Read by QxMD icon Read


Run Liu, Bi-Xia Liu, Mingyue Ma, Dan Kong, Guanglin Li, Junle Yang, Xiaoping Wu, Jiyong Zheng, Yan Dong
Objective: To identify whether the amplitude of low-frequency fluctuations (ALFF) analysis has the potential to serve as a biological marker to detect alcohol-induced spontaneous brain activities and distinguish the patients with alcohol dependence from the healthy subjects. Methods: We utilized the ALFF analysis to report on the alcohol-induced spontaneous brain activities in 29 patients with alcohol dependence (9 female, 20 male) relative to 29 status-matched healthy subjects (11 female, 18 male)...
2018: Neuropsychiatric Disease and Treatment
Yudan Ding, Yangpan Ou, Pan Pan, Xiaoxiao Shan, Jindong Chen, Feng Liu, Jingping Zhao, Wenbin Guo
Schizophrenia (SZ) is a mental disorder that involves cerebral and cerebellar abnormalities. The cerebellum plays an indispensable role in the pathophysiology of SZ. However, individual studies pertaining to the structural and resting-state functional cerebellar abnormalities in patients with SZ have been inconsistent. To make a relatively robust conclusion with little interference, such as different disease episode times and antipsychotic treatment, we conducted this meta-analysis as a first attempt to comprehensively analyze and combine studies of voxel-based morphometry (VBM), amplitude of low-frequency fluctuation (ALFF), and functional connectivity strength (FCS) in first-episode and drug-naive SZ patients, employing the Seed-based d Mapping (SDM) method...
November 22, 2018: Psychiatry research. Neuroimaging
Hong-Hua Kang, Yong-Qiang Shu, Lin Yang, Pei-Wen Zhu, Dan Li, Qing-Hai Li, You-Lan Min, Lei Ye, Qiong Zhou, Yi Shao
OBJECTIVE: The targets of this study was to access the alternations of spontaneous brain activity in RD patients by amplitude of low-frequency fluctuation (ALFF) method and to explore their relationships with clinical behavioral performance. METHODS: 20 patients with RD (6 males and 14 females), and 20 healthy controls (HCs) (6 males and 14 females) were recruited, and were matched in sex and age. All participants finished the functional magnetic resonance imaging (fMRI) scanning...
November 30, 2018: International Journal of Neuroscience
Yunjin Bak, Sunyoung Jun, Jun Yong Choi, Youngjoon Lee, Seung-Koo Lee, Sanghoon Han, Na-Young Shin
PURPOSE: To characterize resting-state brain activation patterns and investigate altered areas for cognitive decline in HIV patients. METHODS: Twelve male HIV patients with intact cognition (HIV-IC), 10 with HIV-associated neurocognitive disorder (HAND), and 11 male healthy controls (HC) underwent resting-state functional MRI (rsfMRI). Three rsfMRI values, regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between groups...
2018: PloS One
Ge-Fei Li, Shiyu Ban, Mengxing Wang, Jilei Zhang, Haifeng Lu, Yan-Hui Shi, Xin-Wei He, Yi-Lan Wu, Peng Peng, Yi-Sheng Liu, Mei-Ting Zhuang, Rong Zhao, Xiao-Lei Shen, Qiang Li, Jian-Ren Liu, Xiaoxia Du
BACKGROUND: Botulinum toxin type A (BoNT-A) is generally considered safe and is widely used to treat a variety of clinical conditions involving muscle hyperactivity and for cosmetic purposes. However, the effects of BoNT-A poisoning (botulism) on brain function are poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Herein, we investigated brain functions in 9 patients who received illegal cosmetic injections of botulinum and 18 matched controls by combining the analysis methods of regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) based on resting-state fMRI...
2018: PloS One
Jing Zhao, Feng Chen, Meiji Ren, Li Li, Aixin Li, Bin Jing, Hongjun Li
Simian immunodeficiency virus (SIV)-infected macaque is a widely used model to study human immunodeficiency virus. The purpose of the study is to discover the amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) changes in SIV-infected macaques. Seven rhesus macaques were involved in the longitudinal MRI scans: (1) baseline (healthy state); (2) SIV infection stage (12 weeks after SIV inoculation). ALFF and fALFF were subsequently computed and compared to ascertain the changes caused by SIV infection...
November 26, 2018: Journal of Neurovirology
Changjun Teng, Jing Zhou, Hui Ma, Yarong Tan, Xin Wu, Chengbin Guan, Huifen Qiao, Jijun Li, Yuan Zhong, Chun Wang, Ning Zhang
BACKGROUND: Women are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, attention bias, memory bias and self-referential bias were closely related among depressed patients. Previous studies have explored the neural mechanism of the cognitive biases by using amplitude of low frequency fluctuations (ALFF) or functional connectivity (FC), and few combined these two metrics, especially focusing on female patients...
