keyword
MENU ▼
Read by QxMD icon Read
search

Intestinal permeability exercise

keyword
https://www.readbyqxmd.com/read/29889141/interaction-between-foods-and-nonsteroidal-anti-inflammatory-drugs-and-exercise-in-the-induction-of-anaphylaxis
#1
Joan Bartra, Giovanna Araujo, Rosa Muñoz-Cano
PURPOSE OF REVIEW: To assess the studies that focus on the study of food-dependent exercise-induced anaphylaxis (FDEIA) and food-dependent NSAID-induced anaphylaxis (FDNIA). RECENT FINDINGS: Cofactors, as exercise and nonsteroidal anti-inflammatory drugs (NSAIDs), are relevant in up to 30% of episodes of anaphylaxis. Gliadin and lipid transfer proteins are the main allergens involved. The attempts to reproduce FDEIA and FDNIA in a controlled setting have an important failure rate...
August 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29790452/does-biological-sex-impact-intestinal-epithelial-injury-small-intestine-permeability-gastrointestinal-symptoms-and-systemic-cytokine-profile-in-response-to-exertional-heat-stress
#2
Rhiannon M J Snipe, Ricardo J S Costa
This study aimed to determine the influence of biological sex on intestinal injury, permeability, gastrointestinal symptoms, and systemic cytokine profile in response to exertional-heat stress. Male (n= 13) and eumenorrheic female (n= 11) endurance runners completed 2 h running at 60% V̇O2max in 35°C. Blood samples were collected pre- and post-exercise and during recovery to determine plasma intestinal fatty-acid binding protein (I-FABP) and systemic cytokine profile. Urinary lactulose:L-rhamnose ratio was used to determine small intestine permeability...
May 23, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29574607/the-effect-of-bovine-colostrum-supplementation-on-intestinal-injury-and-circulating-intestinal-bacterial-dna-following-exercise-in-the-heat
#3
Daniel S March, Arwel W Jones, Rhys Thatcher, Glen Davison
PURPOSE: Exercise-induced changes in intestinal permeability are exacerbated in the heat. The aim of this study was to determine the effect of 14 days of bovine colostrum (Col) supplementation on intestinal cell damage (plasma intestinal fatty acid-binding protein, I-FABP) and bacterial translocation (plasma bacterial DNA) following exercise in the heat. METHODS: In a double-blind, placebo-controlled, crossover design, 12 males completed two experimental arms (14 days of 20 g/day supplementation with Col or placebo, Plac) consisting of 60 min treadmill running at 70% maximal aerobic capacity (30 °C, 60% relative humidity)...
March 24, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29415294/the-impact-of-mild-heat-stress-during-prolonged-running-on-gastrointestinal-integrity-gastrointestinal-symptoms-systemic-endotoxin-and-cytokine-profiles
#4
Rhiannon M J Snipe, Anthony Khoo, Cecilia M Kitic, Peter R Gibson, Ricardo J S Costa
The study aimed to determine the effects of mild exertional heat stress on intestinal injury, permeability, gastrointestinal symptoms, and systemic endotoxin and cytokine responses. Ten endurance runners completed 2 h of running at 60% V̇O2max in warm (WARM: 30°C) and temperate (TEMP: 22°C) ambient conditions. Rectal temperature (Tre ) and gastrointestinal symptoms were recorded every 10 min during exercise. Blood samples were collected pre- and post-exercise, and during recovery to determine plasma intestinal fatty acid-binding protein (I-FABP) and cortisol concentrations, and systemic endotoxin and inflammatory cytokine profiles...
February 7, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29234915/the-impact-of-exertional-heat-stress-on-gastrointestinal-integrity-gastrointestinal-symptoms-systemic-endotoxin-and-cytokine-profile
#5
RANDOMIZED CONTROLLED TRIAL
Rhiannon M J Snipe, Anthony Khoo, Cecilia M Kitic, Peter R Gibson, Ricardo J S Costa
PURPOSE: The study aimed to determine the effects of exertional-heat stress on gastrointestinal integrity, symptoms, systemic endotoxin and inflammatory responses; and assess the relationship between changes in body temperature and gastrointestinal perturbations. METHODS: Ten endurance runners completed 2 h running at 60% [Formula: see text]O2max in hot (HOT: 35 °C) and temperate (TEMP: 22 °C)-ambient conditions. Rectal temperature (T re ) and gastrointestinal symptoms were recorded every 10 min during exercise...
