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Sara R Palmer, Zhi Ren, Geelsu Hwang, Yuan Liu, Ashton Combs, Bill Söderström, Patricia Lara Vasquez, Yalda Khosravi, L Jeannine Brady, Hyun Koo, Paul Stoodley
Proper envelope biogenesis of Streptococcus mutans , a biofilm-forming and dental caries causing oral pathogen, requires two paralogs ( yidC1 and yidC2 ) of the universally conserved YidC/Oxa1/Alb3 family of membrane integral chaperones and insertases. Deletion of either paralog attenuates virulence in vivo but the mechanisms of disruption remain unclear. Here, we determined whether deletion of yidC affects cell surface properties, extracellular glucan production, and/or the structural organization of EPS matrix and biophysical properties of S...
October 15, 2018: Journal of Bacteriology
Muhammad Taqi, Ishak Abdul Razak, Norintan Ab-Murat
OBJECTIVE: To estimate the frequency and pattern of sugar intake among Pakistani school going children and its association with early carious lesion and caries history. METHODS: The cross-sectional study was conducted from January to May 2016 in seven schools of Bhakkar district in the Punjab province of Pakistan, and comprised of school children aged 11-12 years. Diet diaries were used to assess the frequency of sugar intake while caries was assessed using the Modified International Caries Detection and Assessment System...
October 2018: JPMA. the Journal of the Pakistan Medical Association
Adílis Kalina Alexandria, Camila Nassur, Carolina Bezerra Cavalcanti Nóbrega, Luciana Salles Branco-de-Almeida, Katia Regina Netto Dos Santos, Alexandre Rezende Vieira, Aline Almeida Neves, Pedro Luiz Rosalen, Ana Maria Gondim Valença, Lucianne Cople Maia
OBJECTIVE: The aim of this study was to evaluate microbiological changes, oral soft tissue toxicity, and caries-preventive effect of an experimental titanium tetrafluoride (TiF4 ) varnish compared with a commercially available fluoride varnish (NaF), using in situ and in vivo models. MATERIALS AND METHODS: The treatment groups were the following: TiF4 varnish (experimental varnish), Duraphat® (fluoride positive control), placebo varnish (no fluoride), and no treatment (negative control)...
October 12, 2018: Clinical Oral Investigations
Katarzyna Skośkiewicz-Malinowska, Barbara Malicka, Marek Ziętek, Urszula Kaczmarek
Depression is a common disorder among the elderly; however, it is not a standard element of the ageing process. Depression can affect oral health as a result of neglecting oral hygiene procedures, cariogenic nutrition, avoidance of necessary dental care which leads to an increased risk of dental caries and periodontal disease.Assessment of the relationship of oral health parameters with depression.500 subjects aged ≥65 (mean 74.4 ± 7.4) were involved in the study. Dental condition (decay-missing-filled index [DMFT], number of missing teeth [MT], removable denture wearing, teeth mobility), periodontal condition (bleeding on probing [BoP], pocket depth [PD], loss of attachment), oral dryness (the Challacombe Scale) and depression according to the Patient Health Questionnaire-9 (PHQ-9) scale were assessed...
October 2018: Medicine (Baltimore)
Pawitra Pulbutr, Sakulrat Rattanakiat, Natnicha Phetsaardeiam, Patcharapa Modtaku, Rattazart Denchai, Achida Jaruchotikamol, Wanwisa Khunawattanakul
BACKGROUND AND OBJECTIVE: Streptococcus mutans is a dominant causative pathogen of dental caries, which is a major oral health problem affecting million people worldwide. Derris reticulata is a medicinal plant possessing antimicrobial activity against several Gram-positive pathogenic bacteria. None the less, its effects on growth and cariogenic properties of S. mutans has not been clearly established. This study aimed to investigate the antibacterial and anti cariogenic activities of the D...
January 2018: Pakistan Journal of Biological Sciences: PJBS
Cameron A Stewart, Yoav Finer
OBJECTIVES: Despite decades of development and their status as the restorative material of choice for dentists, resin composite restoratives and adhesives exhibit a number of shortcomings that limit their long-term survival in the oral cavity. Herein we review past and current work to understand these challenges and approaches to improve dental materials and extend restoration service life. METHODS: Peer-reviewed work from a number of researchers as well as our own are summarized and analyzed...
October 6, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Nayara Gonçalves Emerenciano, Alberto Carlos Botazzo Delbem, Juliano Pelim Pessan, Gabriel Pereira Nunes, Francisco Nunes Souza Neto, Emerson Rodrigues de Camargo, Marcelle Danelon
OBJECTIVE: To evaluate the effect of a fluoride toothpaste containing nano-sized sodium trimetaphosphate (TMPnano) on enamel demineralization in situ and composition of the biofilm. DESIGN: This crossover double-blind study consisted of four phases (seven days each) and 12 volunteers who wore oral appliances containing four enamel bovine blocks. The cariogenic challenge was performed by 30% sucrose solution (6x/day). The toothpaste treatments (3x/day) were as follows: no F/TMP/TMPnano (Placebo), 1100 ppm F (1100F), 1100F plus 3% micrometric or nano-sized TMP (1100F/TMP; 1100F/TMPnano)...
