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https://www.readbyqxmd.com/read/30120576/plga-film-titanium-nanotubues-as-a-sustained-growth-factor-releasing-system-for-dental-implants
#1
Shengjun Sun, Yilin Zhang, Deliang Zeng, Songmei Zhang, Fuqiang Zhang, Weiqiang Yu
Ti-based implants sometimes fail to integrate with surrounding bone tissue due to insufficiency of new bone formation and surface bonding. To overcome this problem, this research focused on establishing a sustained bone growth factor delivery system by applying anodized TiO2 nanotube arrays and PLGA film on the titanium implant surface. TiO2 nanotube arrays were made by anodic oxidation method, and were then filled with rhBMP2 by vacuum freeze-drying. Next, PLGA was deposition on the surface of this material...
August 17, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/30119643/clinical-impact-of-endocapillary-proliferation-according-to-the-oxford-classification-among-adults-with-henoch-sch%C3%A3-nlein-purpura-nephritis-a-multicenter-retrospective-cohort-study
#2
Koji Inagaki, Ahmad Baseer Kaihan, Asaka Hachiya, Takaya Ozeki, Masahiko Ando, Sawako Kato, Yoshinari Yasuda, Shoichi Maruyama
BACKGROUND: Henoch-Schönlein purpura nephritis (HSPN) is a form of small vessel vasculitis associated with purpura and IgA deposition in the glomeruli. The International Study of Kidney Disease in Children (ISKDC) classification predicts renal prognosis in children with HSPN, but not in adults. Additionally, it is not well known whether the Oxford classification 2016 and/or the Japanese Histologic classification (JHC) are associated with renal outcome. Herein, we investigated the relationship between pathological characteristics and renal outcome among adult patients with HSPN...
August 17, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30118735/cation-dependent-mannose-6-phosphate-receptor-functions-as-a-pattern-recognition-receptor-in-anti-bacterial-immunity-of-marsupenaeus-japonicus
#3
Ke-Yi Zhang, Wen-Jie Yuan, Ji-Dong Xu, Jin-Xing Wang
The cation-dependent mannose-6-phosphate receptor (CD-MPR) is a member of the P-type lectin family. As a type I transmembrane glycoprotein, it functions in the delivery of newly synthesized acid hydrolases from the trans-Golgi network to endosomes for their subsequent transfer to the lysosome by binding the mannose-6-phosphate receptor-recognition moieties in the hydrolases. However, the functions of CD-MPR in immune responses are seldom reported. In the present study, we identified a CD-MPR-like molecule in Marsupenaeus japonicus and designed it as MjCD-MPR...
August 14, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/30115978/cytosolic-nucleic-acid-sensors-of-the-innate-immune-system-promote-liver-regeneration-after-partial-hepatectomy
#4
Sarah Schulze, Christian Stöß, Miao Lu, Baocai Wang, Melanie Laschinger, Katja Steiger, Felicitas Altmayr, Helmut Friess, Daniel Hartmann, Bernhard Holzmann, Norbert Hüser
Stimulation of cytosolic nucleic acid sensors of innate immunity by pathogen-derived nucleic acids is important for antimicrobial defence, but stimulation through self-derived nucleic acids may contribute to autoinflammation and cancer. DNA sensing in the cytosol requires the stimulator of interferon genes (STING), while cytosolic RNA sensors use mitochondrial antiviral-signalling protein (MAVS). In a murine model of two-thirds hepatectomy, combined deficiency of MAVS and STING resulted in strongly impaired hepatocyte proliferation and delayed recovery of liver mass...
August 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30114843/light-emitting-properties-of-si-self-ion-implanted-silicon-on-insulator-from-visible-to-infrared-band
#5
Lingxi Ouyang, Chong Wang, Xiaoxu Feng, Jie Yang, Mengwei Zhou, Feng Qiu, Rongfei Wang, Yu Yang
The photoluminescence (PL) properties of silicon-on-insulator (SOI) samples, modified by the Si+ self-ion-implantation (SII) into Si thin film followed by annealing, have been well investigated. The well-known W-line can also be observed in SII SOI samples, its emitting behavior and structural evolution have been discussed in this article. The parallel PL pattern trend and the similar changes of temperature-dependent intensity suggest that luminescence center of I1 and I2 peaks located in the near-infrared band originates from the same interstitial-clusters (In Cs)...
