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https://www.readbyqxmd.com/read/29782332/detection-of-high-risk-thrombophilia-with-an-automated-global-test-the-coagulation-inhibitor-potential-assay
#1
Barbara Réger, Hajna Losonczy, Ágnes Nagy, Ágnes Péterfalvi, Réka Mózes, László Pótó, Nelli Farkas, Gábor L Kovács, Attila Miseta, Alizadeh Hussain, Orsolya Tóth
: The diagnosis of thrombophilia is a cost-consuming and time-consuming process, as each defect should be separately investigated. The Coagulation Inhibitor Potential (CIP) assay is a promising new global test, sensitive for most of the hereditary thrombophilias, developed for manual methodology. We adapt the original method to an optical coagulation analyser. By this automation, the test will be easier, faster and more precise, and it also allows carrying out 18 measurements simultaneously. The CIP assay was performed in 126 healthy subjects and 193 patients with different types of hereditary thrombophilia conditions...
May 17, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29782306/urticarial-lesions-in-a-pregnant-woman
#2
Sergio Santos-Alarcón, Cesar Benavente-Villegas, Isabel García-Briz, Magdalena Moneva-Léniz, Celia Sanchis-Sánchez, Almudena Mateu-Puchades
Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Herein we report the case of a 45-year-old woman with the distinctive clinical onset of GP. A forty-five-year-old woman, gravida I, para 0, at 27 weeks gestation, was referred for evaluation to our Department with an extensive pruritic eruption that had developed over the previous 7 days...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781404/removal-of-iron-ore-slimes-from-a-highly-turbid-water-by-daf
#3
L M Faustino, A S Braga, G D Sacchi, W Whitaker, M A P Reali, L S Leal Filho, L A Daniel
This paper addresses Dissolved Air Flotation (DAF) process variables, such as the flocculation parameters and the recycle water addition, as well as the pretreatment chemical variables (coagulation conditions), to determine the optimal values for the flotation of iron ore slimes found in a highly turbid water sample from the Gualaxo do Norte River, a tributary of the Doce River Basin in Minas Gerais, Brazil. This work was conducted using a flotatest batch laboratory-scale device to evaluate the effectiveness of DAF for cleaning the water polluted by the Samarco tailings dam leakage and determine the ability of DAF to reduce the water turbidity from 358 NTU to values below 100 NTU, aiming to comply with current legislation...
May 21, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29779622/anticoagulation-during-ecmo-in-neonatal-and-paediatric-patients
#4
Rebecca Barton, Vera Ignjatovic, Paul Monagle
Extracorporeal Membrane Oxygenation (ECMO) is a form of Extracorporeal Life Support (ECLS) which is used frequently in the paediatric and neonatal setting to support either the pulmonary, or both the pulmonary and cardiac systems. Management of ECMO requires the use of systemic anticoagulation to prevent patient and circuit based thrombosis, which in turn increases the risk of haemorrhage. A number of coagulation tests, laboratory and point of care based, are used to monitor anticoagulation, however the evidence for correlation of the test results with level of anticoagulant and clinical outcomes in children remains poor...
May 8, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29765293/recurrent-bleedings-in-newborn-a-factor-vii-deficiency-case-report
#5
Kim Cattivelli, Cristina Distefano, Lorenza Bonetti, Sophie Testa, Simona Maria Siboni, Alessandro Plebani, Carlo Poggiani
Background: Major hemorrhages in newborns can be caused by several conditions, and knowledge of the differential diagnosis is essential in order to ensure prompt recognition and appropriate treatment. Case Report: We describe the case of a male newborn experiencing recurrent hemorrhages from the first days of life. Laboratory findings showed normal platelet count, hepatic function, and C-reactive protein. Coagulation tests detected an isolated prothrombin time (PT) prolongation and severe factor VII (FVII) deficiency...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29761633/verification-of-the-qlabs-international-normalized-ratio-point-of-care-device-for-monitoring-of-patients-attending-an-anticoagulation-clinic
#6
N Mbokota, E Schapkaitz, S Louw
INTRODUCTION: In the developing world, point-of-care (POC) testing for international normalized ratio (INR) plays an important role in the monitoring of patients on long-term warfarin therapy with limited access to healthcare ensuring safe and effective anticoagulation. A newly developed POC device for INR measurement by healthcare workers is the handheld qLabs POC device® (Micropoint Biotechnologies Incorporated, Guangdong, China). METHODS: The qLabs POC device® was evaluated in 262 patients attending an anticoagulation clinic with regards to accuracy and precision of the INR results...
