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https://www.readbyqxmd.com/read/30537114/myd88-l265p-mutations-identify-a-prognostic-gene-expression-signature-and-a-pathway-for-targeted-inhibition-in-cll
#1
Ma Reina Improgo, Bethany Tesar, Josephine L Klitgaard, Reuma Magori-Cohen, Lijian Yu, Siddha Kasar, Divya Chaudhary, Wenyan Miao, Stacey M Fernandes, Kevin Hoang, William F Westlin, Haesook T Kim, Jennifer R Brown
The L265P somatic mutation in the Myeloid Differentiation Primary Response 88 (MYD88) gene is a recurrent mutation in chronic lymphocytic leukaemia (CLL). This mutation has functional effects in various haematological malignancies but its role in CLL remains to be fully elucidated. Here, we report that MYD88 L265P mutations are associated with mutated immunoglobulin heavy-chain gene (IGHV-M) status and that among IGHV-M patients, the presence of MYD88 L265P is associated with younger age at diagnosis. Using microarray and RNA-Seq gene expression analysis, we further observe that the MYD88 L265P mutation is associated with a distinctive gene expression signature that predicts both failure-free survival and overall survival...
December 9, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30531024/eus-guided-antegrade-metal-stenting-with-hepaticoenterostomy-using-a-dedicated-plastic-stent-with-a-review-of-the-literature-with-video
#2
Kenjiro Yamamoto, Takao Itoi, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjo, Shuntaro Mukai, Mitsuru Fujita, Yasutsugu Asai, Yukitoshi Matsunami, Takashi Kurosawa, Atsushi Sofuni, Yuichi Nagakawa
Background and Objectives: Recently, a novel EUS-guided biliary drainage (EUS-BD) technique consisting of EUS-guided antegrade stenting and EUS-guided hepaticoenterostomy (EUS-AS+HES) using two conventional metal stents (MS) has been reported to decrease adverse events and maintain longer stent patency for malignant biliary obstruction (MBO). However, only a few limited reports have evaluated this technique. Finally, dedicated plastic stents (PSs) have been developed to perform EUS-HES safely...
November 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/30530208/what-is-anxious-depression-overlap-and-agreement-between-different-definitions
#3
Mark Zimmerman, Sophie Kerr, Reina Kiefer, Caroline Balling, Kristy Dalrymple
Anxiety is common in depressed patients. However, a problem with the research on the significance of anxiety in depressed patients is that anxiety has been characterized in different ways. Little research has examined the concordance and overlap between the various definitions of anxious depression. With research on the DSM-5 anxious distress specifier just beginning, it will be important to understand how defining anxious depression according to DSM-5 agrees with previously studied definitions. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project we examined the association between the DSM-5 anxious distress specifier and 6 other approaches towards defining anxious depression...
December 1, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/30515447/neurostimulation-for-functional-neurological-disorder-evaluating-longitudinal-neurophysiology
#4
Matthew J Burke, Reina Isayama, Gaayathiri Jegatheeswaran, Carolyn Gunraj, Anthony Feinstein, Anthony E Lang, Robert Chen
No abstract text is available yet for this article.
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30506597/novel-peroral-direct-digital-cholangioscopy-assisted-lithotripsy-using-a-monorail-technique-through-the-overtube-in-patients-with-surgically-altered-anatomy-with-video
#5
Ryosuke Tonozuka, Takao Itoi, Atsushi Sofuni, Takayoshi Tsuchiya, Kentaro Ishii, Reina Tanaka, Mitsuyoshi Honjo, Shuntaro Mukai, Kenjiro Yamamoto, Mitsuru Fujita, Yasutsugu Asai, Yukitoshi Mastunami, Takashi Kurosawa, Hiroyuki Kojima, Hirofumi Kogure, Yuichi Nagakawa
The efficacy of cholangioscopy-assisted lithotripsy for difficult stones such as huge stones, multiple large stones and an impacted stone in patients with non-altered anatomy have been reported. Herein, we describe peroral direct digital cholangioscopy (PDCS)-assisted electrohydraulic lithotripsy (EHL) with a new technique in patients with surgically altered anatomy. Five patients received PDCS-assisted EHL with the monorail technique because of surgically altered anatomy, due to failed conventional stone extraction...
December 1, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/30504420/cd62l-is-a-functional-and-phenotypic-marker-for-circulating-innate-lymphoid-cell-precursors
#6
Yotam E Bar-Ephraim, Jasper J Koning, Estefany Burniol Ruiz, Tanja Konijn, Vera P Mourits, Kim A Lakeman, Louis Boon, Marijn Bögels, J Peter van Maanen, Joke M M Den Haan, Marjolein van Egmond, Gerd Bouma, Rogier M Reijmers, Reina E Mebius
Innate lymphoid cells (ILCs) guard epithelial tissue integrity during homeostasis, but can be potent immune effector cells during inflammation. Precursors to all ILC subsets (ILC precursors [ILCP]) have been identified in human peripheral blood (PB). We found that during homeostasis, ILCP in PB of mouse and human expressed homing receptors for secondary lymphoid organs, mainly CD62L. These ILCP entered mouse lymph nodes in a CD62L-dependent way and relied on S1P receptors for their exit. Importantly, CD62L expression was absent on human ILCs expressing NKp44 in tonsils and PB of Crohn disease patients, and relatively fewer CD62L+ ILCP were present in PB of Crohn disease patients...
