keyword
https://read.qxmd.com/read/38534474/engineered-dual-antioxidant-enzyme-complexes-targeting-icam-1-on-brain-endothelium-reduce-brain-injury-associated-neuroinflammation
#1
JOURNAL ARTICLE
Brian M Leonard, Vladimir V Shuvaev, Trent A Bullock, Kalpani N Udeni Galpayage Dona, Vladimir R Muzykantov, Allison M Andrews, Servio H Ramirez
The neuroinflammatory cascade triggered by traumatic brain injury (TBI) represents a clinically important point for therapeutic intervention. Neuroinflammation generates oxidative stress in the form of high-energy reactive oxygen and nitrogen species, which are key mediators of TBI pathology. The role of the blood-brain barrier (BBB) is essential for proper neuronal function and is vulnerable to oxidative stress. Results herein explore the notion that attenuating oxidative stress at the vasculature after TBI may result in improved BBB integrity and neuroprotection...
February 21, 2024: Bioengineering
https://read.qxmd.com/read/38528711/mofs-based-magnetic-nanozyme-to-boost-cascade-ros-accumulation-for-augmented-tumor-ferroptosis
#2
JOURNAL ARTICLE
Ying Yuan, Bo Chen, Xingxing An, Zhanhang Guo, Xin Liu, Hao Lu, Fangxin Hu, Zhigang Chen, Chunxian Guo, Chang Ming Li
The emerging cell death modality of ferroptosis has garnered increasing attention for antitumor treatment but still suffers from low therapeutic efficacy. We report here a MOFs-based magnetic nanozyme (PZFH) comprising porphyrin-based Zr-MOF (PCN) on zinc ferrite (ZF) nanoparticles modified with hyaluronic acid (HA), delivering excellent magneto-photonic response for efficient ferroptosis. PZFH shows multienzyme-like cascade activity encompassing a photon-triggered oxidase (OXD)-like catalysis to generate O2 - , which is converted to H2 O2 by superoxide dismutase-like activity and subsequent ·OH by magneto-promoted peroxidase (POD) behavior...
March 25, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38493499/dual-responsive-supramolecular-polymeric-nanomedicine-for-self-cascade-amplified-cancer-immunotherapy
#3
JOURNAL ARTICLE
Wenting Hu, Binglin Ye, Guocan Yu, Huang Yang, Hao Wu, Yuan Ding, Feihe Huang, Weilin Wang, Zhengwei Mao
Insufficient tumor immunogenicity and immune escape from tumors remain common problems in all tumor immunotherapies. Recent studies have shown that pyroptosis, a form of programmed cell death that is accompanied by immune checkpoint inhibitors, can induce effective immunogenic cell death and long-term immune activation. Therapeutic strategies to jointly induce pyroptosis and reverse immunosuppressive tumor microenvironments are promising for cancer immunotherapy. In this regard, a dual-responsive supramolecular polymeric nanomedicine (NCSNPs) to self-cascade amplify the benefits of cancer immunotherapy is designed...
