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JOURNAL ARTICLE
Keigo Murata, Daisuke Nagasato, Hayato Tanaka, Shunsuke Nakakura, Toshihiko Nagasawa, Yoshinori Mitamura, Hitoshi Tabuchi
INTRODUCTION: Many adverse occurrences in the eye have been reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. This is the first report of a patient with an unruptured retinal arterial macroaneurysm (RAM) who developed branch retinal artery occlusion (BRAO) one day after SARS-CoV-2 vaccination (BNT162b2 by Pfizer-BioNTech). PATIENT REPORT: A 75-year-old man with a pertinent history of type-2 diabetes mellitus visited the hospital complaining of sudden visual loss in his right eye 1 day after receiving the fourth dose of the SARS-CoV-2 mRNA vaccine; his best-corrected visual acuity (BCVA) decreased from 1...
November 8, 2023: European Journal of Ophthalmology
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JOURNAL ARTICLE
Chuandi Zhou, Shu Li, Luyao Ye, Chong Chen, Shu Liu, Hongxia Yang, Peng Zhuang, Zengye Liu, Hongwen Jiang, Jing Han, Yiping Jiang, Liqin Zhou, Xiyuan Zhou, Jun Xiao, Cangxia Zhang, Lihui Wen, Changjun Lan, Yuqing Wang, Tao Sun, Li Jiang, Peipei Xie, Fan Chen, Ge Liang, Dongdong Fu, Tianzi Zhang, Xuetao Shi, Zhengyu Song, Xinghong Liu, Shanshan Li, Pengcheng Li, Xiangzhou Xu, Qinfeng Wei, Weibang Wang, Xionggao Huang, Zhen De, Aijun Deng, Lin Ding, Xiuhong Pan, Haiyan Wen, Zhongchen Zhang, Hongbin Lv, Jian Zhang, Xuemin Tian, Zhen Deng, Hua Wang, Fang Wang, Yu Wang, Hongchao Zhao, Yanhong Fang, Yuyu Wu, Yufeng Wu, Nian Shen, Bo Li, Xiaorong Li, Hong Dai, Naiqing Zhao, Xiaodong Sun, Zhi Zheng, Kun Liu, Xun Xu
BACKGROUND: Retinal disorders cause substantial visual burden globally. Accurate estimates of the vision loss due to retinal diseases are pivotal to inform optimal eye health care planning and allocation of medical resources. The purpose of this study is to describe the proportion of visual impairment and blindness caused by major retinal diseases in China. METHODS: A nationwide register-based study of vitreoretinal disease covering all 31 provinces (51 treating centres) of mainland China...
November 3, 2023: Journal of Global Health
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JOURNAL ARTICLE
Yann-Guang Chen, Yun-Hsiang Chang, Hsin-Ching Shen, Shu-I Pao, Yu-Chih Hou, I-Chia Liang
Spectral-domain optical coherence tomography is widely used in maculopathy, including diabetic macular edema (DME). Bacillary layer detachment (BALAD) is a novel optical coherence tomography finding, defined as the separation of the intraretinal layer between the inner segment myoids and ellipsoids. A total of 161 treatment-naïve eyes with centrally involved DME that underwent 3 monthly loading doses of anti-vascular endothelial growth factor (anti-VEGF) intravitreal injections were enrolled and analyzed retrospectively...
October 20, 2023: Medicine (Baltimore)
#24
JOURNAL ARTICLE
Nikola Lukic, Mirjana T Macvanin, Zoran Gluvic, Manfredi Rizzo, Djordje Radak, Jasjit S Suri, Esma R Isenovic
Type 2 diabetes mellitus (T2DM) has become a worldwide concern in recent years, primarily in highly developed Western societies. T2DM causes systemic complications, such as atherosclerotic heart disease, ischemic stroke, peripheral artery disease, kidney failure, and diabetes-related maculopathy and retinopathy. The growing number of T2DM patients and the treatment of long-term T2DM-related complications pressurize and exhaust public healthcare systems. As a result, strategies for combating T2DM and developing novel drugs are critical global public health requirements...