November 30, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30502962/exceptional-contact-elasticity-of-human-enamel-in-nanoindentation-test
#7
Naofumi Shimomura, Reina Tanaka, Yo Shibata, Zhongpu Zhang, Qing Li, Jun Zhou, Wurihan, Takuma Tobe, Sachiko Ikeda, Kazuko Yoshikawa, Yukie Shimada, Takashi Miyazaki
OBJECTIVE: Tooth enamel has unsurpassed hardness and stiffness among mammalian tissue structures. Such stiff materials are usually brittle, yet mature enamel can survive for a lifetime. Understanding the nanoscale origin of enamel durability is important for developing advanced load-bearing biomaterials. Here, nanoscale exceptional contact elasticity of the human tooth enamel, based on nanoindentation tests, is reported. METHODS: Spherical indenter tips with radii of 243 and 1041nm were used to determine stress-strain curves of enamel...
November 29, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/30479523/monitoring-heart-rate-variability-before-and-after-a-marathon-in-an-elite-wheelchair-athlete-a-case-study
#8
Santiago Sanz-Quinto, Gabriel Brizuela, Raúl López-Grueso, Andrew A Flatt, Adolfo Aracil-Marco, Raúl Reina, Manuel Moya-Ramón
The purpose of this study was to analyze heart rate variability (HRV) oscillations before and after a marathon which involved trans-meridian air travel and substantial time zone differences in a professional wheelchair athlete with Charcot-Marie-Tooth (CMT) disease. The natural logarithm of the root mean square difference between adjacent normal R-R intervals (Ln rMSSD) was measured daily on the days before, including and following the race. Relative to baseline, small (-3.8 - -4.6%) reductions in LnRMSSD were observed following relocation and on race-day, indicating only minor effects of travel on cardiac-autonomic activity...
December 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/30476868/dynamic-viscosity-of-colloidal-silica-suspensions-at-low-and-high-volume-fractions
#9
Siamak Samavat, Félix Carrique, Emilio Ruiz-Reina, Wei Zhang, Paul Melvyn Williams
A comprehensive study was carried out on the dynamic viscosity of X30 silica dispersions at both high and low volume fractions of colloidal silica particles at various electrolyte ionic strength and pH values. Booth and Ruiz-Reina and Carrique theoretical models (R-R&C) were compared in predicting the primary electroviscous effect (PEE) for viscosity at low volume fractions. To this respect the colloidal dispersion was well characterised with regards to electrolyte properties such as the Debye length, κ-1 , calculated from the ionic strength, and zeta potential, ζ, calculated from the electrophoretic mobility using the full numerical model by O'Brien and White (O'B&W)...
November 17, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30476174/cns-inflammatory-disorder-after-concurrent-radiotherapy-temozolomide-and-nivolumab-in-a-glioblastoma-patient
#10
Anna Luisa Di Stefano, Julien Savatovsky, Loic Feuvret, Chiara Villa, Vincent Reina, Micheline Pha, Caroline Houillier, Giulia Berzero, Ahmed Idbaih, Dimitri Psimaras
No abstract text is available yet for this article.
November 23, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/30473138/how-much-trunk-control-is-affected-in-adults-with-moderate-to-severe-cerebral-palsy
#11
David Barbado, Raúl Reina, Alba Roldan, Katina McCulloch, María Campayo-Piernas, Francisco J Vera-Garcia
Trunk control (TC) impairment is a typical feature in individuals with cerebral palsy (CP), but there are lack of methods that allow to quantify the extent to which static and dynamic TC is impaired in adults with moderate-to-severe CP. Thus, the aims of this study were to analyze the reliability of a posturography protocol to assess TC in adults with CP, and quantify their degree of TC impairment compared to a control sample of adults without CP. Forty-seven adults with moderate-to-severe CP and nineteen control participants were assessed via a protocol of static and dynamic seated trunk tasks, performed on a stable and an unstable surface placed on a force-plate...
November 15, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/30470624/fibroepithelial-breast-lesion-when-sequencing-can-help-to-make-a-clinical-decision-a-case-report
#12
Giacomo Montagna, Charlotte K Y Ng, Tatjana Vlajnic, Viola Paradiso, Sophie Dellas, Hubertina Reina, André Kind, Walter P Weber, Salvatore Piscuoglio, Christian Kurzeder
No abstract text is available yet for this article.
November 1, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/30462223/comparison-of-temperature-dependent-survivorship-and-wood-consumption-rate-among-two-invasive-subterranean-termite-species-blattodea-rhinotermitidae-coptotermes-and-their-hybrids
#13
Jayshree S Patel, Reina L Tong, Thomas Chouvenc, Nan-Yao Su
Two invasive subterranean termite species, Coptotermes formosanus Shiraki and Coptotermes gestroi Wasmann (Blattodea: Rhinotermitidae), established in South Florida have the potential to hybridize owing to their sympatric distribution, overlapping dispersal flight seasons, and interspecies mating behavior. This study examined the effects of temperature on survivorship and wood-consumption rate (WCR) to determine the potential of such hybrid termites as structural pests. Temperature tolerance was tested using groups of termites from incipient colonies established in the laboratory with four mating types (♀C...
