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Delta gamma T-Cells

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https://www.readbyqxmd.com/read/30092874/evaluation-of-leucocytes-from-sputum-samples-of-pulmonary-tuberculosis-patients-using-flow-cytometry
#1
P C Gaspar, R C M Rudolf-Oliveira, L M Wildner, A C R de Moraes, M L Reis, R M da Silva, J Gonçalves, M L Bazzo, M C Santos-Silva
SETTING: Information about the sputum cells of pulmonary tuberculosis (PTB) patients is scarce. The analysis of sputum cells using optical microscopy (OM) is a well-established method, but it has some serious limitations. OBJECTIVE: To establish a new flow cytometry (FC) protocol for the leucocyte evaluation of sputum samples from PTB patients. DESIGN: A new FC protocol using 0.1% dithiothreitol and 0.5% paraformaldehyde was developed to fluidise sputum samples and kill Mycobacterium tuberculosis, respectively, to allow the analysis of sputum samples collected from TB patients...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30085957/atypical-histiocytic-lesion-preceding-a-peripheral-t-cell-lymphoma-involving-the-skin-exhibiting-the-same-molecular-alterations
#2
Salma Machan, Raúl Córdoba, Nerea Carvajal, Luis Requena, Miguel Ángel Piris, Fabio Facchetti, Socorro María Rodríguez-Pinilla
Peripheral T-cell lymphoma (PTCL), not otherwise specified (NOS) is a diagnosis of exclusion, showing extreme cytological and phenotypic heterogeneity. Skin involvement of PTCL may be primary or secondary. Diagnosis of histiocytosis may be difficult, requiring clinical-pathological correlation. We describe a laryngeal atypical histiocytic lesion (AHL) and a nasal PTCL, NOS with cutaneous involvement in the same patient presenting with peculiar histopathologic and immunophenotypic features. The laryngeal neoplasm showed morphological and immunophenotypic evidence of histiocytic differentiation and does not fit any other category of the WHO classification nor the revised classification of histiocytosis...
August 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/30030187/hepatosplenic-gamma-delta-t-cell-lymphoma-involving-the-brain-a-case-report
#3
Shohei Iijima, Tomohiro Chiba, Keisuke Maruyama, Kuniaki Saito, Keiichi Kobayashi, Yuki Yamagishi, Junji Shibahara, Nobuyuki Takayama, Yoshiaki Shiokawa, Motoo Nagane
BACKGROUND: Brain involvement of hepatosplenic T-cell lymphoma (HSTL) has not been reported so far. CASE DESCRIPTION: We experienced an extremely rare case of HSTL, which is a rare and aggressive variant of peripheral T-cell lymphoma, generally showing predominant infiltration to the liver, spleen and bone marrow, involving the brain. A 41-year-old Japanese female patient presented with dysarthria and numbness of the right hand. Radiological examination revealed a single 3 cm mass in the left frontal cortex, which was totally removed...
July 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30014858/characterizaton-of-gamma-delta-t-cells-in-marek-s-disease-virus-gallid-herpesvirus-2-infection-of-chickens
#4
Adrianna M S Laursen, Raveendra R Kulkarni, Khaled Taha-Abdelaziz, Brandon L Plattner, Leah R Read, Shayan Sharif
Immunity against Marek's disease (MD), caused by Gallid herpesvirus 2 (GaHV-2), in chickens is mediated by both innate and adaptive responses. The present study evaluated the effects of GaHV-2 infection on distribution and frequency of γδ T cells in tissues, as well as their expression of cytokines. We found that the infected chickens had significantly higher number of γδ T cells in their spleens by 10 and 21 days post-infection (d.p.i.) and nearly 100% of these γδ T cells were CD8+ at 21 d.p.i. Conversely, the number of γδ T cells in the cecal tonsils of GaHV-2-infected birds decreased compared to uninfected birds...
