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https://www.readbyqxmd.com/read/30103221/-liver-disease-in-systemic-lupus-erythematodes-results-of-an-explorative-observational-study
#1
Dorothee Kübel, Maximilian Tiller, Tobias Mühling, Maximilian Sohn, Inka Vallbracht, Birgit Waschulzik, Wolfgang Schepp, Felix Gundling
INTRODUCTION:  Systemic lupus erythematodes (SLE) represents an autoimmune disease with a highly variable clinical course affecting numerous organs. Hepatic manifestation seems to be rare. It is not clear whether hepatic disease in SLE is of any prognostic importance or whether it correlates with disease activity. METHODS:  Our patient cohort included 172 patients with proven SLE, all treated at Bogenhausen Hospital between 01.2009 and 12.2015. Retrospectively, all admissions as inpatients and outpatients were analyzed (n = 671; mean 3...
August 13, 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/30102778/characteristics-of-immune-response-to-tumor-associated-antigens-and-immune-cell-profile-in-hepatocellular-carcinoma-patients
#2
Yuki Inada, Eishiro Mizukoshi, Takuya Seike, Toshikatsu Tamai, Noriho Iida, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Kazumi Fushimi, Taro Yamashita, Masao Honda, Shuichi Kaneko
Host antitumor immune responses may be different between hepatocellular carcinoma (HCC) caused by metabolic disorders and HCC associated with hepatitis virus infection. In this study, we examined the immune response of tumor-associated antigen (TAA)-specific T cells and immune cell profile in HCC patients separated by cause. Thirty two patients with HBV-related HCC, 42 patients with HCV-related HCC, and 18 patients with non-alcoholic steatohepatitis (NASH)-related HCC were analyzed. The frequencies of TAA-specific T cells, the expression levels of surface markers on each immune cell and the expression of each TAA in HCC tissue were measured...
August 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30101482/the-frequency-of-specific-contact-allergies-is-reduced-in-psoriasis-patients
#3
A Claßen, T Buhl, S Schubert, M Worm, A Bauer, J Geier, S Molin
BACKGROUND: Earlier studies suggested an inverse association between contact allergy and psoriasis, although the results of clinical studies have been inconsistent. Gene-expression studies in human contact allergy focusing on immune responses revealed nickel being an inducer of Th1/Th17 and some Th22 immune polarization, whereas fragrances were found to promote a Th2-dominated immune activation. OBJECTIVES: To investigate (i) the epidemiological association between contact allergy and psoriasis in a large multicenter cohort and (ii) to analyze the sensitization profile to specific allergens in these patients...
August 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30101351/dietary-intake-of-one-carbon-metabolism-nutrients-and-dna-methylation-in-peripheral-blood
#4
James A Chamberlain, Pierre-Antoine Dugué, Julie K Bassett, Allison M Hodge, Maree T Brinkman, JiHoon E Joo, Chol-Hee Jung, Enes Makalic, Daniel F Schmidt, John L Hopper, Daniel D Buchanan, Dallas R English, Melissa C Southey, Graham G Giles, Roger L Milne
Background: Folate and other one-carbon metabolism nutrients are essential to enable DNA methylation to occur, but the extent to which their dietary intake influences methylation in adulthood is unclear. Objective: We assessed associations between dietary intake of these nutrients and DNA methylation in peripheral blood, overall and at specific genomic locations. Design: We conducted a cross-sectional study using baseline data and samples from 5186 adult participants in the Melbourne Collaborative Cohort Study (MCCS)...