May 14, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29741250/how-i-investigate-for-bleeding-disorders
#7
REVIEW
C P M Hayward
INTRODUCTION: Laboratory investigations for bleeding disorders are warranted when an individual has a personal and/or family history of bleeding, and/or laboratory findings that suggest the possibility of an inherited or acquired bleeding disorder. METHODS: This review summarizes author's experience with ordering and reporting on diagnostic investigations for common and rare bleeding disorders, with consideration of recent articles on diagnosing bleeding disorders...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29739078/review-on-vitamin-k-deficiency-and-its-biomarkers-focus-on-the-novel-application-of-pivka-ii-in-clinical-practice
#8
REVIEW
Rui Dong, Nianyue Wang, Yongfeng Yang, Li Ma, Qiang Du, Wei Zhang, Anh H Tran, Haiyoung Jung, Andrew Soh, Yijie Zheng, Shan Zheng
BACKGROUND: Vitamin K (VK) is a co-factor of the γ-glutamyl carboxylase that catalyzes the conversion of glutamate residues to γ-carboxyglutamate in VK-dependent proteins. The carboxylation reaction imparts the essential calcium-binding residues for the biological function of several proteins involved in the process of coagulation and bone metabolism. VK deficiency is frequently encountered in newborns and can lead to fatal hemorrhagic complications. This review describes and discusses the clinical application of VK deficiency testing...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29718941/machine-learning-based-diagnosis-for-disseminated-intravascular-coagulation-dic-development-external-validation-and-comparison-to-scoring-systems
#9
Jihoon G Yoon, JoonNyung Heo, Minkyu Kim, Yu Jin Park, Min Hyuk Choi, Jaewoo Song, Kangsan Wyi, Hakbeen Kim, Olivier Duchenne, Soowon Eom, Yury Tsoy
The major challenge in the diagnosis of disseminated intravascular coagulation (DIC) comes from the lack of specific biomarkers, leading to developing composite scoring systems. DIC scores are simple and rapidly applicable. However, optimal fibrin-related markers and their cut-off values remain to be defined, requiring optimization for use. The aim of this study is to optimize the use of DIC-related parameters through machine learning (ML)-approach. Further, we evaluated whether this approach could provide a diagnostic value in DIC diagnosis...
2018: PloS One
https://www.readbyqxmd.com/read/29718871/neurological-symptoms-and-spinal-cord-embolism-caused-by-endoscopic-injection-sclerotherapy-for-esophageal-varices-a-case-report-and-literature-review
#10
Shiqian Liu, Nannan Wu, Mingkai Chen, Xi Zeng, Fang Wang, Qian She
RATIONALE: Spinal cord embolism is a rare complication of endoscopic injection sclerotherapy (EIS). PATIENT CONCERNS: We report a case of a 56-year-old man who presented neurological symptoms and spinal cord embolism caused by EIS on esophageal varices. Clinical signs and symptoms, laboratory tests, thoracic magnetic resonance imaging (MRI), and related treatment supported its diagnosis. DIAGNOSES:: spinal cord embolism. INTERVENTIONS: We stopped the hemostatic and anti-coagulation treatment, and switched to nerve nutrition, microcirculation, and hormone therapy, along with administering gastric mucosal protective agents...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29715647/citric-acid-assisted-fenton-like-process-for-enhanced-dewaterability-of-waste-activated-sludge-with-in-situ-generation-of-hydrogen-peroxide
#11
Keke Xiao, Kangyue Pei, Hui Wang, Wenbo Yu, Sha Liang, Jingping Hu, Huijie Hou, Bingchuan Liu, Jiakuan Yang
Fenton's reagent has been widely used to enhance sludge dewaterability. However, drawbacks associated with hydrogen peroxide (H2 O2 ) in Fenton's reagents exist, since it is a hazardous chemical and shows carcinogenicity, explosivity, instability, and corrosivity. Moreover, initial acidification and subsequent neutralization are needed as optimal conditions for homogeneous Fenton conditioning and final filtrate discharge. In this study, a Fenton-like process for the enhanced dewaterability of waste activated sludge with in-situ generation of H2 O2 and without extra pH adjustment was firstly proposed, namely citric acid (CA)-assisted oxygen activation in an air/nano zero-valent iron (nZVI) system and chemical re-coagulation with polydiallyldimethylammonium chloride (PDMDAAC)...