March 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38482522/dissolving-microneedle-based-cascade-activation-nanoplatform-for-enhanced-photodynamic-therapy-of-skin-cancer
#4
JOURNAL ARTICLE
Jinyuan Ma, Zongguang Tai, Ying Li, Yang Li, Jiandong Wang, Tao Zhou, Min Shen, Rujuan Xin, Cuie Shen, Quangang Zhu, Zhongjian Chen
PURPOSE: Photodynamic therapy (PDT) has been an attractive strategy for skin tumor treatment. However, the hypoxic microenvironment of solid tumors and further O2 consumption during PDT would diminish its therapeutic effect. Herein, we developed a strategy using the combination of PDT and hypoxia-activated bioreductive drug tirapazamine (TPZ). METHODS: TPZ was linked to DSPE-PEG-NHS forming DSPE-PEG-TPZ to solve leakage of water-soluble TPZ and serve as an antitumor agent and monomer molecule further forming the micellar...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38469056/glutathione-depletion-induced-ros-no-generation-for-cascade-breast-cancer-therapy-and-enhanced-anti-tumor-immune-response
#5
JOURNAL ARTICLE
Jing Wang, Yanxiang Sang, Weijian Chen, Liang Cheng, Wenxiang Du, Hongjie Zhang, Benyan Zheng, Lei Song, Yuan Hu, Xiaopeng Ma
INTRODUCTION: As an effective alternative choice to traditional mono-therapy, multifunctional nanoplatforms hold great promise for cancer therapy. Based on the strategies of Fenton-like reactions and reactive oxygen species (ROS)-mediated therapy, black phosphorus (BP) nanoplatform BP@Cu2 O@L-Arg (BCL) co-assembly of cuprous oxide (Cu2 O) and L-Arginine (L-Arg) nanoparticles was developed and evaluated for synergistic cascade breast cancer therapy. METHODS: Cu2 O particles were generated in situ on the surface of the BP nanosheets, followed by L-Arg incorporation through electrostatic interactions...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38445977/-in-situ-self-assembled-phytopolyphenol-coordinated-intelligent-nanotherapeutics-for-multipronged-management-of-ferroptosis-driven-alzheimer-s-disease
#6
JOURNAL ARTICLE
Yining Liu, Dongju Zhao, Fan Yang, Caihua Ye, Ziyao Chen, Yihan Chen, Xiaomeng Yu, Jiyao Xie, Yan Dou, Jin Chang
Ferroptosis is a vital driver of pathophysiological consequences of Alzheimer's disease (AD). High-efficiency pharmacological inhibition of ferroptosis requires comprehensive coordination of diverse abnormal intracellular events, which is an urgent problem and great challenge for its application in AD treatment. Herein, a triphenylphosphonium-modified quercetin-derived smart nanomedicine (TQCN) is developed for multipronged anti-ferroptosis therapy in AD. Taking advantage of the favorable brain-targeting and mitochondria-locating properties, TQCN can efficiently chelate iron through phytopolyphenol-mediated spontaneous coordination and self-assemble into metal-phenolic nanocomplexes in situ , exerting escalating exogenous offensive effects to attenuate iron overload and its induced free radical burst...
March 6, 2024: ACS Nano
https://read.qxmd.com/read/38442520/lactic-acid-responsive-sequential-production-of-hydrogen-peroxide-and-consumption-of-glutathione-for-enhanced-ferroptosis-tumor-therapy
#7
JOURNAL ARTICLE
Weijuan Zou, Feng Gao, Zheying Meng, Xiaojun Cai, Wu Chen, Yuanyi Zheng, Tao Ying, Longchen Wang, Jianrong Wu
Ferroptosis is characterized by the lethal accumulation of lipid reactive oxygen species (ROS), which has great potential for tumor therapy. However, developing new ferroptosis-inducing strategies by combining nanomaterials with small molecule inducers is important. In this study, an enzyme-gated biodegradable natural-product delivery system based on lactate oxidase (LOD)-gated biodegradable iridium (Ir)-doped hollow mesoporous organosilica nanoparticles (HMONs) loaded with honokiol (HNK) (HNK@Ir-HMONs-LOD, HIHL) is designed to enhance ferroptosis in colon tumor therapy...
March 2, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38432004/an-atpase-mimicking-mxene-nanozyme-pharmacologically-breaks-the-ironclad-defense-system-for-ferroptosis-cancer-therapy
#8
JOURNAL ARTICLE
Huan Wang, Xinchen Liu, Xiangyu Yan, Yong Du, Fang Pu, Jinsong Ren, Xiaogang Qu
Anticancer nanomedicines used for ferroptosis therapy generally rely on the direct delivery of Fenton catalysts to drive lipid peroxidation in cancer cells. However, the therapeutic efficacy is limited by the ferroptosis resistance caused by the intracellular anti-ferroptotic signals. Herein, we report the intrinsic ATPase-mimicking activity of a vanadium carbide MXene nanozyme (PVCMs) to pharmacologically modulate the nuclear factor erythroid 2-related factor 2 (Nrf2) program, which is the master anti-ferroptotic mediator in the ironclad defense system in triple-negative breast cancer (TNBC) cells...
