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https://www.readbyqxmd.com/read/30009894/non-viral-ocular-gene-therapy-peys606-for-the-treatment-of-non-infectious-uveitis-preclinical-evaluation-of-the-medicinal-product
#1
REVIEW
Elodie Touchard, Romain Benard, Karine Bigot, Jean-Denis Laffitte, Ronald Buggage, Thierry Bordet, Francine Behar-Cohen
Non-infectious uveitis (NIU) is the first cause of blindness that can be cured if optimal anti-inflammatory therapy can be achieved. Systemic anti-TNF (Tumor Necrosis Factor) agents have been recently approved for NIU but no local delivery of anti-TNF is available. For sustained production of secreted therapeutic proteins into the eye, non-viral gene therapy using plasmid electrotransfer in the ciliary muscle has been proposed. In this paper, we report the development steps of pEYS606, a clinical-grade plasmid DNA, devoid of antiobiotic selection gene, encoding a fusion protein consisting of the extracellular domain of the soluble p55 TNF-α receptor linked to the human IgG1 Fc domain (hTNFR-Is/hIgG1 or Protein 6), with high affinity for human TNF-α, for non-viral gene transfer into the ocular ciliary muscle...
September 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29678565/simplification-of-first-line-antibacterial-regimen-for-complicated-appendicitis-in-children-is-associated-with-better-adherence-to-guidelines-and-reduced-use-of-antibiotics
#2
Marion Taleb, Nicolas Nardi, Alexis Arnaud, Nathalie Costet, Pierre-Yves Donnio, Charlotte Engrand, Edouard Habonimana, Eric Wodey, Pierre Tattevin
Acute appendicitis in children requires early surgery and short-course antibiotics active against Enterobacteriaceae and anaerobes. Although an aminoglycoside-containing three-drug regimen has been used successfully for decades, simpler regimens with similar efficacy are increasingly used. This study evaluated the impact of a switch from the combination of cefotaxime, metronidazole and gentamicin (regimen 1) to piperacillin/tazobactam (regimen 2) as first-line regimen for complicated acute appendicitis in children...
August 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28946850/bordetella-bronchiseptica-pneumonia-in-a-patient-with-lung-cancer-a-case-report-of-a-rare-infection
#3
Manlio Monti, Danila Diano, Francesco Allegrini, Angelo Delmonte, Valentina Fausti, Paola Cravero, Giulia Marcantognini, Giovanni Luca Frassineti
BACKGROUND: Bordetella bronchiseptica (B.bronchiseptica) is a frequent cause of respiratory infections in animals but rarely causes serious infection in humans. We present a rare case of B. bronchiseptica pneumonia in a patient with lung cancer. CASE PRESENTATION: A 52-year-old white male with non small cell lung cancer developed fever during treatment with nivolumab. A persistent productive cough and a deterioration in his clinical condition led to his hospitalization for evaluation...
September 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28648168/-mitral-valve-endocarditis-diagnosed-after-panophthalmitis-with-enterococcus-faecalis
#4
Kasper Kyhl, Peter Bomholt Hansen, Elin Holm, Torkil Á Steig, Rudi Kollslíð, Shahin Gaïni
An 86-year-old man underwent cataract surgery on the left eye, but suddenly he lost his vision three days after surgery. Topical treatments for panophthalmitis were started according to international guidelines. Later, a broad-range polymerase chain reaction showed Enterococcus faecalis in corpus vitreum, and IV antiobiotic treatment was initiated. To exclude endocarditis an echocardiography was performed, and this showed mitral regurgitation with a small mobile vegetation. Uncertainty concerning a possible causality between panophthalmitis and mitral valve endocarditis remains...
