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https://www.readbyqxmd.com/read/30090141/phenotypical-variation-with-same-genetic-mutation-in-familial-hypokalemic-periodic-paralysis
#1
Sumant Kumar, Eniang E Offiong, Sweta Sangita, Nahin Hussain
Hypokalemic periodic paralysis is a genetic neuromuscular disorder characterized by episodes of painless muscle paralysis associated with low serum potassium, exclusively, during the attack. This may be precipitated by heavy exercise, fasting, or high-carbohydrate meals. We report two siblings, presenting at different ages with varying symptomatology-older sibling with episodic weakness in the morning associated with reduced physical exercise and consumption of large carbohydrate meal, whereas younger sibling complained of muscle stiffness following large carbohydrate meal and at the end of physical exercise...
April 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/30089769/physical-fitness-and-its-relationship-to-plasma-leptin-leptin-soluble-receptor-and-free-leptin-index-in-a-saudi-population-a-comparison-between-diabetic-and-non-diabetic-individuals
#2
Hana Alzamil, Laila Aldokhi, Syed Shahid Habib
BACKGROUND Low physical activity is considered to be a risk factor for type 2 diabetes mellitus (T2DM). One theory suggest that leptin resistance is involved in the pathophysiology of impaired glucose metabolism. In this study we aimed to assess the correlation of physical fitness scores (PFS) with serum total leptin (TL), serum leptin soluble receptor (LSR), and free leptin index (FLI) in a group of Saudi patients with T2DM. MATERIAL AND METHODS This cross-sectional study involved 115 subjects: 52 healthy control subjects and 63 patients with T2DM...
August 9, 2018: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/30089756/relationship-between-cardiorespiratory-fitness-and-non-high-density-lipoprotein-cholesterol-a-cohort-study
#3
Natsumi Watanabe, Susumu S Sawada, Kazunori Shimada, I-Min Lee, Yuko Gando, Haruki Momma, Ryoko Kawakami, Motohiko Miyachi, Yumiko Hagi, Chihiro Kinugawa, Takashi Okamoto, Koji Tsukamoto, Steven N Blair
AIM: Recent studies have suggested that non-high-density lipoprotein cholesterol (non-HDL-C) may be a good marker of coronary heart disease and cardiovascular disease risk. Therefore, we investigated the relationship between cardiorespiratory fitness (CRF) and non-HDL-C. METHODS: We evaluated CRF and the incidence of high level of non-HDL-C in 4,067 Japanese men without dyslipidemia. The participants were given a submaximal exercise test, a medical examination, and questionnaires on their health habits in 1986...
August 8, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30067077/neither-repetition-duration-nor-number-of-muscle-actions-affect-strength-increases-body-composition-muscle-size-or-fasted-blood-glucose-in-trained-males-and-females
#4
Luke Carlson, Brandon Jonker, Wayne L Westcott, James Steele, James P Fisher
A key variable within resistance training (RT) is that of repetition duration; the time (seconds; s) taken to perform the concentric and eccentric muscle actions of a repetition. Research has produced equivocal results with regards to strength and muscle mass increases whilst many studies have created parity in the number of repetitions though there has been a disparity in load used and time-under-load (TUL). The purpose of this study was to compare load, and TUL matched groups performing resistance exercise using differing repetition durations...
August 1, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/30066645/effect-of-physical-activity-on-fasting-blood-glucose-and-lipid-profile-among-low-income-housewives-in-the-mybff-home-study
#5
Azahadi Omar, Mohd Normazlan Husain, Ahmad Taufik Jamil, Noor Safiza Mohamad Nor, Rashidah Ambak, Mansor Fazliana, Nur Liyana Ahamad Zamri, Tahir Aris
BACKGROUND: Regular physical activity has always been strongly recommended for good cardiovascular health. This study aimed to determine the effect of physical activity on fasting blood glucose and lipid profile among low income housewives in Klang Valley. METHODS: Data of 328 eligible housewives who participated in the MyBFF@Home study was used. Intervention group of 169 subjects were provided with an intervention package which includes physical activity (brisk walking, dumbbell exercise, physical activity diary, group exercise) and 159 subjects in control group received various health seminars...
