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sleep-wake disturbance

Kenji Obayashi, Yuki Yamagami, Norio Kurumatani, Keigo Saeki
OBJECTIVES: To evaluate the associations between pre-awake light (PAL) exposure and subjective and objective measures of sleep quality. METHODS: In this cross-sectional study of 1108 elderly participants (mean age, 71.9 years), we measured bedroom light intensity using a bedside light meter for two nights and sleep quality using actigraphy and a questionnaire. PAL was determined as the 2h-average light intensity before rise time, and sleep disturbance was defined as the Pittsburgh sleep quality index score ≥6...
November 14, 2018: Sleep Medicine
Casey Lawless, Elise M Turner, Elizabeth LeFave, Daphne Koinis-Mitchell, David A Fedele
OBJECTIVE: Youth with asthma are at-risk for sleep difficulties due to nocturnal asthma symptoms. Sleep hygiene, or the ability to practice consistent sleep behaviors and habits, impacts youth sleep quality and may, as a result, influence daytime cognitive functioning. The current study sought to examine the impact sleep hygiene has on sleep quality, health-related quality of life (HRQL) and sustained attention among adolescents with asthma. It was hypothesized that worse sleep hygiene would be associated with poorer sleep quality, lower school-related and overall HRQL and worse sustained attention...
December 13, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Dirk Jan Stenvers, Frank A J L Scheer, Patrick Schrauwen, Susanne E la Fleur, Andries Kalsbeek
Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and various peripheral tissue clocks. The circadian timing system is responsible for the coordination of many daily processes, including the daily rhythm in human glucose metabolism. The central clock regulates food intake, energy expenditure and whole-body insulin sensitivity, and these actions are further fine-tuned by local peripheral clocks...
December 7, 2018: Nature Reviews. Endocrinology
I Wayan Pulantara, Bambang Parmanto, Anne Germain
BACKGROUND: Although evidence-based cognitive behavioral sleep treatments have been shown to be safe and effective, these treatments have limited scalability. Mobile health tools can address this scalability challenge. iREST, or interactive Resilience Enhancing Sleep Tactics, is a mobile health platform designed to provide a just-in-time adaptive intervention (JITAI) in the assessment, monitoring, and delivery of evidence-based sleep recommendations in a scalable and personalized manner...
December 7, 2018: Journal of Medical Internet Research
Shakoor Ba-Ali, Adam Elias Brøndsted, Henrik Ullits Andersen, Birgit Sander, Poul Jørgen Jennum, Henrik Lund-Andersen
OBJECTIVE: To assess the diurnal melatonin, cortisol, and activity/rest levels, as well as sleep quality, in patients with and without nonproliferative diabetic retinopathy (DR). METHODS: We included 25 diabetic patients with DR and 29 without DR. A total of 21 healthy subjects constituted the control group. We assessed the circadian rhythm by actigraphy and diurnal salivary melatonin and cortisol measurements. Sleep quality was evaluated by actigraphy and the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) questionnaires...
October 31, 2018: Sleep Medicine
Manreena Kaur, Sharon L Naismith, Jim Lagopoulos, Daniel F Hermens, Rico S C Lee, Joanne S Carpenter, Paul B Fitzgerald, Kate E Hoy, Elizabeth M Scott, Ian B Hickie
The utility of key phenotypes of depression in predicting response to repetitive transcranial magnetic stimulation (rTMS), namely sleep-wake behaviour, cognition and illness chronicity, has been understudied and not been extended to young samples. This study aimed to determine whether sleep-wake disturbance, cognition or depression chronicity are associated with rTMS outcome in young depressed adults. Sixteen depressed young adults diagnosed with mood disorders (aged 18-29 years) completed this open-label study...
December 1, 2018: Psychiatry Research
Edith N Botchway, Celia Godfrey, Vicki Anderson, Cathy Catroppa
OBJECTIVE: To systematically appraise the literature on the prevalence, types, and predictors of sleep-wake disturbances (SWD), and on the relationship between SWD, fatigue, depression, and quality of life in children and adolescents with traumatic brain injury (TBI). METHODS: MEDLINE, PubMed, PsychInfo, Web of Science, and EMBASE databases were searched, reference lists of retrieved articles were also searched for relevant articles, and study methods were evaluated for risk of bias...