February 27, 2024: Biomaterials
https://read.qxmd.com/read/38431935/mri-guided-tumor-therapy-based-on-synergy-of-ferroptosis-immunosuppression-reversal-and-disulfidptosis
#9
JOURNAL ARTICLE
Shuai Guo, Zongheng Li, Ruilong Zhou, Jie Feng, Lin Huang, Bin Ren, Jiaoyang Zhu, Ya Huang, Guochao Wu, Haobin Cai, Qianqian Zhang, Yushen Ke, Tianwang Guan, Peier Chen, Yikai Xu, Chenggong Yan, Caiwen Ou, Zheyu Shen
Triple negative breast cancer (TNBC) cells have a high demand for oxygen and glucose to fuel their growth and spread, shaping the tumor microenvironment (TME) that can lead to a weakened immune system by hypoxia and increased risk of metastasis. To disrupt this vicious circle and improve cancer therapeutic efficacy, a strategy is proposed with the synergy of ferroptosis, immunosuppression reversal and disulfidptosis. An intelligent nanomedicine GOx-IA@HMON@IO is successfully developed to realize this strategy...
March 3, 2024: Small
https://read.qxmd.com/read/38410166/combining-photodynamic-therapy-and-cascade-chemotherapy-for-enhanced-tumor-cytotoxicity-the-role-of-ctt-2-p-b-nanoparticles
#10
JOURNAL ARTICLE
Rongyi Wang, Hongsen Li, Lu Han, Boao Han, Yiting Bao, Hongwei Fan, Chaoyue Sun, Ruijie Qian, Liying Ma, Jiajing Zhang
The mitochondria act as the main producers of reactive oxygen species (ROS) within cells. Elevated levels of ROS can activate the mitochondrial apoptotic pathway, leading to cell apoptosis. In this study, we devised a molecular prodrug named CTT2 P, demonstrating notable efficacy in facilitating mitochondrial apoptosis. To develop nanomedicine, we enveloped CTT2 P within bovine serum albumin (BSA), resulting in the formulation known as CTT2 P@B. The molecular prodrug CTT2 P is achieved by covalently conjugating mitochondrial targeting triphenylphosphine (PPh3 ), photosensitizer TPPOH2 , ROS-sensitive thioketal (TK), and chemotherapeutic drug camptothecin (CPT)...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38319010/a-triple-responsive-polymeric-prodrug-nanoplatform-with-extracellular-ros-consumption-and-intracellular-h-2-o-2-self-generation-for-imaging-guided-tumor-chemo-ferroptosis-immunotherapy
#11
JOURNAL ARTICLE
Yongjuan Li, Yongjian Cao, Kunru Ma, Rong Ma, Mengzhe Zhang, Yichen Guo, Haiwei Song, Nannan Sun, Zhenzhong Zhang, Weijing Yang
High reactive oxygen species (ROS) levels in tumor microenvironment (TME) will impair both immunogenic cell death (ICD) efficacy and T cell activity. Furthermore, tumor escapes immunosurveillance via programmed death-1/programmed death ligand-1 (PD-L1) signal, and the insufficient intracellular hydrogen peroxide will weaken ferroptosis efficacy. To tackle the above issues, we construct a glutathione (GSH)/ROS/pH triple-responsive prodrug nanomedicine that encapsulates Fe2 O3 nanoparticle via electrostatic interaction for magnetic resonance imaging (MRI)-guided multi-mode theranostics with chemotherapy/ferroptosis /immunotherapy...
