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Total Body Cooling

Wendy A Pethick, Holly J Murray, Paula McFadyen, Ryan Brodie, Catherine A Gaul, Trent Stellingwerff
The impact of hydration status was investigated during a 5-day heat acclimation (HA) training protocol versus mild/cool control conditions on plasma volume (PV) and performance (20km time-trial (TT)). Sub-elite athletes were allocated to one of two heat training groups (90 min/day): 1) dehydrated to ~2% body weight (BW) loss in heat (35°C; DEH; n=14); 2) euhydrated heat (35°C; EUH; n=10), where training was isothermally clamped to 38.5°C core temperature (Tc). A euhydrated mild control group (22°C; CON; n=9) was later added, with training clamped to the same relative heart rate (~75% HRmax) as elicited during DEH and EUH; thus all groups experienced the same internal training stress (%HRmax)...
October 13, 2018: Scandinavian Journal of Medicine & Science in Sports
Y N Prashantha, P N Suman Rao, Saudamini Nesargi, B S Chandrakala, Kalyan Chakravarthy Balla, A Shashidhar
BACKGROUND: Different methods have been used for therapeutic hypothermia for neonates with moderate-to-severe hypoxic ischaemic encephalopathy (HIE). As standard cooling devices are expensive, there is a need to establish the safety and efficacy of low-cost devices such as ice packs (IP) and phase changing material (PCM). AIM: To assess the efficacy and safety of therapeutic hypothermia (TH) and the clinico-laboratory profile of neonates who underwent cooling with IP or PCM...
August 15, 2018: Paediatrics and International Child Health
J F Willms, O Boss, E Keller
BACKGROUND: Fever control plays a key role in therapy of patients with acute brain injury. The infusion of cold saline could serve as an alternative or additional method for targeted temperature management. However, it is difficult to estimate the amount of fluid required to achieve normothermia merely on the basis of body weight. There is no standardized load management regarding the administration of cold saline, and no closed-loop systems based on continuous temperature-controlled feedback are available...
August 10, 2018: Neurocritical Care
Jun Zhang, Kaiyin Liu, Omar Elmadhoun, Xunming Ji, Yunxia Duan, Jingfei Shi, Xiaoduo He, Xiangrong Liu, Di Wu, Ruiwen Che, Xiaokun Geng, Yuchuan Ding
Hypothermia is considered as a promising neuroprotective treatment for ischemic stroke but with many limitations. To expand its clinical relevance, this study evaluated the combination of physical (ice pad) and pharmacological [transient receptor potential vanilloid channel 1 (TRPV1) receptor agonist, dihydrocapsaicin (DHC)] approaches for faster cooling and stronger neuroprotection. A total of 144 male Sprague Dawley rats were randomized to 7 groups: sham (n=16), stroke only (n=24), stroke with physical hypothermia at 31ºC for 3 h after the onset of reperfusion (n=24), high-dose DHC (H-DHC)(1...
August 2018: Aging and Disease
Yue Liu, Harry Grier, Terrence R Tiersch
Previous studies of sperm cryopreservation of livebearing fish have been limited to two genera within the family Poeciliidae. The goal of the present study was to investigate the feasibility to produce live young of livebearing goodeids (family Goodeidae) with cryopreserved sperm, using aquarium-trade populations of the endangered species Redtail Splitfin (Xenotoca eiseni, Rutter, 1896). Reproductive condition of females was evaluated by histological categorization of ovarian development. A total of 117 females were inseminated with cryopreserved sperm, 81 were inseminated with fresh sperm, 27 were mixed with males for natural breeding, and 30 were maintained without males or insemination...
September 2018: Animal Reproduction Science
Oliver Rivero-Arias, Oya Eddama, Denis Azzopardi, A David Edwards, Brenda Strohm, Helen Campbell
OBJECTIVE: To assess the impact of hypothermic neural rescue for perinatal asphyxia at birth on healthcare costs of survivors aged 6-7 years, and to quantify the relationship between costs and overall disability levels. DESIGN: 6-7 years follow-up of surviving children from the Total Body Hypothermia for Neonatal Encephalopathy (TOBY) trial. SETTING: Community study including a single parental questionnaire to collect information on children's healthcare resource use...
July 11, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Robyn S Hetem, Duncan Mitchell, Brenda A de Witt, Linda G Fick, Shane K Maloney, Leith C R Meyer, Andrea Fuller
As one of the few felids that is predominantly diurnal, cheetahs (Acinonyx jubatus Von Schreber, 1775) can be exposed to high heat loads in their natural habitat. Little is known about long-term patterns of body temperature and activity (including hunting) in cheetahs because long-term concurrent measurements of body temperature and activity never have been reported for cheetahs, or indeed for any free-living felid. We report here body temperature and locomotor activity measured with implanted data loggers over seven months in five free-living cheetahs in Namibia...
