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Anti-aging sport

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https://www.readbyqxmd.com/read/30295816/hpt-axis-effects-and-urinary-detection-following-clomiphene-administration-in-males
#1
Geoffrey D Miller, Chad Moore, Vinod Nair, Brian Hill, Stuart E Willick, Alan D Rogol, Daniel Eichner
Context: Clomiphene is a commonly abused performance-enhancing drug by males in sport, but the extent to which testosterone increases in healthy males following its use is unknown. Additionally, evidence has suggested that clomiphene, a mixture of cis- and trans-isomers zuclomiphene and enclomiphene, is detectable in urine for months following use; the isomer-specific urinary detection window has yet to be characterized in a controlled study. Objective: To determine the effect of a once daily, 30-day clomiphene treatment on serum testosterone and gonadotropins in the subject population studied, and the urinary clearance and detection window of clomiphene isomers following administration for anti-doping purposes...
October 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30286200/sport-motivation-and-doping-in-adolescent-athletes
#2
Jiri Mudrak, Pavel Slepicka, Irena Slepickova
BACKGROUND: Although performance-enhancing drugs appear to be prevalent in adolescent sports, relatively little attention has been paid to why adolescent athletes decide to use these drugs. In this study, we examine doping among adolescents from a motivational perspective and explore how motivational variables, such as achievement goal orientations and the perceived self-determination of sports activities, may be related to moral attitudes, doping intentions and doping behavior in adolescents who participate in competitive sports...
2018: PloS One
https://www.readbyqxmd.com/read/30185229/a-correction-to-the-age-adjustment-of-the-gh-2000-score-used-in-the-detection-of-growth-hormone-misuse
#3
Dankmar Böhning, Walailuck Böhning, Nishan Guha, David A Cowan, Christiaan Bartlett, Peter H Sönksen, Richard I G Holt
OBJECTIVE: The GH-2000 biomarker test has been introduced by the World Anti-Doping Agency as a method of detecting growth hormone misuse in professional sport. The test involves the measurement insulin-like growth factor-I and the amino-terminal pro-peptide of type III collagen (P-III-NP) which increase in a dose-dependent manner in response to GH. These measurements are combined in sex specific formulae that include an age adjustment. The original age adjustment overcorrects the effect of age in male athletes and could potentially place older men at a disadvantage...
September 5, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30103461/identification-of-factors-associated-with-potential-doping-behavior-in-sports-a-cross-sectional-analysis-in-high-level-competitive-swimmers
#4
Sime Devcic, Jakob Bednarik, Dora Maric, Sime Versic, Damir Sekulic, Zvonimir Kutlesa, Antonino Bianco, Jelena Rodek, Silvester Liposek
Background : Doping behavior, including the misuse of performance-enhancing drugs, is currently a serious problem in sports, and the efficacy of preventive efforts directly depends on information regarding the associations among different precipitating factors (PF) and doping behavior. This study aimed to establish the PF of potential doping behavior (PDB) in competitive swimmers. Methods : The study included 301 swimmers from Slovenia (153 females, 16.4 ± 2.4 years), tested during the 2017 National Championship...
August 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30072909/a-bayesian-approach-for-the-use-of-athlete-performance-data-within-anti-doping
#5
Silvia Montagna, James Hopker
The World Anti-doping Agency currently collates the results of all doping tests for athletes involved in elite sporting competition with the aim of improving the fight against doping. Existing anti-doping strategies involve either the direct detection of use of banned substances, or abnormal variation in metabolites or biological markers related to their use. As the aim of any doping regime is to enhance athlete competitive performance, it is interesting to consider whether performance data could be used within the fight against doping...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29872663/os-acromiale-in-professional-tennis-players
#6
Geoffroy Nourissat, Michel Calò, Bernard Montalvan, Jacques Parier
Background: Os acromiale is a rare condition mostly reported in the literature through case reports, imaging studies, or reports of surgical treatment. This condition is the result of nonunion of growth plates of the acromion during the natural developmental process that occurs between 15 and 25 years of age. Its incidence is low, and few studies are available in the literature on athletes with high functional demands, and particularly on athletes within a specific sport. Purpose: To collect epidemiological data and to report the amount of time out of play as well as the type of treatment and its efficiency in professional tennis players...
