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Nathalie I Caversaccio, Maria D Reina Caro, Raja Prince, Martin Müller, Clayton S Lewis, Vladimir Y Bogdanov, Jean-François Dufour, Anne Angelillo-Scherrer
OBJECTIVES: In patients with chronic liver diseases, hypercoagulability can contribute to the progression of fibrosis and complications of cirrhosis. Tissue factor (TF) is a transmembrane glycoprotein that initiates the extrinsic pathway of blood coagulation. Recent investigations have established that TF is elevated in patients with pancreatic cancer, blood disorders, diabetes, and cardiovascular disease. Alternatively spliced tissue factor (asTF), a secreted form of TF, induces angiogenesis and exhibits low-level procoagulant activity...
August 14, 2018: European Journal of Gastroenterology & Hepatology
Takuya Miura, Reina Makino, Kouhei Yamada, Miku Matsuura, Misaki Okumura, Souichi Yamada, Shinji Watanabe, Naoki Inoue
As congenital cytomegalovirus (CMV) infection is the major cause of developmental abnormalities in children, the development of effective vaccines is critical to public health. Recent studies have demonstrated that the pentameric complex (Pentamer) of glycoproteins, which is required for human CMV infection of endothelial and epithelial cells, could be a potent vaccine antigen. As guinea pig CMV (GPCMV) infects congenitally and encodes homologues of all Pentamer components, GPCMV models are considered to be useful for the development of vaccine strategies...
August 16, 2018: Journal of General Virology
Miguel A Reina, André P Boezaart, Xavier Sala-Blanch, Enrique Monzó, R Shane Tubbs, Anna Server, Paul Bigeleisen
Recent anatomical discoveries indicate the importance of identifying membranes and compartments surrounding peripheral nerves into which local anesthetic agents can be injected and continuous nerve block catheters placed during regional anesthetic procedures. However, current markers used in anatomical studies have multiple drawbacks, specifically extravasation into non-injected locations, which cause confusion. We studied a readily-available new marker, heparinized blood solution (HBS), which is easy to identify by microscopy and can remain in the nerve compartment into which it is deposited without distorting the tissue...
August 16, 2018: Clinical Anatomy
Reina Yamaji, Cindy R Friedman, Julia Rubin, Joy Suh, Erika Thys, Patrick McDermott, Melody Hung-Fan, Lee W Riley
There is increasing evidence that retail food may serve as a source of Escherichia coli that causes community-acquired urinary tract infections, but the impact of this source in a community is not known. We conducted a prospective, population-based study in one community to examine the frequency of recovery of uropathogenic E. coli genotypes from retail meat samples. We analyzed E. coli isolates from consecutively collected urine samples of patients suspected to have urinary tract infections (UTIs) at a university-affiliated health service and retail meat samples from the same geographic region...
August 15, 2018: MSphere
Mariana F Fernández, Iris Reina-Pérez, Juan Manuel Astorga, Andrea Rodríguez-Carrillo, Julio Plaza-Díaz, Luis Fontana
The microorganisms that live symbiotically in human beings are increasingly recognized as important players in health and disease. The largest collection of these microorganisms is found in the gastrointestinal tract. Microbial composition reflects both genetic and lifestyle variables of the host. This microbiota is in a dynamic balance with the host, exerting local and distant effects. Microbial perturbation (dysbiosis) could contribute to the risk of developing health problems. Various bacterial genes capable of producing estrogen-metabolizing enzymes have been identified...
August 14, 2018: International Journal of Environmental Research and Public Health
Nadia Carolina Reina Gamba, Miguel Richart Martinez, Julio Cabrero García
OBJECTIVE: to describe the cross-cultural validation process of the "DISABKIDS" questionnaire in Colombia, for both the children and adolescents' version and the parents' version, an instrument intended to measure the health-related quality of life of Colombian children and adolescents with chronic diseases. METHOD: the cross-cultural validation process was conducted according to an international consensual systematic methodology, called standardized linguistic validation, to ensure linguistic equivalence with the original questionnaire...
August 9, 2018: Revista Latino-americana de Enfermagem
William H Trousdale, Christopher G Salib, Nicolas Reina, Eric A Lewallen, Anthony Viste, Daniel J Berry, Mark E Morrey, Joaquin Sanchez-Sotelo, Andre J van Wijnen, Matthew P Abdel
INTRODUCTION: The inflammatory cascade and production of prostaglandins may play a role in the pathogenesis of arthrofibrosis, a debilitating condition after joint replacement and other orthopedic procedures. Cyclooxygenase 2 (COX-2) inhibitors may mitigate the inflammatory response and formation of arthrofibrosis but oral delivery is associated with risk of systemic side effects in many patients. The non-steroidal anti-inflammatory drug (NSAID) drug celecoxib may have therapeutic benefits for arthrofibrosis, but current methods for its local delivery (e...