April 24, 2018: Water Research
https://www.readbyqxmd.com/read/29710696/viscoelasticity-and-structure-of-blood-clots-generated-in-vitro-by-rheometry-a-comparison-between-human-horse-rat-and-camel
#12
Christoph Dibiasi, Jacek Plewka, Leon Ploszczanski, Veronika Glanz, Helga Lichtenegger, Ursula Windberger
BACKGROUND: Although the coagulation system is evolutionary well preserved, profound species differences exist in viscoelastic as well as in common laboratory tests of coagulation. OBJECTIVE: Evaluating differences in clot formation and material characterisation of clots of four mammalian species on macro-, micro- and nanoscales by the means of rheometry, scanning electron microscopy (SEM) and small angle x-ray scattering (SAXS). METHODS: Blood samples were collected from healthy human volunteers, laboratory rats (HL/LE inbred strain), warmblood horses and dromedary camels...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29708898/activated-partial-thromboplastin-time-derivative-curves-helpful-diagnostic-tool-in-mixing-test-interpretation
#13
Sevim Esmedere Eren, Cigdem Karakukcu, Mehmet Z Ciraci, Yasemin Ustundag, Musa Karakukcu
: The mixing test is used to evaluate whether prolonged activated partial thromboplastin time (APTT) is due to an inhibitor or a factor deficiency. The coagulation reaction is demonstrated with APTT derivative curves on the ACL TOP series. We aimed to determine the utility of APTT derivative curves in the mixing test process. The plasma of a patient was mixed with normal plasma in a 1 : 1 ratio and APTT assay was performed with SynthASil reagent. We observed roughness, biphasic and shoulder patterns in derivative curves during the mixing test...
April 27, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29704268/characteristics-of-hemostasis-during-experimental-ehrlichia-canis-infection
#14
Sarah Shropshire, Christine Olver, Michael Lappin
BACKGROUND: Ehrlichia canis infection in dogs can cause thrombocytopenia and clinical evidence of bleeding. It is unknown why some dogs show signs of bleeding whereas others do not despite clinically relevant thrombocytopenia. HYPOTHESIS/OBJECTIVES: Activated platelets, decreased fibrinolysis or both mitigate bleeding tendency. Assess standard hemostatic variables, platelet dynamics, and specialized coagulation testing in dogs experimentally infected with E. canis to evaluate this clinical discrepancy...
April 27, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29701015/a-case-series-association-of-anaphylaxis-with-a-significant-decrease-in-platelet-levels-and-possible-secondary-risk-of-thrombosis
#15
Brian P Peppers, Anant Vatsayan, Jignesh Dalal, Tracey Bonfield, Haig Tcheurekdjian, Robert Hostoffer
INTRODUCTION: Anaphylaxis is a life threatening systemic inflammatory process that share mediators involved in the coagulation cascade. Platelet activating factor, known to increase platelet aggregation, has also been implicated as an important mediator of anaphylaxis. Although other inflammatory reactions are associated with an increased risk of thrombosis, anaphylaxis is currently not reported as one of them. Furthermore the role platelets may have in the perianaphylaxis period is not well understood...