May 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29621963/detecting-autologous-blood-transfusion-in-doping-control-biomarkers-of-blood-aging-and-storage-measured-by-flow-cytofluorimetry
#7
Francesco Donati, Roberta Acciarini, Ilenia De Benedittis, Xavier de la Torre, Daniela Pirri, Mariangela Prete, Alessandra Stampella, Enza Vernucci, Francesco Botre
BACKGROUND: Blood transfusions are banned by the World Anti-Doping Agency as a form of "blood doping". A method of detection of homologous blood transfusion (HBT) has been implemented by the accredited anti-doping laboratories worldwide; however, no internationally recognized method has been finalized so far for the direct detection of autologous blood transfusions, which can at present be revealed only by targeted longitudinal profiling of key blood parameters. METHODS: The present article reports the results of an investigation aimed to pre-select potential biomarkers of blood aging and storage that can be measured to identify the presence in the sample of reinfused blood...
2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29592979/spondylodiscitis-in-a-54-year-old-female-scuba-diver
#8
Neil Tuttle, Alexandra Brelis, Rachel Brereton, Kerrie Evans
A 54-year-old woman presented to a Sports Physician with a 4-year history of haemochromatosis, and she had a medical history that included a congenital spondylolisthesis resulting in a fusion of L4-S1 at age 16 years, episodic mechanical low back pain and an absence of other significant musculoskeletal symptoms. On presentation, she reported 18 months of severe low back pain that started after a scuba diving trip. After the onset of this low back pain, she developed gastrointestinal symptoms from Salmonella The gastrointestinal symptoms improved with a course of antibiotics, but the back pain persisted in spite of analgesics, non-steroidal anti-inflammatories and several attempts at different conservative management...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29572786/changes-in-hemoglobin-profile-reflect-autologous-blood-transfusion-misuse-in-sports
#9
Nicola Lamberti, Alessia Finotti, Jessica Gasparello, Ilaria Lampronti, Christel Zambon, Lucia Carmela Cosenza, Enrica Fabbri, Nicoletta Bianchi, Francesca Dalla Corte, Maurizio Govoni, Roberto Reverberi, Roberto Gambari, Fabio Manfredini
The changes in hemoglobin (Hb) profile following autologous blood transfusion (ABT) for the first time were studied for anti-doping purposes. Twenty-four healthy, trained male subjects (aged 18‒40) were enrolled and randomized into either the transfusion (T) or control (C) groups. Blood samples were taken from the T subjects at baseline, after withdrawal and reinfusion of 450 ml of refrigerated or cryopreserved blood, and from C subjects at the same time points. Hematological variables (Complete blood count, Reticulocytes, Immature Reticulocytes Fraction, Red-cell Distribution Width, OFF-hr score) were measured...
June 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29535581/examination-of-factors-explaining-coaching-strategy-and-training-methodology-as-correlates-of-potential-doping-behavior-in-high-level-swimming
#10
Silvester Liposek, Natasa Zenic, Jose M Saavedra, Damir Sekulic, Jelena Rodek, Miha Marinsek, Dorica Sajber
Although coaching is considered an important determinant of athletes' potential doping behavior (PDB), there is an evident lack of studies that have examined coaching-strategy-and-training-methodology (CS&TM) in relation to PDB. This study was aimed to identify the specific associations that may exist between CS&TM -factors and other factors, and PDB in high-level swimming. The sample comprised 94 swimmers (35 females; 19.7 ± 2.3 years of age) and consisted of swimmers older than 18 years who participated in the 2017 National Championship...
