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David Brauge, Catherine Horodyckid, Marta Arrighi, Vincent Reina, Christophe Eap, Etienne Mireau, Baussart Bertrand, Sorin Aldéa, Stephan Gaillard
BACKGROUND: Giant thoracic disc herniation (gTDH) is a rare condition. It is defined by a herniation that occupies at least 40% of the thoracic spinal canal and is usually calcified. Several surgical techniques have been described to date but this surgery remains a technically difficult procedure. OBJECTIVE: To report the long-term outcome of 53 patients with myelopathy due to gTDH who were operated on by a thoracoscopic approach. The technical details of the preoperative assessment and the surgical procedure are presented...
October 17, 2018: Operative Neurosurgery (Hagerstown, Md.)
José Ignacio de Granda-Orive, José Francisco Pascual-Lledó, Santos Asensio-Sánchez, Segismundo Solano-Reina, Marcos García-Rueda, Manuel Ángel Martínez-Muñiz, Lourdes Lázaro-Asegurado, Daniel Bujulbasich, Rogelio Pendino, Susana Luhning, Isabel Cienfuegos-Agustín, Carlos A Jiménez-Ruiz
OBJECTIVE: To evaluate the association between degrees of nicotine dependence measured by the Fagerström test (FTCD) and different tests of motivation to stop smoking. MATERIAL AND METHODS: Observational study, multicenter conducted in smoking clinics in daily clinical practice. Demographics, smoking status, FTCD scores, and motivation test results were collected: Richmond test (TR), Henri Mondor Paris motivation test (HMP), Khimji-Watts test (KW), and the visual analog scale of motivation to stop smoking...
October 10, 2018: Archivos de Bronconeumología
Mark Zimmerman, Jacob Martin, Patrick McGonigal, Lauren Harris, Sophie Kerr, Caroline Balling, Reina Kiefer, Kasey Stanton, Kristy Dalrymple
BACKGROUND: DSM-5 introduced the anxious distress specifier in recognition of the clinical significance of anxiety in depressed patients. Recent studies that supported the validity of the specifier did not use measures that were designed to assess the criteria of the specifier but instead approximated the DSM-5 criteria from scales that were part of an existing data base. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we examined the validity of the specifier diagnosed with a semistructured interview...
October 12, 2018: Depression and Anxiety
Samuel Vilar, Jose Manuel Castillo, Pedro V Munuera Martínez, María Reina, Manuel Pabón
Background: One of the most frequent problems caused by diabetes is the so called painful diabetic neuropathy. This condition can be treated through numerous types of therapy. The purpose of this study was to analyze, as a meta-analysis, different treatments used to alleviate painful diabetic neuropathy, with the aim of generating results that help making decisions when applying such treatments to tackle this pathology. Methods: A search was conducted in the main databases for Health Sciences, such as PUBMED, Web of Science (WOS), and IME biomedicina (Spanish Medical Reports in Biomedicine), to gather randomized controlled trials about treatments used for painful diabetic neuropathy...
October 2018: Korean Journal of Pain
Ippei Nagamori, Hisato Kobayashi, Toru Nishimura, Reina Yamagishi, Jun Katahira, Satomi Kuramochi-Miyagawa, Tomohiro Kono, Toru Nakano
Retrotransposon genes are silenced by DNA methylation because of potential harm due to insertional mutagenesis. DNA methylation of retrotransposon genes is erased and re-established during male germ cell development. Both piRNA-dependent and piRNA-independent mechanisms are active during the re-establishment process, with the piRNA-independent mechanism occurring first. In this study, we analyzed the role of PIWIL4/MIWI2 in the modification of histone H3 and subsequent piRNA-dependent DNA methylation. Dimethylation at H3K4 is highly enriched at piRNA-dependent methylated regions and anti-correlated with de novo DNA methylation during the phase of piRNA-independent DNA methylation...