February 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29058112/glutamine-supplementation-reduces-markers-of-intestinal-permeability-during-running-in-the-heat-in-a-dose-dependent-manner
#6
RANDOMIZED CONTROLLED TRIAL
Jamie N Pugh, Stephen Sage, Mark Hutson, Dominic A Doran, Simon C Fleming, Jamie Highton, James P Morton, Graeme L Close
PURPOSE: To examine the dose-response effects of acute glutamine supplementation on markers of gastrointestinal (GI) permeability, damage and, secondary, subjective symptoms of GI discomfort in response to running in the heat. METHODS: Ten recreationally active males completed a total of four exercise trials; a placebo trial and three glutamine trials at 0.25, 0.5 and 0.9 g kg-1 of fat-free mass (FFM) consumed 2 h before exercise. Each exercise trial consisted of a 60-min treadmill run at 70% of [Formula: see text] in an environmental chamber set at 30 °C...
December 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29032392/exercise-and-gastrointestinal-symptoms-running-induced-changes-in-intestinal-permeability-and-markers-of-gastrointestinal-function-in-asymptomatic-and-symptomatic-runners
#7
Elisa Karhu, Richard A Forsgård, Lauri Alanko, Henrik Alfthan, Pirkko Pussinen, Esa Hämäläinen, Riitta Korpela
PURPOSE: Athletes frequently experience gastrointestinal (GI) symptoms during training and competition. Although the prevalence of exercise-induced GI symptoms is high, the mechanisms leading to GI distress during exercise are not fully understood. The aim of this study was to identify running-induced changes in intestinal permeability and markers of GI function and investigate their association with gastrointestinal symptoms. METHODS: We recruited 17 active runners who we allocated as either asymptomatic or symptomatic based on their history of experiencing GI symptoms during running...
December 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28589631/systematic-review-exercise-induced-gastrointestinal-syndrome-implications-for-health-and-intestinal-disease
#8
REVIEW
R J S Costa, R M J Snipe, C M Kitic, P R Gibson
BACKGROUND: "Exercise-induced gastrointestinal syndrome" refers to disturbances of gastrointestinal integrity and function that are common features of strenuous exercise. AIM: To systematically review the literature to establish the impact of acute exercise on markers of gastrointestinal integrity and function in healthy populations and those with chronic gastrointestinal conditions. METHODS: Search literature using five databases (PubMed, EBSCO, Web of Science, SPORTSdiscus, and Ovid Medline) to review publications that focused on the impact of acute exercise on markers of gastrointestinal injury, permeability, endotoxaemia, motility and malabsorption in healthy populations and populations with gastrointestinal diseases/disorders...
August 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28462693/sarcopenia-in-patients-with-advanced-liver-disease
#9
Francesca Romana Ponziani, Antonio Gasbarrini
Sarcopenia is the loss of muscle mass and function, affecting up to 70% of patients with advanced liver disease. Liver cirrhosis is characterized by an altered glucose metabolism, lipid oxidation, ketogenesis and protein catabolism, leading to the loss of adipose and muscle tissue. The gastrointestinal dysfunction of cirrhotic patients results in inadequate nutrients intake and is responsible for muscle weakness thus limiting physical exercise and perpetuating the reduction of muscle mass. Recently, alterations of hormonal pathways involved in muscle growth, increased intestinal permeability and changes in the gut microbiota composition have been reported in cirrhotic patients...
2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28349254/%C3%AE-lipoic-acid-prevents-the-intestinal-epithelial-monolayer-damage-under-heat-stress-conditions-model-experiments-in-caco-2-cells
#10
Soheil Varasteh, Johanna Fink-Gremmels, Johan Garssen, Saskia Braber
PURPOSE: Under conditions of high ambient temperatures and/or strenuous exercise, humans and animals experience considerable heat stress (HS) leading among others to intestinal epithelial damage through induction of cellular oxidative stress. The aim of this study was to characterize the effects of α-Lipoic Acid (ALA) on HS-induced intestinal epithelial injury using an in vitro Caco-2 cell model. METHODS: A confluent monolayer of Caco-2 cells was pre-incubated with ALA (24 h) prior to control (37 °C) or HS conditions (42 °C) for 6 or 24 h and the expression of heat shock protein 70 (HSP70), heat shock factor-1 (HSF1), and the antioxidant Nrf2 were investigated...
