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Roy Schwartz, Philip Hykin, Sobha Sivaprasad
Paracentral acute middle maculopathy (PAMM) refers to band-like hyperreflective lesions seen on spectral-domain optical coherence tomography, mostly confined to the inner nuclear layer. It has been previously demonstrated to involve the deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA). A 29-year-old female presented with PAMM and was investigated using a new OCTA system that shows not just the superficial capillary plexus and DCP, but also the four vascular plexuses as previously demonstrated in histology...
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Mirinae Kim, Seung Yong Choi, Young-Hoon Park
The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy (DR) progression. We quantitatively analyzed OCT-derived vascular parameters at superficial (SCP) and deep retinal capillary plexus (DCP), and choroid. We assessed foveal avascular zone (FAZ), vessel density, vessel length density, and choroidal vascularity index in conjunction with DR stage...
August 14, 2018: Scientific Reports
Jiali Wu, Zheyi Xiang, Le Bai, Lagu He, Li Tan, Min Hu, Yaping Ren
BACKGROUND: It is reported that prothrombin induced by vitamin K absence-II (PIVKA-II) has a better performance of diagnosis for HCC, and has also been known to be an independent risk factor for vascular invasion. Few studies study the relationship between PIVKA-II and HBV DNA. OBJECTIVE: To determine the clinical value of serum Prothrombin induced by vitamin K absence-II (PIVKA-II) in early hepatocellular carcinoma (HCC), and to explore its relationship with vascular invasion and HBV DNA...
July 24, 2018: Cancer Biomarkers: Section A of Disease Markers
Feili Li, Liyuan Zhao, Yifei Jinxu, Wen Shi, Siqi Zhou, Kai Yuan, G Daniel Sheng
Microalgae are surprisingly efficient to remove pollutants in a hermetically closed environment, though its growth is inhibited in the absence of pollutants. The final pH, algal density, Chl-a content, and the removal efficiency of 2,4-dichlorophenol (2,4-DCP) by Chlorellar pyrenoidosa in a closed system were observed under different initial pH, lighting regimes, and various carbon sources. The optimal condition for 2,4-DCP removal was obtained, and adopted to observe the evolution of above items by domesticated and origin strains...
August 9, 2018: Ecotoxicology and Environmental Safety
Shi-Jin Dai, You-Cai Zhao, Dong-Jie Niu, Qiang Li, Yu Chen
Molten salt has been regarded as a versatile and environmental-friendly method for the material preparation and waste destruction. In this work, molten FeCl3 was utilized for the generation of magnetic biochar (MBC) derived from simultaneous activation and magnetization of biomass. The sample characterization indicated that MBC had a rough surface with BET surface area of 404 m2/g and total pore volume of 0.35cm3/g. Highly dispersed Fe3O4 and nitrogen could be deposited on the surface, leading to an excellent magnetization property...
August 10, 2018: Journal of the Air & Waste Management Association
Zhenzhen Huang, Kai He, Zhongxian Song, Guangming Zeng, Anwei Chen, Lei Yuan, Hui Li, Liang Hu, Zhi Guo, Guiqiu Chen
Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+ . Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD)...
August 2, 2018: Chemosphere
Anna Z Pollack, Sunni L Mumford, Jenna R Krall, Andrea E Carmichael, Lindsey A Sjaarda, Neil J Perkins, Kurunthachalam Kannan, Enrique F Schisterman
BACKGROUND: Little is known about the associations of bisphenol A, chlorophenols, benzophenones, and parabens with reproductive hormone levels in women. Our goal was to evaluate the associations between repeated measures of these chemicals and their mixtures with reproductive hormones in women. METHODS: Longitudinal urine samples from healthy, premenopausal women (n = 143 with 3-5 urine samples each) were measured for bisphenol A, five chlorophenols (2,4-dichlorophenol (2,4-DCP), 2,5-dichlorophenol, 2,4,5-trichlorophenol, 2,4,6-trichlorophenol, triclosan), two ultraviolet (UV) filters (benzophenone-1, benzophenone-3), and eight parabens and their metabolites (benzyl, butyl, ethyl, heptyl, methyl, propyl, 4-hydroxybenzoic acid (4-HB), 3,4-dihydroxybenzoic acid (3,4-DHB)) over two menstrual cycles...
August 6, 2018: Environment International
Jing Lu, Baochen Fang, Yixuan Huang, Siyu Tao, Bo Sun, Shuang Guan, Yingli Jin
AIMS: Chloropropanol is a contaminant produced during food processing, and 1,3-dichloro-2-propanol (1,3-DCP) is one of the most-studied and most common chloropropanol-related food contaminants. Epigallocatechin-3-gallate (EGCG) is the most abundant ester catechin in tea polyphenols. We studied the potential therapeutic effect of EGCG on 1,3-DCP-induced lipid accumulation in the liver of mice, and determined the related regulatory mechanisms. MATERIALS AND METHODS: The effects of EGCG were investigated in 6-8-week-old adult male C57BL/6J mice that were given 1,3-DCP (1 mg/kg bw/day; i...
