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Event Segmentation

Ali Çoner, Davran Çiçek, Sinan Akıncı, Serhat Balcıoğlu, Cihan Altın, Haldun Müderrisoğlu
OBJECTIVE: Diffuse coronary artery disease (CAD) is a challenging issue in clinical cardiology practice. There are limited data about percutaneous revascularization in these patients. METHODS: This study was an observational clinical evaluation. The records of patients with diffuse CAD revascularized with new-generation drug-eluting stents (DES) were researched retrospectively. Patients treated with multiple, overlapping new-generation DES (at least 60mm in length per vessel) were included...
December 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Marco Roffi, Dragana Radovanovic, Juan F Iglesias, Franz R Eberli, Philip Urban, Giovanni B Pedrazzini, Paul Erne, Hans Rickli
INTRODUCTION: Limited data are available on the impact of multisite artery disease in patients with acute coronary syndromes. In particular, it is unknown whether the outcomes of those high-risk patients have improved over time. Therefore, we addressed the multisite artery disease patient population enrolled in the Swiss nationwide prospective acute coronary syndromes cohort study AMIS Plus over two decades. METHODS: All patients enrolled from January 1999 to October 2016 were stratified according to the presence of isolated coronary artery disease or multisite artery disease, defined as coronary artery disease with known concomitant vascular disease (i...
December 5, 2018: European Heart Journal. Acute Cardiovascular Care
Basit Iqbal, Geoff Currie, Hosen Kiat
BACKGROUND: Heart failure (HF) involves both mechanical and autonomic nervous system dysfunction that can lead to sudden cardiac death. In the failing human heart, there is increased release of norepinephrine from neurons and reduced uptake. Iodine-123-labeled metaiodobenzylguanidine (123I-mIBG) demonstrates reduced global uptake and increased washout associated with increased mortality in HF. This research examined the potential benefits of single-photon emission computed tomography (SPECT) regional quantitation in risk stratification of HF patients and its role in prediction of cardiac morbidity and mortality...
December 2018: Journal of Medical Imaging and Radiation Sciences
Mojtaba Ziaee, Sina Mashayekhi, Samad Ghaffari, Javad Mahmoudi, Parvin Sarbakhsh, Alireza Garjani
We assessed the prognostic value of serum levels of endocan in patients with the acute coronary syndrome (ACS) through its correlation with the Thrombolysis in Myocardial Infarction (TIMI) risk score and compared the possible association with clinical outcomes. In this prospective cross-sectional study, we enrolled 320 patients with documented ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), or unstable angina (UA) who underwent diagnostic coronary angiography. Endocan was measured soon after admission in the emergency department...
December 4, 2018: Angiology
Songtao Jiu, Muhammad Salman Haider, Mahantesh M Kurjogi, Kekun Zhang, Xudong Zhu, Jinggui Fang
In higher plants, sugars are nutrients and important signal molecules. Sugar transporters (STs) facilitate sugar transport across membranes and are associated with loading and unloading of the conducting complex. Strawberry ( Duchesne ex Rozier) is one of the most economically important and widely cultivated fruit crop and a model plant among fleshy fruits worldwide. In this study, 66 woodland strawberry ( L.) ST (FvST) genes were identified and further classified into eight distinct subfamilies in the woodland strawberry genome based on the phylogenetic analysis...
November 2018: Plant Genome
Anders Sahlén, Petter Ljungman, David Erlinge, Mark Y Chan, Jonathan Yap, Derek J Hausenloy, Khung Keong Yeo, Tomas Jernberg
OBJECTIVE: Studies have related air pollution to myocardial infarction (MI) events over days or weeks, with few data on very short-term risks. We studied risk of ST-segment elevation MI (STEMI) within hours of exposure to air pollution while adjusting for weather. METHODS: We performed a case-crossover study of STEMI cases in Stockholm, Sweden (Jan 2000-June 2014) based on SWEDEHEART. Exposures during hazard periods up to 24 h prior to admission were compared to bidirectionally sampled control periods...
January 15, 2019: International Journal of Cardiology
Doo Sun Sim, Myung Ho Jeong, Hyo Soo Kim, Hyeon Cheol Gwon, Ki Bae Seung, Seung Woon Rha, Shung Chull Chae, Chong Jin Kim, Kwang Soo Cha, Jong Sun Park, Jung Han Yoon, Jei Keon Chae, Seung Jae Joo, Dong Ju Choi, Seung Ho Hur, In Whan Seong, Myeong Chan Cho, Doo Il Kim, Seok Kyu Oh, Tae Hoon Ahn, Jin Yong Hwang
BACKGROUND: Potent P2Y12 blockers are preferred in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI) undergoing percutaneous coronary intervention (PCI). However, the risk of bleeding remains a major concern. We assessed the association of potent P2Y12 blockers with ischemic and bleeding outcomes in patients with NSTEMI. METHODS: From the Korea Acute Myocardial Infarction Registry-National Institute of Health database, 4927 patients with NSTEMI receiving drug-eluting stents (DES) were divided into potent P2Y12 blocker (ticagrelor or prasugrel, n=901) and clopidogrel (n=3180) groups...
