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Pathogenesis Guillain Barre

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https://www.readbyqxmd.com/read/30053656/hsp70-copurifies-with-zika-virus-particles
#1
Ronik Khachatoorian, Whitaker Cohn, Anthony Buzzanco, Rana Riahi, Vaithilingaraja Arumugaswami, Asim Dasgupta, Julian P Whitelegge, Samuel W French
Zika virus (ZIKV) has been identified as a cause of neurologic diseases in infants and Guillain-Barré Syndrome, and currently, no therapeutics or vaccines are approved. In this study, we sought to identify potential host proteins interacting with ZIKV particles to gain better insights into viral infectivity. Viral particles were purified through density-gradient centrifugation and subsequently, size-exclusion chromatography (SEC). Mass spectrometric analyses revealed viral envelope protein and HSP70 to comigrate in only one SEC fraction...
September 2018: Virology
https://www.readbyqxmd.com/read/30002446/negligible-contribution-of-m2634v-substitution-to-zikv-pathogenesis-in-ag6-mice-revealed-by-a-bacterial-promoter-activity-reduced-infectious-clone
#2
Fanfan Zhao, Yongfen Xu, Dimitri Lavillette, Jin Zhong, Gang Zou, Gang Long
ZIKV has emerged as a significant human pathogene for the severe neurological complications, including Guillain-Barré(GBS) syndrome in adults and a variety of fetal abnormalities such as microcephaly. A stable and efficient infectious clone of Brazilian ZIKV isolate is required to study pathogenesis of epidemic ZIKV and virus evolution impact on it. Here we successfully constructed infectious cDNA clone on an early Brazilian isolate by eliminating the activity of predicted bacterial promoter in 1-3000 nt of ZIKV genome, leading to a stable infectious cDNA clone (pZL1)...
July 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29988497/zika-virus-non-structural-protein-4a-blocks-the-rlr-mavs-signaling
#3
Jinzhu Ma, Harshada Ketkar, Tingting Geng, Emily Lo, Leilei Wang, Juemin Xi, Qiangming Sun, Zhanbo Zhu, Yudong Cui, Long Yang, Penghua Wang
Flaviviruses have evolved complex mechanisms to evade the mammalian host immune systems including the RIG-I (retinoic acid-inducible gene I) like receptor (RLR) signaling. Zika virus (ZIKV) is a re-emerging flavivirus that is associated with severe neonatal microcephaly and adult Guillain-Barre syndrome. However, the molecular mechanisms underlying ZIKV pathogenesis remain poorly defined. Here we report that ZIKV non-structural protein 4A (NS4A) impairs the RLR-mitochondrial antiviral-signaling protein (MAVS) interaction and subsequent induction of antiviral immune responses...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29953326/immunotherapy-of-guillain-barr%C3%A3-syndrome
#4
Shuang Liu, Chaoling Dong, Eroboghene Ekamereno Ubogu
Guillain-Barré syndrome (GBS), the most common cause of acute neuromuscular weakness and paralysis worldwide, encompasses a group of acute immune-mediated disorders restricted to peripheral nerves and roots. Immune-mediated attack of peripheral nervous system myelin, axons or both is presumed to be triggered by molecular mimicry, with both cell- and humoral-dependent mechanisms implicated in disease pathogenesis. Good circumstantial evidence exists for a pathogenic role for molecular mimicry in GBS pathogenesis, especially with its axonal forms, providing insights that could guide future immunotherapy...
June 28, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29882008/overview-of-therapeutic-plasma-exchange-in-pediatric-neurology-a-single-center-experience
#5
Murat Özkale, Ilknur Erol, Yasemin Özkale, İlknur Kozanoğlu
Therapeutic plasma exchange (TPE) is used in the treatment of neurological, hematological, renal and autoimmune diseases with known or suspected immune pathogenesis. In comparison with neurological diseases of adults, knowledge about the use of TPE in children is incomplete. We report our experience on TPE in children with neurological diseases in a single institution and describe the underlying etiology, clinical course, treatment and outcome. We retrospectively evaluated 22 consecutive children (12 girls, 10 boys, aged 2-16 years) who underwent TPE in the pediatric intensive care unit between January 2010 and January 2017...
June 7, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29685816/the-complement-story-in-guillain-barr%C3%A3-syndrome-from-pathogenesis-to-therapy
#6
Eduardo Nobile-Orazio
No abstract text is available yet for this article.