October 19, 2023: Current Medicinal Chemistry
#25
JOURNAL ARTICLE
Carolina Arruabarrena, Antonio Rodríguez-Miguel, Fernando de Aragón-Gómez, Purificación Escámez, Ingrid Rosado, Miguel A Teus
PURPOSE: The purpose was to establish normative data for the macular thicknesses and volume using spectral-domain optical coherence tomography (SD-OCT) in a diabetic population without maculopathies for use as a reference in diabetic retinopathy (DR) and diabetic macular edema screening programs. METHODS: This was an observational study nested in a cohort of diabetics from a telemedicine DR screening program. Each patient underwent SD-OCT centered on the fovea. Macular thickness and volume were described and compared using the built-in normative database of the device...
August 11, 2023: Journal of Clinical Medicine
#26
REVIEW
Cameron D Haydinger, Genevieve F Oliver, Liam M Ashander, Justine R Smith
Diabetic retinopathy is the retinal disease associated with hyperglycemia in patients who suffer from type 1 or type 2 diabetes. It includes maculopathy, involving the central retina and characterized by ischemia and/or edema, and peripheral retinopathy that progresses to a proliferative stage with neovascularization. Approximately 10% of the global population is estimated to suffer from diabetes, and around one in 5 of these individuals have diabetic retinopathy. One of the major effects of hyperglycemia is oxidative stress, the pathological state in which elevated production of reactive oxygen species damages tissues, cells, and macromolecules...
August 21, 2023: Antioxidants (Basel, Switzerland)
#27
JOURNAL ARTICLE
José Ignacio Fernández-Vigo, Alicia Valverde-Megías, Sara García-Caride, Bárbara Burgos-Blasco, Carlos Oribio-Quinto, Juan Donate-López
PURPOSE: To describe the incidence, features, and clinical outcomes of photodynamic therapy (PDT)-induced acute exudative maculopathy (PAEM) in circumscribed choroidal hemangioma (CCH). METHODS: Prospective series of 10 patients that underwent standard-fluence PDT for CCH. Best-corrected visual acuity (BCVA) in the Early Treatment Diabetic Retinopathy Score and swept-source optical coherence tomography (SS-OCT) were performed before, 3 days and 1 month after. Central retinal thickness (CRT), CCH retinal thickness and subretinal fluid (SRF) were measured...
August 21, 2023: Retina
#28
Nayumi Ogata, Kohei Ueda, Shuichiro Aoki
In Waldenström's Macroglobulinemia (WM), increased immunoglobulin M causes various signs and symptoms. It sometimes presents with macular edema. A 65-year-old WM patient with a five-year history of diabetes mellitus was evaluated for ocular complications. Fundus examination and optical coherence tomography showed retinal changes consistent with non-proliferative diabetic retinopathy and foveal detachment with intraretinal cysts in the right eye, suggesting diabetic macular edema. However, on fluorescein angiography, there was no leakage over the area of foveal detachment, which led to the diagnosis of immunogammopathy maculopathy secondary to WM for macular edema and foveal detachment...
July 2023: Curēus
#29
JOURNAL ARTICLE
Subash Bhatta, Nayana Pant, Suresh Raj Pant
BACKGROUND: Although diabetes is emerging as growing public health problem, there is limited population based data about the prevalence of the disease in Nepal. METHODS: This cross-sectional population-based survey, conducted in the Far-western province of Nepal from April 2020 to April 2021, used standardized RAAB + DR methodology. Diabetes was diagnosed on the basis of treatment history and random blood sugar test results of greater than 200 mg/dl. Diabetic retinopathy screening was done by ophthalmologists...