March 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29480444/exercise-behavior-and-physical-fitness-in-patients-with-advanced-lung-cancer
#11
Christina Titz, Simone Hummler, Martina E Schmidt, Michael Thomas, Martin Steins, Joachim Wiskemann
PURPOSE: The aim of this work was to evaluate exercise behavior and physical fitness of advanced lung cancer patients shortly after primary diagnosis. METHODS: Between November 2013 and December 2016, advanced lung cancer patients (n = 227, mean age 62.2 years) were enrolled shortly after diagnosis and 211 patients were tested for endurance capacity (six-minute walk test) and strength performance (maximum voluntary isometric contraction of upper and lower extremities)...
August 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29466246/modified-aging-of-elite-athletes-revealed-by-analysis-of-epigenetic-age-markers
#12
Magdalena Spólnicka, Ewelina Pośpiech, Jakub Grzegorz Adamczyk, Ana Freire-Aradas, Beata Pepłońska, Renata Zbieć-Piekarska, Żanetta Makowska, Anna Pięta, Maria Victoria Lareu, Christopher Phillips, Rafał Płoski, Cezary Żekanowski, Wojciech Branicki
Recent progress in epigenomics has led to the development of prediction systems that enable accurate age estimation from DNA methylation data. Our objective was to track responses to intense physical exercise of individual age-correlated DNA methylation markers and to infer their potential impact on the aging processes. The study showed accelerated DNA hypermethylation for two CpG sites in TRIM59 and KLF14 . Both markers predicted the investigated elite athletes to be several years older than controls and this effect was more substantial in subjects involved in power sports...
February 15, 2018: Aging
https://www.readbyqxmd.com/read/29374832/sport-based-physical-activity-recommendations-and-modifications-in-c-reactive-protein-and-arterial-thickness
#13
Suziane Ungari Cayres, Fabio Santos de Lira, Han C G Kemper, Jamile Sanches Codogno, Maurício Fregonesi Barbosa, Romulo Araújo Fernandes
We analyzed the effects of 1 year of engagement in ≥ 300 min/week of organized sports on inflammatory levels and vascular structure in adolescents. The sample was composed of 89 adolescents (11.6 ± 0.7 years old [43 boys and 46 girls]), stratified according to engagement in ≥ 300 min/week of sport practice during at least 12 months of follow-up (n = 15, sport practice; n = 74, non-sport practice). Arterial thickness (carotid and femoral) was assessed by ultrasound scan, while high sensitive C-reactive protein levels were used to assess inflammatory status...
April 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28935680/cardiac-events-during-competitive-recreational-and-daily-activities-in-children-and-adolescents-with-long-qt-syndrome
#14
Kristina D Chambers, Virginie Beausejour Ladouceur, Mark E Alexander, Robyn J Hylind, Laura Bevilacqua, Douglas Y Mah, Vassilios Bezzerides, John K Triedman, Edward P Walsh, Dominic J Abrams
BACKGROUND: The 2005 Bethesda Conference Guidelines advise patients with long QT syndrome against competitive sports. We assessed cardiac event rates during competitive and recreational sports, and daily activities among treated long QT syndrome patients. METHODS AND RESULTS: Long QT syndrome patients aged ≥4 years treated with anti-adrenergic therapy were included. Demographics included mechanism of presentation, corrected QT interval pretreatment, symptom history, medication compliance, and administration of QT-prolonging medications...
September 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28610536/triceps-ruptures-after-fluoroquinolone-antibiotics-a-report-of-2-cases
#15
Theodore B Shybut, Ernest R Puckett
Rupture of the triceps brachii tendon is exceedingly rare, and surgical repair is generally indicated. Fluoroquinolone antibiotics have been implicated in tendon pathology, including tendon ruptures. Triceps rupture has not been previously reported in the setting of fluoroquinolone antibiotic therapy. We present 2 cases of triceps tendon rupture after treatment with fluoroquinolones. In both cases, triceps repair was performed with good outcomes. These cases highlight a risk of fluoroquinolone-induced tendinopathy to athletes...
