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Diabetic maculopathy

M Kováčová, M Meliška, B Kalvodová
PURPOSE: To evaluate OCT findings and long-term follow-up results in patient with optic disc pit (ODP) and associated maculopathy treated with pars plana vitrectomy (PPV). METHODS: Six eyes of 6 patients (3 females, 3 males) were included in a retrospective study. We excluded patients with ODP without maculopathy. Patients were followed in years 2008-2017. Mean age at the first examination was 40,3 years (15-70 years). Duration of worsening of the best corrected visual acuity (BCVA) ranged from 2 days to few years...
2018: Ceská a Slovenská Oftalmologie
Jose Leal, Ramon Luengo-Fernandez, Irene M Stratton, Angela Dale, Katerina Ivanova, Peter H Scanlon
BACKGROUND: Annually 2.7 million individuals are offered screening for diabetic retinopathy (DR) in England. Spectral-Domain Optical Coherence Tomography (SD-OCT) has the potential to relieve pressure on NHS services by correctly identifying patients who are screen positive for maculopathy on two-dimensional photography without evidence of clinically significant macular oedema (CSMO), limiting the number of referrals to hospitals. We aim to assess whether the addition of SDOCT imaging in digital surveillance clinics is a cost-effective intervention relative to hospital eye service (HES) follow-up...
November 30, 2018: Eye
Prisca Loganadane, Bernard Delbosc, Maher Saleh
PURPOSE: To assess the progression of diabetic hard exudates over an 8-week period, using a high-resolution adaptive optics camera. DESIGN: Prospective observational study. METHODS: Five eyes of three patients presenting diabetic maculopathy with hard exudates were studied. An area of clinically visible exudates was imaged sequentially using SD-OCT and high-resolution flood illumination adaptive optics for 2 months, on a weekly basis. A time-lapse video was obtained for each eye studied...
November 22, 2018: Ophthalmic Research
Michael W Stewart, David J Browning, Maurice B Landers
Twenty-five percent of diabetes-related vision loss stems from complications of proliferative diabetic retinopathy (PDR). Panretinal photocoagulation has been the preferred treatment of high-risk PDR for decades and more recently intravitreal injections of drugs that inhibit the actions of vascular endothelial growth factor have become popular. But despite these treatments PDR may progress uncontrollably to advanced pathologies such as traction retinal detachments (TRDs), combined traction/rhegmatogenous retinal detachments (TRD/RRDs), vitreous hemorrhages, rubeosis iridis, and traction maculopathies, which produce mild-to-severe loss of vision...
December 2018: Indian Journal of Ophthalmology
David Gildea
PURPOSE: Diabetic retinopathy (DR) is one of the leading causes of blindness worldwide. Accurate investigative tools are essential for the early diagnosis and monitoring of the disease. Optical coherence tomography angiography (OCTA) is a recently developed technology that enables visualisation of the retinal microvasculature. METHODS: A systematic review of the literature was performed to examine the diagnostic use of OCTA in DR to date. Medline, EMBASE, and Cochrane databases were searched to find relevant studies...
October 31, 2018: International Ophthalmology
Toke Bek, Einar Stefánsson, Sveinn Hákon Hardarson
BACKGROUND: The oxygen saturation in larger retinal vessels has been shown to increase with increasing diabetic retinopathy (DR) grade and to help predict the effect of antivascular endothelial growth factor treatment in patients with diabetic maculopathy. However, it is unknown to what extent the increased oxygen saturation co-varies with other risk factors and whether it is an independent risk factor for the severity of DR. METHODS: Seven hundred and twenty-two successive patients referred for specialist evaluation of diabetic retinopathy including retinal oximetry were studied...
October 18, 2018: British Journal of Ophthalmology
Mariacristina Parravano, Daniele De Geronimo, Fabio Scarinci, Gianni Virgili, Lea Querques, Monica Varano, Francesco Bandello, Giuseppe Querques
PURPOSE: To investigate the progression of diabetic microaneurysms (MAs) according to the SD-OCT and OCT Angiography (OCTA) characteristics and to evaluate their influence on the retinal extracellular fluid accumulation at 1 year follow-up in patients with non proliferative diabetic retinopathy (NPDR). DESIGN: Prospective, observational case series. METHODS: Fourteen patients with NPDR underwent SD-OCT and OCTA at the baseline and at 1 year follow-up...
