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Lingling Chen, Xueliang Qi, Jiyong Zheng
Objective: To investigate acute sleep deprivation (SD)-related regional brain activity changes and their relationships with behavioral performances. Methods: Twenty-two female subjects underwent an MRI scan and an attention network test at rested wakefulness (RW) status and after 24 h SD. The amplitude of low-frequency fluctuations (ALFF) was used to investigate SD-related regional brain activity changes. We used the receiver operating characteristic (ROC) curve to evaluate the ability of the ALFF differences in regional brain areas to distinguish the SD status from the RW status...
2018: Frontiers in Neurology
Xin Huang, Fu-Qing Zhou, Han-Dong Dan, Yin Shen
The study aimed to determine alterations in intrinsic brain activity in retinitis pigmentosa (RP) individuals using the amplitude of low-frequency fluctuation (ALFF)/fractional amplitude of low-frequency fluctuation (fALFF) method. Sixteen RP individuals (10 men and six women) and 14 healthy controls (HCs) (six men and eight women) closely matched in age, sex, and education were enrolled in the study. The ALFF/fALFF method was applied to compare different intrinsic brain activities between the RP group and the HC group...
August 15, 2018: Neuroreport
Zhao Chen, Qiu Wang, Meng Liang, Rui Zhao, Jiajia Zhu, Wuyi Xiong, Zhe Su, Chunshui Yu, Yuan Xue
PURPOSE: We sought to investigate visual cortex neural activity and functional connectivity (FC) alterations in cervical spondylotic myelopathy (CSM) patients using resting-state fMRI (rs-fMRI) and to explore the relationships of these alterations with visual disorder. METHODS: Twenty-seven CSM patients and 11 healthy controls were recruited as the study and control groups. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) values were calculated to represent neural activity, seed-based correlation analysis (SCA) was performed to analyze the FC of visual cortex, and the outcomes were compared between groups...
September 2018: Neuroradiology
Ge Tan, Fenglai Xiao, Sihan Chen, Haijiao Wang, Deng Chen, Lina Zhu, Da Xu, Dong Zhou, Ling Liu
OBJECTIVES: Spontaneous low-frequency oscillations in different frequency bands have diverse physiological meanings. The amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) in different frequency bands in Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS) are unknown and worth exploring. METHOD: Resting-state functional magnetic resonance imaging data were collected in 51 drug-naïve BECTS patients and 76 healthy controls. The ALFF was calculated for the typical (0...
September 2018: Epilepsy Research
Zhe Li, Jun Chen, Jianbo Cheng, Sicong Huang, Yingyu Hu, Yijuan Wu, Guihua Li, Bo Liu, Xian Liu, Wenyuan Guo, Shuxuan Huang, Miaomiao Zhou, Xiang Chen, Yousheng Xiao, Chaojun Chen, Junbin Chen, Xiaodong Luo, Pingyi Xu
Objective: To investigate the effect of acupuncture on Parkinson's disease (PD) patients with tremor and its potential neuromechanism by functional magnetic resonance imaging (fMRI). Methods: Forty-one PD patients with tremor were randomly assigned to true acupuncture group (TAG, n = 14), sham acupuncture group (SAG, n = 14) and waiting group (WG, n = 13). All patients received levodopa for 12 weeks. Patients in TAG were acupunctured on DU20, GB20, and the Chorea-Tremor Controlled Zone, and patients in SAG accepted sham acupuncture, while patients in WG received no acupuncture treatment until 12 weeks after the course was ended...
2018: Frontiers in Aging Neuroscience
Roger C McIntosh, Robert Paul, Lishomwa C Ndhlovu, Melissa Hidalgo, Judith D Lobo, Maegen Walker, Cecilia M Shikuma, Kalpana J Kallianpur
Depression and chronic inflammation are common in persons infected with the human immunodeficiency virus (HIV+). Although depression and response to inflammatory challenge are shown to reflect activity in common neural networks, little is known regarding sub-clinical presentation in persons chronically infected with HIV. The relationship of resting-state functional connectivity (rsFC) between the subgenual anterior cingulate cortex (sgACC) and bilateral amygdala to Beck Depression Inventory-1 (BDI) scores were compared within a group of 23 HIV+ and 23 HIV-negative comparison adults...
July 18, 2018: Journal of Neurovirology
Weitao Zhang, Fangshi Zhao, Wen Qin, Lin Ma
Recent resting-state fMRI studies have revealed neuroplastic alterations after long-term training. However, the neuroplastic changes that occur in professional traditional Chinese Pingju opera actors remain unclear. Twenty professional traditional Chinese Pingju opera actors and 20 age-, sex-, and handedness-matched laymen were recruited. Resting-state fMRI was obtained by using an echo-planar imaging sequence, and two metrics, amplitude of low frequency fluctuation (ALFF) and regional homogeneity (ReHo), were utilized to assess spontaneous neural activity during resting state...