October 1, 2018: Archives of Oral Biology
Matthieu Minty, Thibault Canceill, Sylvie Lê, Pauline Dubois, Oihana Amestoy, Pascale Loubieres, Jeffrey E Christensen, Camille Champion, Vincent Azalbert, Estelle Grasset, Sara Hardy, Jean-Michel Loubes, Jean-Philippe Mallet, François Tercé, Jean-Noël Vergnes, Rémy Burcelin, Matteo Serino, Franck Diemer, Vincent Blasco-Baque
OBJECTIVE: Elite athletes are prone to develop oral diseases, which could increase the risk for injuries. The aim of this study was to evaluate the oral health and the composition of oral microbiota of elite rugby players compared to the general population. METHODS: We set up a case-control study by screening 24 professional rugby players (PRG) and 22 control patients (CG) for dental and gingival examinations and performed a taxonomic analysis and a predicted functional analysis of oral microbiota...
October 4, 2018: Journal of Dentistry
Xiuqing Wang, Yufei Wang, Kun Wang, Qian Ren, Haoran Li, Sainan Zheng, Yumei Niu, Xuedong Zhou, Wei Li, Linglin Zhang
OBJECTIVES: Initial dental caries often occurs in clinic. Reduction of cariogenic bacteria and promotion of remineralization are effective ways to control them. This study was to develop bifunctional anticaries peptides with antibacterial and remineralizing properties. METHODS: We designed peptides TDH19, TNH19 and TVH19, and selected one through comparing their minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) against Streptococcus mutans and their reaction on mineralization...
October 6, 2018: Oral Diseases
Jonny Geber, Eileen Murphy
OBJECTIVES: Despite subsisting on a low-cariogenic diet comprising virtually nothing more than potatoes and dairy products, poor oral health affected the quality of life for the poor of nineteenth-century Ireland. This study investigates potential biocultural reasons that may explain why this was the case. MATERIAL AND METHODS: A total of 6,860 teeth and 9,889 alveoli from 363 permanent dentitions from the skeletal remains of impoverished adult Irish males and females who died between 1847 and 1851 in the Kilkenny Union Workhouse were examined for evidence of dental caries, periodontal disease and ante-mortem tooth loss...
October 3, 2018: American Journal of Physical Anthropology
Salvatore Sauro, Vicente Faus-Matoses, Irina Makeeva, Juan Manuel Nuñez Martí, Raquel Gonzalez Martínez, José Antonio García Bautista, Vicente Faus-Llácer
OBJECTIVES: Resin-modified glass ionomer cements (RMGIC) are considered excellent restorative materials with unique therapeutic and anti-cariogenic activity. However, concerns exist regarding the use of polyacrylic acid as a dentine conditioner as it may influence the bonding performance of RMGIC. The aim of this study was to evaluate the effect of different protocols for cycling mechanical stress on the bond durability and interfacial ultramorphology of a modern RMGIC applied to dentine pre-treated with/without polyacrylic acid conditioner (PAA)...
October 2, 2018: Materials
Fernando Luis Esteban Florez, Rochelle Denise Hiers, Preston Larson, Matthew Johnson, Edgar O'Rear, Adam J Rondinone, Sharukh Soli Khajotia
The development of dental adhesive resins with long-lasting antibacterial properties is a possible solution to overcome the problem of secondary caries in modern adhesive dentistry. OBJECTIVES: (i) Synthesis and characterization of nitrogen-doped titanium dioxide nanoparticles (N_TiO2 ), (ii) topographical, compositional and wettability characterization of thin-films (unaltered and experimental) and, (iii) antibacterial efficacy of N_TiO2 -containing dental adhesives against Streptococcus mutans biofilms...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Bo Huang, Lida Sadeghinejad, Olabisi I A Adebayo, Dengbo Ma, Yizhi Xiao, Walter L Siqueira, Dennis G Cvitkovitch, Yoav Finer
An esterase from S. mutans UA159, SMU_118c, was shown to hydrolyze methacrylate resin-based dental monomers. OBJECTIVE: To investigate the association of SMU_118c to the whole cellular hydrolytic activity of S. mutans toward polymerized resin composites, and to examine how the bacterium adapts its hydrolytic activity in response to environmental stresses triggered by the presence of a resin composites and adhesives biodegradation by-product (BBP). MATERIALS AND METHODS: Biofilms of S...