November 28, 2018: Journal of Head Trauma Rehabilitation
Frank Y Lee, Huei-Bin Wang, Olivia N Hitchcock, Dawn Hsiao Loh, Daniel S Whittaker, Yoon-Sik Kim, Achilles Aiken, Collette Kokikian, Esteban C Dell'Angelica, Christopher S Colwell, Cristina A Ghiani
Mice lacking a functional Biogenesis of Lysosome-related Organelles Complex 1 (BLOC-1), such as those of the pallid line, display cognitive and behavioural impairments reminiscent of those presented by individuals with intellectual and developmental disabilities. Although disturbances in the sleep/wake cycle are commonly lamented by these individuals, the underlying mechanisms, including the possible role of the circadian timing system, are still unknown. In this paper, we have explored sleep/circadian malfunctions and underlying mechanisms in BLOC-1-deficient pallid mice...
2018: Frontiers in Neuroscience
Ashlee B Grierson, Jan Scott, Nick Glozier, Ian B Hickie, Paul G Amminger, Eoin Killackey, Patrick D McGorry, Christos Pantelis, Lisa Phillips, Elizabeth Scott, Alison R Yung, Rosemary Purcell
AIM: Clinical staging models offer a useful framework for understanding illness trajectories, where individuals are located on a continuum of illness progression from stage 0 (at-risk but asymptomatic) to stage 4 (end-stage disease). Importantly, clinical staging allows investigation of risk factors for illness progression with the potential to target trans-diagnostic mechanisms at an early stage, especially in help-seeking youth who often present with sub-threshold syndromes. While depressive symptoms, rumination and sleep-wake disturbances may worsen syndrome outcomes, the role of these related phenomena has yet to be examined as risk factors for trans-diagnostic illness progression in at-risk youth...
November 28, 2018: Early Intervention in Psychiatry
Katie Palmer, Micaela Mitolo, Francesca Burgio, Francesca Meneghello, Annalena Venneri
Objectives: The aims of the current study are to (1) report the frequency of specific sleep disturbance symptoms in Mild Cognitive Impairment (MCI) and cognitive healthy older persons; (2) examine whether overall poor sleep and specific sleep disturbance symptoms are more common in persons with MCI compared to cognitive healthy older controls and; (3) examine the association between sleep disturbances and performance in general and specific cognitive domains in persons with MCI and separately in cognitive healthy older persons...
2018: Frontiers in Aging Neuroscience
Marie Bruyneel, Thomas Sersté
Sleep-wake disturbances are common in liver cirrhosis and associated with impaired quality of life. The most common abnormalities are insomnia (difficulties falling asleep and maintaining sleep, or unrefreshing sleep), excessive daytime sleepiness, and sleep-wake inversion (disturbances of circadian rhythmicity). The underlying pathophysiological mechanisms for sleep disturbances in cirrhosis are complex and may include disturbed metabolism of melatonin and glucose, alterations in thermoregulation, and altered ghrelin secretion profiles...
2018: Nature and Science of Sleep
Ami Cohen, Natali Ben Abu, Iris Haimov
OBJECTIVE/BACKGROUND: Sleep disturbances are considered among the negative consequences of smoking. However, the relationship between sleep quality and smoking among young adults, a population in which the prevalence of smoking is highest, has scarcely been examined. The current study aimed at examining differences in sleep indices, assessed by both subjective and objective (actigraphy) measures, between smokers and nonsmokers, and whether such differences are associated with levels of nicotine dependence...
November 21, 2018: Behavioral Sleep Medicine
Yoko Higami, Miyae Yamakawa, Kazue Shigenobu, Kei Kamide, Kiyoko Makimoto
AIM: Sleep disturbances in patients with Alzheimer's disease have not been systematically evaluated, because sleep monitoring has proved difficult. Our goal was to quantitatively characterize sleep disturbances in patients with Alzheimer's disease. METHODS: The present study was a cross-sectional descriptive study, carried out in dementia care units in Japan. Participants were 63 patients with Alzheimer's disease (mean age 77.6 ± 8.0 years) with severe behavioral and psychological symptoms of dementia...
November 21, 2018: Geriatrics & Gerontology International
Matteo Turco, Nora Cazzagon, Irene Franceschet, Chiara Formentin, Giovanni Frighetto, Francesca Giordani, Nicola Cellini, Gabriella Mazzotta, Rodolfo Costa, Benita Middleton, Debra J Skene, Annarosa Floreani, Sara Montagnese
Patients with Primary Biliary Cholangitis (PBC) exhibit delayed sleep-wake habits, disturbed night sleep and daytime sleepiness/fatigue. Such combination of symptoms is reminiscent of delayed sleep-wake phase disorder (DSPD), which benefits from morning light treatment. The aim of the present pilot study was to test the effect of morning light treatment in a group of 13 well-characterized patients with PBC [all females; (mean ± SD) 53 ± 10 years]. Six healthy individuals (4 females, 57 ± 14 years) and 7 patients with cirrhosis (1 female, 57 ± 12 years) served as controls and diseased controls, respectively...
