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Parkinson’s Tremors

Zhihao Qi, Zhen Huang, Feng Xie, Linxi Chen
Mitochondria play a key role in the maintenance of neuronal function by continuously providing energy. Here, we will give a detailed review about the recent developments in regards to dynamin-related protein 1 (Drp1) induced unbalanced mitochondrial dynamics, excessive mitochondrial division, and neuronal injury in neural system dysfunctions and neurodegenerative diseases, including the Drp1 knockout induced mice embryonic death, the dysfunction of the Drp1-dependent mitochondrial division induced neuronal cell apoptosis and impaired neuronal axonal transportation, the abnormal interaction between Drp1 and amyloid β (Aβ) in Alzheimer's disease (AD), the mutant Huntingtin (Htt) in Huntington's disease (HD), and the Drp1-associated pathogenesis of other neurodegenerative diseases such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS)...
December 4, 2018: Journal of Cellular Physiology
C Buhmann, D Jungnickel, E Lehmann
Background: Stress reduction and relaxation exercises are therapeutically suggested to patients with Parkinson's disease (PD) and tremor, but data regarding efficacy or preferential methods are missing. Objective: To investigate the effect of a standardized stress management training (SMT) according to Kaluza on coping with tremor-boosting psychosocial stress factors. Methods: 8-week SMT was applied to 82 PD patients with tremor and 30 controls...
2018: Parkinson's Disease
Meher R Juttukonda, Giulia Franco, Dario J Englot, Ya-Chen Lin, Kalen J Petersen, Paula Trujillo, Peter Hedera, Bennett A Landman, Hakmook Kang, Manus J Donahue, Peter E Konrad, Benoit M Dawant, Daniel O Claassen
OBJECTIVE: To assess white matter integrity in patients with essential tremor (ET) and Parkinson disease (PD) with moderate to severe motor impairment. METHODS: Sedated participants with ET (n = 57) or PD (n = 99) underwent diffusion tensor imaging (DTI) and fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity values were computed. White matter tracts were defined using 3 well-described atlases. To determine candidate white matter regions that differ between ET and PD groups, a bootstrapping analysis was applied using the least absolute shrinkage and selection operator...
November 30, 2018: Neurology
Roongroj Bhidayasiri, Watchara Rattanachaisit, Onanong Phokaewvarangkul, Thien Thien Lim, Hubert H Fernandez
The proper diagnosis of parkinsonian disorders usually involves three steps: identifying core features of parkinsonism; excluding other causes; and collating supportive evidence based on clinical signs or investigations. While the recognition of cardinal parkinsonian features is usually straightforward, the appreciation of clinical features suggestive of specific parkinsonian disorders can be challenging, and often requires greater experience and skills. In this review, we outline the clinical features that are relevant to the differential diagnosis of common neurodegenerative parkinsonian disorders, including Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration...
November 5, 2018: Parkinsonism & related Disorders
Maju Mathews, Isaac Nuamah, Adam J Savitz, David W Hough, Dean Najarian, Edward Kim, Srihari Gopal
Objective: The aim of this study was to evaluate the safety of 3-monthly paliperidone palmitate (PP3M) vs once-monthly paliperidone palmitate (PP1M) treatment with regard to extrapyramidal symptom (EPS)-related treatment-emergent adverse events (TEAEs) in patients with schizophrenia, previously stabilized on PP1M treatment. Patients and methods: Data on overall incidence, time to onset (TTO), and time to resolution (TTR) of EPS-related TEAEs (overall, subclasses such as dyskinesia, dystonia, hyperkinesia, parkinsonism, and tremor) from a randomized double-blind (DB) non-inferiority study were compared between PP3M and PP1M...
2018: Neuropsychiatric Disease and Treatment
Shi-Shuang Cui, Juan-Juan Du, Shi-Hua Liu, Jie Meng, Yi-Qi Lin, Gen Li, Yi-Xi He, Ping-Chen Zhang, Shengdi Chen, Gang Wang
OBJECTIVE: Lymphocyte activation gene-3 (LAG-3) could mediate pathological α-synuclein transmission in neurodegeneration and may be involved in the pathogenesis of Parkinson's disease (PD). The aim of the present study was to explore soluble LAG-3 (sLAG-3) as a potential diagnostic biomarker for PD. METHODS: Serum sLAG-3 concentrations were measured by a quantitative ELISA for patients with PD, essential tremor (ET) and age- and sex-matched controls. The relationships between sLAG-3 and clinical phenotype were assessed via correlation analysis and logistic regression...