August 13, 2018: Tissue Engineering. Part C, Methods
Mariasanta Napolitano, Salvatrice Mancuso, Lucio Lo Coco, Piera Stefania Arfò, Simona Raso, Giovanni De Francisci, Francesco Dieli, Nadia Caccamo, Amalia Reina, Alberto Dolce, Rosalia Agliastro, Sergio Siragusa
Cryopreservation for the long-term storage of platelets (PLTs) is a useful method to overcome the limits of platelet shortage. This is an in vitro prospective study to evaluate the count, viability, and function of buffy coat-derived pooled platelet concentrates (BC-PLTs), treated with dimethyl sulphoxide (DMSO) and cryopreserved (CRY BC-PLTs) at -80 °C with a modified Valeri method. PLTs were stored in 6% DMSO with a patented kit. Overall, 49 BC-PLTs from 245 healthy volunteer donors were prepared, cryopreserved, and analysed before and after 3, 6, and 9 months of storage...
August 1, 2018: Transfusion and Apheresis Science
Pierre Laumonerie, Meagan E Tibbo, Nicolas Reina, Thuy Trang Pham, Nicolas Bonnevialle, Pierre Mansat
There has been lively debate regarding the rationale behind the use of radial head arthroplasty (RHA) for more than 80 years. Currently, its primary indication is for treatment of non-reconstructible RH fractures. The first RH implant, released in 1941, was a ferrul cap used to prevent heterotopic ossification. Biomechanical studies in the 1980s stimulated a revolution in RHA design by promoting modular implants that replicated the native bony anatomy of the elbow. Subsequent data-driven evolution in design led to the creation of a variety of devices that also accommodated for common ligamentous injuries occurring at the time of RH fracture...
August 10, 2018: International Orthopaedics
Smadar Shiffman, Sayantani Basak, Cleopatra Kozlowski, Reina N Fuji
BACKGROUND: Histologic evaluation of the central nervous system is often a critical endpoint in in vivo efficacy studies, and is considered the essential component of neurotoxicity assessment in safety studies. Automated image analysis is a powerful tool that can radically reduce the workload associated with evaluating brain histologic sections. NEW METHOD: We developed an automated brain mapping method that identifies neuroanatomic structures in mouse histologic coronal brain sections...
August 7, 2018: Journal of Neuroscience Methods
C Camps Herrero, J J Reina Zoilo, D Monge Martín, F Caballero Martínez, V Guillem Porta, E Aranda Aguilar, A Carrato Mena, E Díaz-Rubio García, J García-Foncillas López, M Feijóo Saus, R López López
AIMS: To prove if there is clinical inertia in the identification and treatment of episodes of breakthrough cancer pain (BTcP), comparing actual results from clinical practice with clinical oncologists' prior perception. DESIGN: Observational and descriptive study, using information collected by practising medical oncologists, at three moments: (a) questionnaire regarding their professional judgement of the handling of patients with BTcP in their practice, (b) cross-sectional clinical screening, to detect possible existing cases of BTcP in a representative sample of their patients, (c) retrospective self-audit of clinical case histories of patients diagnosed with BTcP to find out about how it has been handled...
August 9, 2018: Clinical & Translational Oncology
Alejandro Espejo-Baena, Alejandro Espejo-Reina, María Josefa Espejo-Reina, Jaime Dalla Rosa-Nogales, Joaquina Ruiz-Del Pino, María Belén Martín-Castilla
A technique for augmentation of the partial anterior cruciate ligament is presented. The patient is positioned supine with the knee flexed 90°. After addressing intra-articular injuries, the autologous semitendinosus tendon is harvested and measured in a doubled manner; after that, the tibial tunnel is performed in the outside-in direction, of the same diameter of the doubled graft. Both ends of the graft are sutured together, after inserting it through the loop of a suspension device, which is attached in its augmentation piece...
July 2018: Arthroscopy Techniques
Subhayan Sur, Reina Sasaki, Pradip Devhare, Robert Steele, Ranjit Ray, Ratna B Ray
Chronic hepatitis C virus (HCV) infection may lead to end stage liver disease, including hepatocellular carcinoma (HCC). We have previously shown that microRNA-373 (miR-373) is upregulated in HCV infected human liver biopsy specimens. To gain insights the role of miR-373 in HCV mediated pathogenesis, we investigated its interacting partner for hepatocyte growth regulation. RNA-seq data revealed that Wee1 is associated with miR-373, and is a direct target. Interestingly, higher expression of Wee1 was noted in HCV infected hepatocytes, suggesting other factors may block miR-373 mediated Wee1 inhibition...
August 8, 2018: Journal of Virology
Ben F M Wijnen, Scarlett L Schat, Reina J A de Kinderen, Albert J Colon, Pauly P W Ossenblok, Silvia M A A Evers
BACKGROUND: Diagnosing epilepsy can be lengthy and stressful, potentially leading to increased use of healthcare resources and a reduction in quality of life. AIM: This study aims to determine cost and quality of life before and after an optimized diagnostic procedure for people suspected of having epilepsy from a societal perspective with a follow-up of 12 months. In addition, this study aims to differentiate between people diagnosed with epilepsy during the follow-up of the study and the people who are diagnosed as not having epilepsy or for whom diagnosis is still uncertain...
