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Fabiën N Belle, Rahel Kasteler, Christina Schindera, Murielle Bochud, Roland A Ammann, Nicolas X von der Weid, Claudia E Kuehni
BACKGROUND: Glucocorticoids can lead to weight gain during cancer treatment, but to the authors' knowledge, little is known regarding their long-term effects in childhood cancer survivors (CCS). METHODS: As part of the Swiss Childhood Cancer Survivor Study, the authors sent a questionnaire to CCS aged <21 years at diagnosis who were residing in Switzerland, had survived ≥5 years, and were aged 15 to 45 years at the time of the survey. Cumulative doses of glucocorticoids were assessed from medical records and study protocols and body mass index was calculated from self-reported height and weight at the time of the survey...
August 17, 2018: Cancer
Xiang Sun, Zhi-Wei Lin, Xiao-Xiong Hu, Wei-Ming Yao, Bing Bai, Hong-Yan Wang, Duo-Yun Li, Zhong Chen, Hang Cheng, Wei-Guang Pan, Ming-Gui Deng, Guang-Jian Xu, Hao-Peng Tu, Jun-Wen Chen, Qi-Wen Deng, Zhi-Jian Yu, Jin-Xin Zheng
PURPOSE: In this study, we aimed to investigate biofilm formation characteristics in clinical Staphylococcus aureus (S. aureus) isolates with erythromycin (ERY) resistance from China and further analyze their correlations with antimicrobial susceptibility and molecular characteristics. METHOD: ology A total of 276 clinical isolates of ERY-resistant S. aureus, including 142 methicillin-resistant S. aureus (MRSA) strains and 134 methicillin-susceptible S. aureus (MSSA) strains, were retrospectively collected in China...
August 14, 2018: Microbial Pathogenesis
Martí López, Luke Broderick, John J Carey, Francesc Viñes, Michael Nolan, Francesc Illas
CO2 is one of the main actors in the greenhouse effect and its removal from the atmosphere is becoming an urgent need. Thus, CO2 capture and storage (CCS) and CO2 capture and usage (CCU) are intensively investigated technologies to decrease the concentration of atmospheric CO2. Both CCS and CCU require appropriate materials to adsorb/release and adsorb/activate CO2, respectively. Recently, it has been theoretically and experimentally shown that transition metal carbides (TMC) are able to capture, store, and activate CO2...
August 17, 2018: Physical Chemistry Chemical Physics: PCCP
M N Anwar, A Fayyaz, N F Sohail, M F Khokhar, M Baqar, W D Khan, K Rasool, M Rehan, A S Nizami
The quest for a sustainable environment and combating global warming, carbon capture, and storage (CCS) has become the primary resort. A complete shift from non-renewable resources to renewable resources is currently impossible due to its major share in energy generation; making CCS an imperative need of the time. This study, therefore, aims to examine the reckoning of carbon dioxide (CO2 ), measurement methods, and its efficient capture and storage technologies with an ambition to combat global warming and achieve environmental sustainability...
August 13, 2018: Journal of Environmental Management
Rasoul Kowsar, Vahid Norozian Iranshahi, Nima Sadeghi, Ahmad Riasi, Akio Miyamoto
High-protein diets often lead to an increase in urea concentration in follicular fluid of dairy cows, which may reduce oocyte competence. In the present study, maturation media were supplemented with urea (0, 20, 40 mg/dl), and amino acids (AAs) turnover was evaluated in the 24-h spent media of specimens (cell types), bovine cumulus-oocyte complexes (COCs), cumulus cells (CCs), or denuded oocytes (DOs). The main effects of urea and cell type, and their interaction were significant on the individual turnover (expect threonine, glycine, and tyrosine) and total turnover, depletion, and appearance of AAs...
August 15, 2018: Scientific Reports
R Ryan Reyes, Gavin Parker, Stephanie Garies, Cheryl Dolan, Susan Gerber, Beverly Burton, Tracy Burton, Jeff Brockmann, Rebecca Miyagishima, Neil Drummond
OBJECTIVE: To explore clinical indicators among patients with diabetes in southern Alberta and assess changes over time, and to compare patients with diabetes attending a reference clinic (RC), which had adapted its service model to address the specific needs of the patient population, with patients with diabetes attending comparison clinics (CCs) in the same region. DESIGN: Analysis of longitudinal data from the Canadian Primary Care Sentinel Surveillance Network (CPCSSN)...
August 2018: Canadian Family Physician Médecin de Famille Canadien
Felix Heeger, Elizabeth C Bourne, Christiane Baschien, Andrey Yurkov, Boyke Bunk, Cathrin Spröer, Jörg Overmann, Camila J Mazzoni, Michael T Monaghan
DNA metabarcoding is widely used to study prokaryotic and eukaryotic microbial diversity. Technological constraints limit most studies to marker lengths below 600 base pairs (bp). Longer sequencing reads of several thousand bp are now possible with third-generation sequencing. Increased marker lengths provide greater taxonomic resolution and allow for phylogenetic methods of classification, but longer reads may be subject to higher rates of sequencing error and chimera formation. In addition, most bioinformatics tools for DNA metabarcoding were designed for short reads and are therefore unsuitable...