February 2019: Journal of Cardiology
Asma Sriha Belguith, Kaouthar Beltaief, Mohamed Amine Msolli, Wahid Bouida, Hela Abroug, Manel Ben Fredj, Imen Zemni, Mohamed Habib Grissa, Hamdi Boubaker, Mohamed Hsairi, Samir Nouira
BACKGROUND: We aimed to describe diagnosed acute coronary syndrome (ACS) and its care management and outcomes in emergency departments (EDs) and to determine related cardiovascular risk factors (CVRFs). METHODS: We conducted a cross sectional multicenter study that included 1173 adults admitted to EDs for acute chest pain (ACP) in 2015 at 14 sites in Tunisia. Data included patients' baseline characteristics, diagnosis, treatment and output. RESULTS: ACS represented 49...
December 3, 2018: BMC Emergency Medicine
Hagen Kälsch, Amir A Mahabadi, Susanne Moebus, Nico Reinsch, Thomas Budde, Barbara Hoffmann, Andreas Stang, Karl-Heinz Jöckel, Raimund Erbel, Nils Lehmann
Aims: Thoracic aortic calcification (TAC) is measured by computed tomography (CT). We investigated the association of TAC-progression with incident cardiovascular (CV) events and all-cause mortality in a population-based cohort and to determine its predictive value for these endpoints. Methods and results: In 3080 participants (45-74 years, 53.6% women), risk factors and TAC via CT were measured at baseline and at a second examination after 5.1 ± 0.3 years...
December 1, 2018: European Heart Journal Cardiovascular Imaging
Do-Yoon Kang, Cheol Hyun Lee, Pil Hyung Lee, Jung-Min Ahn, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Chang Wook Nam, Yun Seok Choi, Seung-Woon Rha, Jang Hyun Cho, Weon Kim, Sung-Ho Her, Myung Ho Jeong, Joo-Young Yang, Bong-Ki Lee, Hun Sik Park, Duk-Woo Park, Seung-Jung Park
BACKGROUND: Outcomes for stent-based coronary intervention of lesions with long diseased segments remain relatively unfavorable. This study sought to compare the efficacy of Resolute zotarolimus-eluting stents (R-ZES) and Xience everolimus-eluting stents (EES) for very long coronary lesions. METHODS AND RESULTS: This randomized, multicenter, prospective trial compared the use of R-ZES with EES for very long (≥50 mm) native coronary lesions. The primary end point was in-segment late luminal loss at 12-month angiographic follow-up...
November 29, 2018: Coronary Artery Disease
Lobke Desomer, David J Tate, Farzan F Bahin, Brian Chiang, Halim Awadie, Bronte Holt, Karen Byth, Michael J Bourke
INTRODUCTION: and Aims: Clinically significant bleeding (CSPEB) is the most frequent serious adverse event after endoscopic mucosal resection (EMR) of large laterally spreading colonic lesions (LSLs). There is no proven prophylactic therapy, and it remains a significant drawback of EMR. We aimed to systematically describe and evaluate the features of the post-EMR mucosal defect (PED) and their relationship to CSPEB. METHODS: A prospective study of LSLs referred for EMR at a tertiary centre was performed...
November 29, 2018: Gastrointestinal Endoscopy
Emrah Ipek, Mustafa Yolcu, Erkan Yildirim, Konca Altinkaynak, Saime Ozbek Sebin, Kamuran Kalkan, Oktay Gulcu, Emrah Ermis, Mustafa Ozturk
(1) To investigate the role of azurocidin, an antimicrobial protein, in patients with ST segment elevation myocardial infarction (STEMI). (2) This single-center prospective observational study included patients with STEMI and healthy age- and sex-matched control subjects. Baseline demographic, clinical and biochemical data were compared between the two groups. Azurocidin levels at baseline were determined using an enzyme-linked immunosorbent assay. Multivariate linear regression analysis with enter method was used to test the association between azurocidin and independent variables, such as the thrombolysis in myocardial infarction (TIMI) score, synergy between percutaneous coronary intervention with TAXUS and cardiac surgery score, global registry of acute coronary events score, Killip class, C-reactive protein (CRP), and creatinine kinase-myocardial band (CK-MB)...
November 29, 2018: International Journal of Molecular Sciences
William D Lindsay, Christopher A Ahern, Jacob S Tobias, Christopher G Berlind, Chidambaram Chinniah, Peter E Gabriel, James C Gee, Charles B Simone
PURPOSE: To compare the effectiveness of ensemble methods (e.g. random forests) and single-model methods (e.g. logistic regression and decision trees) in predictive modeling of post-RT treatment failure and adverse events (AEs) for breast cancer patients using automatically extracted EMR data. METHODS: Data from 1,967 consecutive breast radiotherapy (RT) courses at one institution between 2008-2015 was automatically extracted from EMRs and oncology information systems using extraction software...