October 9, 2018: Cell Reports
Federico Alberici, Francesco Bonatti, Federica Maritati, Maria Letizia Urban, Gabriella Moroni, Giacomo Emmi, Alessia Adorni, Michele Reina, Augusto Vaglio, Davide Martorana
OBJECTIVES: Chronic periaortitis (CP) is an inflammatory disease associated in 20-60% of the cases with IgG4 related disease. Current evidence supports an autoimmune nature for CP. Fc gamma receptors (FcγRs) are involved in several immune system activities and are associated with autoimmunity in general. We explored the influence of genetic variants within this region on susceptibility to CP. METHODS: Genotyping of 4 candidate single nucleotide polymorphisms (SNPs) of the FCGR region was performed in CP patients and controls...
September 17, 2018: Clinical and Experimental Rheumatology
Agostina Zucotti, Lucrecia Bolaño, Fabiana Alicia Berruezo, Susana Vitozzi, Marina Bottiglieri
Introduction: The presence of C. trachomatis in pregnant women can cause premature rupture of membranes, postpartum endometritis and preterm birth. Clinical diagnosis is more difficult among those who have an asymptomatic infection. Objective: know the prevalence of Chlamydia trachomatis in pregnant women in their first trimester and to detect if there are any factors associated with this bacterium. Material and methods: Prospective, descriptive, cross sectional and correlational study performed at Clínica Universitaria Reina Fabiola, in Córdoba, between October 2016 and April 2017...
September 20, 2018: Revista de la Facultad de Ciencias Médicas
Alejandro Gallego-Schmid, Raphael Ricardo Zepon Tarpani, Sara Miralles-Cuevas, Alejandro Cabrera-Reina, Sixto Malato, Adisa Azapagic
Scarcity of water and concerns about the ecotoxicity of micro-contaminants are driving an interest in the use of advanced tertiary processes in wastewater treatment plants. However, the life cycle environmental implications of these treatments remain uncertain. To address this knowledge gap, this study evaluates through life cycle assessment the following four advanced process options for removal of micro-contaminants from real effluents: i) solar photo-Fenton (SPF) operating at acidic pH; ii) acidic SPF coupled with nanofiltration (NF); iii) SPF operating at neutral pH; and iv) neutral SPF coupled with NF...
October 1, 2018: Science of the Total Environment
Maria Cristina Carvalho do Espírito-Santo, Maíra Reina Magalhães, Naíma Mortari, Francisco Oscar de Siqueira França, Expedito José de Albuquerque Luna, Ronaldo Cesar Borges Gryschek
OBJECTIVE: Schistosomiasis remains a public health problem. This was a descriptive and retrospective study of 42 patients with a severe form of schistosomiasis who were admitted to the outpatient clinic of the Faculdade de Medicina da Universidade de São Paulo, São Paulo, in São Paulo, Brazil. METHODS: A data collection questionnaire was designed from the patient charts, and the following variables were evaluated: age, sex, place of birth, occupation, signs and symptoms of schistosomiasis, data from laboratory and imaging examinations, data regarding treatment outcomes, and the existence of comorbidities...
September 21, 2018: Clinics
Aitor Iturricastillo, Cristina Granados, Jesús Cámara, Raúl Reina, Daniel Castillo, Itziar Barrenetxea, Lander Lozano, Javier Yanci
PURPOSE: The main purpose of the present study was to determine physiological responses in wheelchair basketball (WB) matches in relation to heart rate (HR), match load (ML), differentiated perceived exertion (dRPE), lactate concentrations (LA), and tympanic temperature (TEMP), while specifying the individual player's playing time during different types of matches. METHOD: Nine Spanish First Division WB players participated in the study. Three groups were determined for each observation (i...