November 28, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
JiaYi Wang, XiaoLi Yang, ZhongKui Sun
Excessive synchronization of neurons in cerebral cortex is believed to play a crucial role in the emergence of neuropsychological disorders such as Parkinson's disease, epilepsy and essential tremor. This study, by constructing a modular neuronal network with modified Oja's learning rule, explores how to eliminate the pathological synchronized rhythm of interacted busting neurons numerically. When all neurons in the modular neuronal network are strongly synchronous within a specific range of coupling strength, the result reveals that synaptic plasticity with large learning rate can suppress bursting synchronization effectively...
December 2018: Cognitive Neurodynamics
Crowley E K, Nolan Y M, Sullivan A M
Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons of the nigrostriatal pathway, which leads to the cardinal motor symptoms of the disease - tremor, rigidity and postural instability. A number of non-motor symptoms are also associated with PD, including cognitive impairment, mood disturbances and dysfunction of gastrointestinal and autonomic systems. Current therapies provide symptomatic relief but do not halt the disease process, so there is an urgent need for preventative strategies...
November 24, 2018: Progress in Neurobiology
Paolo Eusebi, Michele Romoli, Federico Paolini Paoletti, Nicola Tambasco, Paolo Calabresi, Lucilla Parnetti
Levodopa-induced dyskinesias (LID) negatively impact on the quality of life of patients with Parkinson's disease (PD). We assessed the risk factors for LID in a cohort of de-novo PD patients enrolled in the Parkinson's Progression Markers Initiative (PPMI). This retrospective cohort study included all PD patients enrolled in the PPMI cohort. Main outcome was the incidence rate of dyskinesia, defined as the first time the patient reported a non-zero score in the item "Time spent with dyskinesia" of the MDS-UPDRS part IV...
2018: NPJ Parkinson's Disease
Yurui Gao, Kurt G Schilling, Iwona Stepniewska, Junzhong Xu, Bennett A Landman, Benoit M Dawant, Adam W Anderson
Background: Clustering thalamic nuclei is important for both research and clinical purposes. For example, ventral intermediate nuclei in thalami serve as targets in both deep brain stimulation neurosurgery and radiosurgery for treating patients suffering from movement disorders (e.g., Parkinson's disease and essential tremor). Diffusion magnetic resonance imaging (dMRI) is able to reflect tissue microstructure in the central nervous system via fitting different models, such as, the diffusion tensor (DT), constrained spherical deconvolution (CSD), neurite orientation dispersion and density imaging (NODDI), diffusion kurtosis imaging (DKI) and the spherical mean technique (SMT)...
March 2018: Proceedings of SPIE
Makoto Kinoshita, Masahito Nakataki, Ryoma Morigaki, Satsuki Sumitani, Satoshi Goto, Ryuji Kaji, Tetsuro Ohmori
No previous reports have described a case in which deep brain stimulation elicited an acute mood swing from a depressive to manic state simply by switching one side of the bilateral deep brain stimulation electrode on and off. The patient was a 68-year-old woman with a 10-year history of Parkinson's disease. She underwent bilateral subthalamic deep brain stimulation surgery. After undergoing surgery, the patient exhibited hyperthymia. She was scheduled for admission. On the first day of admission, it was clear that resting tremors in the right limbs had relapsed and her hyperthymia had reverted to depression...
November 30, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Michael Lawton, Yoav Ben-Shlomo, Margaret T May, Fahd Baig, Thomas R Barber, Johannes C Klein, Diane M A Swallow, Naveed Malek, Katherine A Grosset, Nin Bajaj, Roger A Barker, Nigel Williams, David J Burn, Thomas Foltynie, Huw R Morris, Nicholas W Wood, Donald G Grosset, Michele T M Hu
OBJECTIVES: To use a data-driven approach to determine the existence and natural history of subtypes of Parkinson's disease (PD) using two large independent cohorts of patients newly diagnosed with this condition. METHODS: 1601 and 944 patients with idiopathic PD, from Tracking Parkinson's and Discovery cohorts, respectively, were evaluated in motor, cognitive and non-motor domains at the baseline assessment. Patients were recently diagnosed at entry (within 3...
December 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Meghan Harris, John Steele, Rebecca Williams, Jim Pinkston, Richard Zweig, Jessica Anne Wilden
INTRODUCTION: Medically intractable tremors are a common, difficult clinical situation. Deep brain stimulation decreases Parkinson's disease resting tremor and essential tremor, but not all patients are candidates from a diagnostic, medical, or social standpoint, prompting the need for alternative surgical strategies. METHODS: We describe 13 patients with medically intractable tremor treated with laser interstitial thermal thalamotomy performed under general anesthesia using live MRI-guidance and the Clearpoint stereotactic system...
