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https://www.readbyqxmd.com/read/29161792/-trend-in-the-eradication-rates-of-helicobacter-pylori-infection-over-the-last-10-years-in-west-gyeonggi-do-korea-a-single-center-experience
#1
Jong Seol Park, Ji Eun Park, Byoung Soo Oh, Byung Wook Yoon, Hyun Ki Kim, Jae Won Lee, Nam Ho Kim, Won Seok Cho, Young Sik Woo, Jaehoon Jahng, Yong Sung Kim
Background/Aims: The eradication rate of Helicobacter pylori (H. pylori) has been decreasing recently in Korea due to antibiotics resistance. The aim of this study was to investigate the trend of eradication rate and clinical factors affecting the eradication rate of H. pylori in the last 10 years in west Gyeonggi-do, Korea. Methods: The trends of eradication rate of H. pylori, gender, age, concomitant mediations, and clinical factors were retrospectively evaluated in patients with H...
November 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29161778/highly-efficient-destruction-of-squamous-carcinoma-cells-of-the-head-and-neck-by-photochemical-internalization-of-ranpirnase
#2
Nora Liebers, Tim Holland-Letz, Mona Welschof, Anders Høgset, Dirk Jäger, Michaela A E Arndt, Jürgen Krauss
Introduction: Photochemical Internalization is a novel drug delivery technology for cancer treatment based on the principle of Photodynamic Treatment. Using a photosensitizer that locates in endocytic vesicles membranes of tumor cells, Photochemical internalization enables cytosolic release of endocytosed antitumor agents in a site-specific manner. The purpose of the present in-vitro study was to explore whether Photochemical Internalization is able to enhance the efficacy of Ranpirnase, a cytotoxic amphibian ribonuclease, for eradication of squamous cell carcinoma of the head and neck...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29160725/management-of-neurologic-deformity-of-the-ankle-and-foot-with-concurrent-osteomyelitis-with-the-ilizarov-method
#3
Nikolay Mikhailovich Kliushin, Anatoliy Sergeyevich Sudnitsyn, Koushik Narayan Subramanyam, Jefferson George
BACKGROUND: The combination of neurologic deformity of the ankle and foot with osteomyelitis is a therapeutic challenge. We investigated the role of Ilizarov with regard to eradication of infection, correction of deformities and improvement of patient function. METHODS: We retrospectively reviewed 77 patients (77 feet) with neurologic deformity of the ankle and foot with osteomyelitis treated sequentially in 3 stages by Ilizarov method. The 3 stages were (1) active debridement and Ilizarov stabilization, (2) further strengthening of Ilizarov fixator and active osteosynthesis consisting of strategies like arthrodesis, osteotomy distraction, bone transport, or combination thereof, (3) consolidation of fusion/regeneration achieved in second stage...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29160504/nasal-carriage-rate-of-methicillin-resistant-staphylococcus-aureus-among-iranian-healthcare-workers-a-systematic-review-and-meta-analysis
#4
Mohammad Emaneini, Fereshteh Jabalameli, Hosseinali Rahdar, Willem B van Leeuwen, Reza Beigverdi
Globally, methicillin-resistant Staphylococcus aureus (MRSA) remains a major cause of healthcare-associated infections. Healthcare workers (HCWs), patients and the environment may act as reservoirs for the spread of MRSA to patients and other HCWs. Screening and eradication of MRSA colonization is an effective method of reducing the MRSA infection rate. There are limited data on the prevalence of MRSA among Iranian HCWs. We performed a systematic search by using different electronic databases including Medline (via PubMed), Embase, Web of Science, and Iranian Databases (from January 2000 to July 2016)...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29159979/ultrasound-microbubbles-enhance-the-activity-of-vancomycin-against-staphylococcus-epidermidis-biofilms-in-vivo
#5
Ying Dong, Junshuai Li, Pan Li, Jialin Yu
OBJECTIVES: Staphylococcus epidermidis is the predominant pathogen of device-associated infections. By forming biofilms on the device surface, S epidermidis has substantial resistance to antibiotics and is difficult to eradicate. This study aimed to explore the synergistic effect of ultrasound (US)-mediated microbubbles combined with vancomycin on S epidermidis biofilms in a rabbit model. METHODS: Two polytetrafluoroethene catheters with preformed S epidermidis biofilms were implanted subcutaneously in a rabbit, one on either side of the spine...