June 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/28290057/intestinal-fatty-acid-binding-protein-and-gut-permeability-responses-to-exercise
#11
RANDOMIZED CONTROLLED TRIAL
Daniel S March, Tania Marchbank, Raymond J Playford, Arwel W Jones, Rhys Thatcher, Glen Davison
PURPOSE: Intestinal cell damage due to physiological stressors (e.g. heat, oxidative, hypoperfusion/ischaemic) may contribute to increased intestinal permeability. The aim of this study was to assess changes in plasma intestinal fatty acid-binding protein (I-FABP) in response to exercise (with bovine colostrum supplementation, Col, positive control) and compare this to intestinal barrier integrity/permeability (5 h urinary lactulose/rhamnose ratio, L/R). METHODS: In a double-blind, placebo-controlled, crossover design, 18 males completed two experimental arms (14 days of 20 g/day supplementation with Col or placebo, Plac)...
May 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28117717/endurance-exercise-increases-intestinal-uptake-of-the-peanut-allergen-ara-h-6-after-peanut-consumption-in-humans
#12
Lonneke M JanssenDuijghuijsen, Klaske van Norren, Sander Grefte, Stef J Koppelman, Kaatje Lenaerts, Jaap Keijer, Renger F Witkamp, Harry J Wichers
Controlled studies on the effect of exercise on intestinal uptake of protein are scarce and underlying mechanisms largely unclear. We studied the uptake of the major allergen Ara h 6 following peanut consumption in an exercise model and compared this with changes in markers of intestinal permeability and integrity. Ten overnight-fasted healthy non-allergic men (n = 4) and women (n = 6) (23 ± 4 years) ingested 100 g of peanuts together with a lactulose/rhamnose (L/R) solution, followed by rest or by 60 min cycling at 70% of their maximal workload...
January 21, 2017: Nutrients
https://www.readbyqxmd.com/read/27943148/association-between-exercise-induced-hyperthermia-and-intestinal-permeability-a-systematic-review
#13
REVIEW
Washington Pires, Christiano E Veneroso, Samuel P Wanner, Diogo A S Pacheco, Gisele C Vaz, Fabiano T Amorim, Cajsa Tonoli, Danusa D Soares, Cândido C Coimbra
BACKGROUND: Prolonged and strenuous physical exercise increases intestinal permeability, allowing luminal endotoxins to translocate through the intestinal barrier and reach the bloodstream. When recognized by the immune system, these endotoxins trigger a systemic inflammatory response that may affect physical performance and, in severe cases, induce heat stroke. However, it remains to be elucidated whether there is a relationship between the magnitude of exercise-induced hyperthermia and changes in intestinal permeability...
July 2017: Sports Medicine
https://www.readbyqxmd.com/read/27857954/heat-stress-gastrointestinal-permeability-and-interleukin-6-signaling-implications-for-exercise-performance-and-fatigue
#14
REVIEW
Nicole Vargas, Frank Marino
Exercise in heat stress exacerbates performance decrements compared to normothermic environments. It has been documented that the performance decrements are associated with reduced efferent drive from the central nervous system (CNS), however, specific factors that contribute to the decrements are not completely understood. During exertional heat stress, blood flow is preferentially distributed away from the intestinal area to supply the muscles and brain with oxygen. Consequently, the gastrointestinal barrier becomes increasingly permeable, resulting in the release of lipopolysaccharides (LPS, endotoxin) into the circulation...
April 2016: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/27808433/adaptation-of-exercise-induced-stress-in-well-trained-healthy-young-men
#15
Lonneke M JanssenDuijghuijsen, Jaap Keijer, Marco Mensink, Kaatje Lenaerts, Lars Ridder, Stefan Nierkens, Shirley W Kartaram, Martie C M Verschuren, Raymond H H Pieters, Richard Bas, Renger F Witkamp, Harry J Wichers, Klaske van Norren
What is the central question of this study? Exercise is known to induce stress-related physiological responses, such as changes in intestinal barrier function. Our aim was to determine the test-retest repeatability of these responses in well-trained individuals. What is the main finding and its importance? Responses to strenuous exercise, as indicated by stress-related markers such as intestinal integrity markers and myokines, showed high test-retest variation. Even in well-trained young men an adapted response is seen after a single repetition after 1 week...
January 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/27798350/the-effect-of-endurance-exercise-on-intestinal-integrity-in-well-trained-healthy-men
#16
Lonneke M JanssenDuijghuijsen, Marco Mensink, Kaatje Lenaerts, Ewa Fiedorowicz, Dorien A M van Dartel, Jurriaan J Mes, Yvette C Luiking, Jaap Keijer, Harry J Wichers, Renger F Witkamp, Klaske van Norren
Exercise is one of the external factors associated with impairment of intestinal integrity, possibly leading to increased permeability and altered absorption. Here, we aimed to examine to what extent endurance exercise in the glycogen-depleted state can affect intestinal permeability toward small molecules and protein-derived peptides in relation to markers of intestinal function. Eleven well-trained male volunteers (27 ± 4 years) ingested 40 g of casein protein and a lactulose/rhamnose (L/R) solution after an overnight fast in resting conditions (control) and after completing a dual - glycogen depletion and endurance - exercise protocol (first protocol execution)...
