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UCP Thermogenesis

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https://www.readbyqxmd.com/read/30072816/ectopic-bat-mucp-1-overexpression-in-skm-by-delivering-a-bmp7-prdm16-pgc-1a-gene-cocktail-or-single-prmd16-using-non-viral-utmd-gene-therapy
#1
Shuyuan Chen, Raul A Bastarrachea, Jin-Song Shen, Antonio Laviada-Nagel, Ernesto Rodriguez-Ayala, Edna J Nava-Gonzalez, Pintong Huang, Ralph A DeFronzo, Jack W Kent, Paul A Grayburn
Here we present our progress in inducing an ectopic brown adipose tissue (BAT) phenotype in skeletal muscle (SKM) as a potential gene therapy for obesity and its comorbidities. We used ultrasound-targeted microbubble destruction (UTMD), a novel targeted, non-viral approach to gene therapy, to deliver genes in the BAT differentiation pathway into rodent SKM to engineer a thermogenic BAT phenotype with ectopic mUCP-1 overexpression. In parallel, we performed a second protocol using wild-type Ucp-1-null knockout mice to test whether the effects of the gene therapy are UCP-1 dependent...
August 2, 2018: Gene Therapy
https://www.readbyqxmd.com/read/30060995/effects-of-visfatin-on-brown-adipose-tissue-energy-regulation-using-t37i-cells
#2
Georgios K Dimitriadis, Raghu Adya, Bee K Tan, Terence A Jones, Vinod S Menon, Manjunath Ramanjaneya, Gregory Kaltsas, Alexander D Miras, Harpal S Randeva
The role of brown adipose tissue (BAT) in pathological states of energy homeostasis and impaired adipocyte function, such as obesity has been a major area of research interest in recent years. Herein, we sought to determine the direct effects of adipokines, visfatin and leptin on BAT thermogenesis. The effects of mouse recombinant visfatin, nicotinamide mononucleotide (NMN) and leptin with or without FK866 were studied on differentiated T37i cells. Treated cells were analyzed for key genes and proteins regulating BAT [UCP-1, PRD1-BF1-RIZ1 homologous domain-containing 16 (PRDM-16), PPARgamma-coactivator-1alpha (PGC-1α) and receptor-interacting protein 140 (RIP-140)] using quantitative PCR and western blot analysis...
July 27, 2018: Cytokine
https://www.readbyqxmd.com/read/30056864/metabolome-analysis-of-the-serotonin-syndrome-rat-model-abnormal-muscular-contraction-is-related-to-metabolic-alterations-and-hyper-thermogenesis
#3
Kei Zaitsu, Saki Noda, Akira Iguchi, Yumi Hayashi, Tomomi Ohara, Yuya Kimura, Yuta Koketsu, Tomoko Kosaki, Maiko Kusano, Takako Sato, Tetsuya Ishikawa, Hitoshi Tsuchihashi, Koichi Suzuki, Akira Ishii
AIMS: Serotonin syndrome (SS) is an adverse outcome of selective serotonin reuptake inhibitors, though its mechanism is not understood and there is no specific clinical biomarker. In this article, metabolic profiles of the SS model rats and causes of metabolome disruption were investigated. MAIN METHODS: Gas chromatography-tandem mass spectrometry (GC/MS/MS)-based metabolomics, clinical biomarker measurements and qRT-PCR analysis for UCP-3 in skeletal muscles were performed...
August 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29851217/yerba-mate-stimulates-mitochondrial-biogenesis-and-thermogenesis-in-high-fat-diet-induced-obese-mice
#4
Tanila Wood Dos Santos, Jonatan Miranda, Lucimara Teixeira, Ana Aiastui, Ander Matheu, Alessandra Gambero, María P Portillo, Marcelo Lima Ribeiro
SCOPE: The potential effects of yerba mate (YM) on mitochondrial biogenesis and thermogenesis are evaluated. METHODS AND RESULTS: The in vitro effects of YM on mitochondrial respiration are assessed in C2C12 cells. The expression of genes related to mitochondrial biogenesis and thermogenesis are analyzed by quantitative PCR. The in vivo experiments are performed on mice fed a high-fat diet (HFD) and treated with YM extract. Indirect calorimetry was performed, and the expression of genes and proteins related to mitochondrial biogenesis, thermogenesis, and de novo lipogenesis is determined by quantitative PCR and western blot...