July 12, 2018: Virology
https://www.readbyqxmd.com/read/29997614/engineering-approaches-in-human-gamma-delta-t-cells-for-cancer-immunotherapy
#5
REVIEW
Jonathan Fisher, John Anderson
Sharing both innate and adaptive immune properties, γδT cells are attractive candidates for cellular engineering. As the cancer immunotherapy field becomes increasingly busy, orthogonal approaches are required to drive advancement. Engineering of alternative effector cell types such as γδT cells represents one such approach. γδT cells can be modified using many of the techniques used in αβT cell engineering, with the added advantage of innate-like tumor recognition and killing. Progress has been made in T-cell receptor transfer to and from γδT cells as well as in a number of chimeric antigen receptor-based strategies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29977236/-mycobacterium-tuberculosis-invasion-of-the-human-lung-first-contact
#6
Jeroen Maertzdorf, Mario Tönnies, Laura Lozza, Sandra Schommer-Leitner, Hans Mollenkopf, Torsten T Bauer, Stefan H E Kaufmann
Early immune responses to Mycobacterium tuberculosis (Mtb) invasion of the human lung play a decisive role in the outcome of infection, leading to either rapid clearance of the pathogen or stable infection. Despite their critical impact on health and disease, these early host-pathogen interactions at the primary site of infection are still poorly understood. In vitro studies cannot fully reflect the complexity of the lung architecture and its impact on host-pathogen interactions, while animal models have their own limitations...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29970569/possible-application-of-ascites-infiltrating-gamma-delta-t-cells-for-adoptive-immunotherapy
#7
Yuki Abe, Hirohito Kobayashi, Yoshika Akizawa, Ken Ishitani, Kazunori Hashimoto, Hideo Matsui
BACKGROUND/AIM: Malignant ascites contain many tumour-infiltrating lymphocytes. γδ T cells with antitumour activity have attracted attention as effector cells in cancer immunotherapy. Vδ2 + T cells were cultured from peripheral blood mononuclear cells (PBMCs) and ascites-infiltrating lymphocytes (AILs) to compare the differences in response to 2-methyl-3-butenyl-1-pyrophosphate (2M3B1-PP) and zoledronate (Zol) as antigens in vitro. MATERIALS AND METHODS: To expand Vδ2 + T cells from PBMCs and AILs from 29 patients with cancer, these cells were cultured and subjected to analysis...
July 2018: Anticancer Research
https://www.readbyqxmd.com/read/29963058/functional-plasticity-of-gamma-delta-t-cells-and-breast-tumor-targets-in-hypoxia
#8
Gabrielle M Siegers, Indrani Dutta, Raymond Lai, Lynne-Marie Postovit
Interactions between immune and tumor cells in the tumor microenvironment (TME) often impact patient outcome, yet remain poorly understood. In addition, the effects of biophysical features such as hypoxia [low oxygen (O2 )] on cells within the TME may lead to tumor evasion. Gamma delta T cells (γδTcs) naturally kill transformed cells and are therefore under development as immunotherapy for various cancers. Clinical trials have proven the safety of γδTc immunotherapy and increased circulating γδTc levels correlate with improved patient outcome...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29937769/gamma-delta-t-cell-therapy-for-cancer-it-is-good-to-be-local
#9
REVIEW
C David Pauza, Mei-Ling Liou, Tyler Lahusen, Lingzhi Xiao, Rena G Lapidus, Cristiana Cairo, Haishan Li
Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and is activated by intermediates of isoprenoid biosynthesis or aminobisphosphonate inhibitors of farnesyldiphosphate synthase. Activated cells are potent for killing a broad range of tumor cells and demonstrated the capacity for tumor reduction in murine xenotransplant tumor models. Translating these findings to the clinic produced promising initial results but greater potency is needed...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29928999/a-potentially-important-role-for-t-cells-and-regulatory-t-cells-in-langerhans-cell-histiocytosis
#10
REVIEW
Jenée M Mitchell, Stuart P Berzins, George Kannourakis
Langerhans cell histiocytosis is characterized by lesions containing inflammatory immune cells, including myeloid cells and T cells. Patient mortality remains unacceptably high and new treatment options are required. Several LCH studies have identified aberrant frequencies of T cell subsets with potential immune regulatory properties. High numbers of Foxp3+ regulatory T cells and gamma-delta T cells have been reported in patients with LCH, although, the cause of their presence or their significance is not yet clear...