October 2016: Physiological Reports
https://www.readbyqxmd.com/read/27693299/imi-oral-biopharmaceutics-tools-project-evaluation-of-bottom-up-pbpk-prediction-success-part-3-identifying-gaps-in-system-parameters-by-analysing-in-silico-performance-across-different-compound-classes
#17
Adam S Darwich, Alison Margolskee, Xavier Pepin, Leon Aarons, Aleksandra Galetin, Amin Rostami-Hodjegan, Sara Carlert, Maria Hammarberg, Constanze Hilgendorf, Pernilla Johansson, Eva Karlsson, Dónal Murphy, Christer Tannergren, Helena Thörn, Mohammed Yasin, Florent Mazuir, Olivier Nicolas, Sergej Ramusovic, Christine Xu, Shriram M Pathak, Timo Korjamo, Johanna Laru, Jussi Malkki, Sari Pappinen, Johanna Tuunainen, Jennifer Dressman, Simone Hansmann, Edmund Kostewicz, Handan He, Tycho Heimbach, Fan Wu, Carolin Hoft, Yan Pang, Michael B Bolger, Eva Huehn, Viera Lukacova, James M Mullin, Ke X Szeto, Chester Costales, Jian Lin, Mark McAllister, Sweta Modi, Charles Rotter, Manthena Varma, Mei Wong, Amitava Mitra, Jan Bevernage, Jeike Biewenga, Achiel Van Peer, Richard Lloyd, Carole Shardlow, Peter Langguth, Irina Mishenzon, Mai Anh Nguyen, Jonathan Brown, Hans Lennernäs, Bertil Abrahamsson
Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded "bottom-up" anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (Foral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal surface area, colonic absorption and/or lack of intestinal transporter information...
January 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27357095/zinc-carnosine-works-with-bovine-colostrum-in-truncating-heavy-exercise-induced-increase-in-gut-permeability-in-healthy-volunteers
#18
RANDOMIZED CONTROLLED TRIAL
Glen Davison, Tania Marchbank, Daniel S March, Rhys Thatcher, Raymond J Playford
BACKGROUND: Heavy exercise causes gut symptoms and, in extreme cases, heat stroke that is due to the increased intestinal permeability of luminal toxins. OBJECTIVE: We examined whether zinc carnosine (ZnC), a health-food product taken alone or in combination with bovine colostrum (a natural source of growth factors), would moderate such effects. DESIGN: Eight volunteers completed a 4-arm, double-blind, placebo-controlled crossover protocol (14 d of placebo, ZnC, colostrum, or ZnC plus colostrum) before undertaking standardized exercise 2 and 14 d after the start of treatment...
August 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27116024/use-of-modeling-and-simulation-tools-for-understanding-the-impact-of-formulation-on-the-absorption-of-a-low-solubility-compound-ciprofloxacin
#19
COMMENT
Marilyn Martinez, Bipin Mistry, Viera Lukacova, Jim Polli, Stephen Hoag, Thomas Dowling, Ravikanth Kona, Raafat Fahmy
This study explored the utility of mechanistic absorption models to describe the in vivo performance of a low solubility/low permeability compound in normal healthy subjects. Sixteen healthy human volunteers received three oral formulations and an intravenous infusion in a randomized crossover design. Plasma ciprofloxacin concentrations were estimated by HPLC. In vitro ciprofloxacin release from the oral tablets was tested under a variety of conditions. A mechanistic model was used to explore in vivo dissolution and intestinal absorption...
July 2016: AAPS Journal
https://www.readbyqxmd.com/read/26957295/impaired-function-of-the-intestinal-barrier-in-a-novel-sub-health-rat-model
#20
Sisi Feng, Weidong Liu, Shengnan Zuo, Tingyan Xie, Hui Deng, Qiuhuan Zhang, Baiyun Zhong
Sub-health is a state featuring a deterioration in physiological function between health and illness, and the sub-health condition has surfaced as life-threatening in humans. The aim of the present study was to establish a sub-health model in rats, and investigate the function of the intestinal barrier in the sub-health rats and rats following intervention. To establish a sub‑health model, the rats were subjected to a high‑fat and sugar diet, motion restriction and chronic stress. Their serum glucose and triglyceride levels, immune function and adaptability were then measured...
April 2016: Molecular Medicine Reports
keyword
keyword
166520
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"