November 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29159577/core-curriculum-case-illustration-a-rare-case-of-an-isolated-fallopian-tube-torsion
#6
Nehal Mohamed Ibrahim Saloum, Hayley Wurtz Hunt, Shaimaa Abdelhassib Fadl
This is the 46th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at: http://www.erad.org/page/CCIP_TOC .
November 21, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29159309/hiv-testing-in-urban-transgender-individuals-a-descriptive-study
#7
Adrian Juarez-Cuellar, Yu-Ping Chang
HIV testing is considered the initial component of HIV eradication strategies. This study aimed to describe HIV testing in urban, transgender individuals in western New York. The study uses HIV testing intake data from a sample of self-identified transgender males and females volunteering for an HIV test at a community-based healthcare organization. Transgender individuals with some characteristics were found to have more HIV tests including female gender, black, HIV status (positive), a history of incarceration, sex worker, housing situation, and self-referral...
2017: Transgender Health
https://www.readbyqxmd.com/read/29159029/case-report-unusual-cause-of-difficulty-in-intubation-and-ventilation-with-asthmatic-like-presentation-of-endobronchial-tuberculosis
#8
S Praveena Seevaunnamtum, Nazhan Afeef Mohd Ariff Ghazali, Wan Mohd Nazaruddin, Alwi Muhd Besari, N H Nik Fariza, Sanihah Che Omar, Saedah Ali, M Z Rhendra Hardy, Mohd Erham Mat Hassan, N M Nik Abdullah
Endobronchial Tuberculosis is hazardous in causing circumferential narrowing of tracheobronchial tree despite the eradication of tubercle bacilli in the initial insult from Pulmonary Tuberculosis. They may present as treatment resistant bronchial asthma and pose challenge to airway management in the acute setting. We present a 25 year-old lady who was newly diagnosed bronchial asthma with a past history of Pulmonary Tuberculosis that had completed treatment. She presented with sudden onset of difficulty breathing associated with noisy breathing for 3 days and hoarseness of voice for 6 months...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29158825/noninvasive-imaging-of-cd206-positive-m2-macrophages-as-an-early-biomarker-for-post-chemotherapy-tumor-relapse-and-lymph-node-metastasis
#9
Chenran Zhang, Xinhe Yu, Liquan Gao, Yang Zhao, Jianhao Lai, Dehua Lu, Rui Bao, Bing Jia, Lijun Zhong, Fan Wang, Zhaofei Liu
Tumor relapse after initial regression post-chemotherapy is a major challenge in cancer treatment, as it usually leads to local-regional recurrence or inoperable distant metastasis. M2 macrophages diminish the tumor-inhibitory effect of chemotherapy and correlate with distant metastasis and poor prognosis. In this study, we investigated whether molecular imaging of M2 macrophages could serve as an early biomarker for tumor relapse after chemotherapy and tumor lymph node metastasis in preclinical mouse models...
2017: Theranostics
https://www.readbyqxmd.com/read/29158790/synergy-of-purine-scaffold-tlr7-agonist-with-doxorubicin-on-systemic-inhibition-of-lymphoma-in-mouse-model
#10
Dong Gao, Wang Li, Wanmin Wang, Yongguang Cai, Yuhuan Wang, Xiaoling Luo, Chih-Chang Wei
Chemo- and radio-therapy suffer from certain well-recognized drawbacks for lymphoma therapy. Passive immunotherapy with monoclonal antibody has improved outcome for patients with CD20(+) B cell lymphoma, but not for T cell lymphoma. Therefore, novel treatment approaches are clearly required for T cell lymphoma. To date, the combined application targeting TLR7, 8 and 9 has established long-term antitumor immunity. We previously synthesized a purine-scaffold TLR7 agonist named GD5. Here, we report that the intratumoral administration of GD5 combined with doxorubicin (DOX), a conventional chemotherapeutic agent in T cell lymphoma...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29158778/helicobacter-pylori-and-gut-microbiota-in-multiple-sclerosis-versus-alzheimer-s-disease-10-pitfalls-of-microbiome-studies
#11
Ah-Mee Park, Seiichi Omura, Mitsugu Fujita, Fumitaka Sato, Ikuo Tsunoda
Alteration of microbiota has been associated with intestinal, inflammatory, and neurological diseases. Abundance of "good bacteria" such as Bifidobacterium, or their products have been generally believed to be beneficial for any diseases, while "bad bacteria" such as pathogenic Helicobacter pylori are assumed to be always detrimental for hosts. However, this is not the case when we compare and contrast the association of the gut microbiota with two neurological diseases, multiple sclerosis (MS) and Alzheimer's disease (AD)...
