Shuai Guo, Zongheng Li, Ruilong Zhou, Jie Feng, Lin Huang, Bin Ren, Jiaoyang Zhu, Ya Huang, Guochao Wu, Haobin Cai, Qianqian Zhang, Yushen Ke, Tianwang Guan, Peier Chen, Yikai Xu, Chenggong Yan, Caiwen Ou, Zheyu Shen
Triple negative breast cancer (TNBC) cells have a high demand for oxygen and glucose to fuel their growth and spread, shaping the tumor microenvironment (TME) that can lead to a weakened immune system by hypoxia and increased risk of metastasis. To disrupt this vicious circle and improve cancer therapeutic efficacy, a strategy is proposed with the synergy of ferroptosis, immunosuppression reversal and disulfidptosis. An intelligent nanomedicine GOx-IA@HMON@IO is successfully developed to realize this strategy...
March 3, 2024: Small