August 8, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30099414/pathogenesis-of-insulin-resistance-in-pregnant-women-with-obesity
#5
Kostiantyn V Tarasenko, Antonina M Gromova, Kateryna V Pikul, Ruslan B Lysenko, Leonid A Nesterenko
OBJECTIVE: Introduction: Obesity is one of the most important medical and social problems in many countries of the world, as it is associated with the development of the most common non-communicable diseases: cardiovascular, type II diabetes mellitus, motor disorders, non-alcoholic fatty liver disease (NHAHP) and others. The aim of this paper is to analyze the pathogenetic mechanisms of insulin resistance development in pregnant women with varying obesity degrees in early and late gestation periods...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/30094748/epidemiology-and-management-practices-for-childhood-onset-systemic-lupus-erythematosus-patients-a-survey-in-latin-america
#6
Juliana C O A Ferreira, Vitor C Trindade, Graciela Espada, Zoilo Morel, Eloisa Bonfá, Claudia S Magalhães, Clovis Artur Silva
To assess epidemiology and management practices of Latin America Pediatric Rheumatologists (LAPR) about childhood-onset systemic lupus erythematosus (cSLE). A cross-sectional study was performed in 288 LAPR PANLAR members based on online survey about cSLE practices. The response rate of web-based survey by LAPR was 170/288(59%) and the majority worked in university hospitals (63%). The ACR and/or SLICC classification criteria (99%) and disease activity tools (97%) were almost universally used by LAPR, whereas damage index (70%) and CHAQ (58%) instruments were less frequently used...
August 9, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30093768/prevalence-and-the-risk-factors-of-gastro-esophageal-reflux-disease-in-medical-students
#7
Abhilasha Sharma, Praveen Kumar Sharma, Pankaj Puri
Background: Gastroesophageal reflux disease (GERD) is a commonly prevalent gastrointestinal disorder in adults. Very few studies on magnitude of GERD in student community have been done and there is none so far from India. Rigorous MBBS curriculum makes medical students prone for reflux symptoms. Hence, this study was conducted to determine the prevalence of GERD in medical students and the potential risk factors associated with it. Methods: This was a cross sectional observational study conducted on medical students in a premier medical college of India...
July 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/30093740/cognitive-functions-among-recently-detoxified-patients-with-alcohol-dependence-and-their-association-with-motivational-state-to-quit
#8
Athira Viswam, Padmavathi Nagarajan, Pooja Patnaik Kuppili, Balaji Bharadwaj
Context: Cognitive impairments are common among patients with alcohol dependence. It may involve frontal executive dysfunction, global cognitive impairments, or both. Motivation to quit alcohol involves recognition of alcohol use as a problem. This ability may be construed as a cognitive symptom. Aims: The aim is to study the frequency of cognitive dysfunction among patients with alcohol dependence and to study the association between cognitive dysfunction and the motivation to quit alcohol...
July 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/30091471/do-maternal-dietary-antioxidants-modify-the-relationship-between-binge-drinking-and-small-for-gestational-age-findings-from-a-longitudinal-cohort-study
#9
Victoria Coathup, Kate Northstone, Hooshang Izadi, Simon Wheeler, Lesley Smith
BACKGROUND: Vitamin C, vitamin E and carotenoids are potent dietary antioxidants that have been shown to attenuate ethanol-induced harm in animal models of fetal alcohol spectrum disorder. A diet low in antioxidant-rich foods may induce a state of oxidative stress in the context of maternal alcohol consumption during pregnancy, potentially causing growth restriction in the developing fetus. METHODS: We conducted a secondary analysis of a longitudinal UK birth cohort...
August 9, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/30087251/variables-associated-with-alcohol-consumption-and-abstinence-among-young-adults-in-central-china
#10
Ling Qian, Ian M Newman, Lok-Wa Yuen, Duane F Shell, Jingdong Xu
This paper presents a descriptive analysis of data gathered by personal interviews from a multistage random sample of 1640 residents aged 18⁻34 years in Wuhan, China. First, alcohol drinkers and abstainers were compared based on demographic, attitude, and belief variables. Next, the drinkers from the sample were classified into four groups based on frequency-quantity of alcohol use, and the frequency-quantity groups were compared on the same variables. For Abstainers versus Drinkers, we found no difference by age or gender in this sample...