May 31, 2018: Integrative Zoology
Nobuyuki Kobayashi, Fujiang Hou, Atsushi Tsunekawa, Xianjiang Chen, Tianhai Yan, Toshiyoshi Ichinohe
Objective: In dryland areas of China, alfalfa hay (AH) is a possible substitute for concentrate feed for beef cattle. To evaluate the potential benefits of this substitution, we studied the effect of the ratio of AH intake to total DM intake on average daily body-weight gain (ADG), dietary energy utilization status, and economic benefit in Gansu province. Methods: In each of two feeding trials in 2016 (trial 1 [T1], July 3 to 17; trial 2 [T2], August 15 to September 23), crossbred male Simmental calves were allocated to low AH (LA), medium AH (MA), and high AH (HA) feeding groups (n = 4 per group)...
May 24, 2018: Asian-Australasian Journal of Animal Sciences
Jianhua Zhao, Qing Mao, Zhongxin Qian, Jun Zhu, Zhun Qu, Chao Wang
Mild hypothermia combined with minimally invasive hematoma evacuation was evaluated in the treatment of hypertensive intracerebral hemorrhage to reduce inflammatory response of brain tissue around hematoma and ameliorate brain function, and to investigate its safety, effectiveness and feasibility. A total of 206 patients with acute spontaneous hypertensive intracerebral hemorrhage were collected clinically and randomly divided into minimally invasive hematoma evacuation group (group A) and mild hypothermia combined with minimally invasive hematoma evacuation (group B)...
June 2018: Experimental and Therapeutic Medicine
Cíntia Carol de Melo Costa, Alex Sandro Campos Maia, Tami M Brown-Brandl, Marcos Chiquitelli Neto, Vinicius de França Carvalho Fonsêca
The aim of this work was to evaluate the diurnal patterns of physiological responses and the thermal regulation of adult Nellore bulls. Six 30-mo-old Nellore bulls (669 ± 65 kg BW) were randomly assigned to four 6-h periods in a Latin Square design such that measurements of each animal cover a 24-h cycle. Meteorological variables (air temperature, relative humidity, local solar irradiance, ultraviolet radiation, wind speed and black globe temperature) were recorded at regular one-minute intervals with an automated weather station...
May 2018: Journal of Thermal Biology
Yefeng Yang, Chenghuang Zhen, Bo Yang, Yonghua Yu, Jinming Pan
Though previous study indicated that the 580 nm-yellow-LED-light showed an stimulating effect on growth of chickens, the low luminous efficiency of the yellow LED light cannot reflect the advantage of energy saving. In present study, the cool white LED chips and yellow LED chips have been combined to fabricate the white × yellow mixed LED light, with an enhanced luminous efficiency. A total 300 newly hatched chickens were reared under various mixed LED light. The results indicated that the white × yellow mixed LED light had "double-edged sword" effects on bird's body weight, bone development, adipose deposition, and body temperature, depending on variations in ratios of yellow component...
June 2018: Journal of Photochemistry and Photobiology. B, Biology
M Benjamin Barth, Katja Buchwalder, Akito Y Kawahara, Xin Zhou, Shanlin Liu, Nicolas Krezdorn, Björn Rotter, Ralf Horres, Anna K Hundsdoerfer
Background: The European spurge hawkmoth, Hyles euphorbiae (Lepidoptera, Sphingidae), has been intensively studied as a model organism for insect chemical ecology, cold hardiness and evolution of species delineation. To understand species isolation mechanisms at a molecular level, this study aims at determining genetic factors underlying two adaptive ecological trait candidates, phorbol ester (TPA) detoxification and seasonal cold acclimation. Method: A draft transcriptome of H...
2018: Frontiers in Zoology
Jérôme Rambaud, Fanny Lidouren, Michaël Sage, Matthias Kohlhauer, Mathieu Nadeau, Étienne Fortin-Pellerin, Philippe Micheau, Luca Zilberstein, Nicolas Mongardon, Jean-Damien Ricard, Megumi Terada, Patrick Bruneval, Alain Berdeaux, Bijan Ghaleh, Hervé Walti, Renaud Tissier
BACKGROUND: Ultrafast cooling by total liquid ventilation (TLV) provides potent cardio- and neuroprotection after experimental cardiac arrest. However, this was evaluated in animals with no initial lung injury, whereas out-of-hospital cardiac arrest is frequently associated with early-onset pneumonia, which may lead to acute respiratory distress syndrome (ARDS). Here, our objective was to determine whether hypothermic TLV could be safe or even beneficial in an aspiration-associated ARDS animal model...