August 6, 2018: Life Sciences
Dong-Hyun Lee, Ho Chul Yi, So Hyun Bae, Joon Hee Cho, Sang Wook Choi, Hakyoung Kim
OBJECTIVES: To determine the risk factors for retinal microvascular impairment on optical coherence tomography angiography (OCT-A) in type 2 diabetic patients without clinical diabetic retinopathy (DR). METHODS: This retrospective and cross-sectional study enrolled 74 diabetic patients without clinically evident DR for the study group and 34 healthy subjects for the control group. OCT-A parameters were measured to determine vascular density (VD) and the foveal avascular zone (FAZ) size in the superficial and deep capillary plexuses (SCP/DCP) of the retina...
2018: PloS One
Etsuro Hatano, Shinji Uemoto, Hiroki Yamaue, Masakazu Yamamoto
BACKGROUND: The prognosis of hepatocellular carcinoma (HCC) with tumor thrombus in the major portal vein (PV) is extremely poor. The purpose of this study is to clarify the impact of hepatic resection for HCC with tumor thrombus in the major PV. PATIENTS: Four hundred patients undergoing macroscopic curative resection for HCC involving the first branch or trunk of the PV between 2001 and 2010 at the 22 institutions were enrolled. We examined the effect of adjuvant hepatic arterial infusion chemotherapy (HAIC) on prognosis and validated the prognostic index consisting of ascites, prothrombin activity, and maximal tumor diameter...
August 8, 2018: Journal of Hepato-biliary-pancreatic Sciences
Dejun Huang, Xiaoning Zhang, Chen Zhang, Hui Li, Dong Li, Yan Hu, Feng Yang, Yongmei Qi
2,4-Dichlorophenol (2,4-DCP) is one of the most abundant chlorophenols in the aquatic environment and has been frequently detected in surface waters. Although ecological and cellular toxicity of 2,4-DCP has aroused the public concern, few reports focus on the genotoxicity, especially on DNA double strand breaks (DSBs), of 2,4-DCP in fish. The present study aims to explore the genotoxic effect of 2,4-DCP on DSBs in goldfish Carassius auratus and to further elucidate its potential mechanism. The results showed that 2,4-DCP significantly induced DSBs (detected by neutral comet assay) in erythrocytes and hepatocytes of goldfish in a dose-dependent manner, indicating a genotoxicity of 2,4-DCP on fish...
August 9, 2018: Environmental and Molecular Mutagenesis
Khalil Ghasemi Falavarjani, Hamideh Shenazandi, Dariush Naseri, Pasha Anvari, Pegah Kazemi, Farzaneh Aghamohammadi, Feras Alissmail, Sayyed Amirpooya Alemzadeh
Purpose: To report the normal characteristics and correlations of the foveal microvascular networks using optical coherence tomography angiography (OCTA) in a healthy Iranian population. Methods: Enface 3x3 OCTA images were obtained using the RTVue Avanti spectral-domain optical coherence tomography with AngioVue software (Optovue, Fremont, CA, USA). Foveal avascular zone (FAZ) area, central foveal point thickness and inner retinal thickness at the foveal center and the vascular density of the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP) in the fovea were recorded...
July 2018: Journal of Ophthalmic & Vision Research
Anna Serra-Clusellas, Laura De Angelis, Chung-Ho Lin, Phuc Vo, Mohamed Bayati, Lloyd Sumner, Zhentian Lei, Nathalia B Amaral, Liliana M Bertini, Jose Mazza, Luis R Pizzio, Jorge D Stripeikis, Julián A Rengifo-Herrera, María M Fidalgo de Cortalezzi
The Photo-Fenton-like (PF-like) process with minute Fe(III) concentrations and the Hydrogen Peroxide Photolysis (HPP), using Xe-lamp or solar light as sources of irradiation, were efficiently applied to eliminate the herbicide 2,4-D from water. PF-like experiments concerning ferric and H2 O2 concentrations of 0.6 mg L-1 and 20 mg L-1 respectively, using Xenon lamps (Xe-lamps) as a source of irradiation and 2,4-D concentrations of 10 mg L-1 at pH 3.6, exhibited complete 2,4-D degradation and 77% dissolved organic carbon (DOC) removal after 30 min and 6 h of irradiation respectively whereas HPP (in absence of ferric ions) experiments showed a 2,4-D reduction and DOC removal of 90% and 7% respectively after 6 h of irradiation...
