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Event Segmentation

Ying Tian, Junhua Zhang, Yingqiang Zhao, Jingyuan Mao, Linping Zhu, Rui Gao, Xuemei Wang, Mingjun Zhu, Lihong Ma, Mengyu Zhao, Wenke Zheng
BACKGROUND: Stable angina is a common cardiovascular disease with high mortality and a poor prognosis. Although there are various interventions against stable angina, none are able to significantly reduce the mortality rate. Guanxinjing capsule (GXJ) is made from the classical Chinese prescription Xuefuzhuyutang (). Both basic research and clinical studies have shown that GXJ can relieve the symptoms of angina, but currently, the effects of GXJ lack high-quality clinical evidence. The aim of this study was to evaluate the clinical effectiveness and safety of GXJ compared with placebo...
October 20, 2018: Trials
Philippe Le Corvoisier, Romain Gallet, Pierre-François Lesault, Etienne Audureau, Muriel Paul, Julien Ternacle, Saïd Ghostine, Stéphane Champagne, Raphaele Arrouasse, Dalila Bitari, Gauthier Mouillet, Jean-Luc Dubois-Randé, Alain Berdeaux, Bijan Ghaleh, Jean-François Deux, Emmanuel Teiger
BACKGROUND: Experimental studies suggest that morphine may protect the myocardium against ischemia-reperfusion injury by activating salvage kinase pathways. The objective of this two-center, randomized, double-blind, controlled trial was to assess potential cardioprotective effects of intra-coronary morphine in patients with ST-segment elevation myocardial infarction (STEMI) referred for primary percutaneous intervention. METHODS: Ninety-one patients with STEMI were randomly assigned to intracoronary morphine (1 mg) or placebo at reperfusion of the culprit coronary artery...
October 19, 2018: BMC Cardiovascular Disorders
Long Zhao, Lei Han, Chaoxia Xiao, Xiuyun Lin, Chunming Xu, Chunwu Yang
BACKGROUND: In diverse plant taxa, whole-genome duplication (WGD) events are major sources of phenotypic novelty. Studies of gene expression in synthetic polyploids have shown immediate expression and functional partitioning of duplicated genes among different tissues. Many studies of the tissue-specific homeolog expression partitioning have focused on allopolyploids that have very different parental genomes, while few studies have focused on autopolyploids or allopolyploids that have similar parental genomes...
October 19, 2018: BMC Genomics
Gouri S Jas, Krzysztof Kuczera
Stability of secondary structural elements is an integral component of a structurally stable protein. Presence of protons in the residue sequence and their immediate environment play a significant role in conformational stability. In this study, we show that removing a proton from a single amino acid residue significantly increases the stability of an α-helical heteropeptide in comparison with the unprotonated form. Far-UV circular dichroism spectroscopy, fluorescence spectroscopy, fluorescence energy transfer measurements, and over 10 μs of all-atom molecular dynamics simulations are used to provide an atomically detailed characterization of this event...
October 19, 2018: Journal of Physical Chemistry. B
Elias Ebrahimzadeh, Maede Kalantari, Mohammadamin Joulani, Reza Shahrokhi Shahraki, Farahnaz Fayaz, Fereshteh Ahmadi
BACKGROUND AND OBJECTIVE: Paroxysmal Atrial Fibrillation (PAF) is one of the most common major cardiac arrhythmia. Unless treated timely, PAF might transform into permanent Atrial Fibrillation leading to a high rate of morbidity and mortality. Therefore, increasing attention has been directed towards prediction of PAF, to enable early detection and prevent further progression of the disease. Notwithstanding the pharmacological and electrical treatments, a validated method to predict the onset of PAF is yet to be developed...
October 2018: Computer Methods and Programs in Biomedicine
Anne-Sophie Schuurman, Maxime M Vroegindewey, Isabella Kardys, Rohit M Oemrawsingh, Hector M Garcia-Garcia, Robert-Jan van Geuns, Evelyn Regar, Nicolas M Van Mieghem, Jurgen Ligthart, Patrick W Serruys, Eric Boersma, K Martijn Akkerhuis
BACKGROUND: It has been shown that intravascular ultrasound (IVUS) and radiofrequency (RF-)IVUS can detect high-risk coronary plaque characteristics. OBJECTIVES: The authors studied the long-term prognostic value of (RF-)IVUS-derived plaque characteristics in patients with coronary artery disease (CAD) undergoing coronary angiography. METHODS: From 2008 to 2011, (RF-)IVUS was performed in 1 nonstenotic segment of a nonculprit coronary artery in 581 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina...