February 6, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38286337/supramolecular-prodrug-like-nanotheranostics-with-dynamic-and-activatable-nature-for-synergistic-photothermal-immunotherapy-of-metastatic-cancer
#12
JOURNAL ARTICLE
Yajie Li, Xueluer Mu, Wenbi Feng, Min Gao, Zigeng Wang, Xue Bai, Xiangru Ren, Yingxi Lu, Xianfeng Zhou
Synergistic photothermal immunotherapy has attracted widespread attention due to the mutually reinforcing therapeutic effects on primary and metastatic tumors. However, the lack of clinical approval nanomedicines for spatial, temporal, and dosage control of drug co-administration underscores the challenges facing this field. Here, a photothermal agent (Cy7-TCF) and an immune checkpoint blocker (NLG919) are conjugated via disulfide bond to construct a tumor-specific small molecule prodrug (Cy7-TCF-SS-NLG), which self-assembles into prodrug-like nano-assemblies (PNAs) that are self-delivering and self-formulating...
January 27, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38280502/accelerated-cascade-melanoma-therapy-using-enzyme-nanozyme-integrated-dissolvable-polymeric-microneedles
#13
JOURNAL ARTICLE
Parbeen Singh, Yongli Chen, Brian Youden, David Oakley, Andrew Carrier, Ken Oakes, Mark Servos, Runqing Jiang, Xu Zhang
Dissolvable polymeric microneedles (DPMNs) have emerged as a powerful technology for the localized treatment of diseases, such as melanoma. Herein, we fabricated a DPMN patch containing a potent enzyme-nanozyme composite that transforms the upregulated glucose consumption of cancerous cells into lethal reactive oxygen species via a cascade reaction accelerated by endogenous chloride ions and external near-infrared (NIR) irradiation. This was accomplished by combining glucose oxidase (Gox) with a NIR-responsive chloroperoxidase-like copper sulfide (CuS) nanozyme...
January 25, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38278138/self-supplied-reactive-oxygen-species-responsive-mitoxantrone-polyprodrug-for-chemosensitization-enhanced-chemotherapy-under-moderate-hyperthermia
#14
JOURNAL ARTICLE
Hongjie Zhang, Jing Wang, Ruiying Wu, Benyan Zheng, Yanxiang Sang, Bibo Wang, Lei Song, Yuan Hu, Xiaopeng Ma
Currently, the secondary development and modification of clinical drugs has become one of the research priorities. Researchers have developed a variety of TME-responsive nanomedicine carriers to solve certain clinical problems. Unfortunately, endogenous stimuli such as reactive oxygen species (ROS), as an important prerequisite for effective therapeutic efficacy, are not enough to achieve the expected drug release process, therefore, it is difficult to achieve a continuous and efficient treatment process. Herein, a self-supply ROS-responsive cascade polyprodrug (PMTO) was designed...
January 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38277483/biomimetic-nanomedicine-targeting-orchestrated-metabolism-coupled-with-regulatory-factors-to-disrupt-the-metabolic-plasticity-of-breast-cancer
#15
JOURNAL ARTICLE
Lingtong Meng, Jingpeng Yang, Yang Gao, Qinyan Cao, Shunjie Jiang, Yuyang Xiao, Haoran Wang, Wenzheng Liu, Ahu Yuan, Yanan Li, He Huang
Targeting nutrient metabolism has been proposed as an effective therapeutic strategy to combat breast cancer because of its high nutrient requirements. However, metabolic plasticity enables breast cancer cells to survive under unfavorable starvation conditions. The key mammalian target regulators rapamycin (mTOR) and hypoxia-inducible-factor-1 (HIF-1) tightly link the dynamic metabolism of glutamine and glucose to maintain nutrient flux. Blocking nutrient flow also induces autophagy to recycle nutrients in the autophagosome, which exacerbates metastasis and tumor progression...