June 11, 2018: Optics Express
https://www.readbyqxmd.com/read/30114780/investigation-of-deep-level-defects-on-beryllium-compensation-doping-of-in-0-53-ga-0-47-as-gaas-0-49-sb-0-51-type-ii-superlattice-photodiodes
#6
Jinlan Li, Zhicheng Xu, Ping Han, Jianxin Chen, Xiaoli Ji
In this paper, deep level transient spectroscopy (DLTS) characterization was performed on Beryllium compensation doping of InGaAs/GaAsSb type-II superlattice photodiode. Three electron traps with the energy levels located at Ec -0.11 eV (E1), Ec -0.28 eV (E2), Ec -0.17 eV (E3), and a hole trap situated at Ev + 0.25 eV (H1) were revealed. The position distribution and depth concentration of these traps in SL absorption region was also explored. Furthermore, the bandlike states (E2) and localized states (E1 and H1) of extended defects were confirmed by DLTS measurements as a function of the filling-pulse time, these traps as generation-recombination centers are responsible for dominant dark current...
June 11, 2018: Optics Express
https://www.readbyqxmd.com/read/30113917/monitoring-age-group-swimmers-over-a-training-macrocycle-energetics-technique-and-anthropometrics
#7
Rodrigo Zacca, Rui Azevedo, Phornpot Chainok, João Paulo Vilas-Boas, Flávio A de S Castro, David B Pyne, Ricardo J Fernandes
Zacca, R, Azevedo, R, Chainok, P, Vilas-Boas, JP, Castro, FAdS, Pyne, DB, and Fernandes, RJ. Monitoring age-group swimmers over a training macrocycle: energetics, technique, and anthropometrics. J Strength Cond Res XX(X): 000-000, 2018-The aim of this study was to quantify changes and contributions of energetic, technique, and anthropometric profiles across the first training macrocycle (16-week) in a traditional 3-peak swimming season. Twenty-four age-group swimmers (10 boys and 14 girls age 14.4 ± 0.9 years) of equal maturational stage were monitored through a 400-m test in front crawl (T400)...
August 15, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/30113815/significantly-accelerated-osteoblast-cell-growth-on-tio2-srha-composite-mediated-by-phenolic-compounds-bhm-from-hippocampus-kuda-bleeler
#8
Qiong Yuan, Lei He, Zhong-Ji Qian, Chunxia Zhou, Pengzhi Hong, Zhe Wang, Yi Wang, Shengli Sun, Chengyong Li
Microstructure of hydroxyapatite is known to influence cellular behavior, can be performed as a substrate for osteoblast growth, and exploited as a drug release platform. However, easy delamination and self-decomposition of hydroxyapatite caused by poor adhesion with substrates are the main problems currently. In this paper, we successfully fabricated TiO2/SrHA composite scaffolds by self-generated strontium substituted hydroxyapatite microspheres in TiO2 nanotubes. Moreover, the active compound 1-(5-bromo-2-hydroxy-methoxyphenyl)-ethanone (BHM) from Seahorse (Hippocampus kuda Bleeler) was loaded in this scaffold, and the controlled release kinetics of BHM was studied...
August 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30112029/echinacoside-suppresses-dexamethasone-induced-growth-inhibition-and-apoptosis-in-osteoblastic-mc3t3-e1-cells
#9
Sibo Li, Haitao Jiang, Xiaohua Gu
Glucocorticoids (GCs) are widely used to treat chronic diseases. Prolonged and/or overdose administration of GCs has many side-effects to human health including GC-induced osteoporosis (GIOP). In this investigation, the objective was to assess the influence that echinacoside (ECH) exerts upon dexamethasone-treated murine osteoblastic MC3T3-E1 cells. We found that ECH (5, 10, 20 and 40 mg/l) inhibited dexamethasone (1,000 nM)-suppressed cell viability as demonstrated by Cell Counting Kit-8 (CCK-8) assay. The dose of 10 mg/l was selected for the following experiments because this dose had a better effect than the dose of 5 mg/l, and the doses >10 mg/l had a similar effect as this dose...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30111563/neurl3-is-an-inducible-antiviral-effector-to-inhibit-hcv-assembly-by-targeting-viral-e1-glycoprotein
#10
Yanan Zhao, Xuezhi Cao, Mingzhe Guo, Xuesong Wang, Tao Yu, Liqing Ye, Lin Han, Lei Hei, Wanyin Tao, Yimin Tong, Yongfen Xu, Jin Zhong
Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV can be sensed by host innate immunity to induce expression of interferons (IFNs) and a number of antiviral effectors. In this study, we found HCV infection induced the expression of Neuralized E3 Ubiquitin Protein Ligase 3 (NEURL3), a putative E3 ligase, in a manner that requires the involvement of innate immune sensing but is independent of the IFN action. Furthermore, we showed that NEURL3 inhibited HCV infection, while had little effect on other RNA viruses including zika virus, dengue virus and vesicular stomatitis virus...