September 28, 2018: Acta Biomaterialia
Mohamed Abd-Ellatif El-Patal, Moshabab A Asiry, Ibrahim AlShahrani, Samy Youssef El Bayoumy, Mohammed Abo-Elkasem Ahmed Wakwak, Mona Abdelghafar Mohamed Khalil
Background: Orthodontic bands have been shown to alter oral microbial flora that lead to convert caries-free patients to moderate or high caries risk individuals. Aim: This study aimed to evaluate the effect of conventional band and loop space maintainers versus fiber-reinforced composite (FRC) resin space maintainer on the salivary cariogenic microflora (Lactobacillus and Streptococcus mutans) in children over a period of 6 months. Materials and Methods: The study sample was divided equally into two groups: Group A: 25 patients received FRC (INFIBRA® : Reinforcing ribbon, Bioloren, Italy) space maintainer and Group B: 25 patients received band and loop space maintainers...
July 2018: Journal of the Indian Society of Pedodontics and Preventive Dentistry
Rinrampai Puttipan, Sunee Chansakaow, Sakornrat Khongkhunthian, Siriporn Okonogi
From the previous findings, the ethanolic fractionated extract of Caesalpinia sappan (F-EtOH) has high activity against Streptococcus mutans, the most severe cariogenic bacteria. The present study was aimed to isolate and identify the active compound of F-EtOH and compare its inhibitory activity against the biofilm of S. mutans as well as the cytotoxicity to oral fibroblast cells with F-EtOH. Compound isolation was done by column chromatography. The active compound was identified using liquid chromatography-mass spectrometry with electrospray ionization and nuclear magnetic resonance spectroscopy...
2018: Drug Discoveries & Therapeutics
Roshmi Thomas, S Snigdha, K B Bhavitha, Seethal Babu, Anjitha Ajith, E K Radhakrishnan
In this study, polymethyl methacrylate (PMMA) thin films incorporated with biofabricated silver nanoparticles were used to evaluate the in vitro antimicrobial and antibiofilm activity against the cariogenic bacterium Streptococcus mutans . For this, silver nanoparticles (AgNPs) were generated using Bacillus amyloliquefaciens SJ14 culture (MAgNPs) and extract from Curcuma aromatica rhizome (CAgNPs). The AgNPs were further characterized by UV-Vis spectroscopy and high-resolution transmission electron microscopy...
September 2018: 3 Biotech
Helmut Schweikl, Marialucia Gallorini, Gerd Pöschl, Vera Urmann, Christine Petzel, Carola Bolay, Karl-Anton Hiller, Amelia Cataldi, Wolfgang Buchalla
OBJECTIVE: Resin monomers like 2-hydroxyethyl methacrylate (HEMA) interfere with effects induced by stressors such as lipopolysaccharide (LPS) released from cariogenic microorganisms. In this study, mechanisms underlying monomer-induced inhibition of the LPS-stimulated secretion of inflammatory cytokines from immunocompetent cells were investigated. METHODS: Secretion of pro-inflammatory cytokines TNF-α, IL-6 and the anti-inflammatory IL-10 from RAW264.7 mouse macrophages exposed to LPS and HEMA (0-6-8mM) was determined by ELISA...
September 6, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Shin Ae Kim, Samuel Smith, Carlos Beauchamp, Yang Song, Martin Chiang, Anthony Giuseppetti, Stanislav Frukhtbeyn, Ian Shaffer, Joshua Wilhide, Denis Routkevitch, John M Ondov, Jeffrey J Kim
BACKGROUND: Most electronic-cigarette liquids contain propylene glycol, glycerin, nicotine and a wide variety of flavors of which many are sweet. Sweet flavors are classified as saccharides, esters, acids or aldehydes. This study investigates changes in cariogenic potential when tooth surfaces are exposed to e-cigarette aerosols generated from well-characterized reference e-liquids with sweet flavors. METHODS: Reference e-liquids were prepared by combining 20/80 propylene glycol/glycerin (by volume fraction), 10 mg/mL nicotine, and flavors...
2018: PloS One
Ying Song, Jing-Lin Zhou, Yuan-Li He, Wei Li, Ling Zou
OBJECTIVE: This study intends to explore the mechanism underlying the support of sortase A (SrtA) of the cariogenicity of Streptococcus mutans (S. mutans). METHODS: We performed a metabonomics study based on ¹H nuclear magnetic resonance spectroscopy (NMR), in which we compared the extracellular metabolites of wild-type S. mutans UA159 with those of its SrtA-deficient strain. Metabolite differences among strains were identified using a combination of principal component analysis and orthogonality partial least square discriminant analysis...
August 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
Sadaf Adibi, Anita Amrollahi, Ali Dehghani Nazhvani, Najmeh Movahhedian
Statement of the Problem: After introducing digital radiography, practitioners started reading radiographs from computer monitors; however, many still prefer hard-copy radiographs. Purpose: This study aimed to assess the possible superiority of either type of radiograph recording media (computer monitor, film, or paper) in diagnosis and perception of the depth of the cariogenic lesions. Materials and Method: Twenty digital bitewing radiographs, obtained from 200 posterior extracted teeth, were displayed on an LG monitor and printed on paper and film using Kodak printers...
September 2018: Journal of Dentistry
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