June 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29685815/safety-and-efficacy-of-eculizumab-in-guillain-barr%C3%A3-syndrome-a-multicentre-double-blind-randomised-phase-2-trial
#7
Sonoko Misawa, Satoshi Kuwabara, Yasunori Sato, Nobuko Yamaguchi, Kengo Nagashima, Kanako Katayama, Yukari Sekiguchi, Yuta Iwai, Hiroshi Amino, Tomoki Suichi, Takanori Yokota, Yoichiro Nishida, Tadashi Kanouchi, Nobuo Kohara, Michi Kawamoto, Junko Ishii, Motoi Kuwahara, Hidekazu Suzuki, Koichi Hirata, Norito Kokubun, Ray Masuda, Juntaro Kaneko, Ichiro Yabe, Hidenao Sasaki, Ken-Ichi Kaida, Hiroshi Takazaki, Norihiro Suzuki, Shigeaki Suzuki, Hiroyuki Nodera, Naoko Matsui, Shoji Tsuji, Haruki Koike, Ryo Yamasaki, Susumu Kusunoki
BACKGROUND: Despite the introduction of plasmapheresis and immunoglobulin therapy, many patients with Guillain-Barré syndrome still have an incomplete recovery. Evidence from pathogenesis studies suggests the involvement of complement-mediated peripheral nerve damage. We aimed to investigate the safety and efficacy of eculizumab, a humanised monoclonal antibody against the complement protein C5, in patients with severe Guillain-Barré syndrome. METHODS: This study was a 24 week, multicentre, double-blind, placebo-controlled, randomised phase 2 trial done at 13 hospitals in Japan...
June 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29659541/zika-virus-in-the-male-reproductive-tract
#8
REVIEW
Liesel Stassen, Charles W Armitage, David J van der Heide, Kenneth W Beagley, Francesca D Frentiu
Arthropod-borne viruses (arboviruses) are resurging across the globe. Zika virus (ZIKV) has caused significant concern in recent years because it can lead to congenital malformations in babies and Guillain-Barré syndrome in adults. Unlike other arboviruses, ZIKV can be sexually transmitted and may persist in the male reproductive tract. There is limited information regarding the impact of ZIKV on male reproductive health and fertility. Understanding the mechanisms that underlie persistent ZIKV infections in men is critical to developing effective vaccines and therapies...
April 16, 2018: Viruses
https://www.readbyqxmd.com/read/29652304/-approach-for-identifying-of-treatment-option-for-pediatric-patients-in-guillain-barre-syndrome-considering-results-of-pharmacoeconomic-analysis
#9
A K Shakaryan, A V Rakhteenko, R I Yagudina, A Yu Kulikov, V G Serpik, I V Mitrofanova
AIM: A pharmacoeconomic analysis of direct costs on treatment with high dose intravenous immunoglobulins (IVIG) and plasmapheresis (PP) in children. MATERIAL AND METHODS: Literature data on the pathogenesis of Guillain-Barre syndrome (GBS) were analyzed. The results of pharmacoeconomic analysis of direct costs on treatment of GBS using IVIG and PP are presented. Risks for complications during treatment with IVIG and PP are calculated. RESULTS AND CONCLUSION: The pharmacoeconomic analysis demonstrates comparable costs of treatment with IVIG or PP in the Russian Federation...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29555345/rapid-response-to-an-emerging-infectious-disease-lessons-learned-from-development-of-a-synthetic-dna-vaccine-targeting-zika-virus
#10
Sagar B Kudchodkar, Hyeree Choi, Emma L Reuschel, Rianne Esquivel, Jackie Jin-Ah Kwon, Moonsup Jeong, Joel N Maslow, Charles C Reed, Scott White, J Joseph Kim, Gary P Kobinger, Pablo Tebas, David B Weiner, Kar Muthumani
Vaccines are considered one of the greatest advances in modern medicine. The global burden of numerous infectious diseases has been significantly reduced, and in some cases, effectively eradicated through the deployment of specific vaccines. However, efforts to develop effective new vaccines against infectious pathogens such as influenza, Human immunodeficiency virus (HIV), dengue virus (DENV), chikungunya virus (CHIKV), Ebola virus, and Zika virus (ZIKV) have proven challenging. Zika virus is a mosquito-vectored flavivirus responsible for periodic outbreaks of disease in Africa, Southeast Asia, and the Pacific Islands dating back over 50 years...