August 7, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30087145/loss-of-function-of-canonical-notch-signaling-drives-head-and-neck-carcinogenesis
#11
Patrick Nyman, Darya Buehler, Paul F Lambert
PURPOSE: Head and neck squamous cell carcinoma (HNSCC), a common cancer worldwide, is etiologically associated with tobacco use, high alcohol consumption and high risk human papillomaviruses (HPV). The Notch signaling pathway, which is involved in cell differentiation decisions with differential downstream targets and effects depending on tissue type and developmental stage, has been implicated in human HNSCC. Notch1 is among the most frequently mutated genes in both HPV-positive and HPV-negative HNSCC...
August 7, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30086425/substance-use-patterns-among-women-living-with-hiv-compared-with-the-general-female-population-of-canada
#12
Mostafa Shokoohi, Greta R Bauer, Angela Kaida, Ashley Lacombe-Duncan, Mina Kazemi, Brenda Gagnier, Alexandra de Pokomandy, Mona Loutfy
BACKGROUND: HIV infection and substance use synergistically impact health outcomes of people with HIV. In this study, we assessed the prevalence of substance use among women living with HIV (WLWH) and compared them with expected values from general data. METHODS: Cigarette smoking, frequency of alcohol consumption, last-month non-prescribed cannabis use (vs. last-year use), and last 3 months regular (≥once/week) and occasional (<once/week) use of crack/cocaine, speed (amphetamine), and heroin (vs...
July 29, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/30082581/coffee-drinking-and-associated-factors-in-an-elderly-population-in-spain
#13
Laura Torres-Collado, Manuela García-de la Hera, Eva Maria Navarrete-Muñoz, Laura Maria Compañ-Gabucio, Sandra Gonzalez-Palacios, Jesús Vioque
Coffee consumption is highly prevalent worldwide, and many studies have reported positive and inverse associations of coffee with many diseases. However, factors associated with coffee consumption remain poorly characterized in some populations, such as the elderly. This study aimed to assess the factors associated with total, caffeinated and decaffeinated coffee consumption in an elderly population in Spain. Data were analyzed from 903 participants, aged 65 years and above, from two population-based studies carried out in the Valencia region in Spain (Valencia Nutritional Survey (VNS) and European Eye Study (EUREYE-Study)...
August 6, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30079882/reliability-and-validity-of-a-two-question-version-of-the-world-health-organization-s-alcohol-smoking-and-substance-involvement-screening-test-the-assist-fc
#14
Bonnie McRee, Thomas F Babor, Miranda L Lynch, Janice A Vendetti
OBJECTIVE: The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), developed for the World Health Organization (WHO), screens for risks associated with the use of tobacco, alcohol, and seven categories of drugs. Although the ASSIST has acceptable psychometric properties, it is relatively long for a screening test. This study was designed to identify a subset of questions from the full ASSIST instrument having comparable psychometric properties for the classification of low-, moderate-, and high-risk substance use...
July 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/30079874/cigarette-and-cannabis-use-in-young-swiss-men-examination-of-the-bidirectional-longitudinal-associations-between-frequency-of-use-and-descriptive-norms
#15
Joseph Studer, Nicolas Bertholet, Stéphanie Baggio, Jacques Gaume, Véronique S Grazioli, Ansgar Rougemont-Bücking, Jean-Bernard Daeppen, Gerhard Gmel
OBJECTIVE: Although several studies have investigated longitudinal associations between social norms and alcohol use behaviors, less is known about associations between social norms and use of other substances, such as cigarettes and cannabis. The present study aimed to examine the temporal ordering of descriptive norms and cigarette and cannabis use over time. METHOD: A sample of 5,158 young Swiss men from the Cohort Study on Substance Use Risk Factors (C-SURF) completed baseline and 15-month follow-up questionnaires assessing frequency of use and descriptive norms of cigarette and cannabis use...