July 19, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/30062572/randomized-controlled-trial-of-weight-loss-versus-usual-care-on-telomere-length-in-women-with-breast-cancer-the-lifestyle-exercise-and-nutrition-lean-study
#6
Tara Sanft, Ilana Usiskin, Maura Harrigan, Brenda Cartmel, Lingeng Lu, Fang-Yong Li, Yang Zhou, Anees Chagpar, Leah M Ferrucci, Lajos Pusztai, Melinda L Irwin
PURPOSE: Some studies suggest that telomere shortening may be associated with increased breast cancer risk and mortality. Obesity is also associated with increased breast cancer risk and mortality. Few studies have examined changes in telomere length in overweight or obese breast cancer survivors. The purpose of our study was to examine the effect of a 6-month diet- and exercise-induced weight loss intervention versus usual care on telomere length in breast cancer survivors. METHODS: 151 breast cancer survivors with body mass index (BMI) ≥ 25 kg/m2 were randomly assigned to a 6-month weight loss intervention (n = 93) or to usual care (n = 58)...
July 30, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/30058508/energy-depletion-by-24-h-fast-leads-to-compensatory-appetite-responses-compared-with-matched-energy-depletion-by-exercise-in-healthy-young-males
#7
David Thivel, Graham Finlayson, Maud Miguet, Bruno Pereira, Martine Duclos, Yves Boirie, Eric Doucet, John E Blundell, Lore Metz
Although there is a growing interest for the effects of intermittent fasting on energy balance, this study aimed to compare appetite, energy intake and food reward responses with an energy depletion induced either by 24-h food restriction or an equivalent deficit with exercise in healthy males. In all, twelve healthy lean males (21·5 (sd 0·5) years old; BMI: 22·5 (sd 1·7) kg/m2) participated in this study. Body composition, aerobic capacity, food preferences and energy intake were assessed. They randomly completed three conditions: (i) no depletion (CON); (ii) full 24-h energy restrictions (Def-EI); and (iii) exercise condition (Def-EX)...
July 30, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/30057013/impact-of-respiratory-function-on-the-progression-from-metabolically-healthy-non-overweight-to-metabolically-abnormal-phenotype
#8
Y Hashimoto, T Okamura, M Hamaguchi, A Obora, T Kojima, M Fukui
BACKGROUND AND AIMS: Recent studies identified that metabolically abnormal non-overweight phenotype is a risk factor for cardiovascular diseases. However, only little is known about risk factors for the progression from metabolically healthy non-overweight (MHNO) to metabolically abnormal phenotype. In this study, we investigated the impact of respiratory function on the progression from MHNO to metabolically abnormal phenotype. METHODS AND RESULTS: In this retrospective cohort study, 8949 (3872 men and 5077 women) individuals with MHNO, who participated in a health-checkup program from 2004 to 2015, were enrolled...
June 7, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/30054135/exercise-health-outcomes-and-p%C3%A3-diatric-obesity-a-systematic-review-of-meta-analyses
#9
REVIEW
Antonio García-Hermoso, Robinson Ramírez-Vélez, Jose M Saavedra
OBJECTIVES: This study is a systematic review of meta-analyses that have addressed the effects of exercise-based interventions alone and the health outcomes (anthropometric, body composition, cardiometabolic, hepatic, vascular, and cardiorespiratory fitness parameters) in overweight and obese children and adolescents. DESIGN: Systematic review of meta-analysis. METHODS: Six electronic sources were searched. The inclusion criteria were: children and/or adolescents classified as overweight or obese, and previous systematic reviews and meta-analyses that included exercise interventions compared to a control group...
July 24, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/30051338/delayed-parasympathetic-reactivation-and-sympathetic-withdrawal-following-maximal-cardiopulmonary-exercise-testing-cpet-in-hypoxia
#10
Alessandro Fornasiero, Aldo Savoldelli, Spyros Skafidas, Federico Stella, Lorenzo Bortolan, Gennaro Boccia, Andrea Zignoli, Federico Schena, Laurent Mourot, Barbara Pellegrini
PURPOSE: This study investigated the effects of acute hypoxic exposure on post-exercise cardiac autonomic modulation following maximal cardiopulmonary exercise testing (CPET). METHODS: Thirteen healthy men performed CPET and recovery in normoxia (N) and normobaric hypoxia (H) (FiO2  = 13.4%, ≈ 3500 m). Post-exercise cardiac autonomic modulation was assessed during recovery (300 s) through the analysis of fast-phase and slow-phase heart rate recovery (HRR) and heart rate variability (HRV) indices...
