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https://www.readbyqxmd.com/read/30022831/efficacy-of-zofenopril-in-combination-with-thiazide-diuretics-in-patients-with-acute-myocardial-infarction-a-pooled-individual-data-analysis-of-four-randomized-double-blind-controlled-prospective-studies
#1
Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni
Background: In the Survival of Myocardial Infarction Long-Term Evaluation (SMILE) studies, early administration of zofenopril after acute myocardial infarction (AMI) was prognostically beneficial as compared to placebo and other angiotensin-converting enzyme inhibitors (ACEIs), such as lisinopril and ramipril. Here, we investigated whether zofenopril efficacy could be affected by a concomitant use of thiazide diuretics (TDs). Methods: This was a post hoc analysis of pooled individual patient data from the SMILE studies...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29890483/natural-deep-eutectic-solvents-as-eco-friendly-and-sustainable-dilution-medium-for-the-determination-of-residual-organic-solvents-in-pharmaceuticals-with-static-headspace-gas-chromatography
#2
Meilian Wang, Sheng Fang, Xianrui Liang
Reported here is a simple and rapid static headspace gas chromatography (SHS-GC) method for the determination of trace solvents including ethanol, isopropanol, n-butanol, 1,4-dioxane, tetrahydrofuran, acetonitrile, methanol and acetone which commonly used in drug production process. Natural deep eutectic solvents (NADESs) are firstly used as the matrix medium for this method, which provided high sensitivity for residual solvents detection. With the optimized method, validation experiments were performed and the data showed excellent linearity for all the solvents (R2 ≥ 0...
September 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29866077/effects-of-the-concomitant-administration-of-xanthine-oxidase-inhibitors-with-zofenopril-or-other-ace-inhibitors-in-post-myocardial-infarction-patients-a-meta-analysis-of-individual-data-of-four-randomized-double-blind-prospective-studies
#3
Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni
BACKGROUND: Oxidative stress is increased in hyperuricemic patients with acute myocardial infarction (AMI). Use of sulfhydryl ACE-inhibitors (ACEIs), such as zofenopril or captopril, plus xanthine oxidase inhibitors (XOIs), may potentially result in enhanced antioxidant effects and improved survival. OBJECTIVE: We verified the benefit of such combination in a randomly stratified sample of 525 of the 3630 post-AMI patients of the four randomized prospective SMILE (Survival of Myocardial Infarction Long-term Evaluation) studies...
June 5, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28475676/comparative-effectiveness-of-enalapril-lisinopril-and-ramipril-in-the-treatment-of-patients-with-chronic-heart-failure-a-propensity-score-matched-cohort-study
#4
Hanna Fröhlich, Felix Henning, Tobias Täger, Dieter Schellberg, Morten Grundtvig, Kevin Goode, Anna Corletto, Syed Kazmi, Torstein Hole, Hugo A Katus, Dan Atar, John G F Cleland, Stefan Agewall, Lutz Frankenstein, Andrew L Clark
Aims: Angiotensin-converting enzyme inhibitors (ACEIs) are recommended as first-line therapy in patients with heart failure with reduced ejection fraction (HFrEF). The comparative effectiveness of different ACEIs is not known. Methods and results: A total of 4723 outpatients with stable HFrEF prescribed enalapril, lisinopril, or ramipril were identified from three registries in Norway, England, and Germany. In three separate matching procedures, patients were individually matched with respect to both dose equivalents and their respective propensity scores for ACEI treatment...