November 30, 2018: Medical Physics
Andrea Fabbri, Cristina Bachetti, Filippo Ottani, Alice Morelli, Barbara Benazzi, Sergio Spiezia, Marco Cortigiani, Romolo Dorizzi, Allan S Jaffe, Marcello Galvani
The reliability of initial high-sensitivity cardiac troponin T (hs-cTnT) under limit-of-detection in ruling-out short- and long-term acute coronary events in subjects for suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is not definitely settled. In a retrospective chart review analysis, 1001 subjects with hs-cTnT ≤ 14 ng/L out of 4053 subjects with hs-cTnT measured at Emergency Department (ED) presentation were recruited. The main outcome measure is fatal or non-fatal myocardial infarction (MI) within 30 days; secondary outcomes are MI or major acute coronary events (MACE) as a combination of MI or re-hospitalization for unstable angina within 1 year...
November 29, 2018: Internal and Emergency Medicine
Linda Lee, Joseph Kern, John E Bair, Jonathan Rosenberg, Margaret Lee, Sandeep Nathan
BACKGROUND: Transradial coronary angiography/intervention (TRA/TRI) is associated with reduced rates of bleeding, vascular complications, and major adverse cardiovascular events as compared to the transfemoral approach, but remains underutilized in the United States (U.S.). Small radial caliber is often cited as a technical impediment, however radial artery diameter (RAD) has not yet been systematically studied in the U.S. population using routine, prospective radiobrachial angiography...
September 26, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Maayan Konigstein, Iva Srdanovic, Ankita K Gore, Hussein M Rahim, Philippe Généreux, Ori Ben-Yehuda, Indulis Kumsars, Maciej Lesiak, Annapoorna Kini, Géza Fontos, Ton Slagboom, Imre Ungi, D Christopher Metzger, Aaron Crowley, Martin B Leon, Ziad A Ali
OBJECTIVES: We aimed to evaluate the safety and efficacy of the dedicated Tryton side branch (SB) stent for the treatment of true bifurcations involving large SBs. BACKGROUND: Bifurcation lesions are associated with lower procedural success and a higher risk of adverse cardiac events. Provisional stenting (PS) is currently the default approach for the treatment of bifurcation lesions. The Tryton stent is a dedicated bifurcation stent system for the treatment of true bifurcation lesions...
November 29, 2018: Catheterization and Cardiovascular Interventions
Elena Candela, Francisco Marín, José Miguel Rivera-Caravaca, Nuria Vicente Ibarra, Luna Carrillo, María Asunción Esteve-Pastor, Teresa Lozano, Manuel Jesús Macías, Vicente Pernias, Miriam Sandín, Esteban Orenes-Piñero, Miriam Quintana-Giner, Ignacio Hortelano, Beatriz Villamía, Andrea Veliz, Mariano Valdés, Juan G Martínez-Martínez, Juan M Ruiz-Nodar
INTRODUCTION AND AIMS: Patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) are often managed conservatively. Clinical practice guidelines recommend treating these patients with the same pharmacological drugs as those who receive invasive treatment. We analyze the use of new antiplatelet drugs (NADs) and other recommended treatments in people discharged following an NSTE-ACS according to the treatment strategy used, comparing the medium-term prognosis between groups. METHODS: Prospective observational multicenter registry study in 1717 patients discharged from hospital following an ACS; 1143 patients had experienced an NSTE-ACS...
2018: PloS One
Mohammad Z Siddiqui, Grant Gebhard, Alice Behrens, Ahmed Sallam, Sami Uwaydat
Bilateral spontaneous hyphemas are a rare ophthalmic event. Aplastic anemia is a hematologic condition with well-documented manifestations in the posterior segment but not the anterior segment. We present a patient with aplastic anemia without obvious risk factors for hyphema who developed bilateral spontaneous hyphemas. To our knowledge, this is the first reported case of bilateral spontaneous hyphemas in a patient with aplastic anemia.
September 2018: Case Reports in Ophthalmology
Rui Lu, Jiao Zhang, Dong Liu, Ying-Li Wei, Yao Wang, Xue-Bao Li
BACKGROUND: Basic helix-loop-helix/helix-loop-helix (bHLH/HLH) transcription factors play important roles in plant development. Many reports have suggested that bHLH/HLH proteins participate in brassinosteroid (BR) hormone signaling pathways to promote cell elongation. Cotton fibers are single-cells and derived from seed surface. To explore the roles of bHLH/HLH proteins in cotton fiber development progress by modulating BR signaling pathway, we performed a systematic analysis of the bHLH/HLH gene family in upland cotton (Gossypium hirsutum) genome...
November 27, 2018: BMC Plant Biology
Sangdi Lin, Chen Wang, Shabnam Zarei, Debra A Bell, Sarah E Kerr, George C Runger, Jean-Pierre A Kocher
BACKGROUND: Copy Number Alternations (CNAs) is defined as somatic gain or loss of DNA regions. The profiles of CNAs may provide a fingerprint specific to a tumor type or tumor grade. Low-coverage sequencing for reporting CNAs has recently gained interest since successfully translated into clinical applications. Ovarian serous carcinomas can be classified into two largely mutually exclusive grades, low grade and high grade, based on their histologic features. The grade classification based on the genomics may provide valuable clue on how to best manage these patients in clinic...
November 27, 2018: BMC Genomics
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