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Daiki Kayano, Seigo Kinuya
Metaiodobenzylguanidine (MIBG) is structurally similar to the neurotransmitter norepinephrine and specifically targets neuroendocrine cells including some neuroendocrine tumors. Iodine-131 (I-131)-labeled MIBG (I-131 MIBG) therapy for neuroendocrine tumors has been performed for more than a quarter-century. The indications of I-131 MIBG therapy include treatment-resistant neuroblastoma (NB), unresectable or metastatic pheochromocytoma (PC) and paraganglioma (PG), unresectable or metastatic carcinoid tumors, and unresectable or metastatic medullary thyroid cancer (MTC)...
August 2018: Nuclear Medicine and Molecular Imaging
Arif Oguz Altunel
Watershed planning is a major issue in Turkey and other parts of the world. Surrounded by seawater on almost three-quarters of its international borders and by sheer mountains along the coastal regions and throughout the country, Turkey experiences a range of climatic changes, which constantly shape its topography. Recently, the occurrences of floods, landslides, and torrents have increased, forcing decision-makers to come up with solutions to manage and rehabilitate the upper watersheds in order to stop or limit the impact of disasters on downstream areas...
August 10, 2018: Environmental Monitoring and Assessment
Erik Carvalho, Janet P Bettger, Lynn Bowlby, Marissa Carvalho, Daniel Dore, Misty W Corcoran, Ashley A Harris, Jennifer Bond, Adam P Goode
INTRODUCTION: Annually, >50% of the US population reports musculoskeletal (MSK) pain to a provider, with direct healthcare costs exceeding $185 billion. The number of MSK complaints and the associated costs are projected to rise, increasing demand for and burden on providers. Establishing new care models to decrease inefficiencies may lower costs and optimise care delivery. The purpose of the Integration of Musculoskeletal Physical Therapy Care in the Patient-Centred Medical Home (IMPaC) study is to compare initial evaluation by a physical therapist (PT) integrated into primary care versus initial evaluation by a primary care provider (PCP) for patients with an MSK complaint...
August 8, 2018: BMJ Open
Matthew S Briggs, Katherine K Rethman, Matthew T Lopez
Background and Purpose: Differentiating between cervical nerve root and peripheral nerve injuries can be challenging. A phenomenon known as double crush syndrome may increase the susceptibility to injury and symptoms at other locations along the course of the nerve. The purpose of this case report is to describe the physical therapy differential diagnosis and management of a cyclist with upper extremity pain, weakness, and paresthesia. Case Description: The subject was referred to physical therapy with a diagnosis of cervical disc disease...
April 2018: International Journal of Sports Physical Therapy
Martine Bellanger, Nur Zeinomar, Parisa Tehranifar, Mary Beth Terry
Purpose There remains considerable international variation in breast cancer incidence and mortality, but a comprehensive examination of rates by country level economic, development and cancer prevention policies is lacking. Materials and Methods We compared GLOBOCAN 2012 age-specific breast cancer incidence and mortality rates for 177 countries by using development and policy data available from the WHO Global Cancer Country Profiles data base. We classified each country on the basis of gross national income per capita from the World Development Indicators data base, as follows: low-income country (LIC), lower-middle-income country (LMIC), upper-middle-income country (UMIC), and high-income country (HIC)...
July 2018: Journal of Global Oncology
Elena Stark, John D Christensen, Naomi A Schmalz, Sebastian Uijtdehaage
Early hands-on experience with surgical procedures may help medical students make better-informed choices if considering a surgical specialty. Here, we evaluate a curricular addition in surgical anatomy, formally exposing second-year students to different surgical subspecialties. Students met with surgeons for 7 weeks (one afternoon per week) and practiced surgical procedures on human cadavers with supervision. About a quarter of the participants reported a change in their top choice of specialty upon completing the course, and about half of the students reported changes in their second and third choices...
