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Arata Takeuchi, Madoka Ozawa, Yasuhiro Kanda, Mina Kozai, Izumi Ohigashi, Yoichi Kurosawa, Md Azizur Rahman, Toshihiko Kawamura, Yuto Shichida, Eiji Umemoto, Masayuki Miyasaka, Burkhard Ludewig, Yousuke Takahama, Takashi Nagasawa, Tomoya Katakai
The spatiotemporal regulation of immune responses in the lymph node (LN) depends on its sophisticated tissue architecture, consisting of several subcompartments supported by distinct fibroblastic stromal cells (FSCs). However, the intricate details of stromal structures and associated FSC subsets are not fully understood. Using several gene reporter mice, we sought to discover unrecognized stromal structures and FSCs in the LN. The four previously identified FSC subsets in the cortex are clearly distinguished by the expression pattern of reporters including PDGFRβ, CCL21-ser, and CXCL12...
2018: Frontiers in Immunology
Lun Liu, Jian Gao, Weili Bao, Chengyang Hu, Yajing Xu, Bingying Zhao, Jie Zheng, Lingling Fan, Yehuan Sun
Purpose: To analyze foveal microvascular abnormalities in different stages of diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA) with projection artifact removal (PAR). Methods: We analyzed 93 eyes of 59 patients with diabetes-31 with no DR (no DR), 34 with mild to moderate nonproliferative DR (mild DR), and 28 with severe nonproliferative DR to proliferative DR (severe DR)-and 31 age-matched healthy controls. Sections measuring 3 × 3 mm2 centered on the fovea were obtained using OCTA...
2018: Journal of Ophthalmology
Bijun Cheng, Jing Lu, Tianjiao Li, Zhuoqun Meng, Meitong Liu, Maocheng Sun, Shuang Guan
As a common food processing pollutant, 1,3-Dichloro-2-propanol can be found in foodstuffs, especially in soup spices and instant soups. Mounting researchers have unfolded the relation between 1,3-DCP and various diseases. Autophagy is a process of self-regulation and defects in autophagy have been bound up with multifarious human pathologies and metabolic diseases. Here, we explored the effects of 1,3-DCP on autophagy and traced the molecular mechanism. Our results demonstrated that 1,3-DCP dose-dependently inhibited autophagy...
October 11, 2018: Food and Chemical Toxicology
Mariacristina Parravano, Daniele De Geronimo, Fabio Scarinci, Gianni Virgili, Lea Querques, Monica Varano, Francesco Bandello, Giuseppe Querques
PURPOSE: To investigate the progression of diabetic microaneurysms (MAs) according to the SD-OCT and OCT Angiography (OCTA) characteristics and to evaluate their influence on the retinal extracellular fluid accumulation at 1 year follow-up in patients with non proliferative diabetic retinopathy (NPDR). DESIGN: Prospective, observational case series. METHODS: Fourteen patients with NPDR underwent SD-OCT and OCTA at the baseline and at 1 year follow-up...
October 8, 2018: American Journal of Ophthalmology
Yaofu Liu, Huiling Li, Jianyi Dong, Lei Ma, Aijun Liao, Zhuona Rong, Zhi Zhou, Liang Cao, Fujin Wang, Jingyu Wang, Aiguo Wang
Deficiency of γ-glutamyl carboxylation of coagulation factors, as evidenced by the elevated level of Des-γ-carboxyl prothrombin (DCP), is a common feature in hepatocellular carcinoma patients. Additionally, treatment of cancer patients with mTOR inhibitors significantly increases hemorrhagic events. However, the underlying mechanisms remain unknown. In the present study, Vitamin K epoxide reductase complex subunit 1 (VKORC1) was found to be significantly down-regulated in clinical hepatoma tissues and most tested hepatoma cell lines...
October 10, 2018: Clinical and Experimental Medicine
Christian Kuété Fofié, Elvine Pami Nguelefack-Mbuyo, Nole Tsabang, Albert Kamanyi, Télesphore Benoît Nguelefack
Parts of Ceiba pentandra are wildly used in Africa to treat diabetes and previous works have demonstrated their in vivo antidiabetic effects on type 1 diabetes models. In addition, it has been recently shown that the decoction and the methanol extract from the stem bark of C. pentandra potentiate in vitro, the peripheral glucose consumption by the liver and skeletal muscle slices. But nothing is known about its effect on type II diabetes, especially on insulin resistance condition. We investigated herein the antihyperglycemic, insulin-sensitizing potential, and cardioprotective effects of the dried decoction from the stem bark of Ceiba pentandra (DCP) in dexamethasone-induced insulin resistant rats...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Siqing Yu, Beatrice E Frueh, Dagmar Steinmair, Andreas Ebneter, Sebastian Wolf, Martin S Zinkernagel, Marion R Munk
PURPOSE: To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). METHODS: Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 × 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed...
