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DERMAL ADIPOSE

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https://www.readbyqxmd.com/read/30280960/primary-lymphedema-of-the-upper-extremities-clinical-and-lymphoscintigraphic-features-in-23-patients
#1
Jeremy A Goss, Reid A Maclellan, Arin K Greene
BACKGROUND: Primary idiopathic lymphedema is an uncommon condition that typically affects the lower extremities. Patients have a malformed lymphatic system that causes subcutaneous fluid and adipose deposition. Rarely, the disease also has been described in the upper extremities. The purpose of this study was to investigate a cohort of patients with primary arm lymphedema to better understand the disease. METHODS: Patients evaluated in our Lymphedema Program between 2008 and 2018 were reviewed for individuals with upper extremity primary lymphedema...
October 2, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/30269434/limited-endothelial-plasticity-of-mesenchymal-stem-cells-revealed-by-quantitative-phenotypic-comparisons-to-representative-endothelial-cell-controls
#2
Jeremy A Antonyshyn, Meghan J McFadden, Anthony O Gramolini, Stefan O P Hofer, J Paul Santerre
Considerable effort has been directed toward deriving endothelial cells (ECs) from adipose-derived mesenchymal stem cells (ASCs) since 2004, when it was first suggested that ECs and adipocytes share a common progenitor. While the capacity of ASCs to express endothelial markers has been repeatedly demonstrated, none constitute conclusive evidence of an endothelial phenotype as all reported markers have been detected in other, non-endothelial cell types. In this study, quantitative phenotypic comparisons to representative EC controls were used to determine the extent of endothelial differentiation being achieved with ASCs...
September 30, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/30263873/human-adipose-derived-stem-cell-conditioned-media-and-exosomes-containing-malat1-promote-human-dermal-fibroblast-migration-and-ischemic-wound-healing
#3
Denise R Cooper, Chunyan Wang, Rehka Patel, Andrea Trujillo, Niketa A Patel, Jamie Prather, Lisa J Gould, Mack H Wu
Objective: Chronically ill patients heal recalcitrant ulcerative wounds more slowly. Human adipose-derived stem cells (hADSCs) play an important role in tissue regeneration and exosomes secreted by hADSC contribute to their paracrine signaling. In addition to cytokines, lipids and growth factors, hADSC secrete mRNA, miRNA, and long noncoding (lnc) RNA into exosomes. In this study we examined the role of lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), an abundant lncRNA in exosomes from conditioned media (CM), on cell migration and ischemic wound healing...
September 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/30244256/the-crucial-role-of-vascularization-and-lymphangiogenesis-in-skin-reconstruction
#4
REVIEW
Florian S Frueh, Nadia Sanchez-Macedo, Maurizio Calcagni, Pietro Giovanoli, Nicole Lindenblatt
BACKGROUND: The treatment of extensive skin defects and bradytrophic wounds remains a challenge in clinical practice. Despite emerging tissue engineering approaches, skin grafts and dermal substitutes are still the routine procedure for the majority of skin defects. Here, we review the role of vascularization and lymphangiogenesis for skin grafting and dermal substitutes from the clinician's perspective. SUMMARY: Graft revascularization is a dynamic combination of inosculation, angiogenesis, and vasculogenesis...
September 21, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30182495/aesthetic-dermatology-what-s-new-what-s-true
#5
Uwe Wollina, Piotr Brzezinski
Aesthetic dermatology (AD) is a rapidly growing subspecialty of dermatology. The acceptance of AD in scientific community and the society is associated with its competence, efficiency, and seriousness. This review highlights some recent developments toward new tools, techniques, and understanding in the field of AD. Analyzing the specific needs of patients and assessing the effect by objective measurements is important for further progress. For long time ignored, white adipose tissue has gained increasing interest in biology and rejuvenation...