August 14, 2018: Molecular Ecology Resources
Daimon Syukri, Manasikan Thammawong, Hushna Ara Naznin, Shinichiro Kuroki, Mizuki Tsuta, Makoto Yoshida, Kohei Nakano
The objective of this study was to identify metabolites that quantitatively indicate degrees of freshness of soybean sprouts. Self-cultivated soybean sprouts were stored at 5 °C, 10 °C or 20 °C, and respiratory CO2 production rates were monitored using gas chromatography during storage. Carbonyl compounds (CCs) were analyzed comprehensively using mass-spectroscopic metabolomics analyses. CCs were derivatized using dansyl hydrazine (DH) and were then analyzed using high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-MS/MS) with multiplexed multiple reaction monitoring (MRM)...
December 15, 2018: Food Chemistry
Ivana Blaženović, Tong Shen, Sajjan S Mehta, Tobias Kind, Jian Ji, Marco Piparo, Francesco Cacciola, Luigi Mondello, Oliver Fiehn
Unknown metabolites represent a bottleneck in untargeted metabolomics research. Ion mobility-mass spectrometry (IM-MS) facilitates lipid identification because it yields collision cross section (CCS) information that is independent from mass or lipophilicity. To date, only a few CCS values are publicly available for complex lipids such as phosphatidylcholines, sphingomyelins, or triacylglycerides. This scarcity of data limits the use of CCS values as an identification parameter that is orthogonal to mass, MS/MS, or retention time...
August 10, 2018: Analytical Chemistry
Lisa B Kenney, Bethany Ames, Alexis L Michaud, David N Williams, Peter E Manley, Nicole J Ullrich
BACKGROUND: Evidence is not available to guide management of childhood cancer survivors (CCS) at risk for radiation-associated cerebral vascular disease (CVD) and stroke. We propose to use a consensus-based methodology to describe the collective opinion of regional experts for the care of these patients and identify areas of controversy. PROCEDURE: Thirty physicians from the New England region who care for CCS participated in a Delphi panel querying their management approach (imaging, laboratory tests, medications, counseling, referrals) to a CCS treated with cranial radiation formatted as five clinical scenarios (asymptomatic, small- and large-vessel CVD, transient ischemia, stroke) in three rounds of anonymous questionnaires...
August 9, 2018: Pediatric Blood & Cancer
Stéphan Houdier, Justine Lévêque, Tiphaine Sabatier, Véronique Jacob, Jean-Luc Jaffrezo
Derivatization techniques based on α-effect amines and H+ catalysis are commonly used for the measurement of carbonyl compounds (CCs), whether in environmental, food, or biological samples. Here, we investigated the potential of aniline-based catalysts to improve derivatization rates of selected carbonyls by using dansylacetamidooxyamine (DNSAOA) as a reagent. Kinetic experiments were performed in aqueous solutions by varying catalyst and CC concentrations and delivered insights into the reaction mechanism...
August 9, 2018: Analytical and Bioanalytical Chemistry
Mahmoud Moussa, Meng-Qi Li, Hai-Ying Zheng, Chun-Yan Yang, Sheng-Fei Yan, Nong-Qi Yu, Jia-Xiang Huang, Jiang-Hua Shang
The objectives of the present study were to evaluate the developmental competence of buffalo denuded oocytes (DOs) cocultured with cumulus cells (CCs) during in vitro maturation, and to investigate the mechanisms by which CCs promote oocyte maturation and development. Buffalo oocytes were matured in vitro for 24 h in three groups: (1) intact cumulus-oocyte complexes (COCs) (2) DOs cocultured with CCs (DOsCC), and (3) DOs cultured alone (DOs). Matured oocytes were used to determine the relative mRNA abundance of Gdf-9, Bmp15, Zar1, Caspase-3, Bcl-2, Zp2, Zp3, Cd9 and Pde3a by Rt-qPCR and CASPASE-3 protein expression by immunofluorescence...
July 29, 2018: Theriogenology
Franziska Thomas, Wolf Mathis Rink
Coiled Coils (CCs) are well-understood protein folding motifs. They appear in a variety of oligomer states and as homo- and heteromeric assemblies. This versatility and the general accessibility by de novo design makes them ideal building blocks for synthetic biology. This minireview highlights the efforts being made in designing small peptide catalysts or reaction templates based on the CC scaffold. First reports describe autocatalysis or mediation of peptide ligation based on CC recognition. Over the years, the designs became more advanced, catalyzing ester hydrolysis, acyl transfer and redox reactions with in part enzyme-like reactivity...