March 17, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29550265/cytokine-responses-in-campylobacteriosis-linking-pathogenesis-to-immunity
#11
REVIEW
Nadia A Al-Banna, Farhan Cyprian, M John Albert
Campylobacter jejuni is an important enteric pathogen that causes diarrheas of different degrees of severity and several extra-intestinal manifestations, including Guillain-Barre syndrome. The variability of disease outcomes is thought to be linked to the immune response induced by C. jejuni. The virulence factors of C. jejuni induce a pro-inflammatory response, that is initiated by the intestinal epithelial cells, propagated by innate immune cells and modulated by the cells of the adaptive immune response...
June 2018: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29542024/guillain-barr%C3%A3-syndrome-rare-extra-intestinal-manifestation-of-hepatitis-b
#12
Amey Dilip Sonavane, Sanjiv Saigal, Abhishek Kathuria, Narendra S Choudhary, Neeraj Saraf
Extrahepatic syndromes are uncommon manifestations of acute and chronic hepatitis B. The pathogenesis likely involves an aberrant immunologic response to extrahepatic viral proteins. Antiviral therapy reduces the availability of these viral protein antigens and thus halts immune activation. Approximately 1% of all cases of acute inflammatory demyelinating polyneuropathy are associated with hepatitis B. Guillain-Barre syndrome (GBS) is a remarkably clinically diverse disorder with distinctive variants characterised by an immune-mediated attack to components of the peripheral nervous system...
August 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29541942/recent-advances-in-animal-models-of-zika-virus-infection
#13
Shupeng Dong, Qiming Liang
An infection by Zika virus (ZIKV), a mosquito-borne flavivirus, broke out in South American regions in 2015, and recently showed a tendency of spreading to North America and even worldwide. ZIKV was first detected in 1947 and only 14 human infection cases were reported until 2007. This virus was previously observed to cause only mild flu-like symptoms. However, recent ZIKV infections might be responsible for the increasing cases of neurological disorders such as Guillain-Barré syndrome and congenital defects, including newborn microcephaly...
April 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29518228/nlrp3-inflammasome-activation-mediates-zika-virus-associated-inflammation
#14
Zhenjian He, Jiahui Chen, Xun Zhu, Shu An, Xinhuai Dong, Jianchen Yu, Shihao Zhang, Yun Wu, Ge Li, Yu Zhang, Jueheng Wu, Mengfeng Li
Zika virus (ZIKV) is a mosquito-borne virus that has been identified as a cause of several severe disease manifestations, including congenital microcephaly and Guillain-Barré syndrome, meningoencephalitis, and myelitis. Previous studies showed that ZIKV-infected patients exhibited elevated plasma levels of interleukin 1β (IL-1β), indicating that ZIKV may activate inflammasomes. However, the molecular basis for its viral pathogenesis remains poorly understood. In this current study, we found that ZIKV infection caused severe inflammatory pathological changes and promoted IL-1β production in vitro and in vivo...
May 25, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29467007/enhanced-glycolysis-contributes-to-the-pathogenesis-of-experimental-autoimmune-neuritis
#15
Ru-Tao Liu, Min Zhang, Chun-Lin Yang, Peng Zhang, Na Zhang, Tong Du, Meng-Ru Ge, Long-Tao Yue, Xiao-Li Li, Heng Li, Rui-Sheng Duan
BACKGROUND: With the recognition of the key roles of cellular metabolism in immunity, targeting metabolic pathway becomes a new strategy for autoimmune disease treatment. Guillain-Barré syndrome (GBS) is an acute immune-mediated inflammatory demyelinating disease of the peripheral nervous system, characterized by inflammatory cell infiltration. These inflammatory cells, including activated macrophages, Th1 cells, and Th17 cells, generally undergo metabolic reprogramming and rely mainly on glycolysis to exert functions...