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28364692/the-effect-of-three-angiotensin-converting-enzyme-inhibitors-on-kynurenic-acid-production-in-rat-kidney-in-vitro
#5
COMPARATIVE STUDY
Izabela Zakrocka, Tomasz Kocki, Waldemar A Turski
BACKGROUND: The renin-angiotensin system (RAS) is commonly known to regulate blood pressure, water and electrolyte homeostasis, however it also exerts paracrine and autocrine actions on the kidney. Angiotensin-converting enzyme inhibitors (ACE-Is), alongside their hypotensive properties, have been shown to decrease kidney function decline in animal models of nephropathy. Glutamate (GLU) is the main stimulatory neurotransmitter in the central nervous system, however its importance in the periphery should also be considered...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28294885/-comparative-assessment-of-effects-of-free-and-fixed-combinations-of-hypotensive-drugs-on-quality-of-life-of-patients-with-arterial-hypertension-of-high-and-very-high-risk
#6
COMPARATIVE STUDY
S A Gridina, S V Povetkin
PURPOSE: comparative assessment of effects of free and fixed combinations of hypotensive drugs on quality of life (QL) of patients with arterial hypertension (AH) of high and very high risk of cardiovascular complications. MATERIAL: Study group comprised 120 patients (70% men, 30% women, age 45-65 years) with degree II (20.9%) and III (79.1%) A. Duration of AH was 10.6+/-2.89 years. Risk was high in 58 (48.3%), very high - in 62 (51.7%) patients. Patients were randomized into 3 groups with different second step therapy...
March 2016: Kardiologiia
https://www.readbyqxmd.com/read/28155333/cardioprotective-role-of-zofenopril-in-hypertensive-patients-with-acute-myocardial-infarction-a-pooled-individual-data-analysis-of-the-smile-studies
#7
RANDOMIZED CONTROLLED TRIAL
Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni
PURPOSE: The four SMILE studies demonstrated that early administration of zofenopril following acute myocardial infarction is prognostically beneficial compared to placebo or other angiotensin-converting enzyme (ACE) inhibitors. In the present retrospective pooled analysis of individual SMILE studies, we evaluated the efficacy of zofenopril on cardiovascular (CV) outcomes in 1880 hypertensive and 1662 normotensive patients. MATERIALS AND METHODS: Four hundred and forty-nine hypertensives and 486 normotensives were treated with placebo, 980 and 786 with zofenopril 30-60 mg daily, 252 and 259 with lisinopril 5-10 mg daily, 199 and 131 with ramipril 10 mg daily, for 6 to 48 weeks...
August 2017: Blood Pressure
https://www.readbyqxmd.com/read/27798417/efficacy-of-zofenopril-compared-with-placebo-and-other-angiotensin-converting-enzyme-inhibitors-in-patients-with-acute-myocardial-infarction-and-previous-cardiovascular-risk-factors-a-pooled-individual-data-analysis-of-4-randomized-double-blind-controlled-prospective
#8
COMPARATIVE STUDY
Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni
In the Survival of Myocardial Infarction Long-term Evaluation (SMILE) 1, 3, and 4 studies, early administration of zofenopril in acute myocardial infarction showed to be prognostically beneficial versus placebo or ramipril. The SMILE-2 showed that both zofenopril and lisinopril are safe and showed no significant differences in the incidence of major cardiovascular (CV) complications. In this pooled analysis of individual data of the SMILE studies, we evaluated whether the superior efficacy of zofenopril is maintained also in patients with ≥1 CV risk factor (CV+, n = 2962) as compared to CV- (n = 668)...
January 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27682140/therapeutic-efficacy-and-safety-of-ace-inhibitors-in-the-hypertensive-paediatric-population-a-review
#9
REVIEW
Evelien Snauwaert, Johan Vande Walle, Pauline De Bruyne
PURPOSE: Since 1997, strong incentives have been introduced worldwide to improve access to safe and effective medicines addressing the therapeutic needs of children. ACE inhibitors, the most prescribed antihypertensive drugs in the paediatric population, are one of the prototype drugs targeted by the legislation initiatives. Our purpose in assembling this review is to evaluate and describe the current evidence for the efficacy and safety profile of ACE inhibitors in the paediatric population...
January 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27423316/angiotensin-converting-enzyme-inhibitors-modulate-kynurenic-acid-production-in-rat-brain-cortex-in-vitro
#10
Izabela Zakrocka, Waldemar A Turski, Tomasz Kocki
It is well established that the renin-angiotensin system (RAS) is present in the brain and that glutamate activates the brain centers responsible for blood pressure control. An antagonist of glutamate, kynurenic acid (KYNA) was shown to decrease blood pressure after intracerebral administration. KYNA is an endogenous metabolite of tryptophan produced from the breakdown of kynurenine by kynurenine aminotransferases (KAT), mainly within astrocytes. The purpose of this study was to evaluate the influence of three angiotensin-converting enzyme inhibitors (lisinopril, perindopril and ramipril) on KYNA production and KAT activity in the rat brain cortex in vitro...
