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Event Segmentation

Yusuke Watanabe, Toru Naganuma, Yosuke Kitanaka, Sunao Nakamura
A 70-year-old woman with substernal chest pain lasting 2.5 h presented to the emergency department of our hospital. She had a history of aortic valve replacement with the Freestyle stentless aortic bioprosthesis for severe aortic regurgitation 7 years ago. The initial electrocardiogram showed sinus rhythm at a rate of 71 bpm with ST-segment slight elevation in leads II, III and aVF. She was diagnosed as having acute coronary syndrome and was referred for an urgent catheterization. Urgent coronary angiography revealed total occlusion in the distal segment of the right coronary artery...
August 10, 2018: European Journal of Cardio-thoracic Surgery
Claudio Ponticelli, Rachele Escoli, Gabriella Moroni
Cyclophosphamide is a prodrug that is converted to inactive carboxy-cyclophosphamide, acrolein and phosphoramide mustard, an agent that adds alkyl groups to oxygen and nitrogen atoms of guanine, one of the four nitrogen bases that form the DNA nucleotides, causing DNA cross-links and introducing DNA breaks. These cytotoxic and mutagenic effects mainly occur in proliferating cells. Repair mechanisms may prevent DNA damage in quiescent cells, but they may be insufficient to contrast the side effects of cyclophosphamide if high doses of the drug are used...
August 11, 2018: Autoimmunity Reviews
Ahmet Guner, Alev Kılıcgedik, Macit Kalçık, Mehmet Ozkan
Coronary embolism (CE) is the underlying cause of 3% of acute coronary syndromes but is frequently overlooked in the differential diagnoses of acute coronary syndromes. The CE may be direct (left sided from the native or prosthetic heart valve, the left atrium, left atrial appendage or pulmonary venous bed), paradoxical (from the venous circulation through a patent foramen ovale, atrial septal defect, ventricular septal defects, cyanotic congenital heart defects or pulmonary arteriovenous malformations), or iatrogenic (following cardiac interventions...
August 13, 2018: Echocardiography
Joseph J Titano, Marcus Badgeley, Javin Schefflein, Margaret Pain, Andres Su, Michael Cai, Nathaniel Swinburne, John Zech, Jun Kim, Joshua Bederson, J Mocco, Burton Drayer, Joseph Lehar, Samuel Cho, Anthony Costa, Eric K Oermann
Rapid diagnosis and treatment of acute neurological illnesses such as stroke, hemorrhage, and hydrocephalus are critical to achieving positive outcomes and preserving neurologic function-'time is brain'1-5 . Although these disorders are often recognizable by their symptoms, the critical means of their diagnosis is rapid imaging6-10 . Computer-aided surveillance of acute neurologic events in cranial imaging has the potential to triage radiology workflow, thus decreasing time to treatment and improving outcomes...
August 13, 2018: Nature Medicine
Yuttapong Thawornwattana, Daniel Dalquen, Ziheng Yang
Deep coalescence and introgression make it challenging to infer phylogenetic relationships among closely related species that arose through radiative speciation events. Despite numerous phylogenetic analyses and the availability of whole genomes, the phylogeny in the Anopheles gambiae species complex has not been confidently resolved. Here we extract over 80,000 coding and noncoding short segments from the genomes of six members of the species complex and use a Bayesian method under the multispecies coalescent model to infer the species tree, which takes into account genealogical heterogeneity across the genome and uncertainty in the gene trees...
August 9, 2018: Molecular Biology and Evolution
Udaya Tantry, Rahul Chaudhary, Jacek Kubica, Kevin Bliden, Paul A Gurbel
All oral P2Y12 receptor blockers are associated with some degree of delayed onset and offset of pharmacodynamic (PD) effects in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI). Although intravenous glycoprotein IIb/IIIa inhibitors are associated with rapid onset of action, they are also associated with delayed offset and other limitations such as elevated bleeding risk and thrombocytopenia. Areas covered: In this review, the authors focus on cangrelor, an intravenous, reversible P2Y12 receptor blocker with fast onset and offset of effects...
August 13, 2018: Expert Opinion on Pharmacotherapy
Paul M Macey, Janani P Prasad, Jennifer A Ogren, Ammar S Moiyadi, Ravi S Aysola, Rajesh Kumar, Frisca L Yan-Go, Mary A Woo, M Albert Thomas, Ronald M Harper
Introduction: Obstructive sleep apnea (OSA) patients show hippocampal-related autonomic and neurological symptoms, including impaired memory and depression, which differ by sex, and are mediated in distinct hippocampal subfields. Determining sites and extent of hippocampal sub-regional injury in OSA could reveal localized structural damage linked with OSA symptoms. Methods: High-resolution T1-weighted images were collected from 66 newly-diagnosed, untreated OSA (mean age ± SD: 46...