2018: PloS One
K Vanherle, A M Werkman, E Baete, A Barkmeijer, A Kolm, C Gast, S Ramminger, E Höld, K Kohlenberg-Müller, S Ohlrich-Hahn, M E Walters, D Wewerka-Kreimel, M Adam, L Valentini
BACKGROUND & AIMS: Dietetic interventions contribute to certain health objectives and other outcomes, but are mostly part of a multimodal and multidisciplinary approach what makes evaluating the actual effects of dietitians' involvement rather complex. Although monitoring and outcome evaluation (M&OE) can provide routine data to prove the effectiveness of dietetic interventions, this has not been established yet in different dietetic settings. METHODS: A comprehensive framework for M&OE in dietetics was developed by dietetic experts from five European higher education institutes for dietetics in the course of the EU sponsored project "Improvement of Education and Competences in Dietetics (IMPECD)"...
September 11, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Sehee Yang, Kisung Kwon, Jangduck Choi, Cheon-Ho Jo
Chloropropanols such as 3-monochloropropane-1,2-diol (3-MCPD) and 1,3-dichloropropan-2-ol (1,3-DCP) are produced by heat treatment in the presence of fat and hydrochloric acid during the manufacture of food stuffs such as hydrolyzed vegetable protein and soy sauce. 3-MCPD and 1,3-DCP have been detected in several foods. An efficient, highly selective GC-MS method was developed to determine the concentration of 3-MCPD and 1,3-DCP in food. Calibration curves for 3-MCPD and 1,3-DCP were constructed, and a correlation of determination (r2 ) ≥ 0...
June 2018: Food Science and Biotechnology
Yasin Sakir Goker, Sedat Yılmaz, Hasan Kızıltoprak, Kemal Tekin, Gokhan Demir
PURPOSE: To quantitatively measure the flow, nonflow, density, and foveal avascular zone (FAZ) assessment tool parameters of optical coherence tomography angiography (OCTA) in patients with nonocular Behcet's Disease (BD), and to compare the results with those obtained in healthy controls. METHODS: FAZ parameters, flow area of choriocapillaris, and vessel density values of both superficial (SCP) and deep capillary plexuses (DCP) were measured using OCTA. RESULTS: The FAZ area in SCP, FAZ area in full retinal vasculature, and FAZ perimeter were significantly higher and foveal density-300 was significantly lower in the BD group than in the control group (p = 0...
September 27, 2018: Current Eye Research
Hao Xing, Yi-Jie Zheng, Jun Han, Han Zhang, Zhen-Li Li, Wan-Yee Lau, Feng Shen, Tian Yang
BACKGROUND: As a promising biomarker of hepatocellular carcinoma (HCC), protein induced by vitamin K absence or antagonist-II (PIVKA-II) has been studied extensively. However, its diagnostic capability varies across HCC studies. This study aimed to compare the performance of PIVKA-II with alpha-fetoprotein (AFP) in the diagnosis of HCC. METHODS: A systematic literature search was conducted to identify the studies from MEDLINE, Embase and Cochrane Library Databases, which were published up to December 20, 2017 to compare the diagnostic capability of PIVKA-II and AFP for HCC...
September 15, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Hirokazu Takanashi, Kazuya Abiru, Tomohiro Hama, Yuta Shinfuku, Tsunenori Nakajima, Akira Ohki, Takehiko Ueda, Takashi Kondo, Taku Matsushita, Takashi Kameya
The estimated domestic usage of DD (a typical nematocide) has been the greatest among all the agricultural chemicals in Japan. DD is involved in a document which is used to establish tap water quality standard in Japan. The document indicates that DD is potentially detectable in raw water for tap waters. DD in raw water will be treated with chlorine at waterworks, which raises concerns about formation of mutagenic chlorination by-products through the treatment. The objective of this work was to identify a mutagenic chlorination by-product by using high resolution mass spectrometers and multivariate analyses...
September 14, 2018: Water Research
Hufei Wang, Jiamin Chen, Megumi Suda, Yukie Yanagiba, Zuquan Weng, Rui-Sheng Wang
1,2-Dichloropropane (1,2-DCP) is used as an industrial solvent, insecticide fumigant and household dry cleaning product. Carcinogenicity caused by long-term exposure to 1,2-DCP is well established. However, the possible liver damage and related toxic mechanisms associated with acute inhalation exposure to 1,2-DCP are rarely reported. In this study, we investigated the effects of individual and combined exposure to 1,2-DCP and dichloromethane (DCM) on mice liver. The results showed that 1,2-DCP significantly caused liver necrosis, possibly due to 1,2-DCP-induced inhibition of the mitochondrial respiratory chain complex I-IV activities, resulting in mitochondrial dysfunction and extreme ATP consumption...
September 21, 2018: Journal of Applied Toxicology: JAT
Hengxue Xiang, Ziye Chen, Nan Zheng, Xuzhen Zhang, Liping Zhu, Zhe Zhou, Meifang Zhu
A series of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) composite fibers were prepared via melt reactive processing where tungsten disulphide (WS2 ) and dicumyl peroxide (DCP) was used as heterogeneous nucleating agent and initiator, respectively. Compared with PHBV or PHBV/WS2 fiber, the resultant LCB-PHBV/WS2 fibers showed improving mechanical performance, a higher nucleation temperature and a rapid crystallization rate due to the synergistic effect between heterogeneous nucleation, long chain branched structure and draw-induced crystallization...