October 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26871774/comparison-of-the-efficacy-and-safety-of-different-ace-inhibitors-in-patients-with-chronic-heart-failure-a-prisma-compliant-network-meta-analysis
#11
COMPARATIVE STUDY
WeiPing Sun, HaiBin Zhang, JinCheng Guo, XueKun Zhang, LiXin Zhang, ChunLei Li, Ling Zhang
Heart failure is a public health problem and a great economic burden for patients and healthcare systems. Suppression of the renin-angiotensin system (RAS) by angiotensin-converting enzyme (ACE)-inhibitors remains the mainstay of treatment for heart failure. However, the abundance of ACE inhibitors makes it difficult for doctors to choose.We performed this network meta-analysis of ACEIs in patients with heart failure in order to address this area of uncertainty.We searched PubMed, Embase, CENTRAL, and Medline...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26708684/-ramipril-plus-amlodipine-and-lisinopril-plus-amlodipine-fixed-dose-combinations-and-patient-s-adherence
#12
Gábor Simonyi, Tamás Ferenci
INTRODUCTION: Patient's adherence has a great significance to reach target blood pressure values. The risk of cardiovascular adverse events decreases when patients are on target blood pressure. AIM: The aim of the authors was to investigate the one-year persistence of the ramipril/amlodipine and lisinopril/amlodipine fixed dose combination in hypertensive patients. METHOD: National Health Insurance Found prescriptions database of Hungary on pharmacy-claims between October 1, 2012 and September 30, 2013 was analyzed...
January 3, 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/26382240/angiotensin-converting-enzyme-inhibitor-dialyzability-and-outcomes-in-older-patients-receiving-hemodialysis
#13
Matthew A Weir, Jamie L Fleet, Stephanie N Dixon, Arsh K Jain, Matthew Oliver, Ron Wald, Chris McIntyre, Amit X Garg
BACKGROUND/AIMS: Some angiotensin converting enzyme (ACE) inhibitors are efficiently removed from circulation by hemodialysis ('high dialyzability'), whereas others are not ('low dialyzability'). In patients receiving hemodialysis, this may influence the effectiveness of ACE inhibitors. METHODS: Using linked healthcare databases we identified older patients receiving chronic hemodialysis who filled new ACE inhibitor prescriptions. The low dialyzability group (n = 3,369) included fosinopril and ramipril...
2015: Blood Purification
https://www.readbyqxmd.com/read/26380097/cardioprotective-role-of-zofenopril-in-patients-with-acute-myocardial-infarction-a-pooled-individual-data-analysis-of-four-randomised-double-blind-controlled-prospective-studies
#14
Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni
BACKGROUND: Early administration of zofenopril following acute myocardial infarction (AMI) proved to be prognostically beneficial in the four individual randomised, double-blind, parallel-group, prospective SMILE (Survival of Myocardial Infarction Long-term Evaluation) studies. In the present analysis, we evaluated the cumulative efficacy of zofenopril by pooling individual data from the four SMILE studies. METHODS: 3630 patients with AMI were enrolled and treated for 6-48 weeks with zofenopril 30-60 mg/day (n=1808), placebo (n=951), lisinopril 5-10 mg/day (n=520) or ramipril 10 mg/day (n=351)...
2015: Open Heart
https://www.readbyqxmd.com/read/26155707/-secondary-prevention-of-arterial-hypertension-in-vehicle-drivers-efficiency-specific-safety
#15
A A Elgarov, R M Aramisova, M A Elgarov, M A Kalmykova
AIM: To estimate effectiveness and safety of pharmacotherapy in vehicle drivers with arterial hypertension (AH). MATERIALS AND METHODS: 432 patients with grade I-III AH including 82 with cardiovascular complications largely of II and III grade were under observation during 2.5-4 months using clinical and instrumental methods (24hr AP & ECG monitoring) as well as psychophysiological testing (PPT). RESULTS: Ramipril and atenolol were efficient in 77...