August 2017: Clinical & Experimental Neuroimmunology
https://www.readbyqxmd.com/read/29158178/dissection-enabled-scaffold-assisted-resection-descar-a-novel-technique-for-resection-of-residual-or-non-lifting-gi-neoplasia-of-the-colon-with-video
#12
Matthew W Stier, Christopher G Chapman, Allie Kreitman, John A Hart, Shu-Yuan Xiao, Uzma D Siddiqui, Irving Waxman
BACKGROUND AND AIMS: Due to previous manipulation or submucosal invasion, GI lesions referred for endoscopic mucosal resection (EMR) frequently have flat areas of visible tissue that cannot be snared. Current methods for treating residual tissue may lead to incomplete eradication or not allow complete tissue sampling for histologic evaluation. Our aim is to describe dissection-enabled scaffold-assisted resection (DeSCAR), a new technique combining circumferential ESD with EMR for removal of superficial non-lifting or residual "islands" with suspected submucosal involvement/fibrosis...
November 17, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29157368/livestock-as-sentinels-for-an-infectious-disease-in-a-sympatric-or-adjacent-living-wildlife-reservoir-host
#13
D P Anderson, A M Gormley, M Bosson, P G Livingstone, G Nugent
A central question to address in managing wildlife diseases is how much effort and resources are required to reduce infection prevalence to below a requisite threshold? This requires surveillance for infection in at least one species involved in the infection cycle, a process that is often expensive and time-consuming but one which could be enhanced using additional sources of readily-obtainable surveillance data. We demonstrate how surveillance data from ruminant livestock monitored for bovine tuberculosis (bTB) in New Zealand can be employed in spatially-explicit modelling to help predict the probability of freedom from Mycobacterium bovis infection in a sympatric wildlife reservoir species, the brushtail possum (Trichosurus vulpecula)...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29157306/a-pilot-study-of-the-immunogenicity-of-a-9-peptide-breast-cancer-vaccine-plus-poly-iclc-in-early-stage-breast-cancer
#14
Patrick M Dillon, Gina R Petroni, Mark E Smolkin, David R Brenin, Kimberly A Chianese-Bullock, Kelly T Smith, Walter C Olson, Ibrahim S Fanous, Carmel J Nail, Christiana M Brenin, Emily H Hall, Craig L Slingluff
BACKGROUND: Breast cancer remains a leading cause of cancer death worldwide. There is evidence that immunotherapy may play a role in the eradication of residual disease. Peptide vaccines for immunotherapy are capable of durable immune memory, but vaccines alone have shown sparse clinical activity against breast cancer to date. Toll-like receptor (TLR) agonists and helper peptides are excellent adjuvants for vaccine immunotherapy and they are examined in this human clinical trial. METHODS: A vaccine consisting of 9 MHC class I-restricted breast cancer-associated peptides (from MAGE-A1, -A3, and -A10, CEA, NY-ESO-1, and HER2 proteins) was combined with a TLR3 agonist, poly-ICLC, along with a helper peptide derived from tetanus toxoid...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29157283/the-mouse-viral-outgrowth-assay-avatars-for-the-detection-of-hiv-1-reservoirs
#15
REVIEW
Kelly A Metcalf Pate, Joel N Blankson
Sensitive assays are needed for the detection of residual viral reservoirs in HIV-1-infected subjects on suppressive combination antiretroviral therapy regimens to determine whether eradication strategies are effective. Mouse viral outgrowth assays have recently been developed and have the potential to be more sensitive than traditional in vitro quantitative viral outgrowth assays. In this article we describe these assays and review several studies that have used them to measure the latent reservoir.
