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Parkinson’s Tremors

Ernesto G Miranda-Morales, Ada Sandoval-Carrillo, Francisco X Castellanos-Juárez, Edna M Méndez-Hernández, Osmel La Llave-León, Gerardo Quiñones-Canales, Luis A Ruano-Calderón, Oscar Arias-Carrión, Jose M Salas-Pacheco
Parkinson's disease (PD) is characterized by bradykinesia, resting tremor, rigidity and disequilibrium as well as early symptoms. Previous studies that evaluated the association between H1/H2 MAPT haplotype and PD were mostly conducted in European populations in which the H1 haplotype was a reported risk factor for PD. Despite those findings, some studies have suggested that the association may be ethnically dependent. Since studies conducted in Latin American population have been scarce, we genotyped the H1/H2 MAPT haplotype in Mexican mestizo population as part of a PD case-control study...
October 16, 2018: Neuroscience Letters
Zaman Mirzadeh, Tsinsue Chen, Kristina M Chapple, Margaret Lambert, John P Karis, Rohit Dhall, Francisco A Ponce
BACKGROUND: Deep brain stimulation (DBS) is well-established, evidence-based therapy for Parkinson disease, essential tremor, and primary dystonia. Clinical outcome studies have recently shown that "asleep" DBS lead placement, performed using intraoperative imaging with stereotactic accuracy as the surgical endpoint, has motor outcomes comparable to traditional "awake" DBS using microelectrode recording (MER), but with shorter case times and improved speech fluency...
October 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
Cuiping Xu, Ping Zhuang, Mark Hallett, Yuqing Zhang, Jianyu Li, Yongjie Li
Background and purpose: Subthalamic nucleus deep brain stimulation (STN DBS) is well established for the treatment of advanced Parkinson's disease (PD), substantially improving motor symptoms, quality of life, and reducing the long-term need for dopaminergic medication. However, whether chronic STN DBS produces different effects on PD motor subtypes is unknown. This retrospective study aimed to evaluate the long-term effects of STN DBS on the PD motor subtypes. Methods: Eighty patients undergoing STN DBS were included...
2018: Frontiers in Human Neuroscience
Anwar Ahmed, Juebin Huang, Kun Chen, José M Zubeldia, Jan Booij, Vani Vijayakumar
PURPOSE OF THE REPORT: To compare diagnostic performance of [123 I]ioflupane SPECT imaging in different racial groups. In previous registration trials of [123 I]ioflupane, 99% of the subjects enrolled were Caucasians. MATERIALS AND METHODS: A multicenter retrospective case-control study was conducted to evaluate whether the diagnostic performance of [123 I]ioflupane SPECT imaging is different in non-Caucasians than in Caucasians matched by age, sex, and final clinical diagnosis...
October 3, 2018: Journal of the Neurological Sciences
Junaid H Siddiqui, Zakiyah Aldaajani, Raja Mehanna, Barbara Kelly Changizi, Danish Bhatti, Ziyah Ghazi Al-Johani, Aparna Wagle Shukla, Hubert H Fernandez, Jawad A Bajwa
Parkinson's disease (PD) is increasing in prevalence due to a growing elderly population. Although there is no cure, there are exercise therapies and medications for mild to moderate disease. For more advanced disease, infusion or surgical interventions including deep brain stimulation surgery, levodopa carbidopa intestinal gel and subcutaneous apomorphine infusion are considered. As these interventions become increasingly available, it is imperative for a neurologist involved in the care of advanced PD to be aware of the indications and timing for these interventions...
October 17, 2018: Expert Review of Neurotherapeutics
Carlo Dallocchio, Angela Matinella, Carla Arbasino, Natale Arno', Margaret Glorioso, Massimo Sciarretta, Massimiliano Braga, Michele Tinazzi
INTRODUCTION: Acute movement disorders (MD) are etiologically heterogeneous entities. Since studies on the relative frequency of different MD and their underlying diseases are limited, we performed a prospective study to investigate the spectrum of various MD and their causes in patients presenting with acute MD in an emergency room (ER) setting. OBJECTIVE: To describe the spectrum and outcomes of acute MD in a prospective cohort and to guide its management. METHODS: We investigated acute MD in 96 consecutive patients admitted to ERs between 2013 and 2017...
