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Aged 80 and older

Marco Pahor, Stephen D Anton, Daniel P Beavers, Jane A Cauley, Roger A Fielding, Stephen B Kritchevsky, Christiaan Leeuwenburgh, Kristina H Lewis, Christine K Liu, Laura C Lovato, Jane Lu, Todd M Manini, Mary M McDermott, Michael E Miller, Anne B Newman, Barbara Radziszewska, Cynthia L Stowe, Russell P Tracy, Michael P Walkup, Samuel S Wu, Walter T Ambrosius
BACKGROUND: Low-grade chronic inflammation, characterized by elevations in plasma Interleukin-6 (IL-6), is an independent risk factor of impaired mobility in older persons. Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (ω-3) may reduce IL-6 and may potentially improve physical function. To assess the main effects of the angiotensin receptor blocker losartan and ω-3 as fish oil on IL-6 and 400 m walking speed, we conducted the ENRGISE Pilot multicenter randomized clinical trial...
December 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Christoph B Olivier, Hillary Mulder, William R Hiatt, W Schuyler Jones, F Gerry R Fowkes, Frank W Rockhold, Jeffrey S Berger, Iris Baumgartner, Peter Held, Brian G Katona, Lars Norgren, Juuso Blomster, Manesh R Patel, Kenneth W Mahaffey
Importance: Patients with peripheral artery disease (PAD) are at high risk for myocardial infarction (MI). Objective: To characterize the incidence and types of MI in a PAD population, identify factors associated with MI, and determine the association of MI with cardiovascular mortality and acute limb ischemia. Design, Setting, and Participants: The Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (EUCLID) was a double-blind randomized clinical trial conducted at 811 sites in 28 countries that randomized 13 885 patients with symptomatic PAD to monotherapy with ticagrelor or clopidogrel...
December 12, 2018: JAMA Cardiology
Zhu Zhaowei, Peng Xiaofan, Xie Hebin, Tian Cuihong, Xing Haoran, Liu Qinna, Liu Zhenzhen, Hu Xinqun, Fang Zhenfei, Tang Jianjun, Zhao Yanshu, Yuan Hong, Shi Chun, Tai Shi, Liu Qiming, Jiang Hejun, Lv Xiaoling, Zhou Shenghua
Patients with acute coronary syndrome (ACS) face high postevent mortality. This study aims to evaluate the impact of living without spouse on 1-year mortality of ACS patients. This retrospective study enrolled a total of 600 consecutive patients (≥75 years of age) with ACS hospitalized in our hospital between January 2013 and December 2016. Patients' clinical characteristics, laboratory values, hospital course, demographic characteristics, and angiographic data were collected. Patients were divided into 2 groups according to living with (n = 396) or without (n = 204) spouse...
January 1, 2019: American Journal of Cardiology
Hyun Young Kim
Background: An association between obesity and gastroesophageal reflux disease (GERD) has been reported. However, previous studies have focused on obesity or central obesity. Aims: The aim of this study was to investigate the association of anthropometric index and endoscopic erosive esophagitis (EE) in health check-up of Koreans. Study Design: Case-control study. Methods: A total of 1,207 consecutive subjects (aged 40-80 years) during health checkup underwent upper endoscopy and bioelectrical impedance analysis...
December 12, 2018: Balkan Medical Journal
Simona Hapca, Bruce Guthrie, Vera Cvoro, Feifei Bu, Alasdair C Rutherford, Emma Reynish, Peter T Donnan
Purpose: Cognitive impairment is common in older people admitted to hospital, but the outcomes are generally poorly understood, and previous research has shown inconsistent associations with mortality depending on the type of cognitive impairment examined and duration of follow-up. This study examines mortality in older people with any cognitive impairment during acute hospital admission. Patients and methods: Prospective cohort of 6,724 people aged ≥65 years with a structured cognitive assessment on acute admission were included in this study...
2018: Clinical Epidemiology
Alexa Núñez, Cristina Esquinas, Miriam Barrecheguren, Myriam Calle, Ricard Casamor, Marc Miravitlles
Purpose: The aim of this study was to evaluate the impact of morning symptoms in COPD using the Capacity of Daily Living during the Morning (CDLM) questionnaire and to determine the clinical variables that are related to CDLM scores. Methods: This was an observational, cross-sectional, and multicenter study conducted in stable COPD patients. CDLM scores ranged from 0 to 5 and were transformed into a qualitative variable according to tertile values to compare patient characteristics...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Sławomir Tobis, Katarzyna Wieczorowska-Tobis, Dorota Talarska, Mariola Pawlaczyk, Aleksandra Suwalska
Introduction: No comprehensive needs assessment is performed routinely in Poland. Purpose: The goal of the study was to investigate the patterns of needs in older individuals living in long-term care institutions (LTCIs) using the Camberwell Assessment of Need for the Elderly (CANE) questionnaire, based on a previously published study protocol. Participants and methods: The study included 306 LTCI residents (age: ≥75 years) with the a Mini-Mental State Examination (MMSE) score of at least 10 points...