September 4, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/30158987/differential-proteomic-analysis-predicts-appropriate-applications-for-the-secretome-of-adipose-derived-mesenchymal-stem-stromal-cells-and-dermal-fibroblasts
#6
Stefania Niada, Chiara Giannasi, Alice Gualerzi, Giuseppe Banfi, Anna Teresa Brini
The adult stem cell secretome is currently under investigation as an alternative to cell-based therapy in regenerative medicine, thanks to the remarkable translational opportunity and the advantages in terms of handling and safety. In this perspective, we recently demonstrated the efficient performance of the adipose-derived mesenchymal stem/stromal cell (ASC) secretome in contrasting neuroinflammation in a murine model of diabetic neuropathy, where the administration of factors released by dermal fibroblasts (DFs) did not exert any effect...
2018: Stem Cells International
https://www.readbyqxmd.com/read/30146106/generation-of-trichogenic-adipose-derived-stem-cells-by-expression-of-three-factors
#7
Nahyun Choi, Junjeong Choi, Ji Hye Kim, Yaeji Jang, Joo Hye Yeo, Juwon Kang, Seung Yong Song, Jinu Lee, Jong-Hyuk Sung
BACKGROUND: Previous studies demonstrated that adipose-derived stem cells (ASCs) can promote hair growth, but unmet needs exist for enhancing ASC hair inductivity. OBJECTIVE: Therefore, we introduced three trichogenic factors platelet-derived growth factor-A, SOX2, and β-catenin to ASCs (tfASCs) and evaluated whether tfASCs have similar characteristics as dermal papilla (DP) cells. METHOD: Global gene expression was examined using NGS analysis...
October 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/30142714/giant-fibrous-hamartoma-of-infancy-pitfall-of-cd34-positive-dermal-mesenchymal-tumor
#8
A Miroux-Catarino, C Claro, I Viana
Fibrous hamartoma of infancy (FHI) is a rare benign soft tissue tumor with a triphasic organoid histologic appearance. The authors present a case of a 21-month-old healthy girl with a slowly growing flesh-colored subcutaneous plaque 12cm in size on the lower back, with overlying hypertrichosis. A punch biopsy revealed a proliferation of spindle cells infiltrating the dermis and hypodermis organized in a dense storiform pattern with a strong diffuse positivity for CD34. The diagnosis of congenital dermatofibrosarcoma protuberans (DFSP) was considered and an excision was performed...
June 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/30092820/adipose-tissue-derived-extracellular-fraction-characterization-biological-and-clinical-considerations-in-regenerative-medicine
#9
Barbara Bellei, Emilia Migliano, Marinella Tedesco, Silvia Caputo, Federica Papaccio, Gianluca Lopez, Mauro Picardo
BACKGROUND: Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem cells, intercellular molecule exchange by the adipose tissue complex, a vast array of bioactive secretory factors, demonstrated beneficial effects by reducing tissue damage and stimulation of endogenous repair. However, for therapeutic purposes, the use of secretome derivatives, such as full conditioned media or purified exosomes generated in vitro, may present considerable disadvantages for cell manufacturing, storage, product safety, and their potential as a ready-to-go therapeutic product...
August 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30087356/an-orally-active-adiponectin-receptor-agonist-mitigates-cutaneous-fibrosis-inflammation-and-microvascular-pathology-in-a-murine-model-of-systemic-sclerosis
#10
Takashi Yamashita, Katja Lakota, Takashi Taniguchi, Ayumi Yoshizaki, Shinichi Sato, Wen Hong, Xingchun Zhou, Snezn Sodin-Semrl, Feng Fang, Yoshihide Asano, John Varga
The hallmarks of systemic sclerosis (SSc) are autoimmunity, microangiopathy and fibrosis. Skin fibrosis is accompanied by attrition of the dermal white adipose tissue layer, and alterations in the levels and function of adiponectin. Since these findings potentially implicate adiponectin in the pathogenesis of SSc, we employed a novel pharmacological approach to augment adiponectin signaling using AdipoRon, an orally active adiponectin receptor agonist. Chronic treatment with AdipoRon significantly ameliorated bleomycin-induced dermal fibrosis in mice...