November 26, 2018: BMC Psychiatry
Gaizhi Li, Kathryn Rossbach, Wenqing Jiang, Yasong Du
Background: This study aimed to explore the resting-state fMRI changes in Chinese boys with low functioning autism spectrum disorder (LFASD) and the correlation with clinical symptoms. Methods: The current study acquired resting-state fMRI data from 15 Chinese boys with LFASD and 15 typically developing (TD) boys to examine the local brain activity using the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) indexes; the researchers also examined these measures and their possible relationships with clinical symptoms using the autism behavior checklist...
2018: Annals of General Psychiatry
J-G Du, H Xiao, Y-X Zuo
OBJECTIVE: Our objective was to use Amplitude of Low-Frequency Fluctuation (ALFF) method to investigate the changes in spontaneous brain activity in HM patients and their relationships with clinical features. PATIENTS AND METHODS: This study was set out to observe, using Functional magnetic resonance imaging (fMRI), the changes in spontaneous brain activity in patients with phantom limb pain (PLP). Eleven amputees with PLP closely matched in age, sex, and education in a right side lower limb were scanned using fMRI to measure the amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) in the resting state of the brain (GPLP) before use of prosthetic...
November 2018: European Review for Medical and Pharmacological Sciences
Mengjiao Hu, Fang Ji, Zhongkang Lu, Weimin Huang, Reza Khosrowabadi, Ling Zhao, Kai Keng Ang, Kok Soon Phua, Fatima Ali Nasrallah, Kai-Hsiang Chuang, Mary C Stephenson, John Totman, Xudong Jiang, Effie Chew, Cuntai Guan, Juan Zhou
Mapping the brain alterations post stroke and post intervention is important for rehabilitation therapy development. Previous work has shown changes in functional connectivity based on resting-state fMRI, structural connectivity derived from diffusion MRI and perfusion as a result of brain-computer interface-assisted motor imagery (MI-BCI) and transcranial direct current stimulation (tDCS) in upper-limb stroke rehabilitation. Besides functional connectivity, regional amplitude of local low-frequency fluctuations (ALFF) may provide complementary information on the underlying neural mechanism in disease...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Michael Woletz, André Hoffmann, Martin Tik, Ronald Sladky, Rupert Lanzenberger, Simon Robinson, Christian Windischberger
Resting-state functional magnetic resonance imaging (rs-fMRI) offers the possibility to assess brain function independent of explicit tasks and individual performance. This absence of explicit stimuli in rs-fMRI makes analyses more susceptible to nonneural signal fluctuations than task-based fMRI. Data preprocessing is a critical procedure to minimise contamination by artefacts related to motion and physiology. We herein investigate the effects of different preprocessing strategies on the amplitude of low-frequency fluctuations (ALFFs) and its fractional counterpart, fractional ALFF (fALFF)...
November 15, 2018: Human Brain Mapping
Minlan Yuan, Changjian Qiu, Yajing Meng, Zhengjia Ren, Cui Yuan, Yuchen Li, Meng Gao, Su Lui, Hongru Zhu, Qiyong Gong, Wei Zhang
Background: The chronic phase of post-traumatic stress disorder (PTSD) and the limited effectiveness of existing treatments creates the need for the development of potential biomarkers to predict response to antidepressant medication at an early stage. However, findings at present focus on acute therapeutic effect without following-up the long-term clinical outcome of PTSD. So far, studies predicting the long-term clinical outcome of short-term treatment based on both pre-treatment and post-treatment functional MRI in PTSD remains limited...
2018: Frontiers in Psychiatry
Wenjing Wang, Haijun Li, Dechang Peng, Juan Luo, Huizhen Xin, Honghui Yu, Jingjing Yu
Objective: The majority of previous neuroimaging studies have reported both structural and functional changes in COPD, whereas the intrinsic low-frequency oscillations changes and the relationship between the abnormal brain regions and the clinical performances remain unknown. The present study was conducted with the aim of evaluating the intrinsic brain activity in COPD patients using the amplitude of low-frequency fluctuation (ALFF) method. Methods: All participants, including 19 stable patients with COPD and 20 normal controls (NCs) matched in age, sex, and education, underwent resting-state functional MRI scans and performed cognitive function tests and respiratory functions tests...
2018: Neuropsychiatric Disease and Treatment
Santosh K Yadav, Rakesh K Gupta, Sheema Hashem, Ajaz A Bhat, Ravindra K Garg, Vimala Venkatesh, Pradeep K Gupta, Alok K Singh, Saurabh Chaturvedi, Sabha Nisar Ahmed, Muhammad W Azeem, Mohammad Haris
Delayed brain development in perinatally HIV-infected children may affect the functional brain activity and subsequently cognitive function. The current study evaluated the functional brain activity in HIV-infected children by quantifying the amplitude of low frequency fluctuations (ALFF) and functional connectivity (FC). Additionally, correlation of ALFF and FC with cognitive measures was performed. Twenty-six HIV-infected children and 20 control children underwent neuropsychological (NP) assessment and resting-state functional magnetic resonance imaging (rs-fMRI)...