July 31, 2018: Water Research
Alessio Cerquaglia, Barbara Iaccheri, Tito Fiore, Daniela Fruttini, Federica Benedetta Belli, Moncef Khairallah, Marco Lupidi, Carlo Cagini
PURPOSE: To report optical coherence tomography angiography (OCT-A) findings in eyes with ocular sarcoidosis (OS) and to compare these findings with those of fluorescein angiography (FA). METHODS: Observational, cross-sectional, case-control study. Patients presenting with OS involving the posterior segment were evaluated using FA, structural-OCT and OCT-A. OCT-angiograms of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC) were qualitatively and quantitatively analyzed...
August 6, 2018: Ocular Immunology and Inflammation
Peter L Nesper, Amani A Fawzi
Purpose: To assess the connection among arterioles, venules, and capillaries in three retinal capillary plexuses using optical coherence tomography angiography (OCTA). Methods: This was a prospective, cross-sectional, observational study including 20 eyes of 10 healthy subjects. En face and cross-sectional OCTA images were segmented to study the superficial (SCP), middle (MCP), and deep capillary plexuses (DCP). Using thin slabs and manual segmentation within the three plexuses, we examined the connections between the large-caliber superficial vessels within a 3 × 3 mm2 OCTA scan (arterioles and venules) and the smaller capillaries in each plexus...
August 1, 2018: Investigative Ophthalmology & Visual Science
Yanyan Fu, Jinping Yu, Kaixia Wang, Huan Liu, Yaguo Yu, Ao Liu, Xin Peng, Qingguo He, Huimin Cao, Jiangong Cheng
In this work, we developed two small-molecule probes for real-time and onsite detecting of diethylchlorophosphate (DCP) vapor by incorporating amine groups into Schiff base skeletons. Both probes can be easily synthesized with high yield through one-step and low-cost synthesis. They can detect DCP vapor in the chromophoric-fluorogenic dual mode, which combines both the advantages of the visualization of color sensing and the high sensitivity of the fluores-cence sensing. Furthermore, its sensing is based on the "turn-on" mode which can avoid the interference arising from photobleaching or fluorescence quenching agents based on "turn-off" mode...
July 30, 2018: ACS Sensors
Samuel Mailhot-Larouche, Louis Deschênes, Katherine Lortie, Morgan Gazzola, David Marsolais, David Brunet, Annette Robichaud, Ynuk Bossé
Air volume changes created by a conscious subject breathing spontaneously within a body box are at the basis of plethysmography, a technique used to non-invasively assess some features of the respiratory function in humans as well as in laboratory animals. The present article focuses on the application of the double-chamber plethysmography (DCP) in small animals. It provides background information on the methodology as well as a detailed step-by-step procedure to successfully assess respiratory function in conscious, spontaneously breathing animals in a non-invasive manner...
July 10, 2018: Journal of Visualized Experiments: JoVE
Teiji Kuzuya, Masatoshi Ishigami, Yoji Ishizu, Takashi Honda, Kazuhiko Hayashi, Tetsuya Ishikawa, Yoshiki Hirooka, Hidemi Goto
There have been some reports that a vitamin K2 (VK2) analog is beneficial for the prevention of recurrence in hepatocellular carcinoma (HCC) patients after curative therapy. However, the VK2 analogs in current use do not appear to exhibit dramatic antitumor effects when administered alone. Here, we report the case of a 67-year-old male patient with sorafenib-failure advanced HCC who achieved complete response (CR) after VK2 analog monotherapy. At the time of sorafenib-failure confirmation, the patient had multiple intrahepatic tumors, multiple lung metastases, and Vp3 portal vein tumor thrombosis...
July 27, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Sriram Yennurajalingam, Zhanni Lu, Bernard Prado, Janet L Williams, Kyu-Hyoung Lim, Eduardo Bruera
BACKGROUND: There are limited studies on factors associated with cancer patients' perception of curability. OBJECTIVE: To examine advanced cancer patient's perception of curability and its association with patient's sociodemographic and clinical characteristics, decisional control preference (DCP), symptoms, and end-of-life quality care outcomes. DESIGN: Secondary analysis of a study to determine the DCP and illness understanding of advanced cancer patients receiving palliative care (PC)...
July 26, 2018: Journal of Palliative Medicine
Arjan A van de Loosdrecht, Sandra van Wetering, Saskia J A M Santegoets, Satwinder Kaur Singh, Corien M Eeltink, Yvonne den Hartog, Malika Koppes, Jorn Kaspers, Gert J Ossenkoppele, Ada M Kruisbeek, Tanja D de Gruijl
In elderly acute myeloid leukemia (AML) patients post-remission treatment options are associated with high comorbidity rates and poor survival. Dendritic cell (DC)-based immunotherapy is a promising alternative treatment strategy. A novel allogeneic DC vaccine, DCP-001, was developed from an AML-derived cell line that uniquely combines the positive features of allogeneic DC vaccines and expression of multi-leukemia-associated antigens. Here, we present data from a phase I study conducted with DCP-001 in 12 advanced-stage elderly AML patients...
July 23, 2018: Cancer Immunology, Immunotherapy: CII
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