August 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30030486/prevascularization-of-dermal-substitutes-with-adipose-tissue-derived-microvascular-fragments-enhances-early-skin-grafting
#11
Florian S Frueh, Thomas Später, Christina Körbel, Claudia Scheuer, Anna C Simson, Nicole Lindenblatt, Pietro Giovanoli, Michael D Menger, Matthias W Laschke
Split-thickness skin grafts (STSG) are still the gold standard for the treatment of most skin defects. Hence, there is an ongoing need to improve this procedure. For this purpose, we herein analyzed dermal matrices seeded with adipose tissue-derived microvascular fragments (ad-MVF) in a bradythrophic wound model. In additional experiments, the matrices were covered with autologous STSG 10 days after implantation. Green fluorescence protein (GFP)+ ad-MVF were isolated from C57BL/6-Tg(CAG-EGFP)1Osb/J mice and seeded onto collagen-glycosaminoglycan matrices...
July 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30022246/fgf-2-combined-with-bilayer-artificial-dermis-composed-of-collagen-matrix-prompts-generation-of-fat-pad-in-subcutis-of-mice
#12
Natsuko Kakudo, Naoki Morimoto, Takeshi Ogawa, Shigeru Taketani, Kenji Kusumoto
Fibroblast growth factor (FGF)-2 induces mitogenesis, angiogenesis and adipogenesis. In this study, the adipogenesis-inducing effects of FGF-2 combined with bilayer artificial dermis in mice were evaluated. FGF-2-impregnated bilayer artificial dermis composed of collagen matrix, PELNAC (Gunze Corp., Osaka, Japan) was implanted subcutaneously into the thoracic region of mice. At 1, 2, 3, and 4 weeks, samples were collected for H&E staining, von Willebrand factor immunostaining, and perilipin immunostaining to examine adipose tissue localization and angiogenesis...
July 18, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/30006585/inflammation-linked-adaptations-in-dermal-microvascular-reactivity-accompany-the-development-of-obesity-and-type-2-diabetes
#13
Marie-Sophie Nguyen-Tu, Pierre Nivoit, Valérie Oréa, Sandrine Lemoine, Cécile Acquaviva, Aurélie Pagnon-Minot, Bérengère Fromy, Jaswinder K Sethi, Dominique Sigaudo-Roussel
BACKGROUND/OBJECTIVES: The increased prevalence of obesity has prompted great strides in our understanding of specific adipose depots and their involvement in cardio-metabolic health. However, the impact of obesity on dermal white adipose tissue (dWAT) and dermal microvascular functionality remains unclear. This study aimed to investigate the temporal changes that occur in dWAT and dermal microvascular functionality during the development of diet-induced obesity and type 2 diabetes in mice...
July 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29987390/bone-marrow-derived-versus-adipose-derived-stem-cells-in-wound-healing-value-and-route-of-administration
#14
Basma Emad Aboulhoda, Shereen Abd El Fattah
The stem cells with their distinct ability of self-renewal and differentiation are considered an innovation in wound healing. However, there is lack of studies comparing the differential effect of the type and administration route of stem cells in the wound healing context. Thus, the current study has been designed to elucidate the effect of two of the most important stem cell types-the bone marrow-derived and adipose-derived stem cells in full thickness wound healing-and to evaluate, in this optimized wound model, the effectiveness of intradermal versus intravenous routes using H&E, Masson's trichrome, and PKH26-stained sections...
July 10, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29981277/improved-vasculogenesis-and-bone-matrix-formation-through-coculture-of-endothelial-cells-and-stem-cells-in-tissue-specific-methacryloyl-gelatin-based-hydrogels
#15
Annika Wenz, Iva Tjoeng, Isabelle Schneider, Petra J Kluger, Kirsten Borchers
The coculture of osteogenic and angiogenic cells and the resulting paracrine signaling via soluble factors are supposed to be crucial for successfully engineering vascularized bone tissue equivalents. In this study, a coculture system combining primary human adipose-derived stem cells (hASCs) and primary human dermal microvascular endothelial cells (HDMECs) within two types of hydrogels based on methacryloyl-modified gelatin (GM) as three-dimensional scaffolds was examined for its support of tissue specific cell functions...