June 26, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28068758/strontium-doped-amorphous-calcium-phosphate-porous-microspheres-synthesized-through-a-microwave-hydrothermal-method-using-fructose-1-6-bisphosphate-as-an-organic-phosphorus-source-application-in-drug-delivery-and-enhanced-bone-regeneration
#5
Weilin Yu, Tuan-Wei Sun, Chao Qi, Zhenyu Ding, Huakun Zhao, Feng Chen, Daoyun Chen, Ying-Jie Zhu, Zhongmin Shi, Yaohua He
Nanostructured calcium phosphate porous microspheres are of great potential in drug delivery and bone regeneration due to their large specific surface area, biocompatibility, and similarity to inorganic component of osseous tissue. In this work, strontium (Sr)-doped amorphous calcium phosphate porous microspheres (SrAPMs) were synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate trisodium salt as the source of phosphate ions. The SrAPMs showed a mesoporous structure and a relatively high specific area...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27786105/resistance-in-respiratory-tract-pathogens-an-international-study-1997-1998
#6
C Thornsberry, D F Sahm
Multiple antibiotic resistance threatens current treatment for communityacquired pneumonia (CAP). This paper presents a summary of resistance data for Streptococcus pneumoniae (6223 isolates), Haemophilus influenzae (4016) and Moraxella catarrhalis (1263) collected from 153 centers throughout Japan, China, UK, Germany, Spain, France, Italy, Brazil and USA. Antiobiotics tested were: β-lactams (penicillin, ampicillin, co-amoxiclav, cefuroxime, and ceftriaxone), macrolides (azithromycin and clarithromycin), sulphonamide (trimethoprim-sulfamethoxazole), glycopeptide (vancomycin) and fluoroquinolone (levofloxacin)...
October 2000: Journal of Chemotherapy
https://www.readbyqxmd.com/read/26387069/phospholipidosis-effect-of-drugs-by-adsorption-into-lipid-monolayers
#7
Martina Ceccarelli, Raimondo Germani, Serena Massari, Charlotte Petit, Alessandra Nurisso, Jean-Luc Wolfender, Laura Goracci
Drug-induced phospholipidosis indicates an accumulation of phospholipids within lysosomes, which can occur during therapeutic treatment. Whether or not phospholipidosis represents a toxicological phenomenon is still under investigation, and in the last decade the Food and Drug Administration has been raising concerns about the possible consequences of this adverse event. Cationic amphiphilic drugs represent the majority of phospholipidosis inducers, followed by aminoglycoside and macrolide antibiotics. Although the mechanism of phospholipidosis induction is still uncertain, the interaction of drugs with phospholipids in the lysosomal membrane represents a key step...
December 1, 2015: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/25365877/-bion-m1-biological-activities-of-microorganisms-under-the-conditions-of-a-30-day-space-flight
#8
T A Voeĭkova, B V Tiaglov, L M Novikova, I N Krest'ianova, L K Emel'ianova, D V Korshunov, Iu A Morozova, V K Il'in
It was stated that spaceflight factors (SFF) affect the chromosomal DNA interchange during Streptomyces crossing. Cross polarity and primary input of a parent chromosome fragment in recombinant generation imply a more lasting cells contact in microgravity and a broader horizontal transport of genetic material. SFF had no effect on recombination frequency and mutation in a model of parental auxotrophic markers reversion to prototrophism. It was demonstrated that SFF boosted the fC31 phage exit from S. lividans 66 (fC31) and did not influence phage induction in S...
2014: Aviakosmicheskaia i Ekologicheskaia Meditsina, Aerospace and Environmental Medicine
https://www.readbyqxmd.com/read/24819647/drug-induced-panniculitides
#9
REVIEW
G Borroni, S Torti, R M D'Ospina, C Pezzini
A substantial number of all panniculitides fails to recognize a specific etiology, and that is true also for a relatively frequent type of panniculitis, such as erythema nodosum (EN). Between the recognized causative factors of panniculitides, infectious, physical agents, autoimmune mechanisms and neoplastic disorders are well known. On the contrary, the role of drugs as inducers of panniculitides is marginally considered, and their report limited to anecdotal observations, often without due histopathological support...
April 2014: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/23425020/should-israel-screen-all-mothers-to-be-to-prevent-early-onset-of-neonatal-group-b-streptococcal-disease-a-cost-utility-analysis
#10
Gary M Ginsberg, Arthur I Eidelman, Eric Shinwell, Emilia Anis, Reuven Peyser, Yoram Lotan
BACKGROUND: In Israel, an average of 37 children are born each year with sepsis and another four with meningitis as a result of Group B Streptococcal (GBS) disease. Israel currently only screens mothers with defined risk factors (around 15% of all pregnancies) in order to identify candidates for Intrapartum Antiobiotic Prophyhlaxis (IAP) of GBS. This paper presents a cost-utility analysis of implementing an alternative strategy, which would expand the current protocol to one aiming to screen all pregnant women at 35-37 weeks gestation based on taking a vaginal culture for GBS...