July 26, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/30049509/low-urine-ph-is-a-risk-for-non-alcoholic-fatty-liver-disease-a-population-based-longitudinal-study
#11
Takuro Okamura, Yoshitaka Hashimoto, Masahide Hamaguchi, Akihiro Obora, Takao Kojima, Michiaki Fukui
BACKGROUND: Low urine pH has a close association with insulin resistance. This study was aimed to investigate the association between urine pH and incident non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance. SUBJECTS AND METHODS: In this historical cohort study of 11,012 participants (5503 men and 5509 women), we investigated the effect of urine pH on incident NAFLD. NAFLD was defined as having fatty liver diagnosed by abdominal ultrasonography and excluding the participants consumed ethanol over 60g/day for men and 40g/day for women...
July 23, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30048201/impact-of-venous-return-on-pulmonary-oxygen-uptake-kinetics-during-dynamic-exercise-in-silico-time-series-analyses-from-muscles-to-lungs
#12
Uwe Drescher
Purpose The aim of the present study was to investigate if a single- (SCM) and a multi-compartment venous return model (MCM) will produce significantly different time-delaying and distortive effects on the pulmonary oxygen uptake (V'O2pulm ) responses with equal cardiac outputs (Q') and muscle oxygen uptake (V'O2musc ) inputs. Methods For each model, 64 data sets were simulated with alternating Q' and V'O2musc kinetics - time constants (τ) ranging from 10 to 80 s - as responses to pseudorandom binary sequence work rate (WR) changes...
July 26, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/30045740/exercise-training-modalities-in-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-network-meta-analysis
#13
REVIEW
Bei Pan, Long Ge, Yang-Qin Xun, Ya-Jing Chen, Cai-Yun Gao, Xue Han, Li-Qian Zuo, Hou-Qian Shan, Ke-Hu Yang, Guo-Wu Ding, Jin-Hui Tian
INTRODUCTION: Current international guidelines recommend aerobic, resistance, and combined exercises for the management of type 2 diabetes mellitus (T2DM). In our study, we conducted a network meta-analysis to assess the comparative impact of different exercise training modalities on glycemic control, cardiovascular risk factors, and weight loss in patients with T2DM. METHODS: We searched five electronic databases to identify randomized controlled trials (RCTs) that compared the differences between different exercise training modalities for patients with T2DM...
July 25, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/30042516/soy-protein-supplementation-is-not-androgenic-or-estrogenic-in-college-aged-men-when-combined-with-resistance-exercise-training
#14
Cody T Haun, C Brooks Mobley, Christopher G Vann, Matthew A Romero, Paul A Roberson, Petey W Mumford, Wesley C Kephart, James C Healy, Romil K Patel, Shelby C Osburn, Darren T Beck, Robert D Arnold, Ben Nie, Christopher M Lockwood, Michael D Roberts
It is currently unclear as to whether sex hormones are significantly affected by soy or whey protein consumption. Additionally, estrogenic signaling may be potentiated via soy protein supplementation due to the presence of phytoestrogenic isoflavones. Limited also evidence suggests that whey protein supplementation may increase androgenic signaling. Therefore, the purpose of this study was to examine the effects of soy protein concentrate (SPC), whey protein concentrate (WPC), or placebo (PLA) supplementation on serum sex hormones, androgen signaling markers in muscle tissue, and estrogen signaling markers in subcutaneous (SQ) adipose tissue of previously untrained, college-aged men (n = 47, 20 ± 1 yrs) that resistance trained for 12 weeks...