January 2018: Journal of Medical Education and Curricular Development
Zorimar Rivera-Núñez, J Michael Wright, Amy Meyer
OBJECTIVES: We examined stillbirths in relation to disinfection by-product (DBP) exposures including chloroform, bromodichloromethane (BDCM), dibromochloromethane, bromoform, trichloroacetic acid, dichloroacetic acid (DCAA), monobromoacetic acid and summary DBP measures (trihalomethanes (THM4), haloacetic acids (HAA5), THMBr (brominated trihalomethanes) and DBP9 (sum of THM4 and HAA5)). METHODS: We randomly selected 10 controls for each of the 2460 stillbirth cases with complete quarterly 1997-2004 THM4 and HAA5 town-level drinking water data...
July 30, 2018: Occupational and Environmental Medicine
Thomas A Ostergard, Jonathan P Miller
Surgical resection of the epileptogenic zone within the frontal lobe can be a very effective treatment for medically refractory epilepsy originating from this area. While much of the frontal lobe consists of highly eloquent tissue, surgery is not necessarily contraindicated as long as the epileptogenic zone is well-localized and the tissue resected is limited. Resection of the primary motor cortex was described by Victor Horsley in the 19th century and was used frequently in the early 20th century for a variety of neurological disorders including epilepsy; improvements in surgical techniques and mapping has led to a resurgence of its use in the past few decades...
July 23, 2018: Epilepsy & Behavior: E&B
Scott D Krugman, Carolyn J Cumpsty-Fowler
BACKGROUND AND OBJECTIVES: Sudden unexpected infant deaths (SUID) most often occur because infants are placed in unsafe sleep environments. Although authors of previous literature have demonstrated that parents who receive comprehensive safe sleep education increase knowledge and intention to place children in safe sleep environments, no studies have demonstrated improved outcomes. We describe the development of a hospital-based newborn SUID risk reduction quality improvement project and its effectiveness in reducing subsequent SUIDs in a community using linked outcome data from local Child Fatality Review Teams...
August 2018: Hospital Pediatrics
Seyyed M H Haddad, Sandeep S Dhaliwal, Brian W Rotenberg, Abbas Samani, Hanif M Ladak
Finite element (FE)-based biomechanical simulations of the upper airway are promising computational tools to study abnormal upper airway deformations under obstructive sleep apnea (OSA) conditions and to help guide minimally invasive surgical interventions in case of upper airway collapse. To this end, passive biomechanical properties of the upper airway tissues, especially oropharyngeal soft tissues, are indispensable. This research aimed at characterizing the linear elastic mechanical properties of the oropharyngeal soft tissues including palatine tonsil, soft palate, uvula, and tongue base...
October 2018: Journal of the Mechanical Behavior of Biomedical Materials
Samuel Ohayi Robsam, Emeka Udeh Ihechi, William Odesanmi Olufemi
Background: Human bite is a growing public health concern. It may be seen in both victims and aggressors following assault. Effects of human bite are both social and medical. Objectives: This study aims to determine the prevalence and characteristics of assault-related human bite injuries in Enugu, Nigeria. Methods: In this prospective study, an objective structured questionnaire was administered to assault victims attending the Forensic unit of ESUT Teaching Hospital between November 2013 and October 2014...
March 2018: African Health Sciences
Janine M Wilson, Erica McKenzie, Katja Duesterdieck-Zellmer
To define which biologic, electrophysical and other modalities are used in horses for injury or performance issues, a questionnaire regarding 38 modalities was distributed to eight veterinary groups. A total of 305 complete or partial responses were obtained from over 10 geographic regions; 75.4% from private equine practice or regional private equine referral hospitals, 14.1% from university teaching hospitals or satellite clinics, 8.2% from private mixed animal practice, and 2.3% from veterinary rehabilitation centers...
2018: Frontiers in Veterinary Science
Samson Gebremedhin, Tilahun Bekele, Negusse Retta
Ethiopia's targeted supplementary feeding (TSF) programme aims to rehabilitate moderately malnourished children and pregnant and lactating women in selected chronically food-insecure districts. Screening for malnutrition is made by health extension workers through the quarterly community health days (CHD) events based on mid-upper arm circumference (MUAC) thresholds. This validation study examined the extent of targeting errors of inclusion (providing aid to the nonneedy) and exclusion (failure to reach the needy) in the TSF programme, among preschool children in 6 TSF districts...
