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Zahra Zanjani, Hamid Yaghubi, Mohammadreza Shaeiri, Mohammad Gholami Fesharaki
Objective: In recent years, many researchers have been searching for effective cognitive factors in the development of obsessive-compulsive disorder (OCD). One of the scales designed to measure this characteristic is the contamination cognition scale (CCS) that evaluates 2 dimensions: overestimating the likelihood and severity of contamination. The aim of the present study was to evaluate the psychometric properties of the Persian version of CCS. Method : The study population of this descriptive psychometric study included students of Shahed University...
July 2018: Iranian Journal of Psychiatry
Dafne Pérez-Montarelo, Esther Viedma, Nieves Larrosa, Carmen Gómez-González, Enrique Ruiz de Gopegui, Irene Muñoz-Gallego, Rafael San Juan, Nuria Fernández-Hidalgo, Benito Almirante, Fernando Chaves
Staphylococcus aureus bacteremia (SAB) is associated with high morbidity and mortality, which varies depending on the source of infection. Nevertheless, the global molecular epidemiology of SAB and its possible association with specific virulence factors remains unclear. Using DNA microarrays, a total of 833 S. aureus strains (785 SAB and 48 colonizing strains) collected in Spain over a period of 15 years (2002-2017) were characterized to determine clonal complex (CC), agr type and repertoire of resistance and virulence genes in order to provide an epidemiological overview of CCs causing bloodstream infection, and to analyze possible associations between virulence genes and the most common sources of bacteremia...
2018: Frontiers in Microbiology
Y Li, H Q Luo, D Wu, X W Xue, Y F Luo, Y M Xiao, J Chen, W X Zhou
Objective: To analyze the clinical and pathological features of Cronkhite-Canada syndrome (CCS), and to investigate the significance of IgG4 positive plasma cell infiltration. Methods: Clinical presentations, endoscopic appearances and morphological features of 18 patients diagnosed with CCS at Peking Union Medical College Hospital during 2000-2016 were included in the study.There were 11 male and 7 female patients. IgG4 and IgG immunohistochemical stains were performed in total of 55 biopsies from the patients (36 polyps, 10 adenoma and 9 surrounding mucosa) and a control group of 58 cases (19 colonic mucosa, 7 colonic hyperplastic polyps, 9 inflammatory bowel disease and 23 adenoma)...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Ting Hway Wong, Yu Jie Wong, Zheng Yi Lau, Nivedita Nadkarni, Gek Hsiang Lim, Dennis Chuen Chai Seow, Marcus Eng Hock Ong, Kelvin Bryan Tan, Hai V Nguyen, Chek Hooi Wong
OBJECTIVES: Readmission after acute care is a significant contributor to health care costs, and has been proposed as a quality indicator. Our earlier studies showed that patients aged ≥55 years who are injured by falls from heights of ≤0.5 m were at increased risk for long-term mortality, compared to patients by high-velocity blunt trauma (higher fall heights, road injuries, and other blunt trauma). We hypothesized that these patients are also at higher risk of readmission, compared to patients injured by high-velocity mechanisms...
October 9, 2018: Journal of the American Medical Directors Association
Sendhilnathan Ramalingam, Michaela A Dinan, Jeffrey Crawford
INTRODUCTION: Although metastatic non-small cell lung cancer (NSCLC) is widely treated in both academic and community-based centers, it is unclear whether outcomes are similar across both settings. A growing variety of chemotherapies and targeted agents for an increasingly histology and molecular-based treatment strategy could advantage patients treated in academic centers. Using the National Cancer Database (NCDB), we investigated whether treatment at academic centers was associated with a survival advantage in metastatic NSCLC...