November 21, 2017: Retrovirology
https://www.readbyqxmd.com/read/29156049/management-of-pregnant-women-and-children-focusing-on-preventing-mother-to-infant-transmission
#16
Huey-Ling Chen, Wan-Hsin Wen, Mei-Hwei Chang
Hepatitis B virus (HBV) immunization has been effectively preventing chronic HBV infection with >90% efficacy in countries with universal neonatal immunization. Perinatal mother-to-infant transmission of HBV remains the major cause of chronic HBV infection despite immunization. Maternal hepatitis B e-antigen (HBeAg) and high viral load have been noted to be the most important risk factors for transmission. In recent years, short-term antiviral therapy for pregnant women in the third trimester has been shown to be highly effective in reducing 90% of vaccine failure in children...
November 16, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29156048/unmet-needs-in-clinical-and-basic-hepatitis-b-virus-research
#17
Tung-Hung Su, Jia-Horng Kao
Chronic hepatitis B (CHB) has become a treatable and controllable disease. The current nucleos(t)ide analogue (NUC) and pegylated interferon therapies effectively help slow disease progression and reduce the risk of cirrhosis, hepatocellular carcinoma (HCC), and CHB-associated mortality. Long-term viral suppression is easily achievable by NUC therapy, with limited adverse reactions. However, several unmet requirements still exist, including safety and risk-stratified HCC surveillance among patients who received long-term NUC therapy...
November 16, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29156046/toward-a-cure-for-hepatitis-b-virus-infection-combination-therapy-involving-viral-suppression-and-immune-modulation-and-long-term-outcome
#18
Di Wu, Qin Ning
Chronic hepatitis B virus (HBV) infection remains a major global health burden. Currently, the approved therapeutic regimens include nucleos(t)ide analogues (NAs) and either interferon or pegylated interferon. NA therapy is generally safe and well tolerated, but the rate of posttreatment virologic relapse is high, making NA treatment a lifetime commitment. The benefits of pegylated interferon treatment include a finite duration, more-durable response and absence of viral resistance. However, sustained response to interferon alone is achieved only in a minority of patients, and side effects are common, which limit its clinical use...
November 16, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29155878/irhom2-is-essential-for-innate-immunity-to-rna-virus-by-antagonizing-er-and-mitochondria-associated-degradation-of-visa
#19
Wei-Wei Luo, Shu Li, Chen Li, Zhou-Qin Zheng, Pan Cao, Zhen Tong, Huan Lian, Su-Yun Wang, Hong-Bing Shu, Yan-Yi Wang
VISA (also known as MAVS, IPS-1 and Cardif) is an essential adaptor protein in innate immune response to RNA virus. The protein level of VISA is delicately regulated before and after viral infection to ensure the optimal activation and timely termination of innate antiviral response. It has been reported that several E3 ubiquitin ligases can mediate the degradation of VISA, but how the stability of VISA is maintained before and after viral infection remains enigmatic. In this study, we found that the ER-associated inactive rhomboid protein 2 (iRhom2) plays an essential role in mounting an efficient innate immune response to RNA virus by maintaining the stability of VISA through distinct mechanisms...
November 20, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29155877/immune-response-profiles-of-calves-following-vaccination-with-live-bcg-and-inactivated-mycobacterium-bovis-vaccine-candidates
#20
E M D L van der Heijden, J Chileshe, J C M Vernooij, C Gortazar, R A Juste, I Sevilla, J E Crafford, V P M G Rutten, A L Michel
Conventional control and eradication strategies for bovine tuberculosis (BTB) face tremendous difficulties in developing countries; countries with wildlife reservoirs, a complex wildlife-livestock-human interface or a lack of veterinary and veterinary public health surveillance. Vaccination of cattle and other species might in some cases provide the only suitable control strategy for BTB, while in others it may supplement existing test-and-slaughter schemes. However, the use of live BCG has several limitations and the global rise of HIV/AIDS infections has furthermore warranted the exploration of inactivated vaccine preparations...
2017: PloS One
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