February 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29447264/ebselen-alleviates-testicular-pathology-in-mice-with-zika-virus-infection-and-prevents-its-sexual-transmission
#16
Yogy Simanjuntak, Jian-Jong Liang, Si-Yu Chen, Jin-Kun Li, Yi-Ling Lee, Han-Chung Wu, Yi-Ling Lin
Despite the low case fatality, Zika virus (ZIKV) infection has been associated with microcephaly in infants and Guillain-Barré syndrome. Antiviral and vaccine developments against ZIKV are still ongoing; therefore, in the meantime, preventing the disease transmission is critical. Primarily transmitted by Aedes species mosquitoes, ZIKV also can be sexually transmitted. We used AG129 mice lacking interferon-α/β and -γ receptors to study the testicular pathogenesis and sexual transmission of ZIKV. Infection of ZIKV progressively damaged mouse testes, increased testicular oxidative stress as indicated by the levels of reactive oxygen species, nitric oxide, glutathione peroxidase 4, spermatogenesis-associated-18 homolog in sperm and pro-inflammatory cytokines including IL-1β, IL-6, and G-CSF...
February 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29434217/il-23-and-il-27-levels-in-serum-are-associated-with-the-process-and-the-recovery-of-guillain-barr%C3%A3-syndrome
#17
Jing Peng, Hui Zhang, Peidong Liu, Min Chen, Bing Xue, Rui Wang, Jifei Shou, Juanfeng Qian, Zhikang Zhao, Yanmeng Xing, Hongbo Liu
IL-23 and IL-27 are believed to be involved in the pathogenesis of Guillain-Barré syndrome (GBS). However, changes in these cytokines during the dynamic pathological and recovery processes of GBS are not well described. In the present study, plasma was collected from 83 patients with various stages of GBS, 70 patients with central nervous system demyelinating diseases,70 patients with other neurological diseases (OND) and 70 age- and sex-matched healthy volunteers. Serum levels of IL-23, IL-27, and Campylobacter jejuni (CJ) IgM were assessed using enzyme linked immunosorbent assay (ELISA)...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29433112/-zika-virus-and-guillain-barr%C3%A3-syndrome
#18
Haruki Koike
Recent studies revealed an association between Zika virus infection and a variety of neurological disorders, including microcephaly, meningoencephalitis, myelitis, and Guillain-Barré syndrome (GBS). Following the first report of a patient diagnosed with GBS after Zika virus infection in December 2013, the number of GBS patients significantly increased in endemic countries, such as French-Polynesia and Latin American countries. Electrophysiological studies suggested that patients suffering from GBS associated with Zika virus infection manifest acute inflammatory demyelinating polyneuropathy (AIDP), rather than acute motor axonal neuropathy (AMAN)...
February 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29382894/zika-virus-infection-elicits-auto-antibodies-to-c1q
#19
Takaaki Koma, Veljko Veljkovic, Danielle E Anderson, Lin-Fa Wang, Shannan L Rossi, Chao Shan, Pei-Yong Shi, David W Beasley, Natalya Bukreyeva, Jeanon N Smith, Steven Hallam, Cheng Huang, Veronika von Messling, Slobodan Paessler
Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with an increasing number of patients, various clinical features such as microcephaly, Guillain-Barré syndrome and thrombocytopenia have also been reported. To determine which host factors are related to pathogenesis, the E protein of ZIKV was analyzed with the Informational Spectrum Method, which identifies common information encoded by primary structures of the virus and the respective host protein. The data showed that the ZIKV E protein and the complement component C1q cross-spectra are characterized by a single dominant peak at the frequency F = 0...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29379210/axl-promotes-zika-virus-infection-in-astrocytes-by-antagonizing-type-i-interferon-signalling
#20
Jian Chen, Yi-Feng Yang, Yu Yang, Peng Zou, Jun Chen, Yongquan He, Sai-Lan Shui, Yan-Ru Cui, Ru Bai, Ya-Jun Liang, Yunwen Hu, Biao Jiang, Lu Lu, Xiaoyan Zhang, Jia Liu, Jianqing Xu
Zika virus (ZIKV) is associated with neonatal microcephaly and Guillain-Barré syndrome1,2 . While progress has been made in understanding the causal link between ZIKV infection and microcephaly3-9 , the life cycle and pathogenesis of ZIKV are less well understood. In particular, there are conflicting reports on the role of AXL, a TAM family kinase receptor that was initially described as the entry receptor for ZIKV10-22 . Here, we show that while genetic ablation of AXL protected primary human astrocytes and astrocytoma cell lines from ZIKV infection, AXL knockout did not block the entry of ZIKV...
March 2018: Nature Microbiology
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