July 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/30078774/under-reporting-of-sudden-unexpected-death-in-epilepsy
#16
Sarah Chen, Golsa Joodi, Orrin Devinsky, Murrium I Sadaf, Irion W Pursell, Ross J Simpson
The identification and characterization of sudden unexpected deaths in epilepsy (SUDEP) may be improved, helping to optimize prevention and intervention. We set out to assess the frequency and demographic and clinical characteristics of SUDEP cases in a sudden death cohort. All out-of-hospital deaths were investigated from March 1, 2013 to February 28, 2015 in Wake County, NC, attended by the Emergency Medical Services. Cases were screened and adjudicated by three physicians to identify sudden death cases from any cause among free-living adults, aged 18-64...
July 31, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/30071887/sex-differences-in-outcomes-and-associated-factors-among-stroke-patients-with-small-artery-occlusion-in-china
#17
Qing Qiao, Yan Hong, Wenjuan Zhao, Guanen Zhou, Qian Liu, Xianjia Ning, Jinghua Wang, Zhongping An
BACKGROUND: Sex differences in outcomes after small artery occlusion (SAO) stroke have not been well described, particularly in a Chinese population. We aimed to assess sex differences in outcomes and related risk factors among patients with SAO. METHODS: All consecutive patients with SAO were recruited between May 2005 and September 2014. Clinical features and risk factors were recorded. The mortality, recurrence, and dependency rates at 3 months after stroke were assessed...
August 2, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/30066228/endotoxinemia-contributes-to-steatosis-insulin-resistance-and-atherosclerosis-in-chronic-hepatitis-c-the-role-of-pro-inflammatory-cytokines-and-oxidative-stress
#18
Rosa Zampino, Aldo Marrone, Luca Rinaldi, Barbara Guerrera, Riccardo Nevola, Adriana Boemio, Natalina Iuliano, Mauro Giordano, Nicola Passariello, Ferdinando C Sasso, Emanuele Albano, Luigi E Adinolfi
PURPOSE: Endotoxin is a component of the outer membrane of gram-negative bacteria that live in the intestine. Endotoxinemia is reported in non-alcoholic fatty liver disease and in cirrhotic patients, causing various biological and clinical effects in the host. It is not known whether endotoxinemia occurs in chronic hepatitis C patients (CHC), therefore we evaluated the occurrence of endotoxinemia and its effect on inflammation, liver damage, insulin resistance (IR) and atherosclerosis...
July 31, 2018: Infection
https://www.readbyqxmd.com/read/30066202/enzyme-catalysed-production-of-n-butyl-palmitate-using-ultrasound-assisted-esterification-of-palmitic-acid-in-a-solvent-free-system
#19
Nishat R Khan, Sarita D Gawas, Virendra K Rathod
This work exhibits the implementation of ultrasound technology in solvent-free synthesis study of n-butyl palmitate using Fermase CALB™10000. Sequential experimental design study was instrumental in determining the most significant process variables. The effect of acid-alcohol molar ratio, enzyme dose, temperature, power and duty cycle on the reaction kinetics was studied. Highest conversion of ~ 96.6% was observed in 50 min at 1:1 molar ratio of palmitic acid to n-butanol, 70 °C temperature, 4% w/w enzyme loading, 40 W power, 70% duty cycle, 25 kHz frequency and 100 rpm speed of impeller...
July 31, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/30066178/coffee-consumption-and-mortality-from-all-causes-of-death-cardiovascular-disease-and-cancer-in-an-elderly-spanish-population
#20
L Torres-Collado, M Garcia-de-la-Hera, E M Navarrete-Muñoz, L Notario-Barandiaran, S Gonzalez-Palacios, O Zurriaga, I Melchor, Jesus Vioque
PURPOSE: The effect of coffee consumption on mortality has been scarcely investigated in the elderly. We assessed the association between coffee consumption and mortality from all-cause, cardiovascular disease (CVD) and cancer, in an elderly population of Spain. METHODS: We studied 903 individuals (511 women) aged 65 years and older from two population-based studies, the EUREYE-Spain study and the Valencia Nutritional Survey. Coffee consumption and diet were assessed using a validated food frequency questionnaire...
July 31, 2018: European Journal of Nutrition
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