August 9, 2018: Chemistry: a European Journal
Leide P Cavalcanti, Georgios N Kalantzopoulos, Juergen Eckert, Kenneth D Knudsen, Jon Otto Fossum
In order to mitigate climate change driven by the observed high levels of carbon dioxide (CO2 ) in the atmosphere, many micro and nano-porous materials are being investigated for CO2 selectivity, capture and storage (CCS) purposes, including zeolites, metal organic frameworks (MOFs), functionalized polymers, activated carbons and nano-silicate clay minerals. Key properties include availability, non-toxicity, low cost, stability, energy of adsorption/desorption, sorbent regeneration, sorption kinetics and CO2 storage capacity...
August 7, 2018: Scientific Reports
Chien-Ya Kao, Yen-Chieh Huang, Sheng-Yi Chiu, Ko-Liang Kuo, Pai-An Hwang
The addition of calcined waste clamshells (CCS) into polyethylene (PE) plastic bags imparts antibacterial properties due to the presence of CaO. In this study, different proportions of calcined waste clamshells were added to PE to explore its bacteriostatic effects. The PE plastic bags with 9% and 11% of CCS exhibited antibacterial efficacy. Further, total aerobic viable count (TVC) values for raw fish fillet packaging in 9% and 11% CCS-PE plastic bags for five days were similar to the 0% CCS-PE plastic bag group after three days of incubation...
August 7, 2018: Materials
Willem Verpoest, Catherine Staessen, Patrick M Bossuyt, Veerle Goossens, Gheona Altarescu, Maryse Bonduelle, Martha Devesa, Talia Eldar-Geva, Luca Gianaroli, Georg Griesinger, Georgia Kakourou, Georgia Kokkali, Jana Liebenthron, Maria-Cristina Magli, Monica Parriego, Andreas G Schmutzler, Monica Tobler, Katrin van der Ven, Joep Geraedts, Karen Sermon
STUDY QUESTION: Does preimplantation genetic testing for aneuploidy (PGT-A) by comprehensive chromosome screening (CCS) of the first and second polar body to select embryos for transfer increase the likelihood of a live birth within 1 year in advanced maternal age women aged 36-40 years planning an ICSI cycle, compared to ICSI without chromosome analysis? SUMMARY ANSWER: PGT-A by CCS in the first and second polar body to select euploid embryos for transfer does not substantially increase the live birth rate in women aged 36-40 years...
August 6, 2018: Human Reproduction
Selcuk Anli, Afsaneh Karimian-Tabrizi, Anton Moritz, Nadejda Monsefi
BACKGROUND: The lower patency rate of vein grafts (VG) in comparison to arterial grafts may be related to vein valves, which favor turbulences and thrombosis that lead to graft failure. The aim of this study was to determine the outcome of patients with valvulotomized VG after coronary artery bypass grafting (CABG) procedure. METHODS: From 2007 to 2014, 233 patients with a mean age of 67 ± 9 years had CABG or combined CABG and valve procedures. Valvulotomized saphenous VG and arterial grafts were used...
June 18, 2018: Heart Surgery Forum
Kristof Hirschberg, Manuel Reinhart, Derliz Mereles, Lorenz Uhlmann, Florian André, Johannes Riffel, Marco Ochs, Hugo A Katus
PURPOSE: Calcification of aortic valve and mitral annulus is associated with cardiovascular risk factors, morbidity and mortality. Assessment of cardiac calcification with echocardiography is feasible, however, only few structured scoring systems have been established so far with limited prognostic data. This study aimed to evaluate an echocardiographic calcification score (echo-CCS) in patients with low/intermediate cardiovascular risk. METHODS: Digitally stored echocardiography studies of 151 patients (median age 64, 49...
August 6, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Kalyan Sharma, Sudhir Kumar Yadav, Bimbadhar Valluru, Ling Liu
RATIONALE: Clear cell sarcoma of tendon and aponeurosis (CCSTA) or soft parts is a rare malignant melanin producing tumor entity that is derived from the neural crest cells originating from soft tissues displaying melanocytic differentiation. Diagnosis of CCSTA is difficult as it is dependent on age, size, location, necrosis, calcifications, cystic degeneration, and local to distant metastatic deposits. These tumors have very poor prognosis with a survival rate of 5-10 years because of local recurrence, early to late metastasis to lymph nodes, lungs, bones, and liver...
August 2018: Medicine (Baltimore)
Prashant Kumar Singh, Domantas Jasilionis, Anna Oksuzyan
This study assesses the gender gap in cognitive health among older adults in India and examines the extent to which individual, household and state level characteristics contribute to the male-female difference in cognitive health. The study is based on 6548 women and men who participated in the WHO Study on Global AGEing and Adult Health conducted in six states in India during 2007-08. Multilevel ordinary least square regression was used to examine the gender difference in cognitive health, adjusting for individual, household, health behavior and state-level variables...
August 2018: SSM—Population Health
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