Nicole J Gervais, Luke Remage-Healey, Joseph R Starrett, Daniel J Pollak, Jessica A Mong, Agnès Lacreuse
Breast cancer patients using aromatase inhibitors (AIs) as an adjuvant therapy often report side effects including hot flashes, mood changes, and cognitive impairment. Despite long-term use in humans, little is known about the effects of continuous AI administration on the brain and cognition. We used a primate model of human cognitive aging, the common marmoset, to examine the effects of a 4-week daily administration of the AI Letrozole (20 μg, p.o.) on cognition, anxiety, thermoregulation, brain estrogen content, and hippocampal pyramidal cell physiology...
December 26, 2018: Journal of Neuroscience