July 7, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29973295/iberian-pig-mesenchymal-stem-stromal-cells-from-dermal-skin-abdominal-and-subcutaneous-adipose-tissues-and-peripheral-blood-in-vitro-characterization-and-migratory-properties-in-inflammation
#16
Alexandra Calle, Clara Barrajón-Masa, Ernesto Gómez-Fidalgo, Mercedes Martín-Lluch, Paloma Cruz-Vigo, Raúl Sánchez-Sánchez, Miguel Ángel Ramírez
BACKGROUND: Recently, the capacity of mesenchymal stem/stromal cells (MSCs) to migrate into damaged tissues has been reported. For MSCs to be a promising tool for tissue engineering and cell and gene therapy, it is essential to know their migration ability according to their tissue of origin. However, little is known about the molecular mechanisms regulating porcine MSC chemotaxis. The aim of this study was to examine the migratory properties in an inflammatory environment of porcine MSC lines from different tissue origins: subcutaneous adipose tissue (SCA-MSCs), abdominal adipose tissue (AA-MSCs), dermal skin tissue (DS-MSCs) and peripheral blood (PB-MSCs)...
July 4, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29951590/skin-aging-as-a-mechanical-phenomenon-the-main-weak-links
#17
Ilja L Kruglikov, Philipp E Scherer
From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue (sWAT). Upon exposure to a strain, such a multi-layer system demonstrates structural instabilities in its stiffer layers, which in its simplest form is the wrinkling. These instabilities appear hierarchically when the mechanical strain in the skin exceeds some critical values...
June 15, 2018: Nutrition and Healthy Aging
https://www.readbyqxmd.com/read/29931303/the-effects-of-adipose-stem-cell-conditioned-media-on-fibrogenesis-of-dermal-fibroblasts-stimulated-by-transforming-growth-factor-%C3%AE-1
#18
Bo Yuan, James A Broadbent, Jingning Huan, Huizhong Yang
Adipose-derived stem cells (ASCs) have been shown to enhance wound healing by human dermal fibroblasts; however, the interactions between ASCs and fibroblasts during injury remain unclear. Fibroblasts were treated with ASC-conditioned medium (ASC-CM) with and without transforming growth factor-β1 (TGF-β1) stimulation. Fibroblast proliferation, apoptosis, differentiation and expression of extracellular matrix genes and proteins, type I collagen, and type III collagen were measured. Also, wound-healing effect of ASC-CM was verified with in vivo animal study...
January 1, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29891910/anti-inflammatory-role-of-15-lipoxygenase-contributes-to-the-maintenance-of-skin-integrity-in-mice
#19
Sang-Nam Kim, Seun Akindehin, Hyun-Jung Kwon, Yeon-Ho Son, Abhirup Saha, Young-Suk Jung, Je-Kyung Seong, Kyung-Min Lim, Jong-Hyuk Sung, Krishna Rao Maddipati, Yun-Hee Lee
15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles in resolution and inflammatory responses. Here, we investigated anti-inflammatory role of Alox15 in skin homeostasis. We demonstrated that knockout (KO) of Alox15 led to hair loss and disrupted the structural integrity of the dorsal skin. Alox15 KO resulted in loss of hair follicle stem cells and abnormal transition of dermal adipocytes into fibroblasts. Alox15 deficiency increased infiltration of proinflammatory macrophages and upregulated proinflammatory and necroptotic signaling in dermal adipose tissue in the dorsal skin...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29867527/the-reparative-abilities-of-menstrual-stem-cells-modulate-the-wound-matrix-signals-and-improve-cutaneous-regeneration
#20
Jimena Cuenca, Alice Le-Gatt, Valentina Castillo, Jose Belletti, Macarena Díaz, Mónica Kurte G, Paz L Gonzalez, Francisca Alcayaga-Miranda, Christina M A P Schuh, Fernando Ezquer, Marcelo Ezquer, Maroun Khoury
Considerable advances have been made toward understanding the cellular and molecular mechanism of wound healing, however, treatments for chronic wounds remain elusive. Emerging concepts utilizing mesenchymal stem cells (MSCs) from umbilical cord, adipose tissue and bone marrow have shown therapeutical advantages for wound healing. Based on this positive outcome, efforts to determine the optimal sources for MSCs are required in order to improve their migratory, angiogenic, immunomodulatory, and reparative abilities...
2018: Frontiers in Physiology
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