August 15, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30110677/kidney-protection-effect-of-ginsenoside-re-and-its-underlying-mechanisms-on-cisplatin-induced-kidney-injury
#11
Zi Wang, Yan-Fei Li, Xin-Yue Han, Yin-Shi Sun, Lian-Xue Zhang, Wei Liu, Xiang-Xiang Liu, Wei Li, Ying-Ying Liu
BACKGROUND/AIMS: Cisplatin (CDDP) was the first platinum-containing anti-cancer drug. However, CDDP causes nephrotoxicity as a side effect, which limits its clinic application. The aim of this study was to investigate the renoprotective effect of ginsenoside Re (G-Re) in a murine model of CDDP-induced acute kidney injury. METHODS: Male ICR mice were divided into 4 groups. G-Re was administered to the mice by oral gavage once a day at a dose of 25 mg/kg for 10 days...
August 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30110156/hierarchically-ordered-2-dimensional-coordination-polymers-assembled-from-redox-active-dimolybdenum-clusters
#12
F James Claire, Stephanie M Tenney, Minyuan M Li, Maxime A Siegler, Justine S Wagner, Anthony Shoji Hall, Thomas J Kempa
Coordination polymers (CPs) supporting tunable through-framework conduction and responsive properties are of significant interest for enabling a new generation of active devices. However, such architectures are rare. We report a redox-active CP comprised of two-dimensional (2D) lattices of coordinatively bonded Mo2 (INA)4 clusters (INA=isonicotinate). The 2D lattices are commensurately stacked and their ordering topology can be synthetically tuned. The material has a hierarchical pore structure (pore sizes distributed between 7-33 Å) and exhibits unique CO2 adsorption (nominally Type VI) for an isotherm collected at 195 K...
August 15, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30110131/effects-of-titanium-oxide-surface-properties-on-bone-forming-and-soft-tissue-forming-cells
#13
Sutton E Wheelis, Ana Gabriela Montaño-Figueroa, Manuel Quevedo-Lopez, Danieli C Rodrigues
BACKGROUND: Previous studies have concluded that certain titanium oxide (TiO2 ) surface properties promote bone-forming cell attachment. However, no comprehensive studies have investigated the effects of TiO2 surface and film morphology on hard and soft tissues. PURPOSE: The aim of this study is to understand the effects of TiO2 morphology on the proliferation and differentiation of murine preosteoblasts (MC3T3-E1) and proliferation of human gingival fibroblasts (HGF-1) using in vitro experiments...
August 15, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/30109343/3-d-manipulation-of-a-single-nano-droplet-on-graphene-with-an-electrowetting-driving-scheme-critical-condition-and-tunability
#14
Jian Zeng, Shiwei Zhang, Kairui Tang, Gong Chen, Wei Yuan, Yong Tang
The next generation of micro/nano-fluidic systems, featuring manipulation of a single nanoliter volume of a chemical reactant or bio-substance, is greatly dependent on the accurate manipulation of a single nano-droplet. In this paper, to resolve the lack of efficient methods for 3-D actuation of nano-droplets with high tunability, we proposed an electro-wetting-on-dielectric (EWOD) driving scheme on a graphene surface. The droplet could be actuated when the EWOD-saturated contact angle was reached, which determined the critical magnitude of the E-field...
August 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/30106440/set7-9-promotes-hepatocellular-carcinoma-progression-through-regulation-of-e2f1
#15
Ye Gu, Xinling Wang, Hong Liu, Guimei Li, Weiping Yu, Qing Ma
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Histone‑lysine N‑methyltransferase SET7/9 is a protein lysine monomethylase that methylates histone H3K4 as well as various non‑histone proteins. Deregulation of SET7/9 is frequently detected in human cancers. However, the role of SET7/9 in HCC development remains unclear. In the present study, upregulation of SET7/9 and E2F transcription factor 1 (E2F1) expression was detected in 68 samples of HCC tissues compared with these levels noted in the paired healthy liver samples...
