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High iron levels

Israel P Nyarubeli, Alexander M Tungu, Magne Bråtveit, Erlend Sunde, Akwilina V Kayumba, Bente E Moen
Background: Machines, processes, and tasks in the iron and steel factories may produce noise levels that are harmful to hearing if not properly controlled. Studies documenting noise exposure levels and related determinants in sub-Saharan Africa, including Tanzania are lacking. The aim of this study was to document noise exposure and to identify determinants of noise exposure with a view to establishing an effective hearing conservation programme. Methods: A walk-through survey was conducted to describe the working environment in terms of noise sources in four metal factories (A-D) in Tanzania...
August 3, 2018: Annals of Work Exposures and Health
Matthew Little, Chloe Zivot, Sally Humphries, Warren Dodd, Kirit Patel, Cate Dewey
Background/Objectives: To determine the prevalence and determinants of blood haemoglobin level and mild, moderate, and severe anemia in a sample of adults from rural Tamil Nadu, India. Subjects/Methods: We recruited a sample of men and nonpregnant women aged 20 years and older. Clinical health measures included blood haemoglobin concentration and body mass index. We assessed associations between anemia outcomes and sociodemographic and dietary factors using linear and logistic regression modeling...
2018: Anemia
Francesco Pacifico, Luna Pisa, Stefano Mellone, Michele Cillo, Alessio Lepore, Antonio Leonardi
We have previously shown that Neutrophil Gelatinase-Associated Lipocalin (NGAL) is strongly expressed in thyroid carcinomas, especially of anaplastic type, where it protects neoplastic cells from serum deprivation-induced apoptosis and enhances tumor invasivity by regulating MMP-9 activity. Here we demonstrate that NGAL-containing conditioned medium from human anaplastic thyroid carcinoma (ATC) cells is able to induce monocyte migration via up-regulation of a number of different chemokines. The enhanced chemokines transcription is due to the NGAL-mediated intracellular iron uptake...
July 20, 2018: Oncotarget
Xinyu Wang, Wei Wang, Greg Lowry, Xiaoyan Li, Yajie Guo, Tielong Li
A method developed based on the capillary effect and capillary condensation theory was used to synthesize an innovative Fe/C/Pd composite in this study. This composite (Fe@CNTs@Pd) consists of carbon nanotubes (CNTs) with nanoscale zerovalent iron (NZVI) on the inner surface and palladium nanoparticles supported on the outer surface of CNTs. This structure successfully addresses the problems of high iron corrosion rate and lower utilization rate of hydrogen in the application of bimetal nanoparticles for trichloroethylene (TCE) removal...
June 2018: Royal Society Open Science
Milad Akhondi, Ali A Dadkhah
In this research, a method based on base-catalysed decomposition (BCD) was developed using sodium hydroxide and glycerol for dechlorination of transformer oils with low levels of polychlorinated biphenyls (PCBs). PCB removal and dechlorination efficiencies were measured by gas chromatography and the silver nitrate titration method, respectively. PCB dechlorination and removal efficiencies after 4 h at 250°C and in the presence of iron were 97.4% and 99.8%, respectively. However, in the absence of iron the same efficiencies were calculated to be 79...
June 2018: Royal Society Open Science
Yael Einbinder, Timna Agur, Kirill Davidov, Tali Zitman-Gal, Eliezer Golan, Sydney Benchetrit
BACKGROUND: Anemia management strategies among chronic hemodialysis patients with high ferritin levels remains challenging for nephrologists. OBJECTIVES: To compare anemia management in stable hemodialysis patients with high (≥ 500 ng/ml) vs. low (< 500 ng/ml) ferritin levels. METHODS: In a single center, record review, cohort study of stable hemodialysis patients who were followed for 24 months, an anemia management policy was amended to discontinue intravenous (IV) iron therapy for stable hemodialysis patients with hemoglobin > 10 g/dl and ferritin ≥ 500 ng/ml...
July 2018: Israel Medical Association Journal: IMAJ
Huimin Ma, Hongyu Li, Xiaohua Li, Wen Shi, Yanhui Xu
Herein, we report the first sensitive fluorescence *OH probe (1) that is capable of monitoring the generation of trace *OH in the iron autoxidation. The probe 1 was designed by utilizing both the unique aromatic hydroxylation and the electrophilicity of *OH, and prepared by incorporating a strong electron-donating methoxy group into a cyanine fluorochrome to enhance the trapping ability for *OH. Reaction of 1 with *OH leads to a larger π-conjugation formation and near-infrared fluorescence off-on response...