2013: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/22999078/clinical-course-of-preterm-prelabor-rupture-of-membranes-in-the-era-of-prophylactic-antibiotics
#11
Vorapong Phupong, Lalita Kulmala
BACKGROUND: Preterm prelabor rupture of membrane (PPROM) causes maternal and neonatal complications. Prophylactic antiobiotics were used in the management of PPROM. The objectives of this retrospective study were to compare clinical course and outcome of PPROM managed expectantly with prophylactic antibiotics and antenatal corticosteroids with those without prophylactic antibiotics and antenatal corticosteroids. RESULTS: A total of 170 cases of singleton pregnant women with gestational age between 28-34 weeks suffering from PROM during January 1998 to December 2009 were included; 119 cases received prophylactic antibiotics and antenatal corticosteroids while 51 cases did not received prophylactic antibiotics and antenatal corticosteroids...
September 22, 2012: BMC Research Notes
https://www.readbyqxmd.com/read/22905060/antiobiotic-resistance-pattern-of-biofilm-forming-uropathogens-isolated-from-catheterised-patients-in-pondicherry-india
#12
Pramodhini Subramanian, Niveditha Shanmugam, Umadevi Sivaraman, Shailesh Kumar, Stephen Selvaraj
BACKGROUND: Microbial biofilms pose a public health problem for persons requiring indwelling medical devices, as micro-organisms in biofilms are difficult to treat with antimicrobial agents. Thus the present study includes biofilm formation and antibiotic resistance pattern of uropathogens in hospitalised patients with catheter associated urinary tract infections (UTI). METHOD: This prospective analysis included 100 urine samples from catheterised patients with symptoms of UTI over a period of six months...
2012: Australasian Medical Journal
https://www.readbyqxmd.com/read/22710499/refractory-salmonella-enterica-serotype-choleraesuis-related-renal-cyst-infection-in-a-patient-with-autosomal-dominant-polycystic-kidney-disease-undergoing-hemodialysis-treated-successfully-with-intracystic-ciprofloxacin-infusion
#13
Chih-Chao Yang, Feng-Rong Chuang, Chien-Hsing Wu, Jin-Bor Chen, Chih-Hsiung Lee, Chien-Te Lee
OBJECTIVE: To report a potential salvage therapy for refractory renal cyst infection secondary to Salmonellaenterica serotype choleraesuis (S. choleraesuis). CLINICAL PRESENTATION AND INTERVENTION: A 52-year-old male with autosomal dominant polycystic kidney disease undergoing hemodialysis experienced an episode of S. choleraesuis-related gastroenteritis subsequently complicated by bloodstream and refractory renal cyst infection with formation of multiple pyocysts...
2012: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/22693803/-influence-of-antistaphylococcus-antiobiotic-batumin-on-microorganism-biofilm-formation
#14
O V Bukharin, L N Churkina, N B Perunova, E V Ivanova, I V Novikova, L V Avdeeva, L V Iaroshenko
AIM: Study the influence of batumin on microorganism biofilm formation. MATERIALS AND METHODS: Experimental data on the antimicrobial effect of batumin on microorganisms and biofilm formation (BFF) was obtained by studying 80 strains of bacteria and fungi isolated from microbial biocenosis of the nose of staphylococcus carriers and patients during examination for intestine dysbiosis. 80% pure batumin was used in the experiments. Antimicrobial activity of batumin was studied by serial dilutions method (CLSI, 2005), BFF--by photometry method (O'Toole G...
March 2012: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
https://www.readbyqxmd.com/read/22109925/otogenic-cerebral-abscess-an-unusual-complication-of-otitis-media
#15
Alice E Chang, Teresa M O
Intracranial complications of otitis media are rare in the age of antiobiotics and in the developed world, but they can be life threatening when they occur. We present a case of a 47-year-old woman with no contributory otologic history who developed an otogenic temporal lobe abscess.
November 2011: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/22018665/-endogenous-bacterial-endophthalmitis-related-to-dental-abscess-case-report
#16
R Mascali, M Berguiga, S Delhoum, M Le Loir, C Cochard-Marianowski, B Cochener, J Gambrelle
INTRODUCTION: Endogenous bacterial endophthalmitis (EBE) is an intraocular bacterial infection transmitted via a hemotogenous route, usually occuring in immunocompromised patients with bacteremia spreading from extraocular foci of infection. We report a case of EBE secondary to a dental infection occurring in an immunocompetent patient. CASE REPORT: A 61-year-old-man with no past medical history other than a dental bridge on the 13th tooth was referred for rapid onset hypertensive fibrinous panuveitis of the right eye...