October 23, 2018: Journal of the American College of Cardiology
Krishnaraj S Rathod, Sudheer Koganti, Ajay K Jain, Zoe Astroulakis, Pitt Lim, Roby Rakhit, Sundeep Singh Kalra, Miles C Dalby, Constantinos O'Mahony, Iqbal S Malik, Charles J Knight, Anthony Mathur, Simon Redwood, Alexander Sirker, Philip A MacCarthy, Elliot J Smith, Andrew Wragg, Daniel A Jones
BACKGROUND: A large proportion of patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI) present with multivessel disease (MVD). There is uncertainty in the role of complete coronary revascularization in this group of patients. OBJECTIVES: The aim of this study was to investigate the outcomes of complete revascularization compared with culprit vessel-only intervention in a large contemporary cohort of patients undergoing percutaneous coronary intervention (PCI) for NSTEMI...
October 23, 2018: Journal of the American College of Cardiology
Marcello C Costa, Lauren J Keightley, Lukasz Wiklendt, Timothy James Hibberd, John W Arkwright, Taher I Omari, David A Wattchow, Simon J H Brookes, Philip G Dinning, Nick J Spencer
BACKGROUND: In the guinea pig distal colon, non-propulsive neurally-mediated motor patterns have been observed in different experimental conditions. METHODS: Isolated segments of guinea pig distal colon were used to investigate these neural mechanisms by simultaneously recording wall motion, intraluminal pressure and smooth muscle electrical activity in different conditions of constant distension and in response to pharmacological agents. RESULTS: Three distinct neurally-dependent motor patterns were identified; Transient Neural Events (TNEs), Cyclic Motor Complexes (CMC) and Distal Colon Migrating Motor Complexes (DCMMC)...
October 18, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
Guilherme Pinheiro Machado, Gustavo N Araujo, Christian K Carpes, Mateus C Lech, Stefani Mariani, Felipe H Valle, Luiz C C Bergoli, Rodrigo V Wainstein, Marco V Wainstein
BACKGROUND: Elevated neutrophil-to-lymphocyte ratio (NLR) is an indirect marker of inflammation, and is associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to investigate the usefulness of NLR to predict procedural adverse events is patients who underwent primary percutaneous coronary intervention (PCI). PATIENTS AND METHODS: Consecutive patients with STEMI who underwent primary PCI were divided into low and high NLR, whereas high was defined as an NLR value above 75° percentile (≥9...
October 16, 2018: Coronary Artery Disease
Fatima Boukari, Sokratis Makrogiannis
Automated cell segmentation and tracking enables the quantification of static and dynamic cell characteristics and is significant for disease diagnosis, treatment, drug development and other biomedical applications. This paper introduces a method for fully automated cell tracking, lineage construction, and quantification. Cell detection is performed in the joint spatio-temporal domain by a motion diffusion-based Partial Differential Equation (PDE) combined with energy minimizing active contours. In the tracking stage, we adopt a variational joint local-global optical flow technique to determine the motion vector field...
October 12, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Sung Woo Kwon, Sang Don Park, Jeonggeun Moon, Pyung Chun Oh, Ho Jun Jang, Hyun Woo Park, Tae Hoon Kim, Kyounghoon Lee, Jon Suh, WoongChol Kang
BACKGROUND AND OBJECTIVES: We aimed to compare outcomes of complete revascularization (CR) versus culprit-only revascularization for ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD) in the 2nd generation drug-eluting stent (DES) era. METHODS: From 2009 to 2014, patients with STEMI and MVD, who underwent primary percutaneous coronary intervention (PCI) using a 2nd generation DES for culprit lesions were enrolled. CR was defined as PCI for a non-infarct-related artery during the index admission...
November 2018: Korean Circulation Journal
Hyun-Chul Park, Eun-Jung Lee, Youn-Hyung Nam, Nam-Soo Cho, Si-Keun Lim, Won Kim
Y chromosome short tandem repeats (Y-STRs) are commonly used to analyze male-specific DNA. Although biallelic patterns due to duplication events have been detected at some loci, Y-STRs generally appear as a single peak except for DYS385 because the Y chromosome is haploid. STR loci in regions of segmental duplication by homologous recombination on the Y chromosome exhibit double allelic peaks, rather than single peaks. In this study, we report a bi- and triallelic pattern observed simultaneously in DYS390, DYS518, and DYS643...
October 17, 2018: International Journal of Legal Medicine
Pauline Erpicum, Pascal Rowart, Jean-Olivier Defraigne, Jean-Marie Krzesinski, François Jouret
Renal segmental metabolism is reflected by the complex distribution of the main energy pathways along the nephron, with fatty acid oxidation preferentially used in the cortex area. Ischemia/reperfusion injury (IRI) is due to the restriction of renal blood flow, rapidly leading to a metabolic switch towards anaerobic conditions. Subsequent unbalance between energy demand and oxygen/nutrient delivery compromises kidney cell functions, resulting to a complex inflammatory cascade including the production of reactive oxygen species (ROS)...
