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https://www.readbyqxmd.com/read/30551531/in-vivo-antileishmanial-efficacy-of-a-naphthoquinone-derivate-incorporated-into-a-pluronic-%C3%A2-f127-based-polymeric-micelle-system-against-leishmania-amazonensis-infection
#1
Débora V C Mendonça, Grasiele S V Tavares, Daniela P Lage, Tauane G Soyer, Lívia M Carvalho, Daniel S Dias, Patrícia A F Ribeiro, Flaviano M Ottoni, Luciana M R Antinarelli, Danniele L Vale, Fernanda Ludolf, Mariana C Duarte, Elaine S Coimbra, Miguel A Chávez-Fumagalli, Bruno M Roatt, Daniel Menezes-Souza, José Mário Barichello, Ricardo J Alves, Eduardo A F Coelho
New therapeutic strategies against leishmaniasis are desirable, since the treatment against disease presents problems, such as the toxicity, high cost and/or parasite resistance. As consequence, new antileishmanial compounds are necessary to be identified, as presenting high activity against Leishmania parasites, but low toxicity in mammalian hosts. Flau-A is a naphthoquinone derivative recently showed to presents an in vitro effective action against Leishmania amazonensis and L. infantum species. In the present work, the in vivo efficacy of Flau-A, which was incorporated into a Poloxamer 407-based micelle system, was evaluated in a murine model against L...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30548108/morphology-and-phylogeny-of-calyptospora-paranaidji-n-sp-eimeriorina-calyptosporidae-an-apicomplexan-parasite-of-the-hepatic-tissue-of-cichla-piquiti-kullander-ferreira-2006-from-a-reservoir-in-the-brazilian-amazon-region
#2
Marcelo F Silva, Diehgo T Silva, Elane G Giese, Igor G Hamoy, Edilson R Matos
The coccidians of the family Calyptosporidae are parasites of the tissue and organs of fish and aquatic invertebrates, in particular in the tropical region. In contrast with other apicomplexans of the suborder Eimeriorina, the diversity and ecology of the species of the genus Calyptospora have been poorly investigated, resulting in a lacuna that restricts the understanding of the distribution and prevalence of this group of eukaryote microparasites in the Amazon region. In the present study, the integrated comparative analysis of morphological characteristics, histological and structural traits, and the sequences of a fragment of the 18S rRNA gene, provides support for the identification of a new species of Calyptospora, found parasitising the hepatic tissue of the piscivorous blue peacock bass, Cichla piquiti, captured in the reservoir of the Estreito hydroelectric dam on the middle Tocantins River in northern Brazil...
December 10, 2018: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/30532789/coinfections-between-persistent-parasitic-neglected-tropical-diseases-and-viral-infections-among-prisoners-from-sub-saharan-africa-and-latin-america
#3
Lilian Da Silva Santos, Hans Wolff, François Chappuis, Pedro Albajar-Viñas, Marco Vitoria, Nguyen-Toan Tran, Stéphanie Baggio, Giuseppe Togni, Nicolas Vuilleumier, François Girardin, Francesco Negro, Laurent Gétaz
In Swiss prisons, more than 70% of detained people are foreigners and over one-third originate from sub-Saharan Africa or Latin America. These two regions are endemic for various tropical diseases and viral infections, which persist after migration to nonendemic countries. Parasitic infections (schistosomiasis; strongyloidiasis) and cooccurrent viral infections (HIV, hepatitis B (HBV), and hepatitis C (HCV)) are especially of concern for clinical care but have been neglected in empirical research. These diseases often remain silent for years before causing complications, especially if they occur concomitantly...
2018: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/30503821/interaction-and-involvement-of-cellular-adhesion-molecules-in-the-pathogenesis-of-schistosomiasis-mansoni
#4
REVIEW
Vanessa Ribeiro Figliuolo da Paz, Daniel Figueiredo-Vanzan, Alexandre Dos Santos Pyrrho
Parasites from genus Schistosoma currently infect more than 200 million people worldwide. Infection with Schistosoma mansoni causes intestinal schistosomiasis with geographical distribution across Africa, Middle East, Caribbean, Brazil, Venezuela and Suriname. People with schistosomiasis mansoni suffer from a chronic disease as result of an exacerbated immune response to the eggs deposited in hepatic tissue. The presence of eggs in the tissue triggers the recruitment and activation of immune cells to wall off and isolate them from the rest of the organism...
