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Thomas Morville, Tine Dohlmann, Anja B Kuhlman, Tine Monberg, Mimmi Torp, Bolette Hartmann, Jens J Holst, Steen Larsen, Jørn W Helge, Flemming Dela
Background Statins are widely used to lower cholesterol concentrations in both primary and secondary prevention of cardiovascular disease. The treatment increases the risk of muscle pain (myalgia) and of type 2 diabetes. However, the underlying mechanisms remain disputed. Methods We investigated whether statin induced myalgia is coupled to impaired glucose homeostasis using oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IVGTT) and the hyperinsulinemic euglycemic clamp. We performed a cross-sectional study of statin users without CVD (primary prevention) stratified into a statin myalgic (M; n=25) and a non-myalgic (NM; n=39) group as well as a control group (C; n=20) consisting of non-statin users...
December 5, 2018: Diabetes/metabolism Research and Reviews
Neha Jaiswal, Juber Akhtar, Satya Prakash Singh, Farogh Ahsan
Genistein is the natural isoflavone and a phytoestrogen with a broad range of pharmacological properties, such as tyrosine and topoisomerase inhibition. It also induces apoptosis and cell proliferation inhibition, differentiates cancer cells. Added health benefits include the reduction of osteoporosis by suppressing osteoclasts and lymphocyte functions, decreased the risk of cardiovascular attacks and relieved postmenopausal problems. Genistein traditionally used in Chinese and Ayurvedic medicine and are found to be associated with lower risk of breast, prostate and lung cancer...
December 5, 2018: Drug Research
Rui Feng, Liyang Wang, Zhonguang Li, Rong Yang, Yu Liang, Yuting Sun, Qiuxia Yu, George Ghartey-Kwansah, Yanping Sun, Yajun Wu, Wei Zhang, Xin Zhou, Mengmeng Xu, Joseph Bryant, Guifang Yan, William Isaacs, Jianjie Ma, Xuehong Xu
Cardiovascular disease (CVD) is a major global cause of mortality, which has prompted numerous studies seeking to reduce the risk of heart failure and sudden cardiac death. While regular physical activity is known to improve CVD associated morbidity and mortality, the optimal duration, frequency, and intensity of exercise remains unclear. To address this uncertainty, various animal models have been used to study the cardioprotective effects of exercise and related molecular mechanism such as the mice training models significantly decrease size of myocardial infarct by affecting Kir6...
December 2, 2018: Life Sciences
Mette Nygaard Einfeldt, Anne-Marie Schjerning Olsen, Søren Lund Kristensen, Usman Khalid, Jens Faber, Christian Torp-Pedersen, Gunnar H Gislason, Christian Selmer
Context: Hypothyroidism has detrimental effects on the cardiovascular system, but controversy remains concerning the benefits of levothyroxine (L-T4) substitution in patients with heart failure (HF). Objective: Examining the effects of L-T4 in patients with HF. Design: Retrospective cohort study. Setting and Participants: All Danish citizens aged ≥ 18 years diagnosed with HF between 1997 and 2012. L-T4 treatment was identified from nationwide registers...
December 4, 2018: Journal of Clinical Endocrinology and Metabolism
Pierluigi Macchioni, Luigi Boiardi, Francesco Muratore, Giovanna Restuccia, Alberto Cavazza, Nicolò Pipitone, Mariagrazia Catanoso, Pamela Mancuso, Ferdinando Luberto, Paolo Giorgi Rossi, Carlo Salvarani
Objective: To evaluate the influence of disease-related findings and treatment outcomes on survival in a population-based cohort of Northern Italian patients with GCA. Methods: A total of 281 patients with incident temporal artery biopsy (TAB)-proven GCA, diagnosed over a 26-year period (1986-2012) and living in the Reggio Emilia area, were retrospectively evaluated. We analysed clinical, imaging and laboratory findings at diagnosis, pathological patterns of TAB, CS treatment and therapeutic outcomes, and traditional cardiovascular risk factors as factors predictive of survival...
December 4, 2018: Rheumatology
Chuangshi Wang, Shrikant I Bangdiwala, Sumathy Rangarajan, Scott A Lear, Khalid F AlHabib, Viswanathan Mohan, Koon Teo, Paul Poirier, Lap Ah Tse, Zhiguang Liu, Annika Rosengren, Rajesh Kumar, Patricio Lopez-Jaramillo, Khalid Yusoff, Nahed Monsef, Vijayakumar Krishnapillai, Noorhassim Ismail, Pamela Seron, Antonio L Dans, Lanthé Kruger, Karen Yeates, Lloyd Leach, Rita Yusuf, Andres Orlandini, Maria Wolyniec, Ahmad Bahonar, Indu Mohan, Rasha Khatib, Ahmet Temizhan, Wei Li, Salim Yusuf
Aims: To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events. Methods and results: We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time and examined the associations between them and the composite outcome of deaths and major cardiovascular events in 116 632 participants from seven regions. After a median follow-up of 7...
