keyword
https://read.qxmd.com/read/38467248/amplification-of-mutant-nras-in-melanocytic-tumors-with-features-of-spitz-tumors
#1
JOURNAL ARTICLE
Jeffrey M Cloutier, Meng Wang, Swapna S Vemula, Sonia Mirza, Jingly Weier, Jamie D Aquino, Timothy H McCalmont, Philip E LeBoit, Boris C Bastian, Iwei Yeh
NRAS activating mutations are prevalent in melanocytic neoplasia, occurring in a subset of common acquired melanocytic nevi and approximately 30% of cutaneous melanomas. In this study, we describe a cohort of seven distinctive melanocytic tumors characterized by activating point mutations in codon 61 of NRAS with amplification of the mutant NRAS allele and shared clinicopathologic features. These tumors occurred predominantly in younger patients, with a median age of 20 years (ranging from 6 to 56). They presented as papules on the helix of the ear (four cases) or extremities (three cases)...
March 9, 2024: Modern Pathology
https://read.qxmd.com/read/38464106/dietary-lipid-is-largely-deposited-in-skin-and-rapidly-affects-insulating-properties
#2
Nick Riley, Ildiko Kasza, Greg Barrett-Wilt, Julian Michaud, Raghav Jain, Michaela E Trautman, Judith A Simcox, Chi-Liang E Yen, Ormond A MacDougald, Dudley W Lamming, Caroline M Alexander
Skin has been shown to be a regulatory hub for energy expenditure and metabolism: mutations of skin lipid metabolism enzymes can change the rate of thermogenesis and susceptibility to diet-induced obesity. However, little is known about the physiological basis for this function. Here we show that the thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transfer through skin. In contrast, a dietary manipulation that prevents obesity accelerates energy loss through skins...
February 22, 2024: Research Square
https://read.qxmd.com/read/38438763/round-autoprosthesis-use-of-adipodermaglandular-flap-in-t-scar-mastopexy
#3
JOURNAL ARTICLE
Alpay Duran, Oguz Cortuk, Sinem Eroglu
PURPOSE: This study focuses on the use of round or anatomically shaped breast autoprosthesis with different volumes prepared from the central and lower poles of the breast. The technical details and surgical outcomes for patients with varying degrees of breast ptosis are discussed. MATERIAL AND METHOD: This study involved 42 patients who underwent the Wise-pattern superior pedicle mastopexy procedure using the adipodermaglandular island flap technique. The research spanned from December 2017 to August 2022...
March 4, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38415846/interventions-for-managing-oral-submucous-fibrosis
#4
REVIEW
Adam Jones, Benjamin Veale, Tiffany Li, Vishal R Aggarwal, Joshua Twigg
BACKGROUND: Oral submucous fibrosis (OSF) is a chronic disease of the oral cavity that causes progressive constriction of the cheeks and mouth accompanied by severe pain and reduced mouth opening. OSF has a significant impact on eating and swallowing, affecting quality of life. There is an increased risk of oral malignancy in people with OSF. The main risk factor for OSF is areca nut chewing, and the mainstay of treatment has been behavioural interventions to support habit cessation. This review is an update of a version last published in 2008...
February 28, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38405132/secondary-trigger-point-deactivation-surgery-for-nerve-compression-headaches-a-scoping-review
#5
JOURNAL ARTICLE
Sara Saffari, Tiam M Saffari, Jeffrey E Janis
BACKGROUND: Primary trigger point deactivation surgery has been successful in reducing or eliminating nerve compression headaches between 79% and 90% of the time. The aim of this review article was to discuss the factors that contribute to index trigger point deactivation surgery failure, the importance of reevaluating trigger points following failure, and the options for secondary surgery. METHODS: A literature search was performed using a combination of keywords involving "chronic headache" and "nerve deactivation surgery," in databases until February 2023...
February 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38334788/complete-preservation-of-orbital-fat-by-restoration-of-attenuated-orbital-septa-using-an-acellular-dermal-matrix-in-lower-blepharoplasty
#6
JOURNAL ARTICLE
Jaehoon Choi, Taegyu Lee, Jamin Hong, Junhyung Kim, Woonhyeok Jeong, Taehee Jo, Sang Woo Park
BACKGROUND: We hypothesized that application of acellular dermal matrix (ADM) over the orbital septum overlying the herniated orbital fat to tighten and strengthen the attenuated orbital septum in lower blepharoplasty would allow successful repositioning of the herniated orbital fat within the bony orbit. METHODS: The author prospectively compared the cosmetic outcomes of lower blepharoplasty using ADM with standard blepharoplasty. We evaluated recurrence of eyelid bulging and tear trough deformity, volume of the lower periorbital region, and enophthalmos and eyelid droop 1 year after surgery...