May 2, 2018: Annals of Intensive Care
Yelin Ko, Joo-Young Lee
BACKGROUND: As a way of helping to sleep in winter, methods of warming the feet through footbaths or heating pads before bedtime are tried. In particular, bed socks are popular during winter sleeping in Korea, but scientific evidence about the physiological effects of bed socks on sleep quality is rarely reported. The purpose of this study was to evaluate the effect of feet warming using bed socks on sleep quality and thermoregulatory responses during sleep in a cool environment. METHODS: Six young males (22...
April 24, 2018: Journal of Physiological Anthropology
Jason Ng, Jonathan E Wingo, Phillip A Bishop, Jason C Casey, Elizabeth K Aldrich
INTRODUCTION: Precooling with ice slurry ingestion attenuates the increase in rectal temperature (Tre) during subsequent running and cycling. It remains unclear how this cooling method affects physiological strain during work while wearing protective garments. This study investigated the effect of ice slurry ingestion on physiological strain during work in hot conditions while wearing firefighter protective clothing. METHODS: In three counterbalanced trials, eight men (mean ± SD; age = 21 ± 2 yr, height = 179...
May 1, 2018: Aerospace Medicine and Human Performance
Patrick J Lindsay, Danielle Buell, Damon C Scales
BACKGROUND: Mild therapeutic hypothermia (TH), or targeted temperature management, improves survival and neurological outcomes in patients after out-of-hospital cardiac arrest (OHCA). International guidelines strongly support initiating TH for all eligible individuals presenting with OHCA; however, the timing of cooling initiation remains uncertain. This systematic review and meta-analysis was conducted with all available randomised controlled trials (RCTs) included to explore the efficacy and safety of initiating pre-hospital TH in patients with OHCA...
March 13, 2018: Critical Care: the Official Journal of the Critical Care Forum
Helen Campbell, Oya Eddama, Denis Azzopardi, A David Edwards, Brenda Strohm, Oliver Rivero-Arias
OBJECTIVE: To assess the impact of hypothermic neural rescue at birth on health-related quality of life (HRQL) in middle childhood. DESIGN: Six-year to 7-year follow-up of surviving children from the Total Body Hypothermia for Neonatal Encephalopathy (TOBY) Trial. SETTING: Community study including a single parental questionnaire to collect information on children's HRQL. PATIENTS: 145 children (70 in the control group, 75 in the hypothermia group) whose parents consented and returned the questionnaire...
July 2018: Archives of Disease in Childhood
Jan Rozsypal, Martin Moos, Petr Šimek, Vladimír Koštál
Some insects rely on the strategy of freeze tolerance for winter survival. During freezing, extracellular body water transitions from the liquid to the solid phase and cells undergo freeze-induced dehydration. Here, we present results of a thermal analysis (from differential scanning calorimetry) of ice fraction dynamics during gradual cooling after inoculative freezing in variously acclimated larvae of two drosophilid flies, Drosophila melanogaster and Chymomyza costata Although the species and variants ranged broadly between 0 and close to 100% survival of freezing, there were relatively small differences in ice fraction dynamics...
April 6, 2018: Journal of Experimental Biology
Liam Mahoney, Jose R Fernandez-Alvarez, Hector Rojas-Anaya, Neil Aiton, David Wertheim, Paul Seddon, Heike Rabe
OBJECTIVES: To explore the intra- and inter-rater agreement of superior vena cava (SVC) flow and right ventricular (RV) outflow in healthy and unwell late preterm neonates (33-37 weeks' gestational age), term neonates (≥37 weeks' gestational age), and neonates receiving total-body cooling. METHODS: The intra- and inter-rater agreement (n = 25 and 41 neonates, respectively) rates for SVC flow and RV outflow were determined by echocardiography in healthy and unwell late preterm and term neonates with the use of Bland-Altman plots, the repeatability coefficient, the repeatability index, and intraclass correlation coefficients...
September 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
I Sklempe Kokic, M Ivanisevic, T Kokic, B Simunic, R Pisot
Research on the acute responses to exercise in pregnancy is scarce, especially for women affected by gestational diabetes mellitus (GDM). The aim of this study was to investigate responses to a single bout of exercise performed multiple times throughout the pregnancy in women diagnosed with GDM. Data from 18 pregnant women (aged: 32.8 ± 3.8) diagnosed with GDM, treated with diet only, were analyzed. Participants' pre-pregnancy body mass index was 24.4 ± 4.9 kg/m2 , 50% of them were nulliparous, and 50% of the sample regularly exercised before the pregnancy...
July 2018: Scandinavian Journal of Medicine & Science in Sports
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