August 14, 2018: Angewandte Chemie
Matthew G Siebecker, Rufus L Chaney, Donald L Sparks
Serpentine soils and ultramafic laterites develop over ultramafic bedrock and are important geological materials from environmental, geochemical, and industrial standpoints. They have naturally elevated concentrations of trace metals, such as Ni, Cr, and Co, and also high levels of Fe and Mg. Minerals host these trace metals and influence metal mobility. Ni in particular is an important trace metal in these soils, and the objective of this research was to use microscale (µ) techniques to identify naturally occurring minerals that contain Ni and Ni correlations with other trace metals, such as Fe, Mn, and Cr...
August 14, 2018: Geochemical Transactions
A Janet Tomiyama, Deborah Carr, Ellen M Granberg, Brenda Major, Eric Robinson, Angelina R Sutin, Alexandra Brewis
BACKGROUND: In an era when obesity prevalence is high throughout much of the world, there is a correspondingly pervasive and strong culture of weight stigma. For example, representative studies show that some forms of weight discrimination are more prevalent even than discrimination based on race or ethnicity. DISCUSSION: In this Opinion article, we review compelling evidence that weight stigma is harmful to health, over and above objective body mass index. Weight stigma is prospectively related to heightened mortality and other chronic diseases and conditions...
August 15, 2018: BMC Medicine
Shang Dai, Ye Jin, Tao Li, Yulan Weng, Xiaolin Xu, Genlin Zhang, Jiulong Li, Renjiang Pang, Bing Tian, Yuejin Hua
Iron acquisition by bacteria is well studied, but iron export from bacteria is less understood. Herein, we identified dr1440 with a P-type ATPase motif as a potential exporter of iron from Deinococcus radiodurans, a bacterium known for its extreme resistance to radiation and oxidants. The DR1440 was located in cell membrane as demonstrated by fluorescence labelling analysis. Mutation of dr1440 resulted in cellular accumulation of iron ions, and expression level of dr1440 was up-regulated significantly under iron ion or hydrogen peroxide stress in the wild-type strain, implicating DR1440 as a potential iron efflux protein...
2018: PloS One
Adrienne Clermont, Stephen R Kodish, Amadou Matar Seck, Aichatou Salifou, Joseph Rosen, Rebecca F Grais, Sheila Isanaka
Nutritional status in pregnancy is a key determinant of birth outcomes. In low-income countries, maternal diets are often limited, and daily nutrient supplements are recommended to fill nutrient gaps. As a result, it is important to understand the factors influencing acceptability and utilization of nutrient supplements in these settings. Qualitative data (individual interviews and focus group discussions with pregnant women, household members, and study staff) and quantitative data (unannounced household spot checks) were collected in 24 villages in the Maradi region of south-central Niger...
August 12, 2018: Nutrients
Saika Minegishi, Ikuko Sagami, Shigeru Negi, Koji Kano, Hiroaki Kitagishi
Circadian rhythms are regulated by transcription-translation feedback loops (TTFL) of clock genes. Previous studies have demonstrated that core transcriptional factors, NPAS2 and CLOCK, in the TTFL can reversibly bind carbon monoxide (CO) in vitro. However, little is known about whether endogenous CO, which is continuously produced during a heme metabolic process, is involved in the circadian system. Here we show that selective removal of endogenous CO in mice considerably disrupts rhythmic expression of the clock genes...
August 10, 2018: Scientific Reports
Toshihide Hayashi, Yuri Tanaka, Masaki Iwasaki, Hiroki Hase, Hiroyuki Yamamoto, Yasuhiro Komatsu, Ryoichi Ando, Masato Ikeda, Daijo Inaguma, Toshifumi Sakaguchi, Toshio Shinoda, Fumihiko Koiwa, Shigeo Negi, Toshihiko Yamaka, Takashi Shigematsu, Nobuhiko Joki
OBJECTIVES: High prevalence of iron deficiency (ID) and cardiomyopathy have been observed in patients with end-stage kidney disease (ESKD). Our objective was to clarify associations between ID and cardiac remodeling in patients with ESKD. DESIGN AND METHODS: A cross-sectional study was conducted using 1974 Japanese patients with ESKD at the initiation of maintenance dialysis. Levels of hemoglobin (Hb), iron status, and cardiac enlargement as assessed by the cardiothoracic ratio (CTR) were determined immediately before the first hemodialysis session...