February 9, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38307635/periorbital-rejuvenation
#7
REVIEW
Phillip Hooper Barbee
The periorbital region can be rejuvenated by the application of both neuromodulators and dermal fillers. Neuromodulators can elevate the brows and improve periorbital rhytids. Dermal fillers can camouflage orbital fat pseudoherniation and tear trough deformity.
March 2024: Atlas of the Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/38287664/association-between-osteoporosis-and-skeletal-muscle-mass-in-men
#8
JOURNAL ARTICLE
Masaya Mizutani, Yawara Eguchi, Toru Toyoguchi, Sumihisa Orita, Kazuhide Inage, Yasuhiro Shiga, Satoshi Maki, Junichi Nakamura, Shigeo Hagiwara, Yasuchika Aoki, Masahiro Inoue, Masao Koda, Hiroshi Takahashi, Tsutomu Akazawa, Seiji Ohtori
STUDY DESIGN: Cross-sectional study. PURPOSE: This cross-sectional study aimed to investigate the risk factors for osteoporosis in men by assessing bone mineral density (BMD), skeletal muscle mass, body fat mass, grip strength, and advanced glycation end products (AGEs). OVERVIEW OF LITERATURE: Fewer studies have reported the correlation between BMD and skeletal muscle mass in women. Moreover, a few studies have examined the relationship between osteoporosis and skeletal muscle mass...
January 30, 2024: Asian Spine Journal
https://read.qxmd.com/read/38229847/current-status-of-pre-or-subpectoral-breast-reconstruction-in-japan
#9
REVIEW
Naohiro Ishii
Breast reconstruction using silicone breast implants (SBIs) has been performed for many patients in Japan under the initiative of the Japan Oncoplastic Breast Surgery Society (JOBSS) since SBIs were first covered by insurance in 2013. A change in the lineup of available SBIs owing to the Allergan crisis caused a decrease in the availability of SBIs appropriate to Japanese breast contours. Recently, the number of immediate implant-based breast reconstructions (IBRs) was approximately 4,000 in one year and was slightly decreasing...
December 26, 2023: Gland Surgery
https://read.qxmd.com/read/38227145/cutaneous-ultrasound-of-the-nuchal-type-fibroma-diagnostic-clues-and-surgery-planning
#10
JOURNAL ARTICLE
Júlia Verdaguer-Faja, Nuria Rodríguez-Garijo, Carolina Arean-Cuns, Pedro Redondo Bellón, Francisco Javier García-Martínez
Nuchal-type fibroma is a rare, benign tumour, arising from the connective tissue and characterized by their usual location in the posterior neck, although extra-nuchal locations may also occur. The excision of nuchal-type fibroma is curative, although it presents as a large poorly circumscribed lesion in the dermal and subcutaneous fat layer, with adipose tissue and muscle fascicles entrapment, what can lead to partial excisions and relapses. Due to its rarity, little is known about the sonographic appearances of nuchal-type fibroma...
January 16, 2024: Journal of Ultrasound
https://read.qxmd.com/read/38213807/prepectoral-versus-subpectoral-two-stage-implant-based-breast-reconstruction-u-s-medical-center-experience-and-narrative-review
#11
REVIEW
Joseph M Escandón, Anna Weiss, Jose G Christiano, Howard N Langstein, Lauren Escandón, Peter A Prieto, Jessica C Gooch, Oscar J Manrique
BACKGROUND AND OBJECTIVE: With the incorporation of autologous fat grafting, acellular dermal matrix (ADM) products, and nipple-sparing mastectomy, prepectoral device placement has become more popular in selected patients when compared to partial submuscular (dual plane) or complete submuscular device placement. In this article, we aimed to present a review of the current state-of-the-art for implant-based breast reconstruction (IBBR) using expanders. Additionally, we present a case series of our experience with IBBR evaluating perioperative outcomes, complications, and patient-reported outcomes (PRO)...