November 19, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Stefano Di Santo, Hans R Widmer
Parkinson's disease (PD) is a neurodegenerative disorder that presents with hallmark clinical symptoms of tremor at rest, bradykinesia, and muscle rigidity. Stem cell therapy has emerged as an experimental treatment for PD. However, optimizing the cell culture condition that allows enhanced survival and differentiation of cells toward the dopaminergic phenotype remains a logistical challenge. Here, we discuss the utility of a combination of neurotrophin-4/5 (NT-4/5) and glial cell line-derived neurotrophic factor (GDNF) in increasing the dopaminergic phenotypic expression of rat ventral mesencephalic (VM) tissue...
July 2018: Brain Circulation
Ranbir Singh
Adverse drug reaction (ADR) is a form of unwanted reaction and is the crucial reason for illness and death. Tramadol-induced parkinsonism is a kind of ADR that occurs after the repeated intake of tramadol. Long-term exposure to tramadol has been known to induce tremor and alter the functioning of dopamine. This case report introduces a 75-year-old woman diagnosed with tramadol-induced parkinsonism due to the administration of tramadol for the treatment of post-operated (breast cancer) acute onset of severe pain on the left side of the chest...
November 17, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Richard Nathaniel Rees, Alastair John Noyce, Anette Schrag
Whilst the diagnosis of Parkinson's disease (PD) relies on the motor triad of bradykinesia, rigidity and tremor, the underlying pathological process starts many years before these signs are overt. In this prodromal phase of PD, a diverse range of non-motor and motor features can occur. Individually they do not allow a diagnosis of PD, but when considered together, they reflect the gradual development of the clinical syndrome. Different subgroups within the prodromal phase may exist and reflect different underlying pathology...
November 17, 2018: European Journal of Neuroscience
San San Xu, Paschal K Alexander, Yenni Lie, Vincent Dore, Svetlana Bozinovski, Rachel S Mulligan, Kenneth Young, Victor L Villemagne, Christopher C Rowe
OBJECTIVES: To further validate the diagnostic utility of 18 F-AV-133 vesicular monoamine transporter type 2 (VMAT2) positron emission tomography (PET) in patients with clinically uncertain parkinsonian syndromes (CUPS) by comparison to clinical diagnosis at 3 years follow-up. DESIGN, SETTING AND PARTICIPANTS: In a previous study, we reported that 18 F-AV-133 PET in community patients with CUPS changed diagnosis and management and increased diagnostic confidence...
November 15, 2018: BMJ Open
Tobias R Baumeister, Jowon L Kim, Maria Zhu, Martin J McKeown
BACKGROUND: White matter (WM) microstructural integrity is important for effective brain functioning and alterations have been shown in many neurodegenerative diseases. PURPOSE: To investigate WM myelin profiles and their relation to clinical features of Parkinson's disease (PD). STUDY TYPE: Retrospective cross-sectional. POPULATION: In all, 29 PD subjects and 15 healthy controls. FIELD STRENGTH/SEQUENCE: Multiecho GRASE with 10 msec echo spacing and echo planar imaging (EPI) diffusion-weighted (b-value = 700 with 32 gradient directions) on a 3T scanner...
November 15, 2018: Journal of Magnetic Resonance Imaging: JMRI
Saeed Mehrang, Milla Jauhiainen, Julia Pietil, Juha Puustinen, Jari Ruokolainen, Hannu Nieminen
Parkinson's disease (PD) is a degenerative and long-term disorder of the central nervous system, which often causes motor symptoms, e.g., tremor, rigidity, and slowness. Currently, the diagnosis of PD is based on patient history and clinical examination. Technology-derived decision support systems utilizing, for example, sensor-rich smartphones can facilitate more accurate PD diagnosis. These technologies could provide less obtrusive and more comfortable remote symptom monitoring. The recent studies showed that motor symptoms of PD can reliably be detected from data gathered via smartphones...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Syed A Shah, Gerd Tinkhauser, Chiung Chu Chen, Simon Little, Peter Brown
Deep Brain Stimulation (DBS) is a widely used therapy to ameliorate symptoms experienced by patients with Parkinson's Disease (PD). Conventional DBS is continuously ON even though PD symptoms fluctuate over time leading to undesirable side-effects and high energy requirements. This study investigates the use of a Iogistic regression-based classifier to identify periods when PD patients have rest tremor exploiting Local Field Potentials (LFPs) recorded with DBS electrodes implanted in the Subthalamic Nucleus in 7 PD patients (8 hemispheres)...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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