September 27, 2018: Research Quarterly for Exercise and Sport
Vincent Marot, Jérôme Murgier, Alessandro Carrozzo, Nicolas Reina, Edoardo Monaco, Philippe Chiron, Emilie Berard, Etienne Cavaignac
PURPOSE: The KOOS questionnaire is used to assess the symptoms and function of patients with traumatic or degenerative knee pathology. The WOMAC score has been validated mainly in the context of knee osteoarthritis. The distribution of these scores in a non-diseased population is not known. The hypothesis was that KOOS and WOMAC scores were influenced by patients' age, sex, and BMI. The primary objective of this study was to describe, for the first time, the distribution of KOOS and WOMAC scores in a healthy population based on age, sex, and BMI...
September 24, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Andrea P Quintero, Kely Johana Bonilla-Vargas, Jorge E Correa-Bautista, María A Domínguez-Sanchéz, Héctor R Triana-Reina, Gina P Velasco-Orjuela, Antonio García-Hermoso, Emilio Villa-González, Irene Esteban-Cornejo, María Correa-Rodríguez, Robinson Ramírez-Vélez
There is currently a consensus about the positive effects of physical exercise on cognition. However, the exercise intensity-dependent effect on executive function remains unclear. Thus, the aim of this study was to compare the acute effects of high-intensity aerobic interval training (HIIT), progressive resistance training (PRT), or combined training (PRT + HIIT) on executive function indicators in overweight inactive adult men (aged 18-30 years old). The participants were screened and excluded for medical conditions known to impact cognitive functioning, which was measured with the Montreal Cognitive Assessment (MoCA) screening cognitive test...
December 1, 2018: Physiology & Behavior
Raúl Montoya-Chinchilla, Álvaro Caballero-González, Leandro Reina-Alcaina, Asensio García-Nicolás, Pablo Velilla-Asurmendi, María Dolores Piqueras-Acevedo, Inés Bello-Pombo, Antonio Rosino-Sánchez
OBJECTIVES: Due to the scarcity of scientific articles that review the technical alternatives available for aesthetic modifications in the penis that are the cause of subsequent uro-andrological problems, the existing literature is reviewed after the assistance of a penile infection by injection of subcutaneous hyaluronic acid with aesthetic purposes. MATERIAL AND METHODS: A 38-year-old male patient with no medical or psychiatric remarkable reports who came to the emergency room due to inflammation and abscess in penile skin after injection of hyaluronic acid...
September 20, 2018: Revista Internacional de Andrología
Esperanza Macarena López-Pliego, Juan Mora-Macías, Miguel Ángel Giráldez-Sánchez, Jaime Domínguez, Esther Reina-Romo
INTRODUCTION: Bone transport appears to be a solution for segmental bone defects; specifically, the "docking site" is where the transported segment meets the target segment at the end of the process. A lack of its consolidation is one of the major causes of failure for this technique. Many studies have been performed in order to enhance the consolidation of the docking site, but histological changes occurring in it remain unknown. The aim of this study was to determine microscopic changes present in this area, from distraction to remodeling, in order to clarify the best options to facilitate the success of this technique...
September 14, 2018: Injury
Roger Bresolí-Obach, Luis Busto-Moner, Claudia Muller, Manuel Reina, Santi Nonell
A biocompatible fluorescent nanoprobe for the detection of reactive oxygen species in biological systems has been designed, synthesized and characterized, circumventing some of the limitations of the molecular probe diacetyl 2',7'-dichlorodihydrofluorescein (DCFH-DA). It has been synthetized the nanoparticulate form of DCFH-DA by covalently attaching the widely used fluorescent probe DCFH-DA to a mesoporous silica nanoparticle through a linker. The reactivity of nanoDCFH-DA has been tested toward several reactive oxygen species...
September 21, 2018: Photochemistry and Photobiology
Kanako Nishiyama, Yoshiaki Kamei, Erina Kusakabe, Haruna Yamasawa, Reina Aoki, Saaya Komatsu, Kana Taguchi, Akari Murakami, Michiko Yamashita
Case 1 involved a 75-year-old woman with breast cancer and diffuse large B-cell lymphoma(DLBCL).Although we initially administered the R-CHOP regimen, the breast tumor increased in size and surgery had to be performed.After surgery, the R-CHOP regimen was re-initiated and DLBCL achieved clinical complete response.Case 2 involved a 74-year-old woman with breast cancer and gastric MALT lymphoma.After administration of rituximab and H. pylori eradication, a therapeutic effect was achieved in the lymphoma.A docetaxel and FEC regimen was continuously administered and surgery was performed...