January 26, 2024: ACS Nano
https://read.qxmd.com/read/38229704/hypoxia-and-singlet-oxygen-dual-responsive-micelles-for-photodynamic-and-chemotherapy-therapy-featured-with-enhanced-cellular-uptake-and-triggered-cargo-delivery
#16
JOURNAL ARTICLE
Xuliang Guo, Lefei Han, Wenyu Chen, Huixin He, Weijin Zhang, Chaoqi Huang, Xiu Wang
INTRODUCTION: Combination therapy provides better outcomes than a single therapy and becomes an efficient strategy for cancer treatment. In this study, we designed a hypoxia- and singlet oxygen-responsive polymeric micelles which contain azo and nitroimidazole groups for enhanced cellular uptake, repaid cargo release, and codelivery of photosensitizer Ce6 and hypoxia-activated prodrug tirapazamine TPZ (DHM-Ce6@TPZ), which could be used for combining Ce6-mediated photodynamic therapy (PDT) and PDT-activated chemotherapy to enhance the therapy effect of cancer...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38192634/iron-based-nanovehicle-delivering-fin56-for-hyperthermia-boosted-ferroptosis-therapy-against-osteosarcoma
#17
JOURNAL ARTICLE
Yiran Zhang, Qingcheng Song, Yueyao Zhang, Jiheng Xiao, Xiangtian Deng, Xin Xing, Hongzhi Hu, Yingze Zhang
BACKGROUND: Although systemic chemotherapy is a standard approach for osteosarcoma (OS) treatment, its efficacy is limited by the inherent or acquired resistance to apoptosis of tumor cells. Ferroptosis is considered as an effective strategy capable of stimulating alternative pathways of cancer cell demise. The purpose of this study is to develop a novel strategy boosting ferroptotic cascade for synergistic cancer therapy. METHODS AND RESULTS: A novel nanovehicle composed of arginine-glycine-aspartate (RGD) modified mesoporous silica-coated iron oxide loading Fin56 was rationally prepared (FSR-Fin56)...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38191832/catalytic-gold-nanoparticle-assembly-programmed-by-dnazyme-circuits
#18
JOURNAL ARTICLE
Ranfeng Wu, Yiming Chen, Yongpeng Zhang, Rongming Liu, Qiang Zhang, Cheng Zhang
Assembled gold nanoparticle (AuNP) superstructures can generate unique physicochemical characteristics and be used in various applications, thus becoming an attractive research field. Recently, several DNA-assisted gold nanoparticle assembly methods have been rigorously developed that typically require a non-catalytic equimolar molecular assembly to guarantee the designed assembly. Although efficient and accurate, exploring such non-catalytic nanoparticle assemblies in the complex cellular milieu under low trigger concentrations remains challenging...
January 8, 2024: Small
https://read.qxmd.com/read/38171473/recent-advances-in-drug-delivery-and-targeting-for-the-treatment-of-pancreatic-cancer
#19
REVIEW
Nilkamal Pramanik, Aditya Gupta, Yashwardhan Ghanwatkar, Ram I Mahato
Despite significant treatment efforts, pancreatic ductal adenocarcinoma (PDAC), the deadliest solid tumor, is still incurable in the preclinical stages due to multifacet stroma, dense desmoplasia, and immune regression. Additionally, tumor heterogeneity and metabolic changes are linked to low grade clinical translational outcomes, which has prompted the investigation of the mechanisms underlying chemoresistance and the creation of effective treatment approaches by selectively targeting genetic pathways. Since targeting upstream molecules in first-line oncogenic signaling pathways typically has little clinical impact, downstream signaling pathways have instead been targeted in both preclinical and clinical studies...
January 1, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38098713/an-erythrocyte-membrane-camouflaged-fluorescent-covalent-organic-framework-for-starving-nitric-oxide-immunotherapy-of-triple-negative-breast-cancer
#20
JOURNAL ARTICLE
Fang Yuan, Cuiling Zhang, Xianzhu Luo, Shasha Cheng, Yingxin Zhu, Yuezhong Xian
It is a great challenge to effectively treat triple-negative breast cancer (TNBC) due to lack of therapeutic targets and drug resistance of systemic chemotherapy. Rational design of nanomedicine with good hemocompatibility is urgently desirable for combination therapy of TNBC. Herein, an erythrocyte membrane-camouflaged fluorescent covalent organic framework (COF) loaded with an NO donor (hydroxyurea, Hu), glucose oxidase (GOx) and cytosine-phosphate-guanine oligonucleotides (CPG) (COF@HGC) was developed for imaging-guided starving/nitric oxide (NO)/immunization synergistic treatment of TNBC...
December 13, 2023: Chemical Science
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