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sleep-wake disturbance

Grace E Dean, Patricia Ziegler, Hongbin Chen, Lynn M Steinbrenner, Suzanne S Dickerson
CONTEXT: A knowledge gap exists in our understanding of the illness and insomnia symptom treatment trajectory in adults with inoperable non-small cell lung cancer (NSCLC). OBJECTIVES: Compare valid and reliable sleep-wake measures for insomnia to interpretations of narrative descriptions of sleep to improve our comprehension of sleep-wake disturbances in adults with NSCLC. METHODS: This study employed mixed methods (quantitative and qualitative) in a longitudinal design to study adults (n = 26) from ambulatory thoracic clinics...
October 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Tayyabah Yousaf, Gennaro Pagano, Heather Wilson, Marios Politis
Sleep dysfunction is recognized as a distinct clinical manifestation in movement disorders, often reported early on in the disease course. Excessive daytime sleepiness, rapid eye movement sleep behavior disorder and restless leg syndrome, amidst several others, are common sleep disturbances that often result in significant morbidity. In this article, we review the spectrum of sleep abnormalities across atypical Parkinsonian disorders including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), as well as Parkinson's disease (PD) and Huntington's disease (HD)...
2018: Frontiers in Neurology
Stephane Besnard, Brahim Tighilet, Christian Chabbert, Martin Hitier, Joseph Toulouse, Anne Le Gall, Marie-Laure Machado, Paul F Smith
The vestibular system encodes linear and angular head motion supporting numerous functions from gaze stabilization and postural control, to high-level cortical functions involving spatial cognition, including self-body perception, verticality perception, orientation, navigation and spatial memory. At the brainstem and mesencephalic levels, the vestibular organs also influence postural blood pressure regulation, bone density and muscle composition via specific vestibulo-sympathetic efferences and have been shown to act as a powerful synchronizer of circadian rhythms...
September 8, 2018: Sleep Medicine Reviews
Hui Ding, Xiang-Yu Cui, Su-Ying Cui, Hui Ye, Xiao Hu, Hui-Ling Zhao, Yu-Tong Liu, Yong-He Zhang
Hypothalamic-pituitary-adrenal (HPA) axis activity is commonly dysregulated in stress-related psychiatric disorders. The corticosterone rat model was developed to understand the influence of stress on depression-like symptomatology. To further understand the effects of corticosterone on the development of depression-like behavior, rats were continuously exposed to corticosterone (200 μg/ml) or vehicle via drinking water daily for 21 days. The rats underwent a series of behavioral tests, and electroencephalographical recordings were performed after 7, 14, and 21 days of treatment...
September 29, 2018: Neuroscience Letters
Pura Ballester, María José Martínez, Auxiliadora Javaloyes, María-Del-Mar Inda, Noemí Fernández, Pilar Gázquez, Víctor Aguilar, Agustín Pérez, Luís Hernández, Amanda L Richdale, Ana M Peiró
Sleep problems (SP) are recognized as a common comorbid condition in autism spectrum disorder (ASD) and can influence core autism symptoms and mental and physical health. SPs can be lifelong and have been reported that adults on the autistic spectrum with and without intellectual disability (ID) present SPs (longer sleep latency, frequent night awakenings, and circadian rhythm sleep-wake disorders). A prospective, objective sleep study was conducted in 41 adults with ASD (33 ± 6 years old) and ID and 51 typically developing adults (33 ± 5 years old) using ambulatory circadian monitoring (ACM) recording wrist temperature, motor activity, body position, sleep, and light intensity...
October 1, 2018: Autism Research: Official Journal of the International Society for Autism Research
Tao Zhang, Xin Jiang, Min Xu, Haifang Wang, Xiao Sang, Meiling Qin, Puhua Bao, Ruiqi Wang, Chenchen Zhang, Huiping Lu, Yuzhuo Li, Jin Ren, Hung-Chun Chang, Jun Yan, Qiang Sun, Jin Xu
Mutations in fused in sarcoma (Fus) cause familial amyotrophic lateral sclerosis (ALS) and occasionally frontotemporal dementia. Here we report the establishment and characterization of a novel knockin (KI) rat model expressing a Fus point mutation (R521C) via CRISPR/Cas9. The mutant animals developed adult-onset learning and memory behavioral deficits, with reduced spine density in hippocampal neurons. Remarkably, sleep-wake cycle and circadian abnormalities preceded the onset of cognitive deficit. RNA-seq study further demonstrated altered expression of some key sleep and circadian regulators, such as orexin/hypocretin receptor type 2 and casein kinase 1 epsilon, in the mutant rats...