July 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30040286/-exercise-and-fasting-induced-movement-disorder-in-children-think-of-the-glut1-deficiency-syndrome
#15
Kim E M van Kan, Bianca Panis
BACKGROUND: Glucose transporter type 1 (GLUT1) enables glucose to pass through the blood-brain barrier. A hereditary deficiency of this protein may lead to clinical symptoms when blood glucose levels are decreasing. CASE DESCRIPTION: A 7-year-old girl with therapy-resistant childhood absence epilepsy presented with an exercise and fasting induced dystonic and atactic movement pattern. The movement pattern disappears postprandial. Based on a reduced glucose in the liquor, and also a reduced liquor glucose/serum glucose ratio, the diagnosis of GLUT1 deficiency syndrome was considered...
July 13, 2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/30036896/-disturbances-of-sodium-homeostasis
#16
Florian Dresely
Sodium is the most important osmotically effective cation in the extracellular space and very important for the water balance of the organism. Disturbances in the sodium homeostasis are therefore usually closely associated with disturbances in the water balance. The most important organs involved in the regulation of the sodium homeostasis are the kidneys and the brain. Disturbances of sodium homeostasis are common electrolyte disturbances, which can cause serious complications, as well as their improper therapy...
July 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/30031838/maximal-strength-training-increases-muscle-force-generating-capacity-and-the-anaerobic-atp-synthesis-flux-without-altering-the-cost-of-contraction-in-elderly
#17
Ole Kristian Berg, Oh Sung Kwon, Thomas J Hureau, Heather L Clifton, Taylor Thurston, Yann Le Fur, Eun-Kee Jeong, Markus Amann, Russel S Richardson, Joel D Trinity, Eivind Wang, Gwenael Layec
Aging is associated with a progressive decline in skeletal muscle function, then leading to impaired exercise tolerance. Maximal strength training (MST) appears to be a practical and effective intervention to increase both exercise capacity and efficiency. However, the underlying physiological mechanisms responsible for these functional improvements are still unclear. Accordingly, the purpose of this study was to examine the intramuscular and metabolic adaptations induced by 8 weeks of knee-extension MST in the quadriceps of 10 older individuals (75 ± 9 yrs) by employing a combination of molecular, magnetic resonance 1 H-imaging and 31 P-spectroscopy, muscle biopsies, motor nerve stimulation, and indirect calorimetry techniques...
July 19, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/30028092/electromyostimulation-to-fight-atrophy-and-to-build-muscle-facts-and-numbers
#18
EDITORIAL
Volker Adams
In recent years, electrical myostimulation (EMS) is becoming more and more popular to increase muscle function and muscle weight. Especially it is applied in healthy individual after injury to rebuild muscle mass and in severely atrophic patients who are not able or willing to perform conventional exercise training programs. Studies in experimental models as well as in human subjects confirmed that EMS can increase muscle mass by around 1% and improve muscle function by around 10-15% after 5-6 weeks of treatment...
July 20, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/30025922/prevalence-of-and-risk-factors-for-colorectal-neoplasia-in-asymptomatic-young-adults-20-39-years-old
#19
Nam Hee Kim, Yoon Suk Jung, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND & AIMS: The incidence of colorectal cancer is increasing among persons 50 years old or younger. However, data on the epidemiology of young-onset colorectal neoplasia (CRN) are limited. Although some studies have investigated the epidemiology of CRN in persons younger than 50 years, most have focused on persons 40 years or older. We evaluated the prevalence of and risk factors for CRN in adults younger than 40 years. METHODS: We performed a cross-sectional analysis of 72,356 asymptomatic individuals, 20-39 years old, who underwent colonoscopies as participants in the Kangbuk Samsung Health Study in South Korea, from August 2004 through December 2015...
July 17, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30025428/the-relationship-between-aortic-knob-width-and-metabolic-syndrome
#20
Eun-Ji Lee, Jee-Hye Han, Kil-Young Kwon, Jung-Hwan Kim, Kun-Hee Han, Si-Yeun Sung, Seo-Rim Hong
Background: Both aortic knob width and metabolic syndrome are suggested to be related to atherosclerosis and cardiovascular diseases. However, the association between aortic knob width and metabolic syndrome is unknown. This study aimed to explore this relationship. METHODS: Participants were 3,705 Korean adults aged 18-79 years who visited the health promotion center of a general hospital. Data on chest radiography, physical measurements, medical and social history, and blood tests were collected...
July 2018: Korean Journal of Family Medicine
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