September 2017: Sports Health
https://www.readbyqxmd.com/read/28601589/sharpsports-mental-health-awareness-research-project-prevalence-and-risk-factors-of-depressive-symptoms-and-life-stress-in-elite-athletes
#16
Sarah Beable, Mark Fulcher, Arier C Lee, Bruce Hamilton
OBJECTIVES: Our study aims to estimate the prevalence of symptoms of depression and daily life hassles in elite athletes. DESIGN: A cross-sectional prospective epidemiological study design. METHODS: An online anonymous survey was administered during a 2-month period from May to July 2015. Athletes 18 years of age (or older) who were members of the High Performance Sport New Zealand programme were invited to participate. Of 370 potential participants, 187 completed responses were received (51%)...
December 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28536601/geneticizing-ethnicity-and-diet-anti-doping-science-and-its-social-impact-in-the-age-of-post-genomics
#17
Jaehwan Hyun
While gene doping and other technological means of sport enhancement have become a topic of ethical debate, a major outcome from genomic research in sports is often linked to the regulation of doping. In particular, researchers within the field of anti-doping science, a regulatory science that aims to develop scientific solutions for regulating doped athletes, have conducted genomic research on anabolic-androgenic steroids. Genomic knowledge on anabolic-androgenic steroids, a knowledge base that has been produced to improve doping regulation, has caused the 'geneticization' of cultural objects such as ethnic identities and dietary habits...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28506617/arthroscopic-treatment-of-hip-pain-in-adolescent-patients-with-borderline-dysplasia-of-the-hip-minimum-2-year-follow-up
#18
Peter T Evans, John M Redmond, Jon E Hammarstedt, Yuan Liu, Edwin O Chaharbakhshi, Benjamin G Domb
PURPOSE: To examine arthroscopic treatment of hip pain in patients with borderline hip dysplasia (lateral center edge angle [LCEA] between 20° and 25°). METHODS: From 2008 to 2013, patients below 18 years of age who underwent arthroscopic hip surgery with an LCEA between 20° and 25° were retrospectively matched 1:1 to a control group without dysplasia (LCEA ≥25°) based on age, gender, femoroplasty, labral treatment, and capsular plication. Indications for surgery included failure to improve with nonoperative treatments and anti-inflammatory medications after 3 months...
August 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28249884/unusual-morel-lavallee-lesion-of-the-knee-region-in-an-elderly-patient
#19
Walid El Kininy, Shane Davy, Murali Sayana
The Morel-Lavallee lesion (MLL) of the knee region has been described in the Orthopaedic literature, and all of those were fit and healthy young participants sustaining sports-related trauma to the knee. We describe a case of an elderly woman, on aspirin and prophylactic clexane, who sustained a low-energy injury to the right knee and developed an MLL of the knee region. A delayed recognition, led to the persistence of the MLL as a diffuse haematoma, which subsequently became colonised with methicillin-resistant Staphylococcus aureus We discuss the management of a case and highlight the importance of early identification and management of MLL of the knee region...
March 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28213178/the-atypical-excretion-profile-of-meldonium-comparison-of-urinary-detection-windows-after-single-and-multiple-dose-application-in-healthy-volunteers
#20
Christian Görgens, Sven Guddat, Christina Bosse, Hans Geyer, Valentin Pop, Wilhelm Schänzer, Mario Thevis
Following a one-year monitoring program providing unequivocal analytical evidence for a high prevalence in international elite sports, meldonium has been included in the World Anti-Doping Agency's (WADA) list of prohibited substances that came into effect on 1 January 2016. Despite of the polar and hydrophilic nature of the molecule, an unusual long detection window was observed in pilot elimination studies. Consequently, in the present study, urinary excretion profiles after single-dose (5 volunteers, 1×500mg) and multiple-dose oral application (5 volunteers; 2×500mg/day for 6days) were determined in order to facilitate the result management concerning meldonium findings in doping controls...
May 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
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