November 29, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30501091/improved-biosafety-and-biosecurity-measures-and-or-strategies-to-tackle-laboratory-acquired-infections-and-related-risks
#5
REVIEW
Huasong Peng, Muhammad Bilal, Hafiz M N Iqbal
Herein, we reviewed laboratory-acquired infections (LAIs) along with their health-related biological risks to provide an evidence base to tackle biosafety/biosecurity and biocontainment issues. Over the past years, a broad spectrum of pathogenic agents, such as bacteria, fungi, viruses, parasites, or genetically modified organisms, have been described and gained a substantial concern due to their profound biological as well as ecological risks. Furthermore, the emergence and/or re-emergence of life-threatening diseases are of supreme concern and come under the biosafety and biosecurity agenda to circumvent LAIs...
November 29, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30496849/ex-vivo-liver-resection-and-autotransplantation-versus-allotransplantation-for-end-stage-hepatic-alveolar-echinococcosis
#6
Shu Shen, Junjie Kong, Yiwen Qiu, Shenglong Zhang, Yan Qin, Wentao Wang
OBJECTIVE: To compare the clinical outcomes of ex vivo liver resection and autotransplantation (ERAT) with allotransplantation in end-stage hepatic alveolar echinococcosis (HAE) patients. METHODS: From January 2008 to October 2017, 41 of 254 patients with end-stage HAE fulfilled the inclusion criteria (group ERAT, n=35 versus group allotransplantation, n=6). Each group was assessed for indications and short- and long-term outcomes. RESULTS: The intraoperative mortality was zero in both groups...
November 26, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/30487697/acute-acalculous-cholecystitis-in-children
#7
REVIEW
Dimitri Poddighe, Vitaliy Sazonov
Acute acalculous cholecystitis (AAC) is the inflammatory disease of the gallbladder in the absence of gallstones. AAC is estimated to represent at least 50% to 70% of all cases of acute cholecystitis during childhood. Although this pathology was originally described in critically ill or post-surgical patients, most pediatric cases have been observed during several infectious diseases. In addition to cases caused by bacterial and parasitic infections, most pediatric reports after 2000 described children developing AAC during viral illnesses (such as Epstein-Barr virus and hepatitis A virus infections)...
November 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30487514/role-of-immune-cells-and-cytokines-for-immune-response-in-kala-azar
#8
S R Sarkar, N C Ray, S Nahar, S Roy, M A Aziz, A M Al Amin, S K Paul
Resolution of leishmanial infection is dependent on the coordinated interactions between components of cell mediated immune response, central to which is the activation of targeted T-cell populations for appropriate cytokine production and activation of infected cells. There is a correlation between the clinical outcome of Leishmania infection and the cytokine response profile. While a protective immune response against Leishmania has been clearly identified to be related to the influence of a type-l response and IFN-γ production, the precise role of T helper (TH) 2 cytokines in non-healing infections requires further exploration...
October 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30483256/-schistosoma-mansoni-infection-induced-transcriptional-changes-in-hepatic-macrophage-metabolism-correlate-with-an-athero-protective-phenotype
#9
Diana Cortes-Selva, Andrew F Elvington, Andrew Ready, Bartek Rajwa, Edward J Pearce, Gwendalyn J Randolph, Keke C Fairfax
Hepatic macrophages play an essential role in the granulomatous response to infection with the parasitic helminth Schistosoma mansoni , but the transcriptional changes that underlie this effect are poorly understood. To explore this, we sorted the two previously recognized hepatic macrophage populations (perivascular and Kupffer cells) from naïve and S. mansoni -infected male mice and performed microarray analysis as part of the Immunological Genome Project. The two hepatic macrophage populations exhibited remarkably different genomic profiles...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30481068/wild-boar-a-reservoir-of-foodborne-zoonoses
#10
Maria Fredriksson-Ahomaa
Wild boar populations around the world have increased dramatically over past decades. Climate change, generating milder winters with less snow, may affect their spread into northern regions. Wild boars can serve as reservoirs for a number of bacteria, viruses, and parasites, which are transmissible to humans and domestic animals through direct interaction with wild boars, through contaminated food or indirectly through contaminated environment. Disease transmission between wild boars, domestic animals, and humans is an increasing threat to human and animal health, especially in areas with high wild boar densities...