June 11, 2018: Maternal & Child Nutrition
Majed O Aljuaid, Osama R El-Ghamry
Introduction: The use of radiographic data for determination of age, according to the epiphyseal union stage, is a widely accepted method and considered scientifically approved. The aim of the present work is to estimate the age of epiphyseal union of hand and knee joints bones among Saudi population in Taif City. Subjects and Method: A retrospective cross-sectional study was conducted in the Armed Forces Hospitals (4 hospitals) in Taif City. The five-stage method was used for the union assessment...
2018: Radiology Research and Practice
Allan M Glanzman, Elena S Mazzone, Sally Dunaway Young, Richard Gee, Kristy Rose, Anna Mayhew, Leslie Nelson, Chris Yun, Katie Alexander, Basil T Darras, Zarazuela Zolkipli-Cunningham, Gihan Tennekoon, John W Day, Richard S Finkel, Eugenio Mercuri, Darryl C De Vivo, Ron Baldwin, Kathie M Bishop, Jacqueline Montes
BACKGROUND: Training methodology was established to optimize reliability of outcome measures in the nusinersen clinical trials. The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND), Hammersmith Functional Motor Scale Expanded (HFMSE), and Revised Upper Limb (RULM) were primary or secondary outcomes. METHODS: Video review, quarterly conference calls, and item scoring checks supported evaluator competence. Baseline and screening along with video review established intra and inter-rater reliability...
2018: Journal of Neuromuscular Diseases
Jan Dommerholt, Li-Wei Chou, Michelle Finnegan, Todd Hooks
Twenty-four basic and clinical studies and case reports are included in this quarterly review of the myofascial pain literature. The majority of publications focus on invasive techniques, especially dry needling. We hope, that this not suggest that clinicians and researchers are slowly moving away from manual trigger point (TrP) approaches. While some physiotherapists have bought into the notion that hands-on approaches are a thing of the past, since "pain is in the brain" and "the issues are not in the tissues," there is also a body of research that aims to combine so-called top-down and bottom-up therapies...
April 2018: Journal of Bodywork and Movement Therapies
Heidi J Siddle, Aimie Patience, James Coughtrey, Jean Mooney, Martin Fox, Lindsey Cherry
Background: Ultrasound in podiatry practice encompasses musculoskeletal ultrasound imaging, vascular hand-held Doppler ultrasound and therapeutic ultrasound. Sonography practice is not regulated by the Health and Care Professions Council (HCPC), with no requirement to hold a formal qualification. The College of Podiatry does not currently define ultrasound training and competencies.This study aimed to determine the current use of ultrasound, training received and mentorship received and/or provided by podiatrists using ultrasound...
2018: Journal of Foot and Ankle Research
Christina M Low Kapalu, John J Hall, Dustin P Wallace
Objective: Chronic pain is associated with school difficulties; however, there is limited published evidence on the cognitive or neuropsychological functioning of youth with chronic pain. Method: When beginning intensive interdisciplinary pain treatment, 94 youth (age = 10-18) with chronic pain completed neuropsychological assessment (e.g., intelligence, academic skills, learning and recall, and attention) and clinical questionnaires (e.g., pain and physical and psychological functioning)...
May 25, 2018: Journal of Pediatric Psychology
Falk Schwendicke, Jo Frencken, Nicola Innes
Non-cleansable carious lesions where sealing is no longer an option should be restored in the vast majority of cases. Prior to restoring the cavity, carious tissue removal is performed, mainly to increase the longevity of the restoration. Such removal, however, should not be conducted in a way that the vital pulp is harmed. This means that in teeth with shallow or moderately deep lesions, selective removal to firm dentine is recommended, while in deep lesions (radiographically extending into the pulpal third or quarter of the dentine) selective removal to soft dentine should be performed...
2018: Monographs in Oral Science
Mary-Louise McLaws, Yen Lee Angela Kwok
BACKGROUND: The mandatory national hand hygiene program requires Australian public hospitals to use direct human auditing to establish compliance rates. To establish the magnitude of the Hawthorne effect, we compared direct human audit rates with concurrent automated surveillance rates. METHODS: A large tertiary Australian teaching hospital previously trialed automated surveillance while simultaneously performing mandatory human audits for 20 minutes daily on a medical and a surgical ward...
May 16, 2018: American Journal of Infection Control
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