December 5, 2018: European Heart Journal
Peter Austin Morton Ntenda, Jane Flora Kazambwe
Background: Overweight and obesity are well-known risk factors for non-communicable diseases such as cardiovascular disease, diabetes, some cancers and musculoskeletal disorders. In Malawi, the proportion of women who are overweight/obese has doubled, from 10% in 1992 to 21% in 2015-16. Therefore we aimed to explore the individual- and community-level factors associated with overweight and obesity among non-pregnant women of child-bearing age. Methods: Secondary analysis of the 2015-16 Malawi Demographic and Health Survey was conducted...
December 4, 2018: International Health
Dominik Linz, Kadhim Kadhim, Jonathan M Kalman, R Doug McEvoy, Prashanthan Sanders
No abstract text is available yet for this article.
December 5, 2018: European Heart Journal
Yoriko Heianza, Lu Qi
Obesity and abdominal obesity have been closely related to cardiovascular outcomes, and recent evidence has indicated that environmental and genetic factors act in concert in determining the risks of these conditions. Improving adherence to healthy lifestyle habits and healthy dietary patterns can at least partly counteract genetic variations related risks of obesity and cardiovascular disease (CVD). Other factors, such as epigenetic alterations, may also modulate a relationship between genetic susceptibility and these disorders...
December 3, 2018: Endocrinology
William H Seligman, Matthew Salt, Alethse De la Torre Rosas, Zofia Das-Gupta
As health systems around the world increasingly look to record and improve the value of care that they provide to patients, being able to measure the outcomes that matter most to patients is vital. Clinicians today gather more data than ever before, but what is measured often has little relationship to the results of care that matter most to patients. Through its working groups of global experts in particular diseases, the International Consortium for Health Outcomes Measurement (ICHOM) aims to define minimum Standard Sets of outcomes, along with case-mix factors to support risk-adjustment and meaningful comparison...
December 4, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
Lucas Helal, Filipe Ferrari, Ricardo Stein
Young competitive athletes (≤ 35 years old) with or without a previous diagnosis of cardiovascular disease may suddenly die in competitive activities, potentially leading to an impact in society through the media. Although the relative risk for sudden death (SD) in athletes is twice as high as for their counterparts, the absolute incidence is low. While there is consensus among medical societies worldwide that early detection of causal factors is highly desirable, there is debate among different screening schemes to that end...
December 2018: Arquivos Brasileiros de Cardiologia
Ariene Silva do Carmo, Maíra Macário de Assis, Cristiane de Freitas Cunha, Tatiana Resende Prado Rangel de Oliveira, Larissa Loures Mendes
This study's aim was to characterize the food environment of Brazilian public and private schools. This was a national school-based cross-sectional study with 1,247 schools - among which 81.09% were public and 18.91% were private - in 124 Brazilian municipalities. The data originated from the Questionnaire on Aspects of the School Environment, used in the Study of Cardiovascular Risk in Adolescents (ERICA) in 2013 and 2014. Data analysis was conducted in 2017. The chi-square test was used to compare proportions...
November 29, 2018: Cadernos de Saúde Pública
Maria Teresa Fialho de Sousa Campos, Francisco Miguel Quintão Valente, Raquel Maria Amaral Araújo, Josefina Bressan
This article aims to make reference to some recent mourning aspects considered risk factors for cardiovascular disease, specifically the Takotsubo cardiomyopathy. The objective was to describe the stress from the death of a loved one combining it to the possibility of occurrence of Takotsubo cardiomyopathy through the perception of a traumatic event by the cortex, which triggers the subcortical brain circuit affecting the endocrine response. Given the growing acknowledgement of this cardiomyopathy, it is possible to contextualize the nutritional behaviours and decisions surrounding it, whose benefits must exceed the condition of temporary cardiac dysfunction and extend to food choices that have some influence in the limbic system...
October 2018: Revista da Associação Médica Brasileira
Mónica Vázquez-Del Mercado, Felipe de J Perez-Vazquez, Eduardo Gomez-Bañuelos, Efrain Chavarria-Avila, Arcelia Llamas-García, Karla I Arrona-Rios, Gustavo Ignacio Diaz-Rubio, Sergio Durán-Barragán, Rosa E Navarro-Hernández, Bethel P Jordán-Estrada, Natalia Prado-Bachega, Miguel A A Gonzalez-Beltran, Carlos Ramos-Becerra, Fernando Grover-Paez, David Cardona-Müller, Ernesto G Cardona-Muñoz
It is well known that cardiovascular diseases (CVD) are a major contributor of death in systemic lupus erythematosus (SLE) as well in other rheumatic illness. In the last decades, there has been a growing development of different methodologies with the purpose of early detection of CVD. OBJECTIVE: The aim of this study is to correlate the usefulness of subclinical parameters of vascular aging and QRISK 3-2017 score for early detection of CVD in SLE. METHODS: Clinical assessment including systemic lupus erythematosus disease activity index (SLEDAI) and systemic lupus international collaborating clinics / american college of rheumatology damage index (SLICC/ACR DI), laboratory measurements, carotid ultrasound examination, carotid intima media thickness (cIMT) measurement, carotid distention and diameter analysis, arterial stiffness measurement measured by tonometry and QRISK 3-2017 were done...