2015: Klinicheskaia Meditsina
https://www.readbyqxmd.com/read/25980448/a-population-based-study-of-the-drug-interaction-between-clopidogrel-and-angiotensin-converting-enzyme-inhibitors
#16
Alex M Cressman, Erin M Macdonald, Kimberly A Fernandes, Tara Gomes, J Michael Paterson, Muhammad M Mamdani, David N Juurlink
AIMS: Clopidogrel and angiotensin converting enzyme (ACE) inhibitors are commonly co-prescribed drugs. Clopidogrel inhibits carboxylesterase 1 (CES1), the enzyme responsible for converting prodrug ACE inhibitors (such as ramipril and perindopril) to their active metabolites. The clinical implications of this potential drug interaction are unknown. The clinical consequences of the potential drug interaction between clopidogrel and prodrug ACE inhibitors were examined. METHODS: We conducted a nested case-control study of Ontarians aged 66 years and older treated with clopidogrel between September 1 2003 and March 31 2013 following acute myocardial infarction...
October 2015: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/25922179/design-synthesis-and-evaluation-of-novel-2-butyl-4-chloroimidazole-derived-peptidomimetics-as-angiotensin-converting-enzyme-ace-inhibitors
#17
Anvesh Jallapally, Dinesh Addla, Pankaj Bagul, Balasubramanian Sridhar, Sanjay K Banerjee, Srinivas Kantevari
A series of novel 2-butyl-4-chloro-1-methylimidazole derived peptidomimetics were designed, synthesized and evaluated for their Angiotensin Converting Enzyme (ACE) inhibitor activity. 2-Butyl-4-chloro-1-methylimidazole-5-carboxylic acid 2 obtained after oxidation of respective carboxaldehyde 1, was condensed with various amino acid methyl esters 3a-k to give imidazole-amino acid conjugates 4a-k in very good yields. Ester hydrolysis of 4a-k with aqueous LiOH gave the desired peptidomimetics 5a-k. Screening all the new compounds 4a-k and 5a-k using ACE inhibition assay, resulted five compounds 4i, 4k, 5e, 5h and 5i as potent ACE inhibitors with IC50 of 0...
July 1, 2015: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/25739816/human-health-relevance-of-pharmaceutically-active-compounds-in-drinking-water
#18
Usman Khan, Jim Nicell
In Canada, as many as 20 pharmaceutically active compounds (PhACs) have been detected in samples of treated drinking water. The presence of these PhACs in drinking water raises important questions as to the human health risk posed by their potential appearance in drinking water supplies and the extent to which they indicate that other PhACs are present but have not been detected using current analytical methods. Therefore, the goal of the current investigation was to conduct a screening-level assessment of the human health risks posed by the aquatic release of an evaluation set of 335 selected PhACs...
May 2015: AAPS Journal
https://www.readbyqxmd.com/read/25680080/the-implications-of-angiotensin-converting-enzymes-and-their-modulators-in-neurodegenerative-disorders-current-and-future-perspectives
#19
REVIEW
Parneet Kaur, Arunachalam Muthuraman, Manjinder Kaur
Angiotensin converting enzyme (ACE) is a dipeptidyl peptidase transmembrane bound enzyme. Generally, ACE inhibitors are used for the cardiovascular disorders. ACE inhibitors are primary agents for the management of hypertension, so these cannot be avoided for further use. The present Review focuses on the implications of angiotensin converting enzyme inhibitors in neurodegenerative disorders such as dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, stroke, and diabetic neuropathy...
April 15, 2015: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/25498540/different-angiotensin-converting-enzyme-inhibitors-and-the-associations-with-overall-and-cause-specific-mortalities-in-patients-with-hypertension
#20
COMPARATIVE STUDY
Chia-Hsuin Chang, Jou-Wei Lin, James L Caffrey, Li-Chiu Wu, Mei-Shu Lai
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors have been widely used in the treatment of hypertension, but the comparative effectiveness in reducing mortality among different drugs is seldom reported. METHODS: We identified hypertensive patients who started captopril, enalapril, lisinopril, fosinopril, perindopril, ramipril, or imidapril therapy from Taiwan's National Health Insurance database between 1 January 2004 and 31 December 2009. Overall and cause-specific mortalities were ascertained through a linkage to Taiwan's National Death Registry...
June 2015: American Journal of Hypertension
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