August 2, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30106366/prevention-of-contrast-induced-nephropathy-with-prostaglandin-e1-in-patients-undergoing-percutaneous-coronary-procedures-a-meta-analysis-of-24-randomized-controlled-trials
#16
Xiangying Liu, Yongfu Hang, Lei Shen, Jing Yang, Ling Zhou, Wengang Sha, Guoyuan Lu
BACKGROUND: Contrast-induced nephropathy (CIN) is the third most common cause of acute kidney injury in hospitalized patients. There have been many conflicting results across trials that have evaluated the prophylactic efficacy of prostaglandin E1 (PGE1) for prevention of CIN in patients undergoing percutaneous coronary procedures. PGE1 may have renal-protective effects due to its pleiotropic properties. The aim of this study was to evaluate the efficacy of PGE1 in preventing CIN. MATERIALS AND METHODS: We searched PubMed, Embase, Cochrane Library, Chinese Biomedical Literature, China National Knowledge Infrastructure, VIP Information/Chinese Scientific Journals, and WANFANG databases for randomized controlled trials (RCTs) comparing the preventive effects of PGE1 versus controls (conventional hydration, no PGE1, or placebo) on CIN in patients undergoing percutaneous coronary procedures from January 1999 to June 2016...
August 14, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/30106097/pdgf%C3%A2-bb-promotes-the-differentiation-and-proliferation-of-mc3t3%C3%A2-e1-cells-through-the-src-jak2-signaling-pathway
#17
Qi Liu, Yunfeng Zhou, Zubing Li
Platelet‑derived growth factor‑BB (PDGF‑BB) serves a critical function in human osteoblast differentiation and proliferation. Src and Janus kinase 2 (JAK2) are involved in these processes. In our previous study, it was identified that Src could promote the phosphorylation of JAK2. However, it has yet to be determined whether the Src/JAK2 signaling pathway affects PDGF‑BB‑mediated osteoblast differentiation and proliferation. In the present study, western blotting, polymerase chain reaction, alizarin red staining, alkaline phosphatase and Cell Counting kit‑8 were employed to explore these questions...
August 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30101722/anticancer-mechanism-of-lobaplatin-as-a-aingle-agent-and-in-combination-with-paclitaxel-in-human-gastric-cancer-cell-line-sgc-7901
#18
Suhang Hua, Yongxing Zhang
OBJECTIVE: To explore the mechanism by which lobaplatin, as monotherapy and in combination with paclitaxel, inhibits the proliferation of human gastric cancer SGC-7901 cells. METHODS: After treatment, the MTT assay was used to assess cell viability; cell cycle distribution was evaluated flow-cytometrically. Western blot was used to quantitate cyclin D1, E1, B1, and Cdk2/4 protein levels. RESULTS: Lobaplatin and paclitaxel inhibited SGC-7901 cell growth in a concentration and time-dependent manner, with IC25 values at 48h of 1...
August 12, 2018: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/30101580/performance-of-a-newly-developed-mineral-gel-system-on-erosive-and-erosive-abrasive-enamel-loss-an-in-vitro-study
#19
Florian J. Wegehaupt, Jana Schleich, Blend Hamza, Daniel Wiedemeier, Thomas Attin
We compared the prevention of erosive and erosive/abrasive enamel loss by a medical minerals gel system (R.O.C.S.) to that by an anti-erosive toothpaste. Seventy-two bovine enamel samples were randomly allocated to six groups (E1–E3 and EA1–EA3; n=12). Per day, samples were eroded (2 min) 9 times using HCl (pH 2.6). Between erosive challenges and over night samples were stored in artificial saliva. Per day, samples were stored (100 s; groups E1–E3) or additionally brushed (20 brushing strokes; groups EA1–EA3) in/with slurries prepared from artificial saliva plus: no additional toothpaste (control groups E1 and EA1), elmex erosion protection toothpaste (groups E2 and EA2), or R...
September 10, 2018: Swiss Dental Journal
https://www.readbyqxmd.com/read/30099009/promising-new-therapeutic-targets-for-regulation-of-inflammation-and-immunity-ring-type-e3-ubiquitin-ligases
#20
REVIEW
Emil Bulatov, Aygul Valiullina, Regina Sayarova, Albert Rizvanov
Ubiquitin-proteasome system (UPS) is a primary signaling pathway for regulation of protein turnover and removal of misfolded proteins in eukaryotic cells. Enzymes of the UPS pathway - E1 activating, E2 conjugating, E3 ligating - act together to covalently tag substrate proteins with a chain of ubiquitins, small regulatory proteins. The poly-ubiquitin chain then serves as a recognition motif for 26S proteasome to recognize and degrade the substrate. In recent years UPS has emerged as attractive enzymatic cascade for development of novel therapeutics against various human diseases...
August 9, 2018: Immunology Letters
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