September 22, 2018: Journal of Thoracic Oncology
Astrid Louise Bjørn Bennedsen, Jens Ravn Eriksen, Ismail Gögenur
AIM: The present database study aimed to identify patients with a longer postoperative length of stay (LOS) or patients readmitted, and to characterize both groups based on perioperative factors. METHOD: A retrospective review of the Danish Colorectal Cancer Group (DCCG) database and a local database was performed of all patients undergoing elective resection for colorectal cancer in a 25 month period. Primary outcome was the number of patients with a prolonged hospital stay (LOS ≥10 days after the primary operation), and readmissions within 30 days after discharge...
October 11, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Alena Kvasilova, Martina Gregorovicova, Martin Kundrat, David Sedmera
Human natural killer (HNK)-1 antibody is an established marker of developing cardiac conduction system (CCS) in birds and mammals. In our search for the evolutionary origin of the CCS, we tested this antibody in a variety of sauropsid species (Crocodylus niloticus, Varanus indicus, Pogona vitticeps, Pantherophis guttatus, Eublepharis macularius, Gallus gallus, and Coturnix japonica). Hearts of different species were collected at various stages of embryonic development and studied to map immunoreactivity in cardiac tissues...
October 10, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Yong Liu, Fengrui Wu, Ling Zhang, Xiaoqing Wu, Dengkun Li, Jing Xin, Juan Xie, Feng Kong, Wenying Wang, Qiaoqin Wu, Di Zhang, Rong Wang, Shaorong Gao, Wenyong Li
BACKGROUND: Nuclear reprogramming reinstates totipotency or pluripotency in somatic cells by changing their gene transcription profile. This technology is widely used in medicine, animal husbandry and other industries. However, certain deficiencies severely restrict the applications of this technology. RESULTS: Using single-embryo RNA-seq, our study provides complete transcriptome blueprints of embryos generated by cumulus cell (CC) donor nuclear transfer (NT), embryos generated by mouse embryonic fibroblast (MEF) donor NT and in vivo embryos at each stage (zygote, 2-cell, 4-cell, 8-cell, morula, and blastocyst)...
October 10, 2018: BMC Genomics
Morten Kvistholm Jensen, Lothar Faber, Max Liebregts, Jaroslav Januska, Jan Krejci, Thomas Bartel, Robert M Cooper, Maciej Dabrowski, Peter Riis Hansen, Vibeke Marie Almaas, Hubert Seggewiss, Dieter Horstkotte, Radka Adlova, Jurriën Ten Berg, Henning Bundgaard, Josef Veselka
Aims: We analysed the impact of bundle branch block (BBB) and pacemaker (PM) implantation on symptoms and survival after alcohol septal ablation (ASA) in patients with hypertrophic cardiomyopathy (HCM). Methods and Results: Among 1416 HCM patients from the Euro-ASA registry 58 (4%) patients had a PM and 64 (5%) patients had an implantable cardioverter defibrillator (ICD) before ASA. At latest follow-up (5.0±4.0 years) after ASA, 118 (8%) patients had an ICD and 229 (16%) patients had a PM...
October 9, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
Abhijit Nag, Papri Chakraborty, Ganesan Paramasivam, Mohammad Bodiuzzaman, Ganapati Natarajan, Thalappil Pradeep
We present isomerism in a few supramolecular adducts of atomically precise nanoparticles, [Ag29(BDT)12∩(CD)n]3- (n = 1 - 6), abbreviated as I where BDT and CD are 1, 3-benzenedithiol and cyclodextrins (α, β and γ), respectively; ∩ symbolizes an inclusion complex. The different host-guest complexes of I were characterized in the solution state as well as in the gas phase. The CDs (α, β and γ) encapsulate a pair of BDT ligands protecting the Ag29 core. This unique geometry of the supramolecular adducts makes the system similar to octahedral complexes of transition metals, which manifest various isomers...