November 27, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/30475695/laparoscopic-management-of-hydatid-cysts-with-biliary-communication-clips-may-rescue-when-suture-fails-report-of-3-cases
#11
Saket Kumar, Rugved Kulkarni, Nikhil Chopra, Abhijit Chandra
Hydatid disease is a parasitic zoonosis caused by the larval form of the Echinococcus worm. Hepatic hydatidosis is the most common form of disease in humans. Centrally located, large hydatid cysts have the tendency to rupture into the adjoining bile duct and form a fistulous communication. Suture closure of the cystobiliary communication detected during surgery is recommended to avoid postoperative complications related to bile leak. In the era of minimally invasive surgery, laparoscopic management of the cystobiliary communication can be challenging, and laparoscopic suturing may not always be feasible...
November 20, 2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/30468338/histopathological-changes-and-oxidative-damage-in-hepatic-tissue-of-rats-experimentally-infected-with-babesia-bigemina
#12
B Esmaeilnejad, M Tavassoli, A Samiei, A Abbasi, A Shafipour, N Esmaeilnejad
The present study was aimed to investigate oxidative stress, DNA damage, and histopatholog- ical alterations in hepatic tissues of splenectomized Wistar rats experimentally infected with Ba- besia bigemina. Rats were challenged with 5x106 infected erythrocytes. Babesia infection was con- firmed both with Giemsa's staining blood smears and nested-PCR amplified region of apical membrane antigen-1 (AMA-1) gene. Parasitemia reached approximately 10 % at day 5 post-in- fection. Livers of infected rats were enlarged and darker in color, became extremely brittle with marked congestion...
September 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/30463627/streptococcus-pyogenes-bacteremia-and-toxic-shock-syndrome-related-to-strongyloides-stercoralis-hyperinfection-a-case-report
#13
Regev Cohen, Talya Finn, Frida Babushkin, Maurice Shapiro, Martina Uda, Tamar Grossman
BACKGROUND: We describe a patient with Strongyloides stercoralis hyperinfection associated with Streptococcus pyogenes and with streptococcal toxic shock syndrome. To the best of our knowledge this association has not been previously described. CASE PRESENTATION: A 78 year-old Israeli man, who was born in Iraq but lived in Israel for 66 years, presented with multi-organ failure including acute kidney and hepatic injury, coagulopathy, and lactic acidosis. He had a medical history including aortic valve replacement, diabetes mellitus, spinal stenosis, and low back pain treated with repeated local steroid injections...
November 22, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30462845/tracing-of-selected-viral-bacterial-and-parasitic-agents-on-vegetables-and-herbs-originating-from-farms-and-markets
#14
Veronika Huvarova, Petr Kralik, Petra Vasickova, Monika Kubankova, Veronika Verbikova, Michal Slany, Vladimir Babak, Monika Moravkova
Fresh vegetables and herbs are usually prepared and eaten raw without cooking or heating, which leads to a high risk of foodborne infection. The aim of the present study was to assess the contamination of raw vegetables, herbs, and the environment of food chains. Vegetable and herb samples originating both from the Czech Republic as well as from other countries were examined. The work was focused on the detection of commonly found, but also less frequently monitored foodborne pathogens, including viruses of the genus Norovirus (NoVs), hepatitis A virus (HAV), Listeria monocytogenes and Cronobacter spp...
November 21, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/30457730/-visceral-larva-migrans-syndrome-and-hepatic-abscess-a-case-report
#15
Paula Arighi, Gretel E Hausbauer, Mercedes G Vázquez, Mariana Nastri
Toxocariasis canis or catis is a zoonotic infection disseminated in humans. Human beings can act as non-natural hosts in which the parasite can survive for long periods of time and they become infected by the ingestion of geohelminth eggs. These can be located on the ground, playgrounds and children's games, and are mostly eliminated by dogs or cats. There are different spectra in the clinical presentation of this infection, which can vary from an asymptomatic host to the production of serious organic lesions; some of them are ocular toxocariasis, visceral larva migrans, covert toxocariasis and neurotoxocariasis...