December 20, 2023: Annals of Translational Medicine
https://read.qxmd.com/read/38194457/dido-is-necessary-for-the-adipogenesis-that-promotes-diet-induced-obesity
#12
JOURNAL ARTICLE
María Ángeles García-López, Alfonso Mora, Patricia Corrales, Tirso Pons, Ainhoa Sánchez de Diego, Amaia Talavera Gutiérrez, Karel H M van Wely, Gema Medina-Gómez, Guadalupe Sabio, Carlos Martínez-A, Thierry Fischer
The prevalence of overweight and obesity continues to rise in the population worldwide. Because it is an important predisposing factor for cancer, cardiovascular diseases, diabetes mellitus, and COVID-19, obesity reduces life expectancy. Adipose tissue (AT), the main fat storage organ with endocrine capacity, plays fundamental roles in systemic metabolism and obesity-related diseases. Dysfunctional AT can induce excess or reduced body fat (lipodystrophy). Dido1 is a marker gene for stemness; gene-targeting experiments compromised several functions ranging from cell division to embryonic stem cell differentiation, both in vivo and in vitro...
January 16, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38190791/the-oncological-safety-and-long-term-cosmetic-effect-of-free-dermal-fat-graft-with-epidermis-removal-for-breast-defect-repair-in-breast-conserving-surgery
#13
JOURNAL ARTICLE
Zikui Xiong, Jindi He, Xin Zhao, Xinqing Ye, Manlu Cui, Juan Fu, Jianlun Liu, Qiuyun Li
BACKGROUND: Free dermal fat grafts (FDFG) are used for immediate breast defect repair in breast-conserving surgery (BCS), and have achieved satisfactory immediate postoperative cosmetic effects (Sawai et al., 2004) [1]. However, the oncologic safety and long-term cosmetic outcomes of these surgical procedures remain unknown. Therefore, t,in this study, we aim to investigate the oncological safety and long-term cosmetic outcomes of FDFG in patients with breast cancer. METHODS: This matched retrospective case-control study included patients with non-special types of breast cancer who underwent FDFG for breast defect repair after BCS or BCS alone at two breast cancer research centers in Guangxi Province, China, from January 2016 to December 2019...
January 4, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38174730/quantitative-analysis-of-age-related-changes-in-vascular-structure-oxygen-saturation-and-epidermal-melanin-structure-using-photoacoustic-methods
#14
JOURNAL ARTICLE
Koji Mizukoshi, Hideaki Iwazaki, Taiichiro Ida
BACKGROUND: Vascular structure, blood oxygen saturation, and melanin status of the epidermis are chromophore factors related to light absorption. Therefore, they are likely to be related to skin appearance. Thus, it is important to measure these internal skin features and understand their characteristics. Thus, we aimed to analyze the individual differences and aging changes in the skin by measuring the internal skin characteristics, such as vascular structure, oxygen saturation, and the 3D distribution of melanin in the epidermis, using a noninvasive photoacoustic (PA) measurement method...
January 2024: Skin Research and Technology
https://read.qxmd.com/read/38137571/regeneration-of-panniculus-carnosus-muscle-in-fetal-mice-is-characterized-by-the-presence-of-actin-cables
#15
JOURNAL ARTICLE
Mariko Hamada, Kento Takaya, Qi Wang, Marika Otaki, Yuka Imbe, Yukari Nakajima, Shigeki Sakai, Keisuke Okabe, Noriko Aramaki-Hattori, Kazuo Kishi
Mammalian skin, including human and mouse skin, does not regenerate completely after injury; it is repaired, leaving a scar. However, it is known that skin wounds up to a certain stage of embryonic development can regenerate. The mechanism behind the transition from regeneration to scar formation is not fully understood. Panniculus carnosus muscle (PCM) is present beneath the dermal fat layer and is a very important tissue for wound contraction. In rodents, PCM is present throughout the body. In humans, on the other hand, it disappears and becomes a shallow fascia on the trunk...
December 18, 2023: Biomedicines
https://read.qxmd.com/read/38114085/free-dermal-fat-grafting-a-novel-technique-for-the-correction-of-nasolabial-folds-during-facelift-surgery
#16
JOURNAL ARTICLE
Jiajun Zhi, Cheng Yao, Yanyong Zhao
BACKGROUND: Traditional facelift surgery does not behave well in the correction of nasolabial folds, which is a common clinical problem and needed to be improved. OBJECTIVES: To investigate the effect of free dermal fat grafting during facelift surgery for the treatment of nasolabial folds. METHODS: This prospective cohort study involved 80 patients with moderate to severe nasolabial folds and facial skin dermatolysis. 50 of them underwent facelift surgery combined with free dermal fat grafting and 30 of them underwent traditional facelift surgery...