July 20, 2023: Journal of Nepal Health Research Council
#30
JOURNAL ARTICLE
João Leite, André Ferreira, Catarina Castro, João Coelho, Tânia Borges, Nuno Correia, Bernardete Pessoa
INTRODUCTION: A detailed understanding of the anatomical and structural changes occurring in the retina following intravitreal fluocinolone acetonide implantation may help improve the management and prognosis of persistent or recurrent diabetic macular edema (DME). METHODS: Overall, 45 eyes (from 35 patients) with refractory center-involved DME received an intravitreal fluocinolone acetonide implant. They were monitored at baseline and at 6, 12, 24, and 36 months for best-corrected visual acuity (BCVA), central foveal thickness (CFT), and the seven retinal parameters used in the classification of diabetic maculopathy recently developed at the European School for Advanced Studies in Ophthalmology (ESASO)...
July 20, 2023: European Journal of Ophthalmology
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JOURNAL ARTICLE
Giacomo Panozzo, Elia Franzolin, Diana Giannarelli, Giulia Dalla Mura, Rosa Longo, Maria Vittoria Cicinelli
PURPOSE: To test reliability and reproducibility of ESASO morphologic OCT-based classification of diabetic maculopathy (DM). METHODS: This is a multi-center cross-sectional study including a coordination center (CC) and 18 participating centers (PCs). After instruction on the correct use of ESASO Classification, the validation process was carried out in two consecutive stages. In the first retrospective phase, we evaluated the concordance between PCs and CC in the staging of OCT images collected during PCs' daily activity (608 images)...
July 16, 2023: European Journal of Ophthalmology
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JOURNAL ARTICLE
Ramin Nourinia, Seyed Mohammadjavad Mashhadi, Seyed-Hossein Abtahi, Hosein Nouri
PURPOSE: To investigate the association between retinal vein occlusion (RVO) and evidence of previous, unnoticed inner nuclear layer (INL) infarction in the fellow eye. METHODS: This prospective case-control study compared the prevalence of INL lesions in the fellow eye of consecutive people with hypertension (PwHTN) with unilateral RVO versus a randomly chosen eye of an age-matched control group of PwHTN without RVO. En face slabs above the outer plexiform layer (OPL) were generated from 6 × 6 fovea-centered optical coherence tomography scans...
July 5, 2023: International Journal of Retina and Vitreous
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JOURNAL ARTICLE
Periklis Giannakis, Paul Nderitu, Joan M Nunez do Rio, Laura Webster, Samantha Mann, David Hopkins, Manuel Jorge Cardoso, Marc Modat, Christos Bergeles, Timothy L Jackson
PURPOSE: To determine associations between deprivation using the Index of Multiple Deprivation (IMD and individual IMD subdomains) with incident referable diabetic retinopathy/maculopathy (termed rDR). METHODS: Anonymised demographic and screening data collected by the South-East London Diabetic Eye Screening Programme were extracted from September 2013 to December 2019. Multivariable Cox proportional models were used to explore the association between the IMD, IMD subdomains and rDR...
June 28, 2023: British Journal of Ophthalmology
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JOURNAL ARTICLE
Shubhangi Setia, Pravin Tidake
Background Diabetes presents a significant and ever-growing burden worldwide, impacting populations across the globe. However, this burden is particularly pronounced in developing economies like India. The rise of diabetes in such regions can largely be attributed to two key factors: the increasing prevalence of overweight/obesity and the adoption of unhealthy lifestyles. Aim and objectives The study's objectives encompassed identifying patients with type 2 diabetes mellitus through the oral glucose tolerance test and the diagnosis of diabetic retinopathy (DR) among them, followed by classification based on the severity of the disease...
May 2023: Curēus
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JOURNAL ARTICLE
Selim Cevher, Mehmet Barış Üçer, Mustafa Duran
PURPOSE: This study aimed to investigate the effect of sodium fluorescein on the choroidal vascularity index (CVI). MATERIALS AND METHODS: In this cross-sectional study, a total of 27 eyes of 27 mild nonproliferative diabetic retinopathy patients (without maculopathy and any systemic disease) who performed fluorescein angiography (FA) procedure were included. Choroidal parameters such as choroidal thickness (CT), total choroidal area (TCA), luminal area (LA), stromal area (SA), LA/SA, and CVI were examined with the optical coherence tomography and binarization technique at baseline and 5th, 15th, and 30th minutes after FA...