October 15, 2018: Neurological Sciences
Yanbing Hou, Jing Yang, Chunyan Luo, Ruwei Ou, Yutong Zou, Wei Song, Qiyong Gong, Huifang Shang
BACKGROUND: Parkinson's disease (PD) could be classified into akinetic-rigidity (PDAR ), tremor-dominant (PDTD ) and mixed subtypes. PDAR patients are more prone to develop cognitive deficits. The default mode network (DMN), fronto-parietal network (FPN) and dorsal attention network (DAN) play important roles in cognitive processing. Our aim was to evaluate changes in connectivity patterns of the DMN, and its interrelation with the FPN and DAN in cognitively unimpaired drug-naïve PDAR patients...
October 3, 2018: Journal of the Neurological Sciences
Ruth L O'Gorman Tuura, Christian R Baumann, Heide Baumann-Vogel
Introduction: The axial symptoms of Parkinson disease (PD) include difficulties with balance, posture, speech, swallowing, and locomotion with freezing of gait, as well as axial rigidity. These axial symptoms impact negatively on quality of life for many patients, yet remain poorly understood. Dopaminergic treatments typically have little effect on the axial symptoms of PD, suggesting that disruptions in other neurotransmitter systems beyond the dopamine system may underlie these symptoms. The purpose of the present study was to examine the relationship between the axial symptoms of PD and GABA and glutamate levels quantified with magnetic resonance spectroscopy...
2018: Frontiers in Neurology
German G Miroshnichenko, Alexander Yu Meigal, Irina V Saenko, Liudmila I Gerasimova-Meigal, Liudmila A Chernikova, Natalia S Subbotina, Saara M Rissanen, Pasi A Karjalainen
Dry immersion (DI) is acknowledged as a reliable space flight analog condition. At DI, subject is immersed in water being wrapped in a waterproof film to imitate microgravity (μG). Microgravity is known to decrease muscle tone due to deprivation of the sensory stimuli that activate the reflexes that keep up the muscle tone. In contrary, parkinsonian patients are characterized by elevated muscle tone, or rigidity, along with rest tremor and akinesia. We hypothesized that DI can diminish the elevated muscle tone and/or the tremor in parkinsonian patients...
2018: Frontiers in Neuroscience
Gennaro Pagano, Marios Politis
In the last decades, the main focus of molecular imaging of Parkinson's disease has been on non-dopaminergic systems involved in the disease alongside the pathognomonic dopaminergic changes. Molecular imaging can detect, in vivo, both presynaptic and postsynaptic serotonergic changes in the brain and has played a key role in elucidating the pathophysiology of the serotonergic system in Parkinson's disease. Alterations in the serotonergic system may happen very early in the course of the disease and have shown a leading role in the development of tremor and dyskinesias, and in several non-motor symptoms, including sleep, cognitive and neuropsychiatric disturbances...
2018: International Review of Neurobiology
Li Guo, Eduardo M Normando, Parth Arvind Shah, Lies De Groef, M Francesca Cordeiro
Parkinson's disease (PD) is one of the most common neurodegenerative disorders and the second leading cause of dementia worldwide. With an aging population, the prevalence of the disease has dramatically increased. Clinical management has advanced through recent developments in dopaminergic imaging and genetic risk profiling. However, early and accurate diagnosis of the disorder remains a challenge, largely because of the lack of noninvasive and inexpensive reliable diagnostic tests. Besides the well-studied cerebral neurodegeneration that underlies the cardinal symptoms of PD (ie, bradykinesia, tremor, rigidity, and postural instability), ocular changes have also been described in PD, including visual dysfunction, pupil abnormality, lens opacity, and retinal neuronal loss and dysfunction...
September 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Vaclav Kremen, Benjamin H Brinkmann, Inyong Kim, Hari Guragain, Mona Nasseri, Abigail L Magee, Tal Pal Attia, Petr Nejedly, Vladimir Sladky, Nathanial Nelson, Su-Youne Chang, Jeffrey A Herron, Tom Adamski, Steven Baldassano, Jan Cimbalnik, Vince Vasoli, Elizabeth Fehrmann, Tom Chouinard, Edward E Patterson, Brian Litt, Matt Stead, Jamie Van Gompel, Beverly K Sturges, Hang Joon Jo, Chelsea M Crowe, Timothy Denison, Gregory A Worrell
Brain stimulation has emerged as an effective treatment for a wide range of neurological and psychiatric diseases. Parkinson's disease, epilepsy, and essential tremor have FDA indications for electrical brain stimulation using intracranially implanted electrodes. Interfacing implantable brain devices with local and cloud computing resources have the potential to improve electrical stimulation efficacy, disease tracking, and management. Epilepsy, in particular, is a neurological disease that might benefit from the integration of brain implants with off-the-body computing for tracking disease and therapy...