2018: NeuroImage: Clinical
Rafe A McBeth, Thomas B Borak
Measurements of the incident fluence of HZE particles, as a function of LET, are used to determine absorbed dose as well as Quality Factors for assigning risk estimates to astronauts during manned space missions. These data are often based on thin solid state detectors that measure energy deposition, dE, and the assumption that the trajectory of the particle, dx, is equivalent to the thickness of the detector. Heavy ions often fragment while penetrating shielding materials in vehicles or habitats. Projectile fragments can be clustered spatially and temporally at the location of the thin detector which are then misclassified as a single particle...
August 2018: Life Sciences in Space Research
Olivier Sutter, Amina Fihri, Rafik Ourabia-Belkacem, Nicolas Sellier, Abou Diallo, Olivier Seror
Three-dimensional virtual target fluoroscopic display is a new guidance tool that can facilitate challenging percutaneous ablation. The purpose of this study was to assess the feasibility, local efficacy, and safety of liver ablation assisted by three-dimensional virtual target fluoroscopic display. Sixty-seven hepatocellular carcinomas (mean diameter: 31 mm, range: 9-90 mm, 24 ≥ 30 mm, 16 of an infiltrative form) in 53 consecutive patients were ablated using irreversible electroporation (n = 39), multibipolar radiofrequency (n = 25), or microwave (n = 3) under a combination of ultrasound and three-dimensional virtual target fluoroscopic display guidance because the procedures were considered to be unfeasible under ultrasound alone...
January 1, 2018: Technology in Cancer Research & Treatment
Mohamed Khalfallah, Ayman Elsheikh, Mohamed Abdalaal
BACKGROUND: The proper time for the use of percutaneous coronary intervention (PCI) following the successful fibrinolysis for ST-segment elevation myocardial infarction (STEMI) for maximum efficiency and minimum side effects has not been determined yet. The present study was designed to compare the outcome of myocardial infarction patients who received fibrinolytic therapy with successful results and underwent PCI very early (within 3-12 h) (group 1) versus early (within 12-24 h) (group 2)...
August 8, 2018: Global Heart
Santiago Jesús Camacho Freire, José Francisco Díaz Fernández, Livia Luciana Gheorghe, Antonio Enrique Gómez Menchero, Javier León Jiménez, Jessica Roa Garrido, Rosa Cardenal Piris, Miguel Pedregal González, Teresa Bastante, Marcos García Guimaraes, Alberto Vera, Javier Cuesta, Fernando Rivero, Fernando Alfonso
INTRODUCTION AND OBJECTIVES: Thyroid hormone affects the metabolism of all tissues in the body. The aim of this study was to analyze the prevalence and implications of thyroid disorders in a cohort of consecutive patients with spontaneous coronary artery dissection (SCAD). METHODS: A total of 73 patients with SCAD were analyzed. Baseline characteristics and clinical outcomes were compared between euthyroid and hypothyroid patients. Subsequently, the prevalence of thyroid function abnormalities and the clinical characteristics of SCAD patients were compared with those in 73 patients with acute coronary syndrome but without SCAD, matched by age, sex, and presentation...
August 7, 2018: Revista Española de Cardiología
Devinka Bamunusinghe, Matthew Skorski, Alicia Buckler-White, Christine A Kozak
Naturally-occurring lymphomagenesis is induced by mouse leukemia viruses (MLVs) carried as endogenous retroviruses (ERVs). Replicating the ecotropic MLVs recombines with polytropic (P-ERVs) and xenotropic ERVs (X-ERVs) to generate pathogenic viruses with an altered host range. While most recovered nonecotropic recombinants have a polytropic host range, the X-MLVs are also present in the pre-leukemic tissues. We analyzed two such isolates from the AKR mice to identify their ERV progenitors and to look for evidence of recombination...
August 9, 2018: Viruses
Audrey Dionne, Ragui Ibrahim, Catherine Gebhard, Mitchel Benovoy, Mohamed Leye, Julie Déry, Chantale Lapierre, Patrice Girard, Anne Fournier, Nagib Dahdah
BACKGROUND: Coronary artery (CA) aneurysms are a serious complication of Kawasaki disease (KD). Conventional imaging techniques often described segments with regressed aneurysms as normal, whereas studies have shown significant endothelial dysfunction. METHODS: KD patients with aneurysms scheduled for routine coronary angiography underwent optical coherence tomography (OCT) imaging between 2013 and 2016. Microstructural coronary changes were compared between normal CA segments and those with dilation, regressed aneurysms, and persistent aneurysms...