2018: Frontiers in Physiology
Cecilia M Shikuma, Lindsay Kohorn, Robert Paul, Dominic C Chow, Kalpana J Kallianpur, Maegen Walker, Scott Souza, Louie Mar A Gangcuangco, Beau K Nakamoto, Francis D Pien, Timothy Duerler, Linda Castro, Lorna Nagamine, Bruce Soll
The antiretroviral drug efavirenz (EFV) has been linked to disordered sleep and cognitive abnormalities. We examined sleep and cognitive function and subsequent changes following switch to an alternative integrase inhibitor-based regimen. Thirty-two HIV-infected individuals on EFV, emtricitabine, and tenofovir (EFV/FTC/TDF) without traditional risk factors for obstructive sleep apnea (OSA) were randomized 2:1 to switch to elvitegravir/cobicistat/emtricitabine/tenofovir (EVG/COBI/FTC/TDF) or to continue EFV/FTC/TDF therapy for 12 weeks...
November 19, 2018: HIV Clinical Trials
Barbara L Parry, Charles J Meliska, Ana M Lopez, Diane L Sorenson, L Fernando Martinez, Henry J Orff, Richard L Hauger, Daniel F Kripke
BACKGROUND: Peripartum major depression (MD) disables mothers and impairs emotional and neurocognitive development of offspring. We tested the hypothesis that critically-timed wake therapy (WT) relieves peripartum MD by altering melatonin and sleep timing, differentially, in antepartum vs. postpartum depressed patients (DP). METHODS: In a university clinical research center, we initially randomized 50 women - 26 antepartum (17 healthy comparison-HC, 9 DP) and 24 postpartum (8 HC, 16 DP) - to a cross-over trial of one night of early-night wake therapy (EWT: sleep 3:00-7:00 am) vs...
November 5, 2018: Journal of Affective Disorders
Hans-Peter Landolt, Sebastian C Holst, Amandine Valomon
Sleep and wakefulness are highly complex processes that are elegantly orchestrated by fine-tuned neurochemical changes among neuronal and non-neuronal ensembles, nuclei, and networks of the brain. Important neurotransmitters and neuromodulators regulating the circadian and homeostatic facets of sleep-wake physiology include melatonin, γ-aminobutyric acid, hypocretin, histamine, norepinephrine, serotonin, dopamine, and adenosine. Dysregulation of these neurochemical systems may cause sleep-wake disorders, which are commonly classified into insomnia disorder, parasomnias, circadian rhythm sleep-wake disorders, central disorders of hypersomnolence, sleep-related movement disorders, and sleep-related breathing disorders...
November 16, 2018: Handbook of Experimental Pharmacology
Sean P Prall, Gandhi Yetish, Brooke A Scelza, Jerome M Siegel
OBJECTIVE: To understand the basics of sleep quality in a pastoralist population and to explore predictors of this variation. DESIGN: Cross-sectional. SETTING: Northern Namibia, dry seasons of 2016 and 2017. PARTICIPANTS: The Himba, a nonindustrial seminomadic agropastoralist population without access to the electrical grid. MEASUREMENTS: Using Actiwatch-2 devices, 75 participants completed 721 days of wear...
December 2018: Sleep Health
Kristin M Gunnarsdottir, Charlene E Gamaldo, Rachel M E Salas, Joshua B Ewen, Richard P Allen, Sridevi V Sarma
Overnight polysomnography (PSG) is the gold standard tool used to characterize sleep and for diagnosing sleep disorders. PSG is a non-invasive procedure that collects various physiological data which is then scored by sleep specialists who assign a sleep stage to every 30-second window of the data according to predefined scoring rules. In this study, we aimed to automate the process of sleep stage scoring of overnight PSG data while adhering to expert-based rules. We developed an algorithm utilizing a likelihood ratio decision tree classifier and extracted features from EEG, EMG and EOG signals based on predefined rules of the American Academy of Sleep Medicine Manual...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Vernika Tyagi, Monica Juneja, Rahul Jain
Sleep problems were studied in both typically developing (TD) children and those with autism spectrum disorder (ASD) using the Sleep Disturbance Scale for Children. Factors associated with these problems were also studied in children with ASD. Seventy-three children with ASD and their age and sex matched TD controls in age group of 3-12 years were enrolled in the study. Higher sleep problems were found in children with ASD than TD children. Most common sleep problem reported in children with ASD was Sleep Wake Transition Disorders, followed by Disorder of Initiation and Maintenance; while in TD controls, it was Sleep Breathing Disorders...
November 13, 2018: Journal of Autism and Developmental Disorders
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