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https://www.readbyqxmd.com/read/30314437/multimodal-mri-based-classification-of-migraine-using-deep-learning-convolutional-neural-network
#1
Hao Yang, Junran Zhang, Qihong Liu, Yi Wang
BACKGROUND: Recently, deep learning technologies have rapidly expanded into medical image analysis, including both disease detection and classification. As far as we know, migraine is a disabling and common neurological disorder, typically characterized by unilateral, throbbing and pulsating headaches. Unfortunately, a large number of migraineurs do not receive the accurate diagnosis when using traditional diagnostic criteria based on the guidelines of the International Headache Society...
October 11, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/30310873/the-relationship-between-amplitude-of-low-frequency-fluctuations-and-gray-matter-volume-of-the-mirror-neuron-system-differences-between-low-disability-multiple-sclerosis-patients-and-healthy-controls
#2
Julio Plata-Bello, Yaiza Pérez-Martín, Abril Castañón-Pérez, Cristián Modroño, Estefanía Hernández-Martín, Montserrat González-Platas, Francisco Marcano, José Luis González-Mora
The study of the relationship between function and structure of the brain could be particularly interesting in neurodegenerative diseases like multiple sclerosis (MS). The aim of the present work is to identify differences of the amplitude of low frequency fluctuations (ALFF) in the mirror neuron system (MNS) between MS patients and healthy controls and to study the relationship between ALFF and the gray matter volume (GMV) of the regions that belong to the MNS. Relapsing-remitting MS patients with minor disability were compared to healthy controls (HC) using resting-state functional magnetic resonance imaging (fMRI), anatomic T1 weighted images and diffusion tensor imaging (DTI)...
December 2018: IBRO Reports
https://www.readbyqxmd.com/read/30292041/evaluation-of-the-prognosis-in-severe-traumatic-brain-injury-patients-using-resting-state-fmri
#3
Hong Guo, Raynald Liu, Zhaosheng Sun, Bing Liu, Yi Xiang, Jianhui Mao, Guangjie Li, Mingzhe Zhang
BACKGROUND: Our study is aimed to investigate the change of the default-mode network (DMN) by using Amplitude of Low-Frequency Fluctuation (ALFF) and functional connectivity (FC) methods in acute phase patients after severe traumatic brain injury (sTBI) and to correlate these changes with its prognosis. METHODS: Twenty one patients with severe traumatic brain injury were included in this study. Gender, age and education matched controls were participated in this study...
October 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30281205/altered-cervical-spinal-cord-resting-state-activity-in-fibromyalgia
#4
Katherine T Martucci, Kenneth A Weber, Sean C Mackey
OBJECTIVE: Altered afferent input and central neural modulation are thought to contribute to fibromyalgia symptoms, and these processes converge within the spinal cord. We hypothesized that, using resting state functional magnetic resonance imaging (rs-fMRI) of the cervical spinal cord, we would observe altered frequency dependent activity in fibromyalgia. METHODS: Cervical spinal cord rs-fMRI was performed in fibromyalgia patients and healthy controls. We analyzed a measure of low frequency oscillatory power, the amplitude of low frequency fluctuations (ALFF), for frequencies 0...