2018: Frontiers in Neuroscience
Xiaozheng Liu, Jiuzun Chen, Bangli Shen, Gang Wang, Jiapeng Li, Hongtao Hou, Xingli Chen, Zhongwei Guo, Chuanwan Mao
Neuroimaging studies have demonstrated that major depressive disorder increases the risk of dementia in older individuals with mild cognitive impairment. We used resting-state functional magnetic resonance imaging to explore the intrinsic coupling patterns between the amplitude and synchronisation of low-frequency brain fluctuations using the amplitude of low-frequency fluctuations (ALFF) and the functional connectivity density (FCD) in 16 patients who had mild cognitive impairment with depressive symptoms (D-MCI) (mean age: 69...
2018: Neural Plasticity
Ling Wang, Du Lei, Xueling Suo, Nannan Li, Zhongjiao Lu, Junying Li, Jiaxin Peng, Qiyong Gong, Rong Peng
This study used resting-state functional MRI (r-fMRI) to evaluate intrinsic brain activity in drug-naive patients with essential tremor (ET) with and without head tremor. We enrolled 20 patients with ET with hand and head tremor (h-ET), 27 patients with ET without head tremor (a-ET), and 27 healthy controls (HCs). All participants underwent r-fMRI scans on a 3-T MR system. The amplitude of low-frequency fluctuation (ALFF) of blood oxygen level-dependent signals was used to characterize regional cerebral function...
July 12, 2018: Scientific Reports
Feng Xiao, Tao Wang, Lei Gao, Jian Fang, Zhenmeng Sun, Haibo Xu, Junjian Zhang
"Asymptomatic" carotid artery stenosis (aCAS) patients usually have cognitive impairment in the domains of executive, psychomotor speed, and memory function. However, the pathophysiology of this impairment in aCAS patients is still unclear. In this study, amplitude of low-frequency fluctuation (ALFF) method was used based on resting-state blood oxygenation level dependent (BOLD) signals, to investigate local brain activity in 19 aCAS patients and 24 healthy controls, aimed to explore this pathophysiology mechanism...
2018: Frontiers in Neuroscience
Peng Huang, Tingting Gao, Zhaoyang Dong, Chuying Zhou, Yuling Lai, Ting Pan, Yuan Liu, Xiaoshan Zhao, Xuegang Sun, Heyu Hua, Ge Wen, Lei Gao, Zhiping Lv
BACKGROUND: Depression is a heterogeneous disorder, but the exact neuronal mechanisms causing the disease have not yet been discovered. METHODS/MATERIALS: We have established a chronic unpredictable mild stress (CUMS) mouse model to explore the blood oxygen level-dependent (BOLD) activity in the hippocampus, prefrontal cortex (PFC), and basolateral amygdala (BLA) using amplitude of low-frequency fluctuations (ALFF) in functional magnetic resonance imaging (fMRI)...
June 30, 2018: Brain Research Bulletin
Yu-Ting Shen, Jun-Yi Li, Yong-Sheng Yuan, Xi-Xi Wang, Min Wang, Jian-Wei Wang, Hui Zhang, Lin Zhu, Ke-Zhong Zhang
Apathy is a common non-motor symptom in Parkinson's disease (PD). We aimed to explore its associated neural substrates changes via amplitude of low-frequency fluctuations (ALFF) and granger causality analysis (GCA). Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed in 20 PD patients with apathy (PD-A), 22 PD patients without apathy (PD-NA) and 19 healthy volunteers. GCA, a new method exploring direction from one brain region to another, was based on brain regions showing alterations of neural activity as seeds, which were examined utilizing ALFF approach...
June 25, 2018: Neuroscience Letters
Li Lu, Junpeng Wang, Longjiang Zhang, Zhiqiang Zhang, Ling Ni, Rongfeng Qi, Xiang Kong, Mengjie Lu, Muhammad U Sami, Kai Xu, Guangming Lu
The association between metabolic activity and functional coupling of the posterior cingulate cortex (PCC) in cirrhotic patients remains undefined. Therefore, this study aimed to assess the association of functional coupling with metabolic patterns of PCC in resting cirrhotic patients. Twenty-six cirrhotic patients, including 10 with hepatic encephalopathy (HE) and 16 without HE, were assessed, alongside 21 control participants. Single-voxel proton magnetic resonance spectroscopy (MRS) of the PCC and resting-state functional MRI (rs-fMRI) were performed on a 3...
August 15, 2018: Neuroreport
Jue Wang, Jia-Rong Zhang, Yu-Feng Zang, Tao Wu
Background: Resting-state functional magnetic resonance imaging (RS-fMRI) has frequently been used to investigate local spontaneous brain activity in Parkinson's disease (PD) in a whole-brain, voxel-wise manner. To quantitatively integrate these studies, we conducted a coordinate-based (CB) meta-analysis using the signed differential mapping method on 15 studies that used amplitude of low-frequency fluctuation (ALFF) and 11 studies that used regional homogeneity (ReHo). All ALFF and ReHo studies compared PD patients with healthy controls...