November 21, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/30446698/relationship-between-orgasm-experience-and-sexual-excitation-validation-of-the-model-of-the-subjective-orgasm-experience
#14
Ana I Arcos-Romero, Reina Granados, Juan Carlos Sierra
The aim of this study was to provide validity evidence of the Model of the Subjective Orgasm Experience (MSOE) associating its components with different types of sexual excitation. A total of 96 participants (48 men and 48 women) performed an experimental laboratory task, in which neutral and erotic content films were presented while the genital response was registered. After exposure to sexual stimulus presentation, participants reported their subjective sexual arousal. In addition, four dimensions (affective, sensory, intimacy, and rewards) of the subjective orgasm experience and the individual propensity for sexual excitation were assessed...
November 16, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/30442946/parp3-a-new-therapeutic-target-to-alter-rictor-mtorc2-signaling-and-tumor-progression-in-brca1-associated-cancers
#15
Carole Beck, José Manuel Rodriguez-Vargas, Christian Boehler, Isabelle Robert, Vincent Heyer, Najat Hanini, Laurent R Gauthier, Agnès Tissier, Valérie Schreiber, Mikael Elofsson, Bernardo Reina San Martin, Françoise Dantzer
PARP3 has been shown to be a key driver of TGFβ-induced epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells, emerging as an attractive therapeutic target. Nevertheless, the therapeutic value of PARP3 inhibition has not yet been assessed. Here we investigated the impact of the absence of PARP3 or its inhibition on the tumorigenicity of BRCA1-proficient versus BRCA1-deficient breast cancer cell lines, focusing on the triple-negative breast cancer subtype (TNBC). We show that PARP3 knockdown exacerbates centrosome amplification and genome instability and reduces survival of BRCA1-deficient TNBC cells...
November 15, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/30428363/nup133-is-required-for-proper-nuclear-pore-basket-assembly-and-dynamics-in-embryonic-stem-cells
#16
Benoit Souquet, Ellen Freed, Alessandro Berto, Vedrana Andric, Nicolas Audugé, Bernardo Reina-San-Martin, Elizabeth Lacy, Valérie Doye
No abstract text is available yet for this article.
November 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/30412919/sentinel-lymph-node-biopsy-in-porocarcinoma-a-case-reports
#17
Simona Reina, Denise Palombo, Alexandru Boscaneanu, Nicola Solari, Sergio Bertoglio, Luca Valle, Ferdinando Cafiero
INTRODUCTION: Eccrine porocarcinoma (EPC) is a slow-growing carcinoma arising from the eccrine sweat glands. Based on its clinical presentation it can be confused with malignant and benign skin lesions, both. Histological examination is essential to formulate a correct diagnosis. Surgical excision with clear margins is the standard therapeutic approach while the role of sentinel lymph node biopsy (SNLB) remains controversial. CASE PRESENTATION: The Authors report two cases of EPC of the lower limbs occurred in two women...
October 31, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30409615/influence-of-saccharomyces-cerevisiae-and-lachancea-thermotolerans-co-inoculation-on-volatile-profile-in-fermentations-of-a-must-with-a-high-sugar-content
#18
M L Morales, J Fierro-Risco, R Ríos-Reina, C Ubeda, P Paneque
The aim of this work was to evaluate how the use of mixed cultures of Saccharomyces cerevisiae and Lachancea thermotolerans indigenous yeast strains influences the volatile composition of wine. Multivariate curve resolution (MCR) method has been applied to data analysis. Five fermentation trials were carried out: three co-inoculated with L. thermotolerans:S. cerevisiae, at the ratio of 50:1, 20:1 and 5:1 respectively, and two with a pure culture of each strain. A must from sun-dried Pedro Ximénez grapes was employed...
March 15, 2019: Food Chemistry
https://www.readbyqxmd.com/read/30409525/prevalence-of-influenza-b-yamagata-lineage-in-adults-in-the-2017-2018-flu-season
#19
Jordi Reina, Carmen López de Bilbao, Melchor Riera
No abstract text is available yet for this article.
November 5, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/30406436/the-association-of-the-broader-autism-phenotype-with-emotion-related-behaviors-in-mothers-of-children-with-and-without-autism-spectrum-traits
#20
Hannah M Rea, Reina S Factor, Deanna M Swain, Angela Scarpa
Broader autism phenotype (BAP) characteristics (pragmatic language deficits, aloofness, and rigidity) are prevalent in families of individuals with autism spectrum disorder (ASD) and may influence emotion-related behaviors. The current study analyzed associations among BAP characteristics with emotion-related behaviors in mothers of children with and without ASD. Twenty-seven mothers completed BAP and emotion regulation (ER) questionnaires. Maternal affect was coded during an interaction task. BAP rigidity negatively correlated with the ER strategy reappraisal...
November 7, 2018: Journal of Autism and Developmental Disorders
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