June 18, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29915722/new-therapies-and-immunological-findings-in-cutaneous-t-cell-lymphoma
#11
REVIEW
Kazuyasu Fujii
Primary cutaneous lymphomas comprise a group of lymphatic malignancies that occur primarily in the skin. They represent the second most common form of extranodal non-Hodgkin's lymphoma and are characterized by heterogeneous clinical, histological, immunological, and molecular features. The most common type is mycosis fungoides and its leukemic variant, Sézary syndrome. Both diseases are considered T-helper cell type 2 (Th2) diseases. Not only the tumor cells but also the tumor microenvironment can promote Th2 differentiation, which is beneficial for the tumor cells because a Th1 environment enhances antitumor immune responses...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29893430/tcr-%C3%AE-expression-and-%C3%AE-%C3%AE-t-cell-infiltrates-in-primary-cutaneous-gamma-delta-t-cell-lymphoma-and-other-cutaneous-t-cell-lymphoproliferative-disorders
#12
Melissa Pulitzer, Shamir Geller, Erica Kumar, Denise Frosina, Allison Moskowitz, Steven Horwitz, Patricia Myskowski, Meenal Kheterpal, Alexander Chan, Ahmet Dogan, Achim Jungbluth
AIMS: The diagnosis of cutaneous gamma delta T-cell lymphoma (GDTCL) requires the identification of γδ chains of the T-cell receptor (TCR). Using a new mAb to TCRδ, we evaluated TCRδ expression in formalin fixed paraffin embedded (FFPE) skin tissue from TCRγ-positive cutaneous T-cell lymphoma (CTCL) and assessed TCRδ expression within a spectrum of other cutaneous lymphoproliferative disorders (CLPD). METHODS AND RESULTS: 12 cases (10 patients) with TCRγ-positive CTCL and 132 additional CLPD cases (127 patients) were examined including mycosis fungoides (MF, n=60), cutaneous GDTCL (n=15), subcutaneous panniculitis-like T-cell lymphomas (SPTCL, n=11), and CD30+ lymphoproliferative disorders (CD30+LPDs, n=24)...
June 12, 2018: Histopathology
https://www.readbyqxmd.com/read/29790605/cd57-identifies-t-cells-with-functional-senescence-before-terminal-differentiation-and-relative-telomere-shortening-in-patients-with-activated-pi3-kinase-delta-syndrome
#13
Paola Cura Daball, Monica Sofia Ventura Ferreira, Sandra Ammann, Christian Klemann, Myriam R Lorenz, Ursula Warthorst, Timothy Ronan Leahy, Niall Conlon, Justin Roche, Pere Soler-Palacín, Marina Garcia-Prat, Ilka Fuchs, Sebastian Fuchs, Fabian Beier, Tim H Brümmendorf, Carsten Speckmann, Peter Olbrich, Olaf Neth, Klaus Schwarz, Stephan Ehl, Anne Rensing-Ehl
Premature T-cell immunosenescence with CD57+ CD8+ T-cell accumulation has been linked to immunodeficiency and autoimmunity in primary immunodeficiencies including activated PI3 kinase delta syndrome (APDS). To address whether CD57 marks the typical senescent T-cell population seen in adult individuals or identifies a distinct population in APDS, we compared CD57+ CD8+ T cells from mostly pediatric APDS patients to those of healthy adults with similarly prominent senescent T cells. CD57+ CD8+ T cells from APDS patients were less differentiated with more CD27+ CD28+ effector memory T cells showing increased PD1 and Eomesodermin expression...
