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https://www.readbyqxmd.com/read/29791831/the-lymph-node-and-the-metastasis
#1
Vivianne Tjan-Heijnen, Giuseppe Viale
New England Journal of Medicine, Volume 378, Issue 21, Page 2045-2046, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791830/learning-from-a-trial-stopped-by-a-data-and-safety-monitoring-board
#2
EDITORIAL
David Harrington, Jeffrey M Drazen
New England Journal of Medicine, Volume 378, Issue 21, Page 2031-2032, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791829/burosumab-therapy-in-children-with-x-linked-hypophosphatemia
#3
Thomas O Carpenter, Michael P Whyte, Erik A Imel, Annemieke M Boot, Wolfgang Högler, Agnès Linglart, Raja Padidela, William Van't Hoff, Meng Mao, Chao-Yin Chen, Alison Skrinar, Emil Kakkis, Javier San Martin, Anthony A Portale
BACKGROUND: X-linked hypophosphatemia is characterized by increased secretion of fibroblast growth factor 23 (FGF-23), which leads to hypophosphatemia and consequently rickets, osteomalacia, and skeletal deformities. We investigated burosumab, a monoclonal antibody that targets FGF-23, in patients with X-linked hypophosphatemia. METHODS: In an open-label, phase 2 trial, we randomly assigned 52 children with X-linked hypophosphatemia, in a 1:1 ratio, to receive subcutaneous burosumab either every 2 weeks or every 4 weeks; the dose was adjusted to achieve a serum phosphorus level at the low end of the normal range...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791828/diagnosis-and-management-of-the-antiphospholipid-syndrome
#4
David Garcia, Doruk Erkan
New England Journal of Medicine, Volume 378, Issue 21, Page 2010-2021, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791827/a-shocking-turn-of-events
#5
Ersilia M DeFilippis, Anand Vaidya, David Braun, Neal Lakdawala, Piotr Sobieszczyk
New England Journal of Medicine, Volume 378, Issue 21, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791822/extracorporeal-membrane-oxygenation-for-severe-acute-respiratory-distress-syndrome
#6
Alain Combes, David Hajage, Gilles Capellier, Alexandre Demoule, Sylvain Lavoué, Christophe Guervilly, Daniel Da Silva, Lara Zafrani, Patrice Tirot, Benoit Veber, Eric Maury, Bruno Levy, Yves Cohen, Christian Richard, Pierre Kalfon, Lila Bouadma, Hossein Mehdaoui, Gaëtan Beduneau, Guillaume Lebreton, Laurent Brochard, Niall D Ferguson, Eddy Fan, Arthur S Slutsky, Daniel Brodie, Alain Mercat
BACKGROUND: The efficacy of venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) remains controversial. METHODS: In an international clinical trial, we randomly assigned patients with very severe ARDS, as indicated by one of three criteria - a ratio of partial pressure of arterial oxygen (Pao2 ) to the fraction of inspired oxygen (Fio2 ) of less than 50 mm Hg for more than 3 hours; a Pao2 :Fio2 of less than 80 mm Hg for more than 6 hours; or an arterial blood pH of less than 7...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791821/tinea-capitis-in-a-newborn
#7
Christian Fremerey, Pietro Nenoff
New England Journal of Medicine, Volume 378, Issue 21, Page 2022-2022, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791819/ecmo-for-severe-ards
#8
EDITORIAL
C Corey Hardin, Kathryn Hibbert
New England Journal of Medicine, Volume 378, Issue 21, Page 2032-2034, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791818/retinal-vasculitis-in-takayasu-s-arteritis
#9
Priya Bajgai, Ramandeep Singh
New England Journal of Medicine, Volume 378, Issue 21, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791817/p53-and-me
#10
Shekinah N C Elmore
New England Journal of Medicine, Volume 378, Issue 21, Page 1962-1963, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791816/fast-forward-neoadjuvant-cancer-immunotherapy
#11
EDITORIAL
Thomas F Gajewski
New England Journal of Medicine, Volume 378, Issue 21, Page 2034-2035, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791813/higher-lung-cancer-incidence-in-young-women-than-young-men-in-the-united-states
#12
Ahmedin Jemal, Kimberly D Miller, Jiemin Ma, Rebecca L Siegel, Stacey A Fedewa, Farhad Islami, Susan S Devesa, Michael J Thun
BACKGROUND: Previous studies showed a higher incidence of lung cancer among young women than among young men in the United States. Whether this pattern has continued in contemporary birth cohorts and, if so, whether it can be fully explained by sex differences in smoking behaviors are unknown. METHODS: We examined the nationwide population-based incidence of lung cancer according to sex, race or ethnic group, age group (30 to 34, 35 to 39, 40 to 44, 45 to 49, and 50 to 54 years), year of birth (1945 to 1980), and calendar period of diagnosis (1995-1999, 2000-2004, 2005-2009, and 2010-2014), and we calculated female-to-male incidence rate ratios...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29783850/the-utility-of-anti-inflammatory-agents-in-cardiovascular-disease-a-novel-perspective-on-the-treatment-of-atherosclerosis
#13
Santhosh J Kottoor, Rohit R Arora
Approximately 40% of heart attack survivors remain at increased risk of recurrent cardiovascular events, despite the current treatment options showing that atherothrombosis is not exclusively a disorder of lipoprotein aggregation in the arterial wall. Clinical and experimental data suggest that inflammation plays an important role in atherothrombosis independent of the cholesterol level. Acute-phase reactants, such as C-reactive protein, increase in patients with coronary artery disease and are known to predict adverse outcomes in such patients...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29742381/mri-targeted-versus-ultrasonography-guided-biopsy-for-suspected-prostate-cancer
#14
EDITORIAL
Michael J Barry, Andrew B Rosenkrantz
New England Journal of Medicine, Volume 378, Issue 19, Page 1835-1836, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742380/idiopathic-pulmonary-fibrosis
#15
REVIEW
David J Lederer, Fernando J Martinez
New England Journal of Medicine, Volume 378, Issue 19, Page 1811-1823, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742376/essential-tremor
#16
REVIEW
Dietrich Haubenberger, Mark Hallett
New England Journal of Medicine, Volume 378, Issue 19, Page 1802-1810, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742375/investigational-testing-for-zika-virus-among-u-s-blood-donors
#17
MULTICENTER STUDY
Paula Saá, Melanie Proctor, Gregory Foster, David Krysztof, Colleen Winton, Jeffrey M Linnen, Kui Gao, Jaye P Brodsky, Ronald J Limberger, Roger Y Dodd, Susan L Stramer
BACKGROUND: Because of the potential severe clinical consequences of Zika virus (ZIKV) infection, the large numbers of asymptomatic travelers returning from ZIKV-active areas, the detection of ZIKV nucleic acid in blood, and reports of transmission of ZIKV through transfusion, in 2016 the Food and Drug Administration released recommendations for individual-unit nucleic acid testing to minimize the risk of transmission of ZIKV through blood transfusions. METHODS: The American Red Cross implemented investigational screening of donated blood for ZIKV RNA by means of transcription-mediated amplification (TMA)...
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742371/moving-on
#18
Abigail Zuger
New England Journal of Medicine, Volume 378, Issue 19, Page 1763-1765, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742369/xanthoma-striatum-palmare
#19
Viktoria F Koehler, Klaus G Parhofer
New England Journal of Medicine, Volume 378, Issue 19, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742367/tackling-tumors-with-small-rnas-derived-from-transfer-rna
#20
Frank J Slack
New England Journal of Medicine, Volume 378, Issue 19, Page 1842-1843, May 2018.
May 10, 2018: New England Journal of Medicine
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