October 8, 2018: American Journal of Ophthalmology
Taimur Hassan, M Usman Akram, Mahmood Akhtar, Shoab Ahmad Khan, Ubaidullah Yasin
Maculopathy is the group of diseases that affects central vision of a person and they are often associated with diabetes. Many researchers reported automated diagnosis of maculopathy from optical coherence tomography (OCT) images. However, to the best of our knowledge there is no literature that presents a complete 3D suite for the extraction as well as diagnosis of macula. Therefore, this paper presents a multilayered convolutional neural networks (CNN) structure tensor Delaunay triangulation and morphing based fully autonomous system that extracts up to nine retinal and choroidal layers along with the macular fluids...
October 4, 2018: Journal of Medical Systems
Alastair K Denniston, Aaron Y Lee, Cecilia S Lee, David P Crabb, Clare Bailey, Peck-Lin Lip, Paul Taylor, Maria Pikoula, Esther Cook, Toks Akerele, Richard Antcliff, Christopher Brand, Usha Chakravarthy, Randhir Chavan, Narendra Dhingra, Louise Downey, Haralabos Eleftheriadis, Faruque Ghanchi, Rehna Khan, Vineeth Kumar, Aires Lobo, Andrew Lotery, Geeta Menon, Rajarshi Mukherjee, Helen Palmer, Sudeshna Patra, Bobby Paul, Dawn A Sim, James Stephen Talks, Elizabeth Wilkinson, Adnan Tufail, Catherine A Egan
AIM: To assess the impact of deprivation on diabetic retinopathy presentation and related treatment interventions, as observed within the UK hospital eye service. METHODS: This is a multicentre, national diabetic retinopathy database study with anonymised data extraction across 22 centres from an electronic medical record system. The following were the inclusion criteria: all patients with diabetes and a recorded, structured diabetic retinopathy grade. The minimum data set included, for baseline, age and Index of Multiple Deprivation, based on residential postcode; and for all time points, visual acuity, ETDRS grading of retinopathy and maculopathy, and interventions (laser, intravitreal therapies and surgery)...
September 29, 2018: British Journal of Ophthalmology
Aditya Kelkar, Jai Kelkar, Hetal Mehta, Winfried Amoaku
India is considered the diabetes capital of the world, and a significant proportion of patients undergoing cataract surgery are diabetic. Considering this, we reviewed the principles and guidelines of managing cataract in patients with diabetes. The preoperative, intraoperative, and postoperative factors are of paramount importance in the management of diabetic cataract patients. Particularly, the early recognition and treatment of diabetic retinopathy or maculopathy before cataract surgery influence the final visual outcome and play a major role in perioperative decision-making...
October 2018: Indian Journal of Ophthalmology
Amir H Kashani, Kyle M Green, Julie Kwon, Zhongdi Chu, Qinqin Zhang, Ruikang K Wang, Sean Garrity, David Sarraf, Carl B Rebhun, Nadia K Waheed, Karen B Schaal, Marion R Munk, Sarra Gattoussi, K Bailey Freund, Fang Zheng, Guanghui Liu, Philip J Rosenfeld
Objective: To characterize features of extra-vascular optical coherence tomography angiography (OCTA) signals corresponding to hyperreflective intraretinal fluid across various exudative maculopathies. Design: Multicenter, retrospective, observational study. Participants: Eyes with various forms of exudative maculopathy including diabetic retinopathy (DR), retinal vein occlusion (RVO), and neovascular-age related macular degeneration (nvAMD)...
July 2018: Ophthalmology Retina
Hiroshi Nakashima, Yasuaki Iwama, Kensuke Tanioka, Kazuyuki Emi
PURPOSE: To report the incidence of, risk factors for, and characteristics of paracentral acute middle maculopathy (PAMM) after 25-gauge pars plana vitrectomy for proliferative diabetic retinopathy (PDR). DESIGN: Retrospective, consecutive, interventional case series. PARTICIPANTS: Five hundred thirty eyes of 427 patients who underwent primary vitrectomy for PDR from 2013 through 2016. METHODS: The patients underwent measurement of best-corrected visual acuity (BCVA), fundus photography, and OCT before and within 2 weeks after vitrectomy...
August 17, 2018: Ophthalmology
Giovanni Cennamo, Maria Angelica Breve, Nunzio Velotti, Federica Sparnelli, Claudio Iovino, Antonio Farella, Raffaele Liuzzi, Giuseppe de Crecchio, Gilda Cennamo
AIM: The purpose of this paper was to evaluate whether optical coherence tomography angiography (OCT-A) can be used to quantify the vascular changes in radiation maculopathy, and changes in the tumor vasculature in eyes treated with plaque radiotherapy for choroidal melanoma. METHODS: In this prospective study, we evaluated 39 Caucasian patients with choroidal melanoma (39 eyes) treated with ruthenium-106 plaque radiotherapy. The patients underwent complete ophthalmic examination, bulbar echography, and OCT-A before and 1 year after treatment...