September 5, 2018: Neurobiology of Aging
Alessandro Amaddeo, Livio De Sanctis, Jorge Olmo Arroyo, Sonia Khirani, Nadia Bahi-Buisson, Brigitte Fauroux
INTRODUCTION: Rett syndrome (RS) is a severe neurodevelopment disorder associated with abnormal breathing during wakefulness and disturbed nocturnal behaviour. Breathing abnormalities during daytime have been extensively reported but polysomnographic (PSG) findings have been poorly studied. MATERIALS AND METHODS: Consecutive patients with RS carrying distinct mutations in MECP2 gene, who underwent a PSG between October 2014 and January 2018, were included in the study...
September 12, 2018: European Journal of Paediatric Neurology: EJPN
Chaowapong Jarasvaraparn, Kimberly Zlomke, Noelle C Vann, Bin Wang, Karen D Crissinger, David A Gremse
OBJECTIVE: The aim of this prospective cross sectional study was to assess the prevalence of sleep disturbance in children with inflammatory bowel disease (IBD), including the relationships between sleep, inflammatory markers, and disease activity of pediatric patients with IBD. METHODS: Pediatric IBD patients and parents were enrolled in the study. Patients completed the Pittsburgh Sleep Quality Index (PSQI), the Pediatric Daytime Sleepiness Scale (PDSS), and the Adolescent Sleep Wake Scale (ASWS) surveys...
September 25, 2018: Journal of Pediatric Gastroenterology and Nutrition
Sharon L Naismith, Jonathon Pye, Zoe Terpening, Simon Lewis, Delwyn Bartlett
OBJECTIVE/BACKGROUND: Sleep-wake disturbance is associated with poor cognitive functioning and several other adverse outcomes that increase dementia risk in older adults. Targeting sleep-wake disturbance in individuals at risk for dementia may be an important treatment. This study evaluated the efficacy of a four-session multicomponent group intervention for participants with mild cognitive impairment (MCI). PARTICIPANTS: Thirty-five older adults with MCI (mean age = 69...
September 24, 2018: Behavioral Sleep Medicine
Jessica R Lunsford-Avery, Matthew M Engelhard, Ann Marie Navar, Scott H Kollins
Sleep disturbances, including insufficient sleep duration and circadian misalignment, confer risk for cardiometabolic disease. Less is known about the association between the regularity of sleep/wake schedules and cardiometabolic risk. This study evaluated the external validity of a new metric, the Sleep Regularity Index (SRI), among older adults (n = 1978; mean age 68.7 ± 9.2), as well as relationships between the SRI and cardiometabolic risk using data from the Multi-Ethnic Study of Atherosclerosis (MESA)...
September 21, 2018: Scientific Reports
Maria Korman, Denise Palm, Adriana Uzoni, Frank Faltraco, Oliver Tucha, Johannes Thome, Andrew N Coogan
OBJECTIVES: The current paper addresses the evidence for circadian clock characteristics associated with Attention-Deficit Hyperactivity Disorder (ADHD), and possible therapeutic approaches based on chronomodulation through bright light therapy. METHODS: We review the data reported in ADHD on genetic risk factors for phase-delayed circadian rhythms and on the role of photic input in circadian re-alignment. RESULTS: Single nucleotide polymorphisms (SNPs) in circadian genes were recently associated with core ADHD symptoms, increased evening-orientation and frequent sleep problems...
September 20, 2018: World Journal of Biological Psychiatry
Érica Lui Reinhardt, Pedro Augusto Carlos Magno Fernandes, Regina P Markus, Frida Marina Fischer
Shift work is unavoidable in modern societies, but at the same time disrupts biological rhythms and contributes to social distress and disturbance of sleep, health and well-being of shift workers. Shift work has been associated with some chronic diseases in which a chronic inflammatory condition may play a role. However, few studies investigating the association of cytokine and other inflammation markers with shift workers have been published in recent years. In this study we evaluated the effects of permanent night work on the production of tumor necrosis factor (TNF), interleukin-1β (IL-1β), IL-6 and melatonin in saliva...
September 19, 2018: Chronobiology International
Vibhash D Sharma, Samarpita Sengupta, Shilpa Chitnis, Amy W Amara
Sleep-wake disturbances are common non-motor manifestations in Parkinson Disease (PD). Complex pathophysiological changes secondary to neurodegeneration in combination with motor symptoms and dopaminergic medications contribute to development of sleep-wake disturbances. The management of sleep complaints in PD is important as this symptom can affect daily activities and impair quality of life. Deep brain stimulation (DBS) is an effective adjunctive therapy for management of motor symptoms in PD. However, its effect on non-motor symptoms including sleep-wake disturbances is not widely understood...
2018: Frontiers in Neurology
Kazue Okamoto-Mizuno, Koh Mizuno, Motoko Tanabe, Katsuko Niwano
Effects of the environment of a simulated shelter in a gymnasium on sleep were investigated in 20 healthy school-aged children. Measurements were obtained during a one-night stay in a school gymnasium during the summer (C). Activity levels were monitored using a wrist actigraph, and temperature and humidity of the bedrooms in the subjects' homes were monitored from 3 days before to 3 days after C. The subjects were asked to provide information regarding subjective sleep estimations and thermal sensations...