May 31, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29746591/brown-adipose-tissue-plays-a-central-role-in-systemic-inflammation-induced-sleep-responses
#5
Éva Szentirmai, Levente Kapás
We previously identified brown adipose tissue (BAT) as a source of sleep-inducing signals. Pharmacological activation of BAT enhances sleep while sleep loss leads to increased BAT thermogenesis. Recovery sleep after sleep loss is diminished in mice that lack uncoupling protein 1 (UCP-1), and also in wild-type (WT) mice after sensory denervation of the BAT. Systemic inflammation greatly affects metabolism and the function of adipose tissue, and also induces characteristic sleep responses. We hypothesized that sleep responses to acute inflammation are mediated by BAT-derived signals...
2018: PloS One
https://www.readbyqxmd.com/read/29643769/the-role-of-physical-exercise-to-improve-the-browning-of-white-adipose-tissue-via-pomc-neurons
#6
REVIEW
Kellen C da Cruz Rodrigues, Rodrigo M Pereira, Thaís D P de Campos, Rodrigo F de Moura, Adelino S R da Silva, Dennys E Cintra, Eduardo R Ropelle, José R Pauli, Michel B de Araújo, Leandro P de Moura
Obesity is a public health issue that affects more than 600 million adults worldwide. The disease is characterized by fat accumulation, mainly in the abdominal area. The human body is mainly composed of two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT); however, the browning process generates a different type of brown fat-like adipocyte in WAT, which similar to BAT has thermogenic capacity by activating UCP-1. The hypothalamic arcuate nucleus plays an important role in WAT browning via POMC neurons, which are influenced by synergistic insulin and leptin signaling...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29626477/chronic-cold-exposure-results-in-subcutaneous-adipose-tissue-browning-and-altered-global-metabolism-in-qinghai-tibetan-plateau-pika-ochotona-curzoniae
#7
Jia Li, Quanyu Yang, Zhenzhong Bai, Wenhua Zhou, Gregg L Semenza, Ri-Li Ge
The plateau pika (Ochotona curzoniae), one of the indigenous animals of the Qinghai-Tibet Plateau, is adapted to life in a cold and hypoxic environment. We conducted a series of genomic, proteomic and morphological studies to investigate whether changes in energy metabolism contribute to adaptation of the plateau pika to cold stress by analyzing summer and winter cohorts. The winter group showed strong morphological and histological features of brown adipose tissue (BAT) in subcutaneous white adipose tissue (sWAT)...
June 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29554135/thermogenic-capacity-of-human-periaortic-adipose-tissue-is-transformed-by-body-weight
#8
Diana Vargas, Carolina López, Edward Acero, Edgar Benitez, Angélica Wintaco, Jaime Camacho, Marisol Carreño, Juan Umaña, Daniela Jimenez, Said Díaz, Fernando Lizcano
The anatomical location of adipose tissue might have direct implications for its functionality and risk of cardiovascular disease. Adipose tissue surrounding blood vessels may be thermogenically more active in specific areas of the body, releasing substances that regulate vascular metabolism. In humans, the phenotypic characteristics of adipose tissue surrounding the aorta and the cardiovascular disease risk that it might entail remain largely unknown. Here, we compared thermogenesis-related molecular features of human periaortic adipose tissue samples with those of subcutaneous adipose tissue, obtained by sternotomy from 42 patients undergoing cardiovascular surgery...
2018: PloS One
https://www.readbyqxmd.com/read/29512723/susceptibilities-of-epicardial-and-subcutaneous-fat-tissue-for-browning-gene-expression-and-diet-induced-volume-reduction-are-different
#9
Hiroshi Mikamo, Meizi Jiang, Mahito Noro, Yasuo Suzuki, Nobuyuki Hiruta, Hiroyuki Unoki-Kubota, Wolfgang J Schneider, Hideaki Bujo
The upregulation of brown or brown-like beige adipocytes is a potential strategy for the prevention or treatment of diabetes and coronary artery diseases in obese patients. Epicardial adipose tissue (EAT) differs significantly from subcutaneous fat tissue (SAT) in metabolic properties. To investigate properties of EAT further, thermogenesis gene expression was investigated in human autopsy and murine samples, and adipocytes differentiated from EAT mesenchymal cells. Subsequently, analyzed EAT volume alterations were observed to be associated with weight reduction in obese patients by imaging...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29358227/inflammatory-pathways-regulated-by-tumor-necrosis-receptor-associated-factor-1-protect-from-metabolic-consequences-in-diet-induced-obesity
#10
Nathaly Anto Michel, Christian Colberg, Konrad Buscher, Björn Sommer, Akula Bala Pramod, Erik Ehinger, Bianca Dufner, Natalie Hoppe, Katharina Pfeiffer, Timoteo Marchini, Florian Willecke, Peter Stachon, Ingo Hilgendorf, Timo Heidt, Constantin von Zur Muhlen, Dominik von Elverfeldt, Dietmar Pfeifer, Roland Schüle, Ulrich Kintscher, Sebastian Brachs, Klaus Ley, Christoph Bode, Andreas Zirlik, Dennis Wolf
RATIONALE: The coincidence of inflammation and metabolic derangements in obese adipose tissue has sparked the concept of met-inflammation. Previous observations, however, suggest that inflammatory pathways may not ultimately cause dysmetabolism. OBJECTIVE: We have revisited the relationship between inflammation and metabolism by testing the role of TRAF (tumor necrosis receptor-associated factor)-1, an inhibitory adapter of inflammatory signaling of TNF (tumor necrosis factor)-α, IL (interleukin)-1β, and TLRs (toll-like receptors)...