2018: Clinical Interventions in Aging
A Collignon, C Houillier, G Ahle, O Chinot, S Choquet, A Schmitt, P Agape, C Soussain, K Hoang-Xuan, Emeline Tabouret
Recurrent primary central nervous system lymphomas (PCNSL) have a very poor prognosis. For young and fit patients, intensive chemotherapy followed by autologous stem cell transplantation could be proposed at relapse. In the other cases (unfit or elderly patients), therapeutic options are limited with no consensual regimen. The poly-chemotherapy by (R)-GEMOX is associated with anti-tumor activity in systemic lymphomas and a favorable toxicity profile. Our objective was to evaluate the activity and tolerance of (R)-GEMOX in PCNSL patients enrolled in the French nation-wide LOC cohort...
December 7, 2018: Annals of Hematology
Treicy Jaramillo, Carolina Vidal, Patricia Moya, Lorena Hoffmeister
BACKGROUND: Infectious diseases are important causes of burden of illness and mortality. AIM: To describe the temporal trends of hospital discharges due to infectious in Chile from 2004 to 2014. METHODS: Descriptive study. National Hospital Discharge Registry were used. We included all hospital discharges with main diagnosis of infectious diseases including parasitic diseases. Rates were calculated and standardized. The anual percentage change (APC) was estimated by Poisson regression...
August 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Paul Mini, Bonnefoy Marc, Subtil Fabien, Michel Chuzeville
Background: The latest studies presented at the American Heart Association (AHA) meeting on heart failure and the update of the European Cardiology Society's (ECS) recommendations on heart failure in 2016 recommend intravenous iron supplementation in patients with heart failure, reduced ejection fraction and iron deficiency for improves walking performance and quality of life, and reduces morbidity. In the present study, we investigated the prevalence of iron deficiency in heart failure patients aged 75 years or older, as there is currently no data on these patients...
November 2018: Journal of Geriatric Cardiology: JGC
Patrick D Gajewski, Eva Hanisch, Michael Falkenstein, Sven Thönes, Edmund Wascher
Working memory (WM) declines with increasing age. The WM capacity is often measured by means of the computerized version of the n -back task. Although the n -back task is widely used in aging research, little is known about its construct validity and specific cognitive functions involved in this task. Moreover, to date, no studies analyzed the construct validity as a function of age. To this end, we conducted a study in a sample of N = 533 individuals aged between 20 and 80 years. The sample was divided into three age groups: young (20-40), middle-aged (41-60), and old (61-80 years)...
2018: Frontiers in Psychology
Nanna Notthoff, Johanna Drewelies, Paulina Kazanecka, Elisabeth Steinhagen-Thiessen, Kristina Norman, Sandra Düzel, Martin Daumer, Ulman Lindenberger, Ilja Demuth, Denis Gerstorf
The huge inter-individual differences in how people age have prompted researchers to examine whether people's own perception of how old they are-their subjective age-could be a better predictor of relevant outcomes than their actual chronological age. Indeed, how old people feel does predict mortality hazards, and health-related measures such as walking speed may account for this association. In the present study, we extended this line of work by investigating whether subjective age also predicts walking speed and running speed in daily life or whether the predictive effects of subjective age for behavior manifest only within a controlled performance situation...
December 2018: European Journal of Ageing
Dominika Seblova, Maria Lopez Quiroga, Stefan Fors, Kristina Johnell, Martin Lövdén, Antonio Ponce de Leon, Anna Christina Svensson, Susanne Wicks, Anton Lager
Background: The continuous growth of the current dementia epidemic is contingent on the stability of age- and sex-specific trends over time. However, recent evidence suggests declining or stable trends. The aim of this study was to evaluate the real-world changes in the burden of dementia in older adults in Sweden from 1987 to 2016 by estimating age- and sex-specific incidence of dementia diagnosis in hospital inpatient records (dementia incidence). Differences in trends by sex, age, and educational levels were also examined...