November 2018: International Journal of Biometeorology
Mireille Salas-Crisostomo, Pablo Torterolo, André Barciela Veras, Nuno Barbosa Rocha, Sérgio Machado, Eric Murillo-Rodríguez
OBJECTIVE: Aging is a natural biological phenomenon that occurs in human beings. With increasing of age, there is an appearance of deleterious changes related with progression onto pathological conditions, including hypertension, heart disease, diabetes, hearing and vision impairments, as well as sleep disorders. It is important to recognize that some sleep disturbances reported by aged subjects include insomnia, obstructive sleep apnea, restless legs syndrome, among others. Moreover, accumulating evidence indicates that coexistence of medical issues with sleep disorders constitutes clinical challenges for treatment of comorbidities in elderly...
September 3, 2018: Current Medicinal Chemistry
Edith N Botchway, Celia Godfrey, Vicki Anderson, Christian L Nicholas, Cathy Catroppa
Sleep-wake disturbances (SWD) are frequent following traumatic brain injury (TBI) in childhood. However, outcomes of SWD following transition into young adulthood remain unknown. This study investigated prevalence and factors associated with subjective sleep quality, insomnia, and excessive daytime sleepiness in young adults with a history of childhood TBI. Participants included 54 young adults with mild (n = 14), moderate (n = 27), and severe (n = 13) TBI (age: mean = 27.7, SD = 3.3), and 13 typically developing controls (TDC) (age: mean = 25...
October 4, 2018: Journal of Neurotrauma
Patricia A Vu, Laura B Tucker, Jiong Liu, Eileen H McNamara, Thanhlong Tran, Amanda H Fu, Yeonho Kim, Joseph T McCabe
The employment of explosive weaponry in modern warfare exposes populations to shock wave-induced and impact-related brain injuries. Among the most common clinical complaints resulting from traumatic brain injury (TBI) are sleep-wake disturbances. The current study assessed the acute effects of mild concussive brain injury (CBI) and mild blast wave-induced brain injury (BTBI) on mouse behavior and orexin-A expression. Male C57BL/6J mice were exposed to CBI, BTBI, or sham procedures. Injured animals and their shams were further divided into the following subgroups: 24-h survival in standard group (SG) housing, 72-h survival in SG housing, and 72-h survival in Any-Maze cages (AMc)...
August 31, 2018: Brain Research
Maria Del Mar Capella, Antonio Martinez-Nicolas, Ana Adan
There is evidence of the reciprocal influence between the alteration of circadian rhythms and Substance Use Disorders (SUD), and part of the success of the SUD treatment lays in the patient's rhythmic recovery. We aim to elucidate the effect of the SUD treatment in circadian rhythmicity considering, for the first time, the age of onset of substance use (OSU) and duration of abstinence. We registered the sleep-wake schedules, the chronotype and the distal skin temperature of 114 SUD patients with at least 3 months of abstinence, considering whether they had begun consumption at age 16 or earlier (OSU ≤ 16, n = 56) or at 17 or later (OSU ≥ 17, n = 58), and duration of abstinence as short (SA: 3 to 5 months, n = 38), medium (MA: 6 to 9 months, n = 35) or long (LA: more than 9 months, n = 41)...
2018: Frontiers in Psychiatry
Giulia Menculini, Norma Verdolini, Andrea Murru, Isabella Pacchiarotti, Umberto Volpe, Antonella Cervino, Luca Steardo, Patrizia Moretti, Eduard Vieta, Alfonso Tortorella
BACKGROUND: The present systematic review was aimed at critically summarizing the evidence about interventions focused on circadian rhythms and mood symptoms in seasonal affective disorder (SAD). METHODS: A systematic search of the electronic databases PUBMED, PsycINFO and Web of Science was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Original papers reporting data about the effects of treatments on both mood and circadian rhythms disturbances in SAD patients were considered for inclusion...
December 1, 2018: Journal of Affective Disorders
Ava Katherine Bittner, Jennifer A Haythornthwaite, Chandni Patel, Michael T Smith
SIGNIFICANCE: Objectively measured limitations in daytime activity levels appear to be inextricably linked with sleep disturbances in retinitis pigmentosa (RP) patients, as well as associated with unemployment status and central vision loss. Innovative interventional strategies should be developed to help improve these issues and overall quality of life for RP patients. PURPOSE: Novel sensor devices are emerging as valuable tools to objectively assess behavior. We used validated measures of wrist accelerometry to determine relationships between sleep, vision, and physical activity in RP subjects...
September 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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