March 2, 2018: Circulation Research
https://www.readbyqxmd.com/read/29212043/inhibition-of-mitochondrial-ucp1-and-ucp3-by-purine-nucleotides-and-phosphate
#11
COMPARATIVE STUDY
Gabriel Macher, Melanie Koehler, Anne Rupprecht, Jürgen Kreiter, Peter Hinterdorfer, Elena E Pohl
Mitochondrial membrane uncoupling protein 3 (UCP3) is not only expressed in skeletal muscle and heart, but also in brown adipose tissue (BAT) alongside UCP1, which facilitates a proton leak to support non-shivering thermogenesis. In contrast to UCP1, the transport function and molecular mechanism of UCP3 regulation are poorly investigated, although it is generally agreed upon that UCP3, analogous to UCP1, transports protons, is activated by free fatty acids (FFAs) and is inhibited by purine nucleotides (PNs)...
March 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29077154/the-differentiation-of-beige-adipocyte-in-pericardial-and-epicardial-adipose-tissues-induces-atrial-fibrillation-development
#12
Y He, N Ma, M Tang, Z-L Jiang, H Liu, J Mei
OBJECTIVE: Growing evidence has identified that excessive accumulation of pericardial adipose tissues (PAT) and epicardial adipose tissues (EAT) is associated with atrial fibrillation (AF) development. Moreover, beige adipocytes, present in PAT and EAT, have been proved beneficial in consumption of fatty acid and promotion of weight lose by nonshivering thermogenesis. The objective of this prospective, observational study was to reveal the potential association between beige adipocytes and AF development...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29040448/male-brown-fat-specific-double-knockout-of-igfir-ir-atrophy-mitochondrial-fission-failure-impaired-thermogenesis-and-obesity
#13
Vanesa Viana-Huete, Carlos Guillén, Gema García, Silvia Fernández, Ana García-Aguilar, C R Kahn, Manuel Benito
It is unknown how the lack of insulin receptor (IR)/insulinlike growth factor I receptor (IGFIR) in a tissue-specific manner affects brown fat development and mitochondrial integrity and function, as well as its effect on the redistribution of the adipose organ and the metabolic status. To address this important issue, we developed IR/IGFIR double-knockout (DKO) in a brown adipose tissue-specific manner. Lack of those receptors caused severe brown fat atrophy, enhanced beige cell clusters in inguinal fat; loss of mitochondrial mass; mitochondrial damage related to cristae disruption; and the loss of proteins involved in autophagosome formation, mitophagy, mitochondrial quality control, and dynamics and thermogenesis...
January 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/28599882/saponins-from-stems-and-leaves-of-panax-ginseng-prevent-obesity-via-regulating-thermogenesis-lipogenesis-and-lipolysis-in-high-fat-diet-induced-obese-c57bl-6-mice
#14
Guilin Chen, Haijun Li, Yan Zhao, Hongyan Zhu, Enbo Cai, Yugang Gao, Shuangli Liu, He Yang, Lianxue Zhang
In this study, high-fat diet (HFD)-induced obesity in mouse model was used to evaluate the dietary effect of saponins from stems and leaves of Panax ginseng (SLG), and to explore its mechanism of action in producing anti-obesity effects. The results indicate that SLG showed significant anti-obesity effects in diet-induced obese mice, represented by decreased serum levels of free fatty acids (FFA), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL)-cholesterol, glucose, leptin and insulin, as well as a reduction in overall body and liver weight, epididymal adipose tissue weight, and food efficiency, and inhibition of abnormal increases in acyl carnitine levels normally caused by an HFD...