2018: Ophthalmic Research
Yifan Feng, Senmiao Zhu, Eirini Skiadaresi, Colm McAlinden, Ruixue Tu, Rongrong Gao, Jeffrey W Stephens, Qinmei Wang, Jinhai Huang
PURPOSE: To evaluate the clinical effectiveness of intravitreal bevacizumab (IVB) injection combined with cataract surgery in the treatment of patients with cataract and coexisting diabetic retinopathy (DR). METHODS: Pertinent comparative studies were identified through systemic searches of PubMed, EMBASE, and the Cochrane Controlled Trials Register up to March 1, 2016. Outcome measures included corrected distance vision acuity, central macular thickness, and progression of DR and maculopathy...
June 28, 2018: Retina
Anthea Burnett, Ling Lee, Fabrizio D'Esposito, Geoffrey Wabulembo, Anaseini Cama, Georgia Guldan, Marleen Nelisse, Samuel Peter Koim, Drew Keys, Alison J Poffley, Hans Limburg, Jambi Garap
BACKGROUND/AIMS: To conduct an assessment of avoidable blindness, diabetes mellitus and diabetic retinopathy (DR) in adults aged 50 years and older in the National Capital District (NCD) region of Papua New Guinea (PNG). METHODS: A cross-sectional population-based survey was performed for which 25 clusters of 50 people aged ≥50 years were randomly selected from the NCD region. The standardised rapid assessment of avoidable blindness (RAAB) with diabetic retinopathy (+DR) methodology was used...
July 4, 2018: British Journal of Ophthalmology
Marie-Christine Bruender, Nicola Benjamin, Hansjuergen Thomas Agostini, Andreas Stahl, Christoph Ehlken
BACKGROUND: Patients with exudative maculopathies (neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO)) are faced with a high burden of examinations and treatments. This study was conceived to analyze the accuracy of a subjective evaluation of visual acuity (VA) and metamorphopsia to detect disease reactivation, compared to morphological signs of reactivation assessed by means of SD-OCT. METHODS: Retrospective study of 888 patients treated for nAMD (n = 638), DME (84), BRVO (110), and CRVO (56) was conducted...
September 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Dana Ahnood, Ahmad Souriti, Gwyn Samuel Williams
OBJECTIVE: To explore the views of patients with diabetic retinopathy and maculopathy on their acceptance of virtual clinic review in place of face-to-face clinic appointments. METHODS: A postal survey was mailed to all 813 patients under the care of the diabetic eye clinic at Singleton Hospital with 7 questions, explanatory information, and a stamped, addressed envelope available for returning completed questionnaires. RESULTS: Four hundred and ninety-eight questionnaires were returned indicating that 86...
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Nanna Staehr Jakobsen, Dorte Ancher Larsen, Toke Bek
PURPOSE: Diabetic maculopathy can be treated with intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors. However, the therapy is not effective in all patients, and it would be desirable to have parameters for differentiating patients who will benefit from treatment from those who will not. Retinal fixation has been shown to be impaired in patients with low visual acuity (VA) secondary to macular disease, but the changes in fixational eye movements after anti-VEGF treatment for diabetic maculopathy have not been investigated...
April 24, 2018: Acta Ophthalmologica
Masaki Tanito, Ichiya Sano, Yoshifumi Ikeda, Etsuko Fujihara
Purpose: To report the results using an ologen Collagen Matrix as a patch graft in eyes with tubal exposure after tube shunt surgery. Case Reports: Case 1 was an 82-year-old man with tubal exposure in his right eye 26 months after receiving a Baerveldt glaucoma implant. The tube was covered by surrounding conjunctival tissue combined with subconjunctival placement of an ologen Collagen Matrix as a patch graft. Two years after implantation, the tube was not exposed...
January 2018: Case Reports in Ophthalmology
Louis Arnould, Christine Binquet, Charles Guenancia, Seydou Alassane, Ryo Kawasaki, Vincent Daien, Christophe Tzourio, Yumiko Kawasaki, Abderrahmane Bourredjem, Alain Bron, Catherine Creuzot-Garcher
PURPOSE: To identify patterns summarizing the retinal vascular network in the elderly and to investigate the relationship of these vascular patterns with cardiovascular history. METHODS: We conducted a population-based study, the Montrachet study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases), in participants older than 75 years. The history of cardiovascular disease and a score-based estimation of their 10-year risk of cardiovascular mortality (Heart SCORE) were collected...
2018: PloS One
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