October 10, 2018: Journal of the American Chemical Society
Tianjuan Wang, Yajing Liu, Mingrong Lv, Qiong Xing, Zhiguo Zhang, Xiaojin He, Yuping Xu, Zhaolian Wei, Yunxia Cao
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic heterogeneous disorder. The incidence of which reaches 5% to 10% among reproductive-age women. Abnormal folliculogenesis is considered to be a common characteristic of PCOS, but the cause of this disorder and its pathogenesis still remain uncertain. Previous studies had proved that dysregulation of microRNAs is related to the pathogenesis of PCOS. In this study, we investigated the effect of miR-323-3p on the human cumulus cells (CCs). We also investigated the underlying mechanisms of miR-323-3p on human granulosa-like tumor cell line (KGN) or primary human CCs by stimulating with Dihydrotestosterone (DHT)...
October 6, 2018: Gene
Guto G Rhys, Christopher W Wood, Eric J M Lang, Adrian J Mulholland, R Leo Brady, Andrew R Thomson, Derek N Woolfson
In coiled-coil (CC) protein structures α-helices wrap around one another to form rope-like assemblies. Most natural and designed CCs have two-four helices and cyclic (Cn ) or dihedral (Dn ) symmetry. Increasingly, CCs with five or more helices are being reported. A subset of these higher-order CCs is of interest as they have accessible central channels that can be functionalised; they are α-helical barrels. These extended cavities are surprising given the drive to maximise buried hydrophobic surfaces during protein folding and assembly in water...
October 8, 2018: Nature Communications
Jennie Shepheard
Philip Hoyle presents a compelling argument for the significant and highly valued role that the management of health information plays in the Australian healthcare system and the delivery of health services in this country. However, he also brings to our attention the ill-defined nature of the ethical oversight of this very information. Hoyle uses words such as "honesty," "commitment to beneficence," "commitment to equity" and "respect for variation" when describing the characteristics of ethical leadership...
October 7, 2018: Health Information Management: Journal of the Health Information Management Association of Australia
Matías Angel Sirini, Juan Patricio Anchordoquy, Silvina Quintana, Cecilia Furnus, Alejandro Enrique Relling, Juan Mateo Anchordoquy
Energy balance is regulated by ghrelin which is a neuroendocrine modulator. Ghrelin is expressed in reproductive organs. However, the role of ghrelin during in vitro maturation (IVM) and bovine preimplantational development is limited. The purpose of this study was to measure the expression of ghrelin (GHRL) and its receptor growth hormone secretagogue receptor 1A (GHS-R1A) mRNA, and determine cumulus oocyte complex (COC) viability after IVM with 0, 20, 40 and 60 pM of ghrelin. Also, pronuclear formation was recorded after in vitro fertilization (IVF)...
January 2019: International Journal of Fertility & Sterility
Kathy Ainul Møen, Laura Terragni, Bernadette Kumar, Esperanza Diaz
OBJECTIVE: To explore health care providers' (HCPs) experiences regarding cervical cancer screening (CCS) among immigrant women, their strategies to facilitate these consultations and their need for further information. DESIGN: Exploratory qualitative design. SETTING: HCPs who perform CCS: general practitioners, midwives and private gynaecologists, working in Oslo, Norway. SUBJECTS: We interviewed 26 general practitioners, 3 midwives and 3 gynaecologists...
October 5, 2018: Scandinavian Journal of Primary Health Care
Guoqiang Zhang, Min Sun, Jianfeng Wang, Meng Lei, Chenji Li, Duojun Zhao, Jun Huang, Wenjie Li, Shuangli Li, Jing Li, Jin Yang, Yingfeng Luo, Songnian Hu, Bing Zhang
In eukaryotes, alternative splicing (AS) greatly expands the diversity of transcripts. However, it is challenging to accurately determine full-length splicing isoforms. Recently, more studies have taken advantage of Pacific Bioscience (PacBio) long-read sequencing to identify full-length transcripts. Nevertheless, the high error rate of PacBio reads seriously offsets the advantages of long reads, especially for accurately identifying splicing junctions. To best capitalize on the features of long reads, we used Illumina RNA-seq reads to improve PacBio circular consensus sequence (CCS) quality and to validate splicing patterns in the rice transcriptome...