2018: Clinical Epidemiology
Anne Postler, Andres Luque Ramos, Jens Goronzy, Klaus-Peter Günther, Toni Lange, Jochen Schmitt, Angela Zink, Falk Hoffmann
Objective: Osteoarthritis (OA) is highly prevalent throughout the world, especially in the elderly population, and is strongly associated with patients' frailty. However, little is known about the prevalence and treatment of OA in elderly patients in routine clinical care in Germany. Materials and methods: As a part of Linking Patient-Reported Outcomes with CLAIms Data for Health Services Research in Rheumatology (PROCLAIR), a cross-sectional study using claims data from a large Germany statutory health insurance (BARMER) was conducted...
2018: Clinical Interventions in Aging
Tomonori Iwata, Kazunari Honma, Hideyuki Hanano, Ayana Kadokura, Eiichiro Nagata, Shunya Takizawa
BACKGROUND: Embolic stroke of undetermined source has not been thoroughly investigated in older patients. In this study, we investigated the features of this condition in patients greater than or equal to 80 years of age. METHODS: All patients with acute ischemic stroke in our hospital underwent diffusion-weighted imaging, magnetic resonance angiography, T2-weighted imaging, and fluid-attenuated inversion recovery sequence imaging. Embolic stroke of undetermined source was defined as a radiologically confirmed nonlacunar brain infarct on diffusion-weighted imaging without (1) extracranial or intracranial atherosclerosis causing greater than or equal to 50% luminal stenosis in arteries supplying the ischemic area, (2) major-risk cardioembolic source, and (3) any other specific cause of stroke...
October 24, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Antonia Scobie, Sanch Kanagarajah, Ross J Harris, Lisa Byrne, Corinne Amar, Kathie Grant, Gauri Godbole
Listeriosis is a foodborne illness that can result in septicaemia, Central Nervous System (CNS) disease, foetal loss and death in high risk patients. OBJECTIVES: To analyse the demographic trends, clinical features and treatment of non-perinatal listeriosis cases over a ten year period and identify mortality-associated risk factors. METHODS: Reported laboratory-confirmed non-pregnancy associated cases of listeriosis between 2006 and 2015 in England were included and retrospectively analysed...
December 5, 2018: Journal of Infection
Eleuterio A Sánchez-Romero, Daniel Pecos-Martín, Cesar Calvo-Lobo, David García-Jiménez, Victoria Ochoa-Sáez, Verónica Burgos-Caballero, Josué Fernández-Carnero
BACKGROUND: A source of myofascial pain and myofascial trigger points (MTrPs) in muscles of the knee area could play a crucial role in the management of pain in osteoarthritis patients. The aim of this study was to describe and compare demographic, clinical and myofascial pain syndrome characteristics in older adults with knee osteoarthritis by sex and age distribution. METHODS: A cross-sectional study was carried out. 114 patients with osteoarthritis were recruited in older-adult care centers...
December 6, 2018: Knee
Ling-Shan Syue, Hung-Jen Tang, Yuan-Pin Hung, Po-Lin Chen, Chia-Wen Li, Ming-Chi Li, Pei-Fang Tsai, Ching-Chuan Liu, Nan-Yao Lee, Wen-Chien Ko
BACKGROUND: Dengue is an important mosquito-borne tropical viral disease and dual infection, though rare, has been regarded as a risk factor for severe disease and mortality. However, few studies focused on bloodstream infections (BSIs) and empirical antibiotic therapy rarely addressed. METHODS: Dengue patients with concurrent or subsequent BSIs between July 1 and December 31, 2015 were included. Clinical information, laboratory data, and drug susceptibility data were collected...
November 23, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Sabina Chiaretti, Robin Foà
Management of older patients - defined by convention above the age of 60 years, but varying widely within study groups - with acute lymphoblastic leukemia (ALL) is still a challenge. The complete remission (CR) rate in these patients is lower than in other age groups and the percentage of deaths in induction or in CR remains high, ranging from 7 to 40%. Overall survival rates do not exceed 30%, depending on the age group included in the different trials group and on the follow-up duration. These unsatisfactory results are sustained by the fact that pre-existing comorbidities often hamper treatment delivery and if treatment intensification improves the CR rates it also increases toxicity and the percentage of deaths...
December 2018: European Journal of Internal Medicine
Yu-Ting Yang, Ai-Long Huang, Yao Zhao
BACKGROUND & AIMS: After nearly 30 years of immunization, there is little known about the prevalence of hepatitis B core antibody (anti-HBc) in Chinese children. The clinical significance of anti-HBc would be more and more important. In this study, we had tried to analyse the prevalence of anti-HBc in vaccinated Chinese children, exploring the post-immunization status based on a large sample sized investigation. METHODS: Proportions of anti-HBc were analysed among 215,627 hospitalized Chinese children immunized with HBV vaccination in this study...
December 4, 2018: Vaccine
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