June 1, 2018: Canadian Journal of Cardiology
Dany-Michel Marcadet, Bruno Pavy, Gilles Bosser, Frédérique Claudot, Sonia Corone, Hervé Douard, Marie-Christine Iliou, Bénédicte Vergès-Patois, Pascal Amedro, Thierry Le Tourneau, Caroline Cueff, Taniela Avedian, Alain Cohen Solal, François Carré
The exercise test is still a key examination in cardiology, used for the diagnosis of myocardial ischemia, as well as for the clinical evaluation of other heart diseases. The cardiopulmonary exercise test can further define functional capacity and prognosis for any given cardiac pathology. These new guidelines focus on methods, interpretation and indications for an exercise test or cardiopulmonary exercise test, as summarized below. The safety rules associated with the exercise test must be strictly observed...
August 6, 2018: Archives of Cardiovascular Diseases
Johannes Gerwien, Christiane von Stutterheim
Events, as fundamental units in human perception and cognition, are limited by quality changes of objects over time. In the present study, we investigate the role of language in shaping event units. Given fundamental cross-linguistic differences in the concepts encoded in the verb, as in French compared to German, event unit formation was tested for motion events in a verbal (online event description, experiment 1), as well as a non-verbal task (Newtson-test, experiment 2). In German, motion and direction are described by a single assertion, i...
August 6, 2018: Cognition
Xiaoyu Du, Yulin Li, Yuan Wang, Hongzhao You, Peng Hui, Yang Zheng, Jie Du
AIMS: The long-term prognosis of ST-segment elevation myocardial infarction (STEMI) with acute heart failure (AHF) is poor. Identification of metabolic changes could provide understanding of the underlying pathological progress associated with adverse events in patients with STEMI and AHF. Therefore, the study aimed to identify new plasm metabolites associated with long-term adverse cardiovascular events in patients with STEMI and AHF. MATERIALS AND METHODS: Mass spectrometry measurements of 26 amino acids were performed in 138 patients with STEMI and AHF...
August 6, 2018: Life Sciences
Thierry Pécot, Liu Zengzhen, Jérôme Boulanger, Jean Salamero, Charles Kervrann
Analysis of the spatial distribution of endomembrane trafficking is fundamental to understand the mechanisms controlling cellular dynamics, cell homeostasy, and cell interaction with its external environment in normal and pathological situations. We present a semi-parametric framework to quantitatively analyze and visualize the spatio-temporal distribution of intracellular events from different conditions. From the spatial coordinates of intracellular features such as segmented subcellular structures or vesicle trajectories, QuantEv automatically estimates weighted densities that are easy to interpret and performs a comprehensive statistical analysis from distribution distances...
August 9, 2018: ELife
Adrien Nougarède, Chloé Tesnière, Jarkko Ylanko, Ruth Rimokh, Germain Gillet, David W Andrews
In response to a variety of insults the unfolded protein response (UPR) is a major cell program quickly engaged to promote either cell survival or if stress levels cannot be relieved, apoptosis. UPR relies on three major pathways, named from the endoplasmic reticulum (ER) resident proteins IRE1α, PERK, and ATF6 that mediate response. Current tools to measure the activation of these ER stress response pathways in mammalian cells are cumbersome and not compatible with high-throughput imaging. In this study, we present IRE1α and PERK sensors with improved sensitivity, based on the canonical events of xbp1 splicing and ATF4 translation at ORF3...
August 8, 2018: Assay and Drug Development Technologies
Stephane Legriel, Wulfran Bougouin, Richard Chocron, Frankie Beganton, Lionel Lamhaut, Nadia Aissaoui, Nicolas Deye, Daniel Jost, Armand Mekontso-Dessap, Antoine Vieillard-Baron, Eloi Marijon, Xavier Jouven, Florence Dumas, Alain Cariou
PURPOSE: To explore diagnostic pitfalls and treatment issues in out-of-hospital cardiac arrest of neurological cause (OHCA-NC). METHODS: Retrospective analysis of all consecutive patients from the Paris Sudden Death Expertise Centre (France) registry from May 2011 to September 2015 presenting with a sustained return of spontaneous circulation (ROSC) at hospital admission and a final diagnosis of OHCA-NC. Description of the early diagnostic check-up performed to identify the cause of cardiac arrest...
August 4, 2018: Resuscitation
Robert J Ingram
The emergency responder community trains for and responds to many types of incidents on a daily basis and has done so for years. This experience with fires, emergency medical calls, chemical spills, confined spaces, and other common calls for assistance has helped responders develop an understanding of the problems and a confidence in solving them. Radiation from an accidental release in a facility or during transportation, or from a terrorist incident that causes radioactive materials to be released from their containment vessel, remains a cause of concern and fear...
February 2018: Health Physics
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