June 27, 2023: Cutaneous and Ocular Toxicology
#36
REVIEW
Negin Ansari-Mohseni, Adel Ghorani-Azam, Seyed Ahmad Mohajeri
OBJECTIVE: Retinopathy is an ocular manifestation of systemic diseases such as diabetes and vascular diseases. Herbal drugs have been considered as an effective therapeutic option with minimal side effects for the treatment of retinopathy by reducing the symptoms and improving visual acuity. The purpose of this systematic review was to collect studies on the effectiveness of medicinal plants in the treatment or prevention of retinopathy. MATERIALS AND METHODS: A systematic literature search was performed in PubMed, Scopus, Google Scholar, and other databases in April 2021 using "herbal products" and "Retinopathy" with all their equivalent and similar terms...
2023: Avicenna Journal of Phytomedicine
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JOURNAL ARTICLE
Kevin Thomas, Nichola Albutt, Aisha Hamid, Helen Wharton, Sarita Jacob
OBJECTIVE: To assess the incidence of referable diabetic retinopathy (DR) in patients aged 80 and 85 years to determine whether screening interval can be extended safely in this age group. METHODS: Patients who were aged 80 and 85 years when they attended digital screening during April 2014-March 2015 were included. Screening results at baseline and over the next four years were analysed. RESULTS: 1880 patients aged 80 and 1105 patients aged 85 were included...
May 20, 2023: Eye
#38
JOURNAL ARTICLE
Vijaya Sahu, Snehal Kharole
Purpose The purpose of the study is to assess whether standard automated perimetry (SAP) was capable of detecting early neuroretinal changes by comparing foveal sensitivity in diabetic and non-diabetic subjects. Settings and design This is an observational and cross-sectional study that compared foveal sensitivity between a case group of 47 subjects with no or mild-to-moderate diabetic retinopathy (DR) without maculopathy and a control group of 43 healthy subjects. Materials and Methods After a thorough ocular examination, all patients were put through tests using a Humphrey visual field analyzer with the Swedish interactive threshold algorithm (SITA) standard system (10-2 software)...
March 2023: Curēus
#39
JOURNAL ARTICLE
Anastasios Mangelis, Piyumi Wijewickrama, Abbeyramei Nirmalakumaran, Nikolaos Fountoulakis, Prashanth Vas, Laura Webster, Samantha Mann, Julian Collins, David Hopkins, Stephen Thomas, Salma Ayis, Janaka Karalliedde
OBJECTIVE: There is limited information on the effect of ethnicity on the development of referable sight-threatening diabetic retinopathy (STDR) in people with type 1 diabetes. This study describes the risk factors for STDR in a diverse cohort of people with type 1 diabetes attending a regional diabetes eye screening service. RESEARCH DESIGN AND METHODS: Clinical and digital retinal imaging data from 1,876 people with type 1 diabetes (50% women, 72.1% Caucasian, 17...
April 16, 2023: Diabetes Care
#40
JOURNAL ARTICLE
José Edísio da Silva Tavares Neto, Francyne Veiga Reis Cyrino, Moises Moura Lucena, Ingrid U Scott, André Márcio Vieira Messias, Rodrigo Jorge
BACKGROUND: Given the persistently large public health impact of neovascular age-related macular degeneration (nARMD) despite many years of anti-VEGF therapy as the first-line treatment and the demonstrated ability of b-blockers to reduce neovascularization, a synergistic effect between an anti-VEGF agent and an intravitreal beta-blocker is important to investigate in the quest for therapeutic alternatives that maximize efficacy and/or reduce costs. The main purpose of this study is to investigate the safety of a 0...
April 13, 2023: International Journal of Retina and Vitreous
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