellular Biochemistry
Jian Wang, Chengchuang Song, Xiukai Cao, Hui Li, Hanfang Cai, Yilei Ma, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Yun Ma, Yueyu Bai, Fengpeng Lin, Hong Chen
Skeletal muscle is the most abundant tissue in the body. The development of skeletal muscle cell is complex and affected by many factors. A sea of microRNAs (miRNAs) have been identified as critical regulators of myogenesis. MiR-208b, a muscle-specific miRNA, was reported to have a connection with fiber type determination. However, whether miR-208b has effect on proliferation of muscle cell was under ascertained. In our study, cyclin-dependent kinase inhibitor 1A (CDKN1A), which participates in cell cycle regulation, was predicted and then validated as one target gene of miR-208b...
October 14, 2018: Journal of Cellular Physiology
Lijuan Yang, Guancheng Xu, Jinjin Ban, Li Zhang, Gui Xu, Yan Lv, Dianzeng Jia
Nitrogen-doped carbon materials are promising oxygen reduction reaction (ORR) electrocatalysts owing to high performance and stability. Herein, a three-dimensional porous bio-MOF-1, Zn8 (Ad)4 (Bpdc)6 O·2Me2 NH2 (Ad = adeninate; Bpdc = biphenyldicarboxylate), was used as precursor to fabricate N-doped porous carbon materials (NPC-1000-ts, where 1000 stands for the carbonization temperature and t represents the carbonization time, t = 2, 3 and 4 h) by simple carbonization under Ar atmosphere. The porous carbon materials had different contents of graphitic N and graphitization degrees of carbon...
October 4, 2018: Journal of Colloid and Interface Science
Xian Tong, Dechuang Zhang, Xiaotuan Zhang, Yingchao Su, Zimu Shi, Kun Wang, Jianguo Lin, Yuncang Li, Jixing Lin, Cuie Wen
Zinc (Zn)-based alloys are considered a new class of biodegradable implant materials due to their superior chemical stability and processability compared to biodegradable magnesium (Mg) alloys. In this study, we report a new biodegradable Zn-5Ge alloy with highly desirable mechanical, corrosion, and biological properties. Microstructural characterization revealed the effective grain-refining effect of germanium (Ge) on the Zn alloy. Tensile test results indicated that the hot-rolled Zn-5Ge alloy showed an ultimate tensile strength of 237...
October 11, 2018: Acta Biomaterialia
Emely Thompson, Jodene Eldstrom, Maartje Westhoff, Donald McAfee, David Fedida
The delayed potassium rectifier current, IKs, is assembled from tetramers of KCNQ1 and varying numbers of KCNE1 accessory subunits in addition to calmodulin. This channel complex is important in the response of the cardiac action potential to sympathetic stimulation, during which IKs is enhanced. This is likely due to channels opening more quickly, more often, and to greater sublevel amplitudes during adrenergic stimulation. KCNQ1 alone is unresponsive to cyclic adenosine monophosphate (cAMP), and thus KCNE1 is required for a functional effect of protein kinase A phosphorylation...
September 27, 2018: Biophysical Journal
Luna Ge, Yazhou Cui, Kai Cheng, Jinxiang Han
Isopsoralen (IPRN), one of the main effective ingredients in Psoralea corylifolia Linn, has a variety of biological effects, including antiosteoporotic effects. In vivo studies show that IPRN can increase bone strength and trabecular bone microstructure in a sex hormone deficiency-induced osteoporosis model. However, the mechanism underlying this osteogenic potential has not been investigated in detail. In the present study, we investigated the molecular mechanism of IPRN-induced osteogenesis in MC3T3-E1 cells...
October 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Piyawan Paisrisarn, Surapun Tepaamorndech, Mattaka Khongkow, Pongtanawat Khemthong, Panita Kasamechonchung, Wantana Klysubun, Tuksadon Wutikhun, Liping Huang, Kanittha Chantarasakha, Suwimon Boonrungsiman
The present study investigated the effect of lead (Pb) on bone ultrastructure and chemistry using an in vitro bone model. MC3T3-E1 preosteoblasts were differentiated and treated with lead acetate at 0.2, 0.4, 2, 10, and 50 µM. No abnormalities in either cell growth or bone nodule formation were observed with the treated dose of lead acetate. However, Pb treatments could significantly increase Pb accumulation in differentiated osteoblast cultures and upregulate expression of Divalent metal transporter 1 (Dmt1) in a dose dependent manner...
October 9, 2018: Toxicology Letters
Dehua Zhu, Jianping Zhou, Jinbo Zhao, Guiyang Jiang, Xiupeng Zhang, Yong Zhang, Ming Dong
ZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame-shift mutation in colorectal cancer (CRC). However, its expression and biological function were still uncertain. In the current study, we found that ZC3H13 was served as a tumor suppressor in CRC cells, which decreased the expression of Snail, Cyclin D1, and Cyclin E1, and increased the expression of Occludin and Zo-1 through inactivating Ras-ERK signaling pathway. Furthermore, reduction of ZC3H13 associated with advanced TNM stage (p = 0...
October 12, 2018: Journal of Cellular Physiology
Xin Li, Ming Dong, Jianping Zhou, Dehua Zhu, Jinbo Zhao, Weiwei Sheng
C6orf106 was highly expressed in lung and breast cancer, and proposed as clinicopathologic factor for the development of those types of cancer. However, its expression in pancreatic cancer and the mechanism that C6orf106 functions as an oncogene has not been confirmed. In the present study, we found that C6orf106 was also up-regulated in pancreatic cancer tissues and cell lines. Furthermore, C6orf106 expression was associated with advanced T stage (P = 0.010), positive regional lymph node metastasis (P = 0...
October 11, 2018: Molecular and Cellular Biochemistry
Liping Ren, Shuang Pan, Haiqing Li, Yanping Li, Lina He, Shuang Zhang, Jingyi Che, Yumei Niu
Graphene oxide (GO) has attracted considerable attention for biomedical applications such as drug delivery because of its two-dimensional structure, which provides a large surface area on both sides of the nanosheet. Here, a new method for titanium (Ti) surface modification involving a GO coating and aspirin (A) loading (A/Ti-GO) was developed, and the bioactive effects on mouse osteoblastic MC3T3-E1 cells were preliminarily studied. The X-ray photoelectron spectrometry indicated new C-O-N, C-Si-O-C, and C-N=C bond formation upon GO coating...
October 11, 2018: Scientific Reports
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