August 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28380369/now-ucp-rotein-now-you-don-t-ucp1-is-not-mandatory-for-thermogenesis
#15
COMMENT
Ildiko Szabo, Mario Zoratti
Adipocyte-targeted therapies could potentially combat obesity and metabolic disorders; however, our understanding of adipogenesis and the characterization of the various adipose tissues are incomplete. In this issue, Bertholet et al. (2017) report the existence of two types of heat-producing beige-like adipocytes, those with and those without the mitochondrial uncoupling protein 1 (UCP1).
April 4, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28138103/turning-up-the-heat-against-metabolic-syndrome-and-non-alcoholic-fatty-liver-disease
#16
COMMENT
William T Festuccia
Brown adipose tissue (BAT), an organ specialized in the conversion of chemical energy from nutrients into heat through a process denominated as nonshivering thermogenesis, plays an important role in defence of body weight and homoeothermy in mammals. BAT nonshivering thermogenesis relies on the activity of the uncoupling protein 1 (UCP-1), a mitochondrial protein that, on demand, deviates proton gradient from ATP synthesis to heat generation. Energetically, this process is supported by BAT-elevated mitochondrial density and outstanding capacity to oxidize fatty acids and glucose...
February 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28099124/browning-of-white-adipose-tissue-lessons-from-experimental-models
#17
REVIEW
Thereza Cristina Lonzetti Bargut, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Beige or brite (brown-in-white) adipocytes are present in white adipose tissue (WAT) and have a white fat-like phenotype that when stimulated acquires a brown fat-like phenotype, leading to increased thermogenesis. This phenomenon is known as browning and is more likely to occur in subcutaneous fat depots. Browning involves the expression of many transcription factors, such as PR domain containing 16 (PRDM16) and peroxisome proliferator-activated receptor (PPAR)-γ, and of uncoupling protein (UCP)-1, which is the hallmark of thermogenesis...
January 18, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28026903/impaired-adrenergic-agonist-dependent-beige-adipocyte-induction-in-aged-mice
#18
Woongchul Shin, Yuko Okamatsu-Ogura, Ken Machida, Ayumi Tsubota, Junko Nio-Kobayashi, Kazuhiro Kimura
OBJECTIVE: There are two types of thermogenic adipocytes expressing uncoupling protein (UCP)-1: the brown adipocyte activated by adrenergic stimulation and the beige adipocyte that appears within the white adipose tissue (WAT) in response to chronic adrenergic stimulation. This study examined age-related changes in responses of both types of adipocytes to adrenergic stimulation in mice. METHODS: Aged (age 20 months) and young (4 months) mice were injected daily with either saline or β3-adrenergic receptor agonist CL316,243 (CL; 0...
February 2017: Obesity
https://www.readbyqxmd.com/read/27686967/rapamycin-negatively-impacts-insulin-signaling-glucose-uptake-and-uncoupling-protein-1-in-brown-adipocytes
#19
Ester García-Casarrubios, Carlos de Moura, Ana I Arroba, Nuria Pescador, María Calderon-Dominguez, Laura Garcia, Laura Herrero, Dolors Serra, Susana Cadenas, Flavio Reis, Eugenia Carvalho, Maria Jesus Obregon, Ángela M Valverde
New onset diabetes after transplantation (NODAT) is a metabolic disorder that affects 40% of patients on immunosuppressive agent (IA) treatment, such as rapamycin (also known as sirolimus). IAs negatively modulate insulin action in peripheral tissues including skeletal muscle, liver and white fat. However, the effects of IAs on insulin sensitivity and thermogenesis in brown adipose tissue (BAT) have not been investigated. We have analyzed the impact of rapamycin on insulin signaling, thermogenic gene-expression and mitochondrial respiration in BAT...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27561621/brown-adipose-tissue-updates-in-cellular-and-molecular-biology
#20
REVIEW
Thereza Cristina Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Brown adipose tissue (BAT) is mainly composed of adipocytes, it is highly vascularized and innervated, and can be activated in adult humans. Brown adipocytes are responsible for performing non-shivering thermogenesis, which is exclusively mediated by uncoupling protein (UCP) -1 (a protein found in the inner mitochondrial membrane), the hallmark of BAT, responsible for the uncoupling of the proton leakage from the ATP production, therefore, generating heat (i.e. thermogenesis). Besides UCP1, other compounds are essential not only to thermogenesis, but also to the proliferation and differentiation of BAT, including peroxisome proliferator-activated receptor (PPAR) family, PPARgamma coactivator 1 (PGC1)-alpha, and PRD1-BF-1-RIZ1 homologous domain protein containing protein (PRDM) -16...
October 2016: Tissue & Cell
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