December 19, 2023: Aesthetic Surgery Journal
https://read.qxmd.com/read/38086356/effects-of-poly-l-lactic-acid-on-adipogenesis-and-collagen-gene-expression-in-cultured-adipocytes-irradiated-with-ultraviolet-b-rays
#17
JOURNAL ARTICLE
Hyun-Wook Kim, Yun-A Jung, Ji-Min Yun, Yura Kim, Sung-Ae Kim, Seong-Il Suh, Young-Wook Ryoo
BACKGROUND: Poly-L-lactic acid (PLLA), a synthetic, biocompatible, and biodegradable polymer, has been safely used in several clinical applications. Recently, PLLA has been widely used in the field of dermatology to treat wrinkles in aging skin. Reportedly, PLLA directly acts on dermal fibroblasts causing a significant increase in the expression of type I collagen. However, little is known about the effect of PLLA on adipocytes. OBJECTIVE: This study aimed to analyze the effect of PLLA on adipocytes and examine its potential in treating deep wrinkles engendered by the loss of subcutaneous fat because of aging and photoaging...
December 2023: Annals of Dermatology
https://read.qxmd.com/read/38074500/facial-contouring-after-permanent-filler-removal-with-combined-facelift-and-fat-grafting-a-case-series
#18
JOURNAL ARTICLE
Ahmed Gadallah, Adnan Gamal Etman, Mohamed Mamdouh Abd Elhalim
BACKGROUND: Aesthetic procedures for addressing aging range from simple injection of dermal fillers to facelift surgery. The last few decades have witnessed the development of diverse techniques to minimize facial wrinkles, volumize the face, and restore a youthful appearance. For example, fillers are a group of compounds used for cosmetic and reconstructive purposes, especially related to the face. Therefore, this study aimed to demonstrate specific cases where problematic dermal fillers were evacuated in combination with facelift procedures and fat grafting...
December 2023: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38061720/methotrexate-induced-accelerated-nodulosis-in-a-patient-with-systemic-lupus-erythematosus
#19
Hyeong Mok Kwon, Eun Hye Jeong, Jung Eun Yim, Hye Ri Kim, Dong Hoon Shin, Jong Soo Choi, Young Kyung Bae
Methotrexate (MTX)-induced accelerated nodulosis (MIAN) reportedly occurs in patients with rheumatic arthritis receiving MTX therapy. However, it has also been reported in patients with other autoinflammatory conditions, such as systemic lupus erythematosus (SLE). A 38-year-old woman diagnosed with SLE presented with multiple movable, firm, flesh-colored nodules on both hands that had developed 3 years ago. She was taking oral medications, specifically hydroxychloroquine, azathioprine, and MTX. Histopathological examination revealed palisaded granulomatous inflammation, surrounded by histiocytes and lymphocytes, along the dermis to the subcutaneous fat layer...
November 2023: Annals of Dermatology
https://read.qxmd.com/read/38041896/epidermal-and-dermal-cells-from-adult-rat-eccrine-sweat-gland-containing-skin-can-reconstruct-the-three-dimensional-structure-of-eccrine-sweat-glands
#20
JOURNAL ARTICLE
Cangyu Wang, Manxiu Cao, Junhong Zhao, Anqi Hu, Xiang Liu, Zihua Chen, Cuiping Zhang, Haihong Li
BACKGROUND: Previously, we have demonstrated that eccrine sweat gland cells (ESGCs) can reconstruct the three-dimensional (3D) structure of eccrine sweat glands (ESGs). However, there is still a need to explore source cells capable of regenerating ESG to address the issue of ESG regeneration in ESGC-deficient conditions, such as severe burns. METHODS: The epidermal cells and dermal cells in adult rat ventral foot skin (ESG-bearing) were isolated. The isolated single epidermal cells and dermal cells were mixed with Matrigel, and then the mixture was implanted into the axillary/inguinal fat pads of nude mice...
December 1, 2023: Acta Histochemica
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