August 7, 2018: Journal of Renal Nutrition
Stephanie J Maiocco, Lindsey M Walker, Sean J Elliott
While protein film electrochemistry (PFE) has proven to be an effective tool in the interrogation of redox cofactors and assessing the electrocatalytic activity of many different enzymes, recently it has been proven to be useful for the study of the redox potentials of the cofactors of AdoMet radical enzymes (AREs). In this chapter, we review the challenges and opportunities of examining the redox cofactors of AREs in a high level of detail, particularly for the deconvolution of redox potentials of multiple cofactors...
2018: Methods in Enzymology
Julia Ruhe, Christoph Waldeyer, Francisco Ojeda, Alev Altay, Renate B Schnabel, Sarina Schäfer, Karl J Lackner, Stefan Blankenberg, Tanja Zeller, Mahir Karakas
Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (<24 ng/mL) and high levels of sTfR (≥2 mg/L)...
August 9, 2018: Biomolecules
B P Mallikarjuna Swamy, Gwen Iris L Descalsota, Chau Thanh Nha, Amery Amparado, Mary Ann Inabangan-Asilo, Christine Manito, Frances Tesoro, Russell Reinke
Rice provides energy and nutrition to more than half of the world's population. Breeding rice varieties with the increased levels of bioavailable micronutrients is one of the most sustainable approaches to tackle micronutrient malnutrition. So, high zinc and iron content in the grain are primary targets in rice biofortification breeding. In this study, we conducted QTL mapping using doubled haploid (DH) populations, PSBRc82 x Joryeongbyeo and PSBRc82 x IR69428, phenotyped for agronomic traits and micronutrients during two growing seasons and using genotypic information from analysis with the 6K SNP chip...
2018: PloS One
Keegan Burrow, Wayne Young, Michelle McConnell, Alan Carne, David Barr, Malcom Reid, Alaa El-Din Bekhit
SCOPE: The aim of the study was to determine the effects of sheep milk consumption in comparison to cow milk on the mineral distribution in the soft organs and serum in a growing animal model system. As the mineral composition of cow and sheep milk differs, different effects on the bio-accumulations in the body may be observed. Differences in the mineral composition of cow and sheep milk may lead to different bioavailability or accumulation of minerals in the body. Newly weaned rats were fed either cow milk, sheep milk, or sheep milk diluted so that it had the same solids content as cow milk...
August 10, 2018: Molecular Nutrition & Food Research
Pengfei Yang, Hengyi Xu, Zhihong Zhang, Lin Yang, Huijuan Kuang, Zoraida P Aguilar
Various surface modifications of iron oxide magnetic nanoparticles (IOMNs) can improve their stability and long-term retention time in vivo , expanding applications of biomedical fields. However, whether the long-term retention of IOMNs coated with different surface modifications has toxic effects remains poorly understood. Here, the toxicity of IOMNs modified with polyethylene glycol (PEG), bovine serum albumin (BSA), and carboxyl group (COOH), forming PEG-IOMNs, BSA-IOMNs, and COOH-IOMNs, respectively, were evaluated in the rats...
August 2018: IET Nanobiotechnology
Sweta Mukherjee, Mukti Sharma, Amit Devgan, S K Jatana
Background: Iron deficiency anemia (IDA) in cyanotic congenital heart disease (CCHD) and its association with cyanotic spells has been documented in literature. However, Indian data especially in the pediatric age group is scarce. This study was conducted to find out the prevalence of IDA in this population. Methods: An observational study was conducted in a tertiary care hospital. Children with CCHD in the age group of birth-12 years were included in the study...
July 2018: Medical Journal, Armed Forces India
Giridhar Kanuri, Deepti Chichula, Ritica Sawhney, Kevin Kuriakose, Sherwin De'Souza, Fay Pais, Karthika Armugam, Arun S Shet
The detection of iron deficiency anaemia is challenged by the paucity of diagnostic tests demonstrating high sensitivity and specificity. Using two biomarkers zinc-protoporphyrin/heme and hepcidin, we established the diagnostic cut-off values for iron deficiency anaemia in preschool children and women. We randomly selected non-anaemic individuals (n=190; women=90, children=100) and individuals with iron deficiency anaemia (n=200; women=100, children=100) from a preexisting cohort of healthy preschool children and their mothers...
August 9, 2018: Haematologica
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