July 31, 2018: Epilepsy Research
Marcelo Rudzinski, Carina Argüelles, Cristóbal Couto, José R Oubiña, Silvia Reina
PURPOSE: The purpose of this article is to analyze possible associations between systemic and ocular cytokine levels and specific clinical ophthalmologic signs from patients with a reactivation of toxoplasmic retinochoroiditis (RTR). METHODS: A total of 18 patients with an active RTR episode, 8 patients with inactive scars, and 14 control patients were included in the study. Serum samples and aqueous humor (AH) samples were analyzed for IFN (interferon)-γ, interleukin (IL)-10, and IL-6 levels by ELISA...
August 6, 2018: Ocular Immunology and Inflammation
Tara DeBoer, Niren Murthy, Nicole Tarlton, Reina Yamaji, Sheila Adams-Sapper, Tiffany Wu, Santanu Maity, Giri Vegesna, Corinne Sadlowski, Peter DePaola, Lee W Riley
Biochemical assays that can identify β-lactamase activity directly from patient samples have the potential to significantly improve the treatment of bacterial infections. However, current β-lactamase probes do not have the sensitivity needed to measure β-lactam resistance directly from patient samples. Here, we report the development of an instrument-free signal amplification technology, DETECT, that connects the activity of two enzymes in series to effectively amplify the activity of β-lactamase by 40,000-fold, compared to the standard β-lactamase probe nitrocefin...
August 5, 2018: Chembiochem: a European Journal of Chemical Biology
Reina Yamamoto, Kosuke Robert Shima, Hirobumi Igawa, Yuka Kaikoi, Yasuo Sasagawa, Yasuhiko Hayashi, Naoko Inoshita, Hidenori Fukuoka, Yutaka Takahashi, Toshinari Takamura
A 43-year-old woman with an 8-year history of diabetes, hypertension, and dyslipidemia presented with amenorrhea and convulsion. Her MRI scan revealed a 3.5-cm T2-hyperintense pituitary macroadenoma with suprasellar extension to the frontal lobe and bilateral cavernous sinus invasion. Her serum levels of GH and insulin-like growth factor-I (IGF-I) were elevated to 9.08 ng/mL (normal range: <2.1 ng/mL) and 1,000 ng/mL (normal range: 90-233 ng/mL, SD score +10.6), respectively. Bromocriptine insufficiently suppressed her GH levels, while octreotide paradoxically increased her GH levels...
August 4, 2018: Endocrine Journal
Shuntaro Mukai, Takao Itoi, Atsushi Sofuni, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjo, Mitsuru Fujita, Kenjiro Yamamoto, Yuichi Nagakawa
BACKGROUND AND AIMS: Although balloon enteroscopy-assisted ERCP (BE-ERCP) is effective and safe for benign biliary diseases in patients with surgically altered anatomy (SAA), BE-ERCP is not always successful. Recently, EUS-guided antegrade intervention (EUS-AI) including a 1-stage or 2-stage procedure has been developed for BE-ERCP failure cases. The aim of the present study was to evaluate the outcome of EUS-AI for benign biliary diseases with SAA. METHODS: Of 48 patients in whom BE-ERCP failed, percutaneous transhepatic intervention was performed in 11 patients...
August 1, 2018: Gastrointestinal Endoscopy
Francesca Audino, Gerard Campanyà, Montserrat Pérez-Moya, Antonio Espuña, Moisès Graells
The photo-Fenton process is a photochemical process that has proved to be highly efficient in degrading new potentially harmful contaminants. Despite of this, scarce attention has been paid to the development of systematic procedures and optimisation strategies to efficiently operate such a process. The present work aims at investigating the effectiveness of a model-based approach in carrying out the dynamic optimisation of the recipe of a photo-Fenton process, performed in fed-batch mode (reactant dosage)...
July 29, 2018: Science of the Total Environment
Pierre Laumonerie, Meagan E Tibbo, Panagiotis Kerezoudis, Marc Olivier Gauci, Nicolas Reina, Nicolas Bonnevialle, Pierre Mansat
BACKGROUND: The MoPyC implant is an uncemented long-stemmed radial head prosthesis that obtains primary press-fit fixation via controlled expansion of the stem. Current literature regarding MoPyC implants appears promising; however, sample sizes in these studies are small. Our primary objective was to evaluate the short- to midterm clinical outcomes of a large sample of the MoPyC prostheses. The secondary objective was to determine the reasons for failure of the MoPyC devices. METHODS: Four electronic databases were queried for literature published between January 2000 and March 2017...
July 30, 2018: International Orthopaedics
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