January 2012: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/21996046/d-lactic-acidosis-25-years-after-bariatric-surgery-due-to-salmonella-enteritidis
#17
Antonietta Gigante, Liborio Sardo, Maria Ludovica Gasperini, Antonio Molinaro, Oliviero Riggio, Alessandro Laviano, Antonio Amoroso
D-Lactic acidosis is a rare complication that occurs in patients with short bowel syndrome due to surgical intestine resection for treatment of obesity. The clinical presentation is characterized by neurologic symptoms and high anion gap metabolic acidosis. The incidence of this syndrome is unknown, probably because of misdiagnosis and sometimes symptoms may be incorrectly attributed to other causes. Therapy is based on low carbohydrate diet, sodium bicarbonate intravenous, rehydratation, antiobiotics, and probiotics that only produce L-lactate...
January 2012: Nutrition
https://www.readbyqxmd.com/read/21947785/ascochlorin-suppresses-tgf-%C3%AE-1-induced-pai-1-expression-through-the-inhibition-of-phospho-egfr-in-rat-kidney-fibroblast-cells
#18
Hyun-Ji Cho, Jeong-Han Kang, Ji-Hak Jeong, Yun-Jeong Jeong, Kwan-Kyu Park, Yoon-Yub Park, Yong-Suk Moon, Hong-Tae Kim, Il-Kyung Chung, Cheorl-Ho Kim, Hyeun-Wook Chang, Young-Chae Chang
Fibrosis is induced by the excessive and abnormal deposition of extracellular matrix (ECM) with various growth factors in tissues. Transforming growth factor-β1 (TGF-β1), the growth factor involved in fibrosis, modulates ECM synthesis and accumulation. TGF-β1 enhances the production of stimulators of ECM synthesis such as plasminogen activator inhibitor type 1 (PAI-1). As such, PAI-1 expression directly influences the proteolysis, invasion, and accumulation of ECM. It was shown in this study that ascochlorin, a prenylpenl antiobiotic, prevents the expression of profibrotic factors, such as PAI-1 and collagen type I, and that the TGF-β1-induced PAI-1 promoter activity is inhibited by ascochlorin...
April 2012: Molecular Biology Reports
https://www.readbyqxmd.com/read/21903609/micelle-encapsulated-thiostrepton-as-an-effective-nanomedicine-for-inhibiting-tumor-growth-and-for-suppressing-foxm1-in-human-xenografts
#19
Ming Wang, Andrei L Gartel
The thiazole antiobiotic, thiostrepton, has been found to induce cell death in cancer cells through proteasome inhibition. As a proteasome inhibitor, thiostrepton has also been shown to suppress the expression of FOXM1, the oncogenic forkhead transcription factor overexpressed in cancer cells. In this study, we explored the potential in vivo anticancer properties of thiostrepton, delivered through nanoparticle encapsulation to xenograft models of breast and liver cancer. We encapsulated thiostrepton into micelles assembled from amphiphilic lipid-PEG (polyethylene glycol) molecules, where thiostrepton is solubilized within the inner lipid compartment of the micelle...
December 2011: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/21451505/effect-of-abcc2-mrp2-transport-function-on-erythromycin-metabolism
#20
COMPARATIVE STUDY
R M Franke, C S Lancaster, C J Peer, A A Gibson, A M Kosloske, S J Orwick, R H Mathijssen, W D Figg, S D Baker, A Sparreboom
The macrolide antiobiotic erythromycin undergoes extensive hepatic metabolism and is commonly used as a probe for cytochrome P450 (CYP) 3A4 activity. By means of a transporter screen, erythromycin was identified as a substrate for the transporter ABCC2 (MRP2) and its murine ortholog, Abcc2. Because these proteins are highly expressed on the biliary surface of hepatocytes, we hypothesized that impaired Abcc2 function may influence the rate of hepatobiliary excretion and thereby enhance erythromycin metabolism...
May 2011: Clinical Pharmacology and Therapeutics
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