December 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/30450204/hepatic-echinococcosis-a-review
#16
REVIEW
Namita Bhutani, Pradeep Kajal
Cystic echinococcosis (CE) is a widely endemic helminthic disease caused by infection with metacestodes (larval stage) of the Echinococcus granulosus tapeworm and transmitted by dogs. E. granulosus are common parasites in certain parts of the world, and are present on every continent with the exception of Antarctica. As a result, a large number of people are affected by CE. In humans, the disease is characterized by slowly growing cyst commonly occurring in liver and lungs. Clinical features are mainly right upper quadrant pain, feeling of lump and enlarged tender liver...
December 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30411030/synthesis-and-evaluation-of-antiplasmodial-efficacy-of-%C3%AE-carboline-derivatives-against-murine-malaria
#17
Varun Gorki, Rahul Singh, Neha Sylvia Walter, Upma Bagai, Deepak B Salunke
The difficulty of developing an efficient malaria vaccine along with increasing spread of multidrug resistant strain of Plasmodium falciparum to the available antimalarial drugs poses the need to discover safe and efficacious antimalarial drugs to control malaria. An alternative strategy is to synthesize compounds possessing structures similar to the active natural products or marketed drugs. Several biologically active natural products and drugs contain β-carboline moiety. In the present study, few selected β-carboline derivatives have been synthesized and tested for their in vitro and in vivo antiplasmodial activity against the rodent malaria parasite Plasmodium berghei (NK-65)...
October 31, 2018: ACS Omega
https://www.readbyqxmd.com/read/30404221/amp-activated-protein-kinase-and-host-defense-against-infection
#18
REVIEW
Prashanta Silwal, Jin Kyung Kim, Jae-Min Yuk, Eun-Kyeong Jo
5'-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some viral infections, including hepatitis B and C viral infections, AMPK activation is beneficial, but in others such as dengue virus, Ebola virus, and human cytomegaloviral infections, AMPK plays a detrimental role. AMPK-targeting agents or small molecules enhance the antiviral response and contribute to the control of microbial and parasitic infections...
November 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30401957/live-imaging-of-collagen-deposition-during-experimental-hepatic-schistosomiasis-and-recovery-a-view-on-a-dynamic-process
#19
Marina C G Harvie, Donald P McManus, Hong You, Vanessa A Rivera, Sujeevi K Nawaratna, Kelli P A MacDonald, Grant A Ramm, Geoffrey N Gobert
Hepatic fibrosis is the central cause of chronic clinical pathology resulting from infection by the blood flukes Schistosoma japonicum or S. mansoni. Much has been elucidated regarding the molecular, cellular and immunological responses that correspond to the formation of the granulomatous response to trapped schistosome eggs. A central feature of this Th2 response is the deposition of collagen around the periphery of the granuloma. To date, traditional histology and transcriptional methods have been used to quantify the deposition of collagen and to monitor the formation of the hepatic granuloma during experimental animal models of schistosomiasis...
November 6, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/30385267/antileishmanial-activity-of-a-4-hydrazinoquinoline-derivative-induction-of-autophagy-and-apoptosis-related-processes-and-effectiveness-in-experimental-cutaneous-leishmaniasis
#20
Luciana Maria Ribeiro Antinarelli, Isabela de Oliveira Souza, Priscila Vanessa Zabala Capriles, Jacy Gameiro, Elizandra Aparecida Britta, Celso Vataru Nakamura, Wallace Pacienza Lima, Adilson David da Silva, Elaine Soares Coimbra
Currently, available treatment options for leishmaniasis are limited and unsatisfactory. In a previous study, a quinoline derivative (AMQ-j), exhibited a strong effect against Leishmania amazonensis and its antileishmanial activity was preliminarily associated with mitochondrial dysfunction. The present study further explores the antileishmanial effect of this compound against L. amazonensis, as well as determines the main cellular processes involved in the death of the parasite. Moreover, this study evaluated the in vivo effect of the AMQ-j in BALB/c mice experimentally infected by L...
December 2018: Experimental Parasitology
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