2018: IEEE Journal of Translational Engineering in Health and Medicine
Silke Nuber, Molly Rajsombath, Georgia Minakaki, Jürgen Winkler, Christian P Müller, Maria Ericsson, Barbara Caldarone, Ulf Dettmer, Dennis J Selkoe
α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in Parkinson's disease (PD). Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutations shift tetramers to aggregation-prone monomers. Here, we generated mice expressing the fPD E46K mutation plus 2 homologous E→K mutations in adjacent KTKEGV motifs...
October 10, 2018: Neuron
Jennifer Wojtala, Ines Ann Heber, Petra Neuser, Julia Heller, Elke Kalbe, Sarah P Rehberg, Alexander Storch, Katharina Linse, Christine Schneider, Susanne Gräber, Daniela Berg, Judith Dams, Monika Balzer-Geldsetzer, Rüdiger Hilker-Roggendorf, Carola Oberschmidt, Simon Baudrexel, Karsten Witt, Nele Schmidt, Günther Deuschl, Brit Mollenhauer, Claudia Trenkwalder, Inga Liepelt-Scarfone, Annika Spottke, Sandra Roeske, Ullrich Wüllner, Hans-Ulrich Wittchen, Oliver Riedel, Richard Dodel, Jörg B Schulz, Kathrin Reetz
OBJECTIVES: Parkinson's disease (PD) is the second most common neurodegenerative disorder and is further associated with progressive cognitive decline. In respect to motor phenotype, there is some evidence that akinetic-rigid PD is associated with a faster rate of cognitive decline in general and a greater risk of developing dementia.The objective of this study was to examine cognitive profiles among patients with PD by motor phenotypes and its relation to cognitive function. METHODS: Demographic, clinical and neuropsychological cross-sectional baseline data of the DEMPARK/LANDSCAPE study, a multicentre longitudinal cohort study of 538 patients with PD were analysed, stratified by motor phenotype and cognitive syndrome...
October 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Rick C Helmich, Mark Hallett, Michiel F Dirkx
No abstract text is available yet for this article.
October 9, 2018: Neurology
Joseph Jankovic
No abstract text is available yet for this article.
October 9, 2018: Neurology
Chafic Karam, Steven Galetta
No abstract text is available yet for this article.
October 9, 2018: Neurology
José Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Robert Fekete
Hand deformities are well-known abnormalities observed in patients with Parkinson's disease (PD). We determined the frequency and diagnostic accuracy of hand deformities in PD. We studied 44 consecutive patients with PD, 44 age- and gender-matched normal controls and 22 patients with essential tremor (ET). By means of photographs taken in both hands of all participants, the degree of metacarpophalangeal (MCP) joint flexion was quantified by software and by blinded evaluations using a semiquantitative scale from the radial aspect, we grouped hands into four grades...
October 5, 2018: Journal of Neural Transmission
Rachel M J van der Velden, Anne E P Mulders, Marjan Drukker, Mark L Kuijf, Albert F G Leentjens
BACKGROUND: Around 50% of Parkinson's disease patients experience motor fluctuations after long-term treatment with levodopa. These fluctuations may be accompanied by mood fluctuations. Routine cross-sectional assessments cannot capture the extent of these motor and mood fluctuations and their possible associations. Experience sampling techniques that use frequently repeated measurements of symptoms over time are able to capture such fluctuations. Based on such data, longitudinal associations between symptoms can be studied using network analysis...
October 4, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Clarice Listik, Natally Santiago, Paul Rodrigo Reis, Fabio Godinho, Kleber Duarte, Manoel Jacobsen Teixeira, Egberto Reis Barbosa, Rubens Gisbert Cury
INTRODUCTION: Thalamic ventralis intermedius deep brain stimulation (VIM-DBS) is generally effective in treating refractory tremor in Parkinson's disease (PD) and in essential tremor (ET), but some patients do not respond well due to side effects or from loss of the effect of stimulation over time. The caudal zona incerta (ZI) has emerged as a promising target in ET, and the effects of ZI-DBS on PD tremor are less studied. Here, we describe a rare situation in which both ET and PD coexist in a 72-year-old male referred for ZI-DBS due to refractory tremor...
September 26, 2018: Clinical Neurology and Neurosurgery
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