October 3, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30275692/altered-spontaneous-brain-activity-patterns-in-strabismus-with-amblyopia-patients-using-amplitude-of-low-frequency-fluctuation-a-resting-state-fmri-study
#5
You-Lan Min, Ting Su, Yong-Qiang Shu, Wen-Feng Liu, Ling-Long Chen, Wen-Qing Shi, Nan Jiang, Pei-Wen Zhu, Qing Yuan, Xiao-Wei Xu, Lei Ye, Yi Shao
Objective: Previous studies have demonstrated that strabismus or amblyopia can result in markedly brain function and anatomical alterations. However, the differences in spontaneous brain activities of strabismus with amblyopia (SA) patients still remain unclear. This current study intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in SA subjects. Patients and methods: A total of 16 patients with SA (6 males and 10 females) and 16 healthy controls (HCs; 6 males and 10 females) similarly matched in age, gender, and education status were recruited and examined with the resting-state functional MRI...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/30260561/connectomic-imaging-reveals-huntington-related-pathological-and-pharmaceutical-effects-in-a-mouse-model
#6
Wei-Tang Chang, Fiftarina Puspitasari, Marta Garcia-Miralles, Ling Yun Yeow, Hui-Chien Tay, Katrianne Bethia Koh, Liang Juin Tan, Mahmoud A Pouladi, Kai-Hsiang Chuang
Recent studies suggest that neurodegenerative diseases could affect brain structure and function in disease-specific network patterns; however, how spontaneous activity affects structural covariance network (SC) is not clear. We hypothesized that hyper-excitability in Huntington disease (HD) disrupts the coordinated structural and functional connectivity, and treatment with memantine helps to reduce excitotoxicity and normalize the connectivity. MRI was conducted to measure somatosensory activation, resting-state functional-connectivity (rsFC), SC, amplitude of low frequency fluctuation (ALFF) and ALFF covariance (ALFFC) in the YAC128 mouse model of HD...
September 27, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/30260540/alterations-in-intrinsic-fronto-thalamo-parietal-connectivity-are-associated-with-cognitive-control-deficits-in-psychotic-disorders
#7
Rebekka Lencer, Li Yao, James L Reilly, Sarah K Keedy, Jennifer E McDowell, Matcheri S Keshavan, Godfrey D Pearlson, Carol A Tamminga, Elliot S Gershon, Brett A Clementz, Su Lui, John A Sweeney
Despite a growing number of reports about alterations in intrinsic/resting brain activity observed in patients with psychotic disorders, their relevance to well-established cognitive control deficits in this patient group is not well understood. Totally 88 clinically stabilized patients with a psychotic disorder and 50 healthy controls participated in a resting-state magnetic resonance imaging study (rs-MRI) and performed an antisaccade task in the laboratory to assess voluntary inhibitory control ability. Deficits on this task are a well-established biomarker across psychotic disorders as we found in the present patient sample...
September 10, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/30220306/electroacupuncture-ameliorates-cognitive-impairment-and-spontaneous-low-frequency-brain-activity-in-rats-with-ischemic-stroke
#8
Tao Wen, Xiufeng Zhang, Shengxiang Liang, Zuanfang Li, Xuemei Xing, Weilin Liu, Jing Tao
BACKGROUND: To evaluate whether electroacupuncture (EA) at Baihui (DU20) and Shenting (DU24) acupoints could improve cognitive function and enhance spontaneous low-frequency brain activity in rats with ischemic stroke. METHODS: Total 36 rats were randomly divided into 3 groups-the sham surgery (Sham) group, the middle cerebral artery occlusion induced cognitive deficit (MICD) group, and the MICD with EA (MICD + EA) treatment group. The rats in MICD + EA group received EA treatment at DU20 and DU24 acupoints for 14 consecutive days after the surgery...
October 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/30214422/sex-differences-in-spontaneous-brain-activity-in-adolescents-with-conduct-disorder
#9
Wanyi Cao, Xiaoqiang Sun, Daifeng Dong, Shuqiao Yao, Bingsheng Huang
Purpose: Sex differences in conduct disorder (CD) pathophysiology have yet to be resolved. In this study, we applied the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) to compare spontaneous brain activity in male versus female adolescents diagnosed with CD in light of the gender paradox hypothesis. Materials and Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) examinations were conducted with 51 CD patients (35 males) and 53 age-matched healthy controls (HCs; 35 males)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30186131/intra-and-inter-scanner-reliability-of-voxel-wise-whole-brain-analytic-metrics-for-resting-state-fmri
#10
Na Zhao, Li-Xia Yuan, Xi-Ze Jia, Xu-Feng Zhou, Xin-Ping Deng, Hong-Jian He, Jianhui Zhong, Jue Wang, Yu-Feng Zang
As the multi-center studies with resting-state functional magnetic resonance imaging (RS-fMRI) have been more and more applied to neuropsychiatric studies, both intra- and inter-scanner reliability of RS-fMRI are becoming increasingly important. The amplitude of low frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC) are 3 main RS-fMRI metrics in a way of voxel-wise whole-brain (VWWB) analysis. Although the intra-scanner reliability (i.e., test-retest reliability) of these metrics has been widely investigated, few studies has investigated their inter-scanner reliability...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/30178423/sex-differences-in-resting-state-cerebral-activity-alterations-in-internet-gaming-disorder
#11
Yawen Sun, Yao Wang, Xu Han, Wenqing Jiang, Weina Ding, Mengqiu Cao, Yasong Du, Fuchun Lin, Jianrong Xu, Yan Zhou
Although evidence has shown that the prevalence rates of Internet gaming disorder (IGD) differ between males and females, few studies have examined whether such sex differences extend to brain function. This study aimed to explore the sex differences in resting-state cerebral activity alterations in IGD. Thirty male participants with IGD (IGDm), 23 female participants with IGD (IGDf), and 30 male and 22 female age-matched healthy controls (HC) underwent resting-state functional MRI. Maps of the amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) were constructed...