September 13, 2018: International Journal of Biological Macromolecules
Hirohisa Okabe, Tomoharu Yoshizumi, Yo-Ichi Yamashita, Katsunori Imai, Hiromitsu Hayashi, Shigeki Nakagawa, Shinji Itoh, Norifumi Harimoto, Toru Ikegami, Hideaki Uchiyama, Toru Beppu, Shinichi Aishima, Ken Shirabe, Hideo Baba, Yoshihiko Maehara
AIM: The clinical impact of pathological classification based on architectural pattern in hepatocellular carcinoma (HCC) remains elusive in spite of its well-known and common feature. METHODS: The prognostic impact of pathological classification was examined with prospective database. Three hundred and eighty HCC patients who underwent curative hepatectomy as an initial treatment in Kumamoto University were enrolled as a test cohort. The outcome was confirmed with a validation cohort in Kyushu University...
2018: PloS One
Xu Bao, Takayuki Yokoe, Tu M Ha, Qian Wang, Jieping Zhu
Trifluoromethylative difunctionalization and hydrofunctionalization of unactivated alkenes have been developed into powerful synthetic methodologies. On the other hand, methylative difunctionalization of olefins remains an unexplored research field. We report in this paper the Cu-catalyzed alkoxy methylation, azido methylation of alkenes using dicumyl peroxide (DCP), and di-tert-butyl peroxide (DTBP) as methyl sources. Using functionalized alkenes bearing a tethered nucleophile (alcohol, carboxylic acid, and sulfonamide), methylative cycloetherification, lactonization, and cycloamination processes are subsequently developed for the construction of important heterocycles such as 2,2-disubstituted tetrahydrofurans, tetrahydropyrans, γ-lactones, and pyrrolidines with concurrent generation of a quaternary carbon center...
September 13, 2018: Nature Communications
Felice Cardillo Piccolino, Marco Lupidi, Carlo Cagini, Daniela Fruttini, Massimo Nicolò, Chiara Maria Eandi, Silvia Tito
Purpose: To investigate the retinal vascular response to the isometric exercise in patients with central serous chorioretinopathy (CSCR) by using optical coherence tomography angiography (OCT-A). Methods: This was a multicenter case-control study including 35 CSCR patients and 25 age-matched healthy controls. All subjects underwent macular OCT-A scans in resting conditions and during a handgrip isometric exercise. Hemodynamic data, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and ocular perfusion pressure (OPP), were recorded at baseline and during the stress test...
September 4, 2018: Investigative Ophthalmology & Visual Science
Yoshihiro Kaizu, Shintaro Nakao, Haruka Sekiryu, Iori Wada, Muneo Yamaguchi, Toshio Hisatomi, Yasuhiro Ikeda, Junji Kishimoto, Koh-Hei Sonoda
PURPOSE: Fluorescein angiography (FA) has been conventionally used for detection of retinal nonperfused area (NPA) in diabetic retinopathy (DR) in spite of its qualitative evaluation. Optical coherence tomography angiography (OCTA) has been recently reported to be useful for the quantification of retinal vascular disorder in DR. In this study, we examined whether retinal flow density (FD) measurement in OCTA was useful for NPA detection in DR. METHODS: The study included 41 eyes from 29 patients with DR who underwent FA and OCTA...
September 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Yun Qin, Yanan Li, Bo Sun, Hui He, Rui Peng, Tao Zhang, Jianfu Li, Cheng Luo, Chengyan Sun, Dezhong Yao
Cerebral palsy (CP) has long been investigated to be associated with a range of motor and cognitive dysfunction. As the two most common CP subtypes, spastic cerebral palsy (SCP) and dyskinetic cerebral palsy (DCP) may share common and distinct elements in their pathophysiology. However, the common and distinct dysfunctional characteristics between SCP and DCP on the brain network level are less known. This study aims to detect the alteration of brain functional connectivity in children with SCP and DCP based on resting-state functional MRI (fMRI)...
2018: Neural Plasticity
Razvan Cerban, Carmen Ester, Speranta Iacob, Liliana Paslaru, Radu Dumitru, Mugur Grasu, Georgiana Constantin, Irinel Popescu, Liliana Gheorghe
Introduction: The aim of the study is to evaluate the role of alpha-fetoprotein (AFP) and des-y-carboxy prothrombin (DCP) in the assessment of treatment response at one month in patients with hepatocellular carcinoma (HCC) treated with trans-arterial chemoembolization (TACE). Methods: From March 2016 to April 2017 a number of 59 patients diagnosed with HCC were prospectively enrolled. A TACE procedure as initial treatment modality was performed in 41 patients. AFP and DCP serum levels were measured and clinical features were determined for all the patients that were included...
July 2018: Chirurgia
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