2018: NeuroImage: Clinical
Xiaoyan Jia, Shuai Ma, Sisi Jiang, Honbin Sun, Debo Dong, Xuebin Chang, Qiong Zhu, Dezhong Yao, Liang Yu, Cheng Luo
Purpose: The purpose of this study was to comprehensively evaluate alterations of resting-state spontaneous brain activity in patients with idiopathic generalized epilepsy (IGE) and its subgroups [juvenile myoclonic epilepsy (JME) and generalized tonic-clonic seizures (GTCS)]. Methods: Resting state functional magnetic resonance imaging (fMRI) data were acquired from 60 patients with IGE and 60 healthy controls (HCs). Amplitude of low frequency fluctuation (ALFF), global functional connectivity density (gFCD), local FCD (lFCD), and long range FCD (lrFCD) were used to evaluate spontaneous brain activity in the whole brain...
2018: Frontiers in Neurology
X-B Lu, Y Zhang, D-Y Yang, Y-Z Yang, F-C Wu, Y-P Ning, K Wu
OBJECTIVE: The brain structure and function differences among first-episode schizophrenia (FESZ) patients, chronic schizophrenia (CSZ) patients, and normal control (NC) subjects were investigated using structural and functional magnetic resonance imaging (MRI). Also, a support vector machine (SVM) combined with recursive feature elimination (RFE) was used for classification. PATIENTS AND METHODS: First, 44 FESZ patients, 44 CSZ patients, and 56 NC subjects were recruited, and structural MRI images were acquired...
October 2018: European Review for Medical and Pharmacological Sciences
Junling Li, Ran Yang, Kai Xia, Tian Wang, Binbin Nie, Kuo Gao, Jianxin Chen, Huihui Zhao, Yubo Li, Wei Wang
BACKGROUND: The etiology of depression and its effective therapeutic treatment have not been clearly identified. Using behavioral phenotyping and resting-state functional magnetic resonance imaging (r-fMRI), we investigated the behavioral impact and cerebral alterations of chronic unpredictable mild stress (CUMS) in the rat. We also evaluated the efficacy of telmisartan therapy in this rodent model of depression. METHODS: Thirty-two rats were divided into 4 groups: a control group(C group), a stress group(S group), a stress + telmisartan(0...
October 17, 2018: BMC Psychiatry
Hao Yang, Junran Zhang, Qihong Liu, Yi Wang
BACKGROUND: Recently, deep learning technologies have rapidly expanded into medical image analysis, including both disease detection and classification. As far as we know, migraine is a disabling and common neurological disorder, typically characterized by unilateral, throbbing and pulsating headaches. Unfortunately, a large number of migraineurs do not receive the accurate diagnosis when using traditional diagnostic criteria based on the guidelines of the International Headache Society...
October 11, 2018: Biomedical Engineering Online
Julio Plata-Bello, Yaiza Pérez-Martín, Abril Castañón-Pérez, Cristián Modroño, Estefanía Hernández-Martín, Montserrat González-Platas, Francisco Marcano, José Luis González-Mora
The study of the relationship between function and structure of the brain could be particularly interesting in neurodegenerative diseases like multiple sclerosis (MS). The aim of the present work is to identify differences of the amplitude of low frequency fluctuations (ALFF) in the mirror neuron system (MNS) between MS patients and healthy controls and to study the relationship between ALFF and the gray matter volume (GMV) of the regions that belong to the MNS. Relapsing-remitting MS patients with minor disability were compared to healthy controls (HC) using resting-state functional magnetic resonance imaging (fMRI), anatomic T1 weighted images and diffusion tensor imaging (DTI)...
December 2018: IBRO Reports
Hong Guo, Raynald Liu, Zhaosheng Sun, Bing Liu, Yi Xiang, Jianhui Mao, Guangjie Li, Mingzhe Zhang
BACKGROUND: We investigate the change of the default mode network (DMN) by using amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) methods in acute phase patients after severe traumatic brain injury (sTBI) and correlate these changes with prognosis. METHODS: Twenty-one patients with sTBI were included. Twenty-one healthy sex-, age-, and education-matched control subjects were recruited for the control group. Of the 21 patients with sTBI, 12 patients regained consciousness (Glasgow Outcome Scale [GOS] score >2) and 9 patients remained unconscious (GOS score <2)...
October 3, 2018: World Neurosurgery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"