September 4, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/30161187/neural-correlates-of-creative-insight-amplitude-of-low-frequency-fluctuation-of-resting-state-brain-activity-predicts-creative-insight
#12
Jiabao Lin, Xuan Cui, Xiaoying Dai, Yajue Chen, Lei Mo
Creative insight has attracted much attention across cultures. Although previous studies have explored the neural correlates of creative insight by functional magnetic resonance imaging (fMRI), little is known about intrinsic resting-state brain activity associated with creative insight. In the present study, we used amplitude of low-frequency fluctuation (ALFF) as an index in resting-state fMRI (rs-fMRI) to identify brain regions involved in individual differences in creative insight, which was measured by the response time of creative Chinese character chunk decomposition...
2018: PloS One
https://www.readbyqxmd.com/read/30137637/brain-activity-mediates-the-relation-between-emotional-but-not-instrumental-support-and-trait-loneliness
#13
Yangyang Yi, Liman Man Wai Li, Yu Xiao, Junji Ma, Linlin Fan, Zhengjia Dai
Loneliness results from lacking satisfied social connections. However, little is known how trait loneliness, which is a stable personal characteristic, is influenced by different types of social support (i.e. emotional and instrumental support) through the brain activity associated with loneliness. To explore these questions, data of resting-state functional magnetic resonance imaging (R-fMRI) of 92 healthy participants were analyzed. We identified loneliness-related brain regions by correlating participants' loneliness scores with amplitudes of low-frequency fluctuation (ALFF) of R-fMRI data...
September 11, 2018: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/30123144/resting-state-activity-of-prefrontal-striatal-circuits-in-internet-gaming-disorder-changes-with-cognitive-behavior-therapy-and-predictors-of-treatment-response
#14
Xu Han, Yao Wang, Wenqing Jiang, Xiaochen Bao, Yawen Sun, Weina Ding, Mengqiu Cao, Xiaowei Wu, Yasong Du, Yan Zhou
Cognitive behavior therapy (CBT) is effective for the treatment of Internet gaming disorder (IGD). However, the mechanisms by which CBT improves IGD-related clinical symptoms remain unknown. This study aimed to discover the therapeutic mechanism of CBT in IGD subjects using resting-state functional magnetic resonance imaging (rsfMRI). Twenty-six IGD subjects and 30 matched healthy controls (HCs) received rsfMRI scan and clinical assessments; 20 IGD subjects completed CBT and then were scanned again. The amplitude of low-frequency (ALFF) values and the functional connectivity (FC) between the IGD group and the HC group were compared at baseline, as well as the ALFF values and FC before and after the CBT in the IGD group...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30123120/multiple-frequency-bands-analysis-of-large-scale-intrinsic-brain-networks-and-its-application-in-schizotypal-personality-disorder
#15
Shouliang Qi, Qingjun Gao, Jing Shen, Yueyang Teng, Xuan Xie, Yueji Sun, Jianlin Wu
The human brain is a complex system composed by several large scale intrinsic networks with distinct functions. The low frequency oscillation (LFO) signal of blood oxygen level dependent (BOLD), measured through resting-state fMRI, reflects the spontaneous neural activity of these networks. We propose to characterize these networks by applying the multiple frequency bands analysis (MFBA) to the LFO time courses (TCs) resulted from the group independent component analysis (ICA). Specifically, seven networks, including the default model network (DMN), dorsal attention network (DAN), control executive network (CEN), salience network, sensorimotor network, visual network and limbic network, are identified...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/30122932/resting-state-functional-changes-in-the-precuneus-within-first-episode-drug-naive-patients-with-mdd
#16
Gaizhi Li, Kathryn Rossbach, Aixia Zhang, Penghong Liu, Kerang Zhang