April 26, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29688191/-decreased-retraction-of-blood-clots-in-patients-with-venous-thromboembolic-complications
#16
R A Bredikhin, A D Peshkova, D V Maliasev, M V Batrakova, J Le Min, M V Panasiuk, L S Fatkhullina, I M Ignat'ev, R N Khaĭrullin, R I Litvinov
Haemostatic disorders play an important role in the pathogenesis of acute venous thrombosis. One of the least studied reactions of blood coagulation and thrombogenesis is spontaneous contraction of blood clots, which takes place at the expense of the contractility apparatus of activated blood platelets adhered to fibrin fibres. The work was aimed at studying the parameters of contraction of blood clots, formed in vitro, in blood of 41 patients with acute venous thromboses as compared with the same parameters in apparently healthy donors...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29685474/the-evaluation-and-management-of-rocky-mountain-spotted-fever-in-the-emergency-department-a-review-of-the-literature
#17
Michael Gottlieb, Brit Long, Alex Koyfman
BACKGROUND: Rocky Mountain spotted fever (RMSF) is potentially deadly and can present subtly with signs and symptoms overlapping with other clinical conditions. Delayed diagnosis can be fatal. OBJECTIVE: This review provides an evidence-based summary of the current data for the evaluation and management of RMSF in the emergency department. DISCUSSION: RMSF occurs through transmission of Rickettsia rickettsii by an infected tick. Exposure in the United States occurs most commonly from April to September, and high-risk locations include wooded, shrubby, or grassy areas...
April 20, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29683797/uncertainty-evaluation-in-clinical-chemistry-immunoassay-hematology-and-coagulation-analytes-using-only-external-quality-assessment-data
#18
Yanyan Qin, Rui Zhou, Wei Wang, Hongyi Yin, Yanmin Yang, Yuhong Yue, Qing Tong, Lu Liu, Yali Jin, Yankun Shi, Shunli Zhang, Jianping Zhang, Rui Zhang, Chang Zuo, Tingting Jia, Ning Wang, Qingtao Wang
BACKGROUND: Measurement uncertainty (MU) is a parameter associated with the result of a measurement that characterizes its dispersion. We report results for estimating MU following the application of a top-down procedure using only proficiency test data to establish uncertainty levels for various analytes. METHODS: Data were obtained from 142 laboratories participating in the Beijing Center for Clinical Laboratory (BCCL) proficiency testing/external quality assessment (PT/EQA) schemes...
April 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29668440/towards-harmonization-of-external-quality-assessment-proficiency-testing-in-hemostasis
#19
Emmanuel J Favaloro, Ian Jennings, John Olson, Elizabeth M Van Cott, Roslyn Bonar, Robert Gosselin, Piet Meijer
Quality in diagnostic testing represents a key target of laboratory medicine, for which an assurance around the quality of testing is expected from all involved in the process. Laboratories attempt to assure the quality of their testing by various processes, but especially by performance of internal quality control and external quality assessment (EQA). This is especially true for tests of hemostasis and coagulation. EQA in general provides information on test accuracy and on evaluation of long-term laboratory performance...
April 18, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29656962/treatment-of-platelet-concentrates-and-plasma-with-riboflavin-and-uv-light-impact-in-bacterial-reduction
#20
J M Bello-López, L Delgado-Balbuena, D Rojas-Huidobro, J Rojo-Medina
OBJECTIVES: Transfusion of hemocomponents is essential for clinical and surgical procedures and therefore their safety has increased. An option for pathogen reduction includes the combination of riboflavin and UV light. To our knowledge, there are no studies in Latin America that demonstrate the effectiveness of the pathogen reduction in hemocomponents. The objective of this work was to evaluate the efficiency of a pathogens reduction system in platelets concentrates (PC) and plasma. MATERIALS AND METHODS: PC and plasma were contaminated with Escherichia coli, Klebsiella pneumoniae, Streptococcus pyogenes and Staphylococcus epidermidis at 104 to 106  CFU and subjected to bacterial reduction...
April 12, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
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