September 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Gabriela Noronha de Toledo, Pamela Rodrigues Reina Moreira, Daniele Santos Rolemberg, Andréia Coutinho Facin, Julio Edward Hough Monteiro, Mareliza Possa de Menezes, Maria Eduarda Bastos Andrade Moutinho da Conceição, Felipe Augusto Ruiz Sueiro, Rosemeri de Oliveira Vasconcelos, Paola de Castro Moraes, Mirela Tinucci Costa, Andrigo Barboza de Nardi
Osteosarcoma is the most commonly reported bone tumor in dogs, typically affecting the axial and appendicular skeleton. Involvement of the paranasal sinuses and the nasal cavity is extremely rare. This report describes a 6-year-old, female, cross-breed dog presented with signs of 90 days duration and diagnosed with a mass located in the right nasal cavity. Radiography, rhinoscopy, and computed tomography findings suggested the presence of an intranasal tumor. Osteosarcoma in the nasal cavity was diagnosed based on histopathological examination and clinical and imaging findings...
June 2018: Topics in Companion Animal Medicine
Gang Lu, Stephanie Weng, Mary Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana Couto, Brian Cathers, James Carmichael, Philip Chamberlain, Mark Rolfe
The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN ) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjunction with E2 ubiquitin-conjugating enzymes, which have until now remained elusive. Here we show that the ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 cooperatively promote the K48-linked polyubiquitination of CRL4CRBN neomorphic substrates via a sequential ubiquitination mechanism...
September 20, 2018: ELife
Stephen Salloway, Lee A Honigberg, William Cho, Michael Ward, Michel Friesenhahn, Flavia Brunstein, Angelica Quartino, David Clayton, Deborah Mortensen, Tobias Bittner, Carole Ho, Christina Rabe, Stephen P Schauer, Kristin R Wildsmith, Reina N Fuji, Shehnaaz Suliman, Eric M Reiman, Kewei Chen, Robert Paul
BACKGROUND: We investigated the effect of crenezumab, a humanized anti-amyloid-beta (Aβ) immunoglobulin (Ig)G4 monoclonal antibody, on biomarkers of amyloid pathology, neurodegeneration, and disease progression in patients with mild-to-moderate Alzheimer's disease (AD). METHODS: This double-blind, placebo-controlled, randomized phase II study enrolled patients with mild-to-moderate AD and a Mini-Mental State Examination (MMSE) score of 18-26. In part 1 of the study, patients were 2:1 randomized to receive low-dose subcutaneous (SC) 300 mg crenezumab every 2 weeks (q2w) or placebo for 68 weeks; in part 2, patients were 2:1 randomized to receive high-dose intravenous (IV) 15 mg/kg crenezumab every 4 weeks (q4w) or placebo for 68 weeks...
September 19, 2018: Alzheimer's Research & Therapy
Javier Troyano, Arnau Carné-Sánchez, Javier Pérez-Carvajal, Laura León-Reina, Inhar Imaz, Aurelio Cabeza, Daniel Maspoch
Here, we exploit the well-known swelling behaviour of metal-organic frameworks (MOFs) to create a self-folding polymer film. Namely, we show that incorporating crystals of the flexible MOF MIL-88A into a polyvinylidene difluoride (PVDF) matrix affords a polymer composite film that undergoes reversible shape transformations upon exposure to polar solvents and vapours. Since the self-folding properties of this film correlate directly with the swelling properties of the MIL-88A crystals, it selectively bends to certain solvents and its degree of folding can be controlled by controlling the relative humidity...
September 18, 2018: Angewandte Chemie
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