October 4, 2018: Plant Journal: for Cell and Molecular Biology
Julianne Byrne, Daniela Alessi, Rodrigue S Allodji, Francesca Bagnasco, Edit Bárdi, Andrea Bautz, Chloe J Bright, Morven Brown, Ibrahima Diallo, Elizabeth A M Lieke Feijen, Miranda M Fidler, Eva Frey, Stanislaw Garwicz, Desiree Grabow, Thorgerdur Gudmundsdottir, Oskar Hagberg, Arja Harila-Saari, Eva M Hau, Riccardo Haupt, Mike M Hawkins, Zsuzsanna Jakab, Momcilo Jankovic, Peter Kaatsch, Melanie Kaiser, Leontien C M Kremer, Claudia E Kuehni, Rahel Kuonen, Ruth Ladenstein, Päivi Maria Lähteenmäki, Gill Levitt, Helena Linge, Damien LLanas, Gisela Michel, Vera Morsellino, Renee L Mulder, Raoul C Reulen, Cécile M Ronckers, Carlotta Sacerdote, Roderick Skinner, Eva Steliarova-Foucher, Helena J van der Pal, Florent de Vathaire, Giao Vũ Bezin, Finn Wesenberg, Thomas Wiebe, David L Winter, Jeanette Falck Winther, Elise Witthoff, Lorna Zadravec Zaletel, Lars Hjorth
BACKGROUND: Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing multi-country collaborations needed to assemble the numbers of survivors required to clarify the health issues arising after successful cancer treatment...
October 1, 2018: European Journal of Cancer
Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu
Here, time-decoupled comprehensive two-dimensional ultra-high liquid chromatography (UHPLC) coupled with an ion mobility (IM)-high resolution mass spectrometer (HRMS) was established and used to analyze ginsenosides from the main roots of white ginseng (WG) and red ginseng (RG), which enabled the separation of complex samples in four dimensions (2D-LC, ion mobility, and mass spectrometry). The incompatibility of mobile phases, dilution effect, and long analysis time, which are the main shortcomings of traditional comprehensive 2D-LC methods, were largely avoided in this newly established 2D-UHPLC method...
September 21, 2018: Journal of Pharmaceutical and Biomedical Analysis
Rachel B Simon, Christina Dowe, Samuel Grinberg, Frank P Cammisa, Celeste Abjornson
Background: To alleviate the symptoms of lumbar spinal stenosis, widely accepted methods of surgical treatment include decompression alone and decompression with fusion. As an alternative to these methods, interlaminar stabilization (ILS) devices with decompression were introduced. There is a large amount of research dedicated to examining the efficacy of ILS devices in single-level procedures, but fewer studies focus on their efficacy in 2-level procedures. The purpose of this study was to compare decompression with instrumented posterolateral fusion to decompression with interlaminar stabilization in patients who require surgical treatment at 2 levels for lumbar spinal stenosis at 5 years postoperation...
August 2018: International Journal of Spine Surgery
Pinar Altinci, Murat Mutluay, Leo Tjäderhane, Arzu Tezvergil-Mutluay
OBJECTIVE: Matrix metalloproteinases (MMPs) and cysteine cathepsins (CCs) are two distinct enzymatic pathways responsible for the degradation of collagen fibrils in demineralized dentin. NaF and KF have been shown to inhibit salivary MMP-2, -9 and CCs. This study investigated the inhibitory effect of calcium fluoride (CaF2 ) on the dentin matrix-bound MMPs and CCs. DESIGN: Phosphoric acid (10%)-demineralized dentin beams (1 × 2×6 mm) were incubated at 37 °C in an 1 ml of artificial saliva (AS, control), or AS with 6, 12, 24, 48, 120...
September 11, 2018: Archives of Oral Biology
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