Background: Major depressive disorder (MDD) is a leading psychiatric disorder that has a lack of biomarkers for a diagnosis. Purpose: The objective of this study was to examine the structural and functional change in the precuneus within first-episode drug naive patients with MDD. Methods: Thirty-two first episode drug-naive patients with MDD and thirty healthy controls (HCs) were recruited in this study; the structural MRI and fMRI data were collected using the 3...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/30120987/test-retest-reliability-of-dynamic-functional-connectivity-in-resting-state-fmri
#17
Chao Zhang, Stefi A Baum, Viraj R Adduru, Bharat B Biswal, Andrew M Michael
While static functional connectivity (sFC) of resting state fMRI (rfMRI) measures the average functional connectivity (FC) over the entire rfMRI scan, dynamic FC (dFC) captures the temporal variations of FC at shorter time windows. Although numerous studies have implemented dFC analyses, only a few studies have investigated the reliability of dFC and this limits the biological interpretation of dFC. Here, we used a large cohort (N = 820) of subjects and four rfMRI scans from the Human Connectome Project to systematically explore the relationship between sFC, dFC and their test-retest reliabilities through intra-class correlation (ICC)...
August 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/30116216/altered-regional-cortical-brain-activity-in-healthy-subjects-after-sleep-deprivation-a-functional-magnetic-resonance-imaging-study
#18
Lingling Chen, Xueliang Qi, Jiyong Zheng
Objective: To investigate acute sleep deprivation (SD)-related regional brain activity changes and their relationships with behavioral performances. Methods: Twenty-two female subjects underwent an MRI scan and an attention network test at rested wakefulness (RW) status and after 24 h SD. The amplitude of low-frequency fluctuations (ALFF) was used to investigate SD-related regional brain activity changes. We used the receiver operating characteristic (ROC) curve to evaluate the ability of the ALFF differences in regional brain areas to distinguish the SD status from the RW status...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30113921/abnormal-intrinsic-brain-activity-in-individuals-with-peripheral-vision-loss-because-of-retinitis-pigmentosa-using-amplitude-of-low-frequency-fluctuations
#19
Xin Huang, Fu-Qing Zhou, Han-Dong Dan, Yin Shen
The study aimed to determine alterations in intrinsic brain activity in retinitis pigmentosa (RP) individuals using the amplitude of low-frequency fluctuation (ALFF)/fractional amplitude of low-frequency fluctuation (fALFF) method. Sixteen RP individuals (10 men and six women) and 14 healthy controls (HCs) (six men and eight women) closely matched in age, sex, and education were enrolled in the study. The ALFF/fALFF method was applied to compare different intrinsic brain activities between the RP group and the HC group...
October 17, 2018: Neuroreport
https://www.readbyqxmd.com/read/30066277/visual-cortex-neural-activity-alteration-in-cervical-spondylotic-myelopathy-patients-a-resting-state-fmri-study
#20
Zhao Chen, Qiu Wang, Meng Liang, Rui Zhao, Jiajia Zhu, Wuyi Xiong, Zhe Su, Chunshui Yu, Yuan Xue
PURPOSE: We sought to investigate visual cortex neural activity and functional connectivity (FC) alterations in cervical spondylotic myelopathy (CSM) patients using resting-state fMRI (rs-fMRI) and to explore the relationships of these alterations with visual disorder. METHODS: Twenty-seven CSM patients and 11 healthy controls were recruited as the study and control groups. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) values were calculated to represent neural activity, seed-based correlation analysis (SCA) was performed to analyze the FC of visual cortex, and the outcomes were compared between groups...
September 2018: Neuroradiology
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