October 17, 2018: American Journal of Physiology. Renal Physiology
Tohru Suzuki, Daisuke Inoue
Rotavirus species H (RVH) has been detected in pigs, humans and bats. Moreover, porcine RVHs have often been identified in several swine-producing countries in recent years. Despite their zoonotic impact, genome information for RVHs is still limited. This study aimed to establish a tentative complete genome-based genotyping system for RVH by appending genomic sequences from 12 porcine RVHs identified in Japan between 2013 and 2015 to those from human and other porcine RVHs reported in previous studies. Phylogenetic analysis of 11 RNA segments indicated that porcine RVHs could be classified into multiple genotypes...
October 17, 2018: Journal of General Virology
Serkan Ünlü, Serdar Gökhan Nurkoç, Burak Sezenöz, Mehmet Cingirt, Özlem Gülbahar, Adnan Abacı
BACKGROUND: High-sensitive cardiac troponin (hsTn) levels can be elevated due to non-pathological events such as strenuous exercise. However, the effect of statins on circulating hsTnT levels with moderate exercise is uncertain. Therefore, we evaluated the impact of statins on hsTnT level with moderate exercise. METHODS: We enrolled a total of 56 patients: 26 statin users and 30 non-users. All patients were shown to have no coronary artery disease before participating in the study...
October 17, 2018: Acta Cardiologica
Shafik Khoury, Gilad Margolis, Dor Ravid, Zach Rozenbaum, Gad Keren, Yacov Shacham
OBJECTIVE: Acute kidney injury (AKI) is a frequent complication in patients with ST segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). While AKI occurring post-PCI has been well studied, the incidence and clinical significance of early renal impairment evident on hospital admission prior to PCI and which resolves towards discharge has not been investigated. METHODS: We retrospectively studied 2339 STEMI patients treated with primary PCI...
October 17, 2018: European Heart Journal. Acute Cardiovascular Care
Yoshiyuki Okuya, Yuichi Saito, Yoshiaki Sakai, Iwao Ishibashi, Yoshio Kobayashi
Clinical impact of tissue protrusion (TP) after coronary stenting is still controversial, especially in patients with ST-segment elevation myocardial infarction (STEMI). A total of 104 STEMI patients without previous MI who underwent primary percutaneous coronary intervention (PCI) under intravascular ultrasound (IVUS)-guidance were included. Post-stenting grayscale IVUS analysis was performed, and the patients were classified according to the presence or absence of post-stenting TP on IVUS. Coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) with 99m Tc tetrofosmin were analyzed...
October 16, 2018: International Journal of Cardiovascular Imaging
Xiaomin Wang, Siyang Tang, Xiaoxu Wen, Lang Hong, Feifan Hong, Yuezhou Li
The mechanosensitive channel MscS functions as an osmolyte emergency release-valve in the event of a sudden decrease in external environmental osmolarity. MscS has served as a paradigm for studying how channel proteins detect and respond to mechanical stimuli. However, the inter-domain interactions and structural rearrangements that occur in the MscS gating process remain largely unknown. Here, we determined the interactions between the transmembrane domain and cytoplasmic domain of MscS. Using in vivo cellular viability, single-channel electrophysiological recording, and cysteine disulfide trapping, we demonstrated that N117 of the TM3b helix and N167 of the Cyto-helix are critical residues that function at the TM3b-Cyto helix interface...
2018: Frontiers in Physiology
Alex Dickson
The interaction between a ligand and a protein involves a multitude of conformational states. To achieve a particular deeply bound pose, the ligand must search across a rough free-energy landscape with many metastable minima. Creating maps of the ligand binding landscape is a great challenge, as binding and release events typically occur on timescales that are beyond the reach of molecular simulation. The WExplore enhanced sampling method is well suited to build these maps because it is designed to broadly explore free-energy landscapes and is capable of simulating ligand release pathways that occur on timescales as long as minutes...
September 29, 2018: Biophysical Journal
William F Lavelle, K Daniel Riew, Allan Levi, Jeffrey E Florman
STUDY DESIGN: Prospective, randomized multicenter IDE Trial between May 2002 and October 2004. OBJECTIVE: Report on the 10-year safety and efficacy of BRYAN® cervical disc (CDA). SUMMARY OF BACKGROUND DATA: Cervical disc arthroplasty (CDA) is a potential alternative for anterior cervical decompression and fusion (ACDF) with the hope that maintenance of motion may decrease the likelihood of adjacent segment disease. METHODS: This is an analysis of a FDA investigation comparing CDA with ACDF for single level patients...
October 15, 2018: Spine
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