June 1, 2018: GigaScience
Yi Zhang, Gang Ji, Guanya Li, Yang Hu, Li Liu, Qingchao Jin, Qianqian Meng, Jizheng Zhao, Kai Yuan, Jixn Liu, Karen M von Deneen, Antao Chen, Guangbin Cui, Huaning Wang, Qingchuan Zhao, Kaichun Wu, Jie Tian, Peter Manza, Dardo Tomasi, Nora D Volkow, Yongzhan Nie, Gene-Jack Wang
BACKGROUND/OBJECTIVE: Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery to treat obesity, and involves removal of the gastric fundus where ghrelin is mainly produced. Ghrelin stimulates appetite and regulates food intake through its effect on the hypothalamus and hippocampus (HIPP). While ghrelin's role on the hypothalamus has been explored, little is known about its role on HIPP. We tested the hypothesis that LSG-induced reductions in ghrelin levels would be associated with changes in HIPP activity...
June 18, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Jill B De Vis, Alex A Bhogal, Jeroen Hendrikse, Esben T Petersen, Jeroen C W Siero
BACKGROUND AND PURPOSE: The BOLD signal amplitude as a response to a hypercapnia stimulus is commonly used to assess cerebrovascular reserve. Despite recent advances, the implementation remains cumbersome and alternative ways to assess hemodynamic impairment are desirable. Resting-state BOLD signal fluctuations (rsBOLD) have been proposed however data on its sensitivity and dependence on baseline venous cerebral blood volume (vCBV) is limited. The primary aim of this study was to compare the effect sizes of resting-state and hypercapnia induced BOLD signal changes in the detection of hemodynamic impairment...
October 1, 2018: NeuroImage
Chunxia Yang, Aixia Zhang, Aixiang Jia, Jack X Ma, Ning Sun, Yanfang Wang, Xinrong Li, Zhifen Liu, Sha Liu, Yong Xu, Kerang Zhang
This study aims to identify and characterize neurobiological markers for major depressive disorder (MDD) from resting-state brain functional MRI. We examined the abnormality in the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive major depressive disorder (fMDD), and remitted major depressive disorder (rMDD) and correlated these fluctuations with clinical markers of MDD. We conducted a retrospective study and reviewed the medical records of 43 patients with fMDD...
August 1, 2018: Neuroreport
Jiao Li, Xujun Duan, Qian Cui, Huafu Chen, Wei Liao
BACKGROUND: Major depressive disorder (MDD) is associated with high risk of suicide. Conventional neuroimaging works showed abnormalities of static brain activity and connectivity in MDD with suicidal ideation (SI). However, little is known regarding alterations of brain dynamics. More broadly, it remains unclear whether temporal dynamics of the brain activity could predict the prognosis of SI. METHODS: We included MDD patients (n = 48) with and without SI and age-, gender-, and education-matched healthy controls (n = 30) who underwent resting-state functional magnetic resonance imaging...
June 18, 2018: Psychological Medicine
Li-Xia Yuan, Jian-Bao Wang, Na Zhao, Yuan-Yuan Li, Yilong Ma, Dong-Qiang Liu, Hong-Jian He, Jian-Hui Zhong, Yu-Feng Zang
Scaled Subprofile Model of Principal Component Analysis (SSM-PCA) is a multivariate statistical method and has been widely used in Positron Emission Tomography (PET). Recently, SSM-PCA has been applied to discriminate patients with Parkinson's disease and healthy controls with Amplitude of Low Frequency Fluctuation (ALFF) from Resting-State Functional Magnetic Resonance Imaging (RS-fMRI). As RS-fMRI scans are more readily available than PET scans, it is important to investigate the intra- and inter-scanner reliability of SSM-PCA in RS-fMRI...
2018: Frontiers in Neuroscience
Mengmeng Zhi, Zhenghua Hou, Qiong We, Yuqun Zhang, Ling Li, Yonggui Yuan
Hyperthyroid patients undergo emotional and cognitive dysfunction. However, the neurological basis for it remains ambiguous. Amplitude of low frequency fluctuation (ALFF) and regional homogeneity (ReHo) were used to investigate abnormal spontaneous activity in hyperthyroidism for the first time. 29 hyperthyroid patients and 29 healthy controls (HC) received 3.0T magnetic resonance imaging (MRI) scans and neuropsychological assessments. Compared with HC, hyperthyroid patients showed decreased ALFF in left medial frontal gyrus (MeFG) and left posterior cingulate cortex (PCC)...
October 1, 2018: Behavioural Brain Research
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