2018: PloS One
Giacomo Buso, Luca Calanca, Barbara Ney, Marco Fresa, Luvia Mazzolai
Lower extremity artery disease is a very common disease, which is frequently associated with consistent disability in terms of both clinical symptoms and functioning. It is also associated with important morbidity and mortality, because of a significant increase in overall cardiovascular risk in affected patients. The establishment of an optimal medical treatment, including a careful management of the different cardiovascular risk factors through a healthy lifestyle, a regular and structured physical activity and the administration (if indicated) of antihypertensive, lipid-lowering, antidiabetic and antithrombotic drugs is a fundamental component in the clinical management of these patients and should always be considered by the clinicians facing the disease...
December 5, 2018: Revue Médicale Suisse
Krish C Dewan, Karan S Dewan, Jay J Idrees, Suparna M Navale, Brad F Rosinski, Lars G Svensson, A Marc Gillinov, Douglas R Johnston, Faisal Bakaeen, Edward G Soltesz
Importance: Persistent opioid use is currently a major health care crisis. There is a lack of knowledge regarding its prevalence and effect among patients undergoing cardiac surgery. Objective: To characterize the national population of cardiac surgery patients with opioid use disorder (OUD) and compare outcomes with the cardiac surgery population without OUD. Design, Setting, and Participants: In this retrospective population-based cohort study, more than 5...
December 5, 2018: JAMA Surgery
Duygu Koçyiğit, Lale Tokgözoğlu, Meral Kayıkçıoğlu, Servet Altay, Sinan Aydoğdu, Cem Barçın, Cem Bostan, Hüseyin Altuğ Çakmak, Alp Burak Çatakoğlu, Samim Emet, Oktay Ergene, Ali Kemal Kalkan, Barış Kaya, Cansın Kaya, Cihangir Kaymaz, Nevrez Koylan, Hakan Kültürsay, Aytekin Oğuz, Ebru Özpelit, Serkan Ünlü
OBJECTIVE: It has been reported that women receive fewer preventive recommendations regarding pharmacological treatment, lifestyle modifications, and cardiac rehabilitation compared with men who have a similar risk profile. This study was an investigation of the impact of gender on cardiovascular risk profile and secondary prevention measures for coronary artery disease (CAD) in the Turkish population. METHODS: Statistical analyses were based on the European Action on Secondary and Primary Prevention through Intervention to Reduce Events (EUROASPIRE)-IV cross-sectional survey data obtained from 17 centers in Turkey...
December 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Andrew J Ghio, Joleen M Soukup, Michael C Madden
The epidemiologic investigation has successively delineated associations of air pollution exposure with non-malignant and malignant lung disease, cardiovascular disease, cerebrovascular disease, pregnancy outcomes, perinatal effects and other extra-pulmonary disease including diabetes. Defining these relationships between air pollution exposure and human health closely parallels results of an earlier epidemiologic investigation into cigarette smoking and environmental tobacco smoke (ETS), two other particle-related exposures...
December 5, 2018: Inhalation Toxicology
Marco Roffi, Dragana Radovanovic, Juan F Iglesias, Franz R Eberli, Philip Urban, Giovanni B Pedrazzini, Paul Erne, Hans Rickli
INTRODUCTION: Limited data are available on the impact of multisite artery disease in patients with acute coronary syndromes. In particular, it is unknown whether the outcomes of those high-risk patients have improved over time. Therefore, we addressed the multisite artery disease patient population enrolled in the Swiss nationwide prospective acute coronary syndromes cohort study AMIS Plus over two decades. METHODS: All patients enrolled from January 1999 to October 2016 were stratified according to the presence of isolated coronary artery disease or multisite artery disease, defined as coronary artery disease with known concomitant vascular disease (i...
December 5, 2018: European Heart Journal. Acute Cardiovascular Care
Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Tomoaki Funamoto, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Toshinari Takamura, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Shuichi Kaneko, Hitoshi Yokoyama, Takashi Wada
AIMS/INTRODUCTION: This retrospective study investigated the impact of renal arteriosclerosis (AS) and hypertension (HT) on long-term renal and cardiovascular outcomes in Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy. MATERIALS AND METHODS: A total of 185 patients were enrolled. Patients were divided into four groups stratified by renal AS status and presence of HT. The outcomes for this study were the first occurrence of renal events (a need for dialysis or a 30% decline in estimated glomerular filtration rate from baseline) and cardiovascular events (cardiovascular death, nonfatal myocardial infarction, coronary intervention, or nonfatal stroke)...
December 5, 2018: Journal of Diabetes Investigation
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