May 23, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29782465/gamma-delta-t-lymphocytes-in-the-diagnostic-approach-of-coeliac-disease
#14
Petula Nijeboer, Tom van Gils, Martine Reijm, Rogier Ooijevaar, Birgit I Lissenberg-Witte, Hetty J Bontkes, Chris J J Mulder, Gerd Bouma
GOALS: To validate cut-off values of CD3 T-cell receptor gamma-delta chain (TCRγδ) intraepithelial lymphocyte (IEL) in the (differential) diagnosis of celiac disease (CD). BACKGROUND: CD is characterized by an increase in gamma-delta IEL (CD3TCRγδ IEL). STUDY: Percentages were determined by flow cytometric analysis of IELs from small bowel biopsies in 213 CD and 13 potential CD (PCD) patients and in total 112 controls. A cut-off value for percentages of CD3TCRγδ IEL to differentiate active CD and controls was obtained from a receiver operating characteristic curve and implemented in controls and PCD patients...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29773448/the-role-of-the-common-gamma-chain-family-cytokines-in-%C3%AE-%C3%AE-t-cell-based-anti-cancer-immunotherapy
#15
REVIEW
Heleen H Van Acker, Diana Campillo-Davo, Gils Roex, Maarten Versteven, Evelien L Smits, Viggo F Van Tendeloo
Cytokines of the common gamma-chain receptor family, comprising interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15 and IL-21, are vital with respect to organizing and sustaining healthy immune cell functions. Supporting the anti-cancer immune response, these cytokines inspire great interest for their use as vaccine adjuvants and cancer immunotherapies. It is against this background that gamma delta (γδ) T cells, as special-force soldiers and natural contributors of the tumor immunosurveillance, also received a lot of attention the last decade...
June 2018: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29770915/cytolytic-activity-score-to-assess-anticancer-immunity-in-colorectal-cancer
#16
Sumana Narayanan, Tsutomu Kawaguchi, Li Yan, Xuan Peng, Qianya Qi, Kazuaki Takabe
BACKGROUND: Elevated tumor-infiltrating lymphocytes (TILs) within the tumor microenvironment is a known positive prognostic factor in colorectal cancer (CRC). We hypothesized that since cytotoxic T cells release cytolytic proteins such as perforin (PRF1) and pro-apoptotic granzymes (GZMA) to attack cancer cells, a cytolytic activity score (CYT) would be a useful tool to assess anticancer immunity. METHODS: Genomic expression data were obtained from 456 patients from The Cancer Genome Atlas (TCGA)...
May 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29769011/evolving-strategies-for-the-treatment-of-t-cell-lymphoma-a-systematic-review-and-recent-patents
#17
Kamel Laribi, Mustapha Alani, Catherine Truong, Alix Baugier de Materre
OBJECTIVE: Mature T-cell lymphomas are a heterogeneous group of T-cell malignancies with a poor outcome. The discovery of new molecular biomarkers has led to the emergence of new drugs in recent years that target various signaling pathways. METHOD: We examined all pertinent published patents through 2015 that analyzed novel methods for the diagnosis and treatment of T cell lymphoma, as well as related published and unpublished studies. Selection criteria were established before data collection...
May 16, 2018: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29755847/-18-f-fdg-pet-ct-findings-in-hepatosplenic-gamma-delta-t-cell-lymphoma-case-reports-and-review-of-the-literature
#18
Michael W Cho, Bennett B Chin
Hepatosplenic Gamma Delta T cell lymphoma (γδHSTL) is a rare, highly aggressive, and rapidly lethal T cell lymphoma which manifests 18 F-FDG PET/CT findings that can mimic benign conditions. Patients with γδHSTL present with unexplained symptoms of a hematologic malignancy like the B symptoms of lymphoma including weight loss, fevers, and night sweats, as well as, splenomegaly and hepatomegaly. Thrombocytopenia, anemia, or neutropenia are also common due to spleen, liver and bone marrow involvement. The peripheral blood, however, typically does not show abnormal T cells...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755480/molecular-determinants-of-target-cell-recognition-by-human-%C3%AE-%C3%AE-t-cells
#19
REVIEW
André E Simões, Biagio Di Lorenzo, Bruno Silva-Santos
The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a mechanistic standpoint, numerous studies have unveiled a remarkable flexibility of γδ T cells in employing their T cell receptor and/or NK cell receptors for target cell recognition, even if the relevant ligands often remain uncertain...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29739416/correction-to-gamma-delta-%C3%AE-%C3%AE-t-cells-friend-or-foe-in-cancer-development
#20
Yijing Zhao, Chao Niu, Jiuwei Cui
Following publication of the original article [1], the authors reported that they omitted to state that parts of Fig. 2 were adapted from Van Acker et al. [2] published by Taylor & Francis Ltd ( www.tandfonline.com ). The authors apologise for this omission. Figure 2 and its corrected caption are given below.
May 8, 2018: Journal of Translational Medicine
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