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Osteosarcopenia

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https://www.readbyqxmd.com/read/30149984/body-composition-igf1-status-and-physical-functionality-in-nonagenarians-implications-for-osteosarcopenia
#1
Eleonora Poggiogalle, Katie E Cherry, L Joseph Su, Sangkyu Kim, Leann Myers, David A Welsh, S Michal Jazwinski, Eric Ravussin
OBJECTIVES: Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old. SETTING AND PARTICIPANTS: Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included. MEASURES: The definition of sarcopenia was based on appendicular lean mass (ALM)...
August 24, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/30032209/does-combined-osteopenia-osteoporosis-and-sarcopenia-confer-greater-risk-of-falls-and-fracture-than-either-condition-alone-in-older-men-the-concord-health-and-ageing-in-men-project
#2
David Scott, Markus Seibel, Robert Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Louise M Waite, Vasant Hirani
Background: It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so called "osteosarcopenia") are at greater risk of falls and fractures than those with either condition alone. Methods: 1,575 community-dwelling men aged ≥70 years had appendicular lean mass, total hip and lumbar spine bone mineral density (BMD) determined by dual-energy X-ray absorptiometry, and completed hand grip strength and gait speed tests. Osteopenia/osteoporosis was defined as a T-score at any site ≤-1...
July 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/30003169/the-impact-of-probiotics-administration-on-glycemic-control-body-composition-gut-microbiome-mitochondria-and-other-hormonal-signals-in-adolescents-with-prediabetes-a-randomized-controlled-trial-study-protocol
#3
Charikleia Stefanaki, Flora Bacopoulou, Athanasios Michos
Background: Recent studies have demonstrated that a significant proportion of adolescents exhibit abdominal obesity in early-middle adolescence, and impaired glucose metabolism. Dysregulation of glucose metabolism is aggravated by the existing osteosarcopenia not only in obese but also in overweight youth. Biochemical inflammation, derived from glucose metabolism dysregulation, in combination with increased stress levels lead to the accumulation of reactive oxygen species, also known as ROS, which seem to afflict the integrity of the gastrointestinal wall, gut mucosa, and commensal, intestinal gut microflora...
September 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29903644/high-parathyroid-hormone-levels-are-associated-with-osteosarcopenia-in-older-individuals-with-a-history-of-falling
#4
Pushpa Suriyaarachchi, Fernando Gomez, Carmen L Curcio, Derek Boersma, Lavanya Murthy, Vivian Grill, Gustavo Duque
OBJECTIVES: The combination of osteopenia/osteoporosis and sarcopenia (osteosarcopenia) defines a diagnostic subset of individuals at higher risk of falls, fractures and institutionalization. In this study we aimed to assess the potential role of high serum levels of parathyroid hormone (PTH) in osteosarcopenia. We hypothesized that a high PTH level is one of the major determinants of this syndrome. STUDY DESIGN: Cross-sectional study in 400 subjects (mean age = 79, 65% women) assessed between 2009 and 2014 at the Falls and Fractures Clinic, Nepean Hospital (Penrith, Australia)...
July 2018: Maturitas
https://www.readbyqxmd.com/read/29858868/chronic-stress-and-body-composition-disorders-implications-for-health-and-disease
#5
REVIEW
Charikleia Stefanaki, Panagiota Pervanidou, Dario Boschiero, George P Chrousos
Recent studies have suggested that body composition is key to health and disease. First, fat tissue is a complex, essential, and highly active metabolic and endocrine organ that responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine, metabolic, and immune functions. Second, skeletal muscle mass is an important predictor of health in adult life, while severe mass loss has been associated with the frailty of old age...
March 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29727228/osteosarcopenia
#6
James Paintin, Cyrus Cooper, Elaine Dennison
Osteosarcopenia is a newly described syndrome that describes the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. Osteoporosis, a condition of low bone mass and micro-architectural deterioration of bone, and sarcopenia, the loss of muscle mass, strength and function, often co-exist in a frail subset of the elderly population, leading to significantly worsened outcomes than seen in either condition alone. These include a greater risk of falls, fractures and institutionalization, and significant socioeconomic costs...
May 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29564300/review-of-epidemiology-diagnosis-and-treatment-of-osteosarcopenia-in-korea
#7
REVIEW
Jun-Il Yoo, Yong-Chan Ha
Sarcopenia was listed in the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) as M62.84, on October 1, 2016. Sarcopenia is primarily associated with metabolic diseases, such as diabetes, obesity, and cachexia, as well as chronic renal failure, congestive heart failure, and chronic obstructive pulmonary disease. Sarcopenia is also significantly associated with osteoporosis in elderly populations and the combined disease is defined as osteosarcopenia. Several studies have confirmed that sarcopenia and osteoporosis (osteosarcopenia) share common risk factors and biological pathways...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29541625/diagnostic-imaging-of-osteoporosis-and-sarcopenia-a-narrative-review
#8
REVIEW
Carmelo Messina, Gabriele Maffi, Jacopo Antonino Vitale, Fabio Massimo Ulivieri, Giuseppe Guglielmi, Luca Maria Sconfienza
Osteoporosis and sarcopenia represent two major health problems with an increasing prevalence in the elderly population. The correlation between these diseases has been widely reported, leading to the development of the term "osteosarcopenia" to diagnose those patients suffering from both diseases. Several imaging methods for the diagnosis and management of osteoporosis exist, with dual-energy X-ray absorptiometry (DXA) being the most commonly used for measuring bone mineral density (BMD). Imaging technique other than DXA is represented by conventional radiography, computed tomography (CT) and ultrasound (US)...
February 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29318794/osteosarcopenia-in-patients-with-hip-fracture-is-related-with-high-mortality
#9
Jun Il Yoo, Hyunho Kim, Yong Chan Ha, Hyuck Bin Kwon, Kyung Hoi Koo
BACKGROUND: This study evaluated the prevalence of osteosarcopenia, as well as the relationship between one-year mortality and osteosarcopenia, as defined by criteria of the Asian Working Group on Sarcopenia in patients age 60 or older with hip fracture. METHODS: A total of 324 patients age 60 years or older with hip fracture were enrolled in this retrospective observational study. The main outcome measure was the prevalence of osteosarcopenia, as well as the relationship between osteosarcopenia and 1-year mortality...
January 22, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29203402/lamin-a-expression-in-circulating-osteoprogenitors-as-a-potential-biomarker-for-frailty-the-nepean-osteoporosis-and-frailty-nof-study
#10
Ahmed Al Saedi, Piumali Gunawardene, Sandra Bermeo, Sara Vogrin, Derek Boersma, Steven Phu, Lakshman Singh, Pushpa Suriyaarachchi, Gustavo Duque
Lamin A is a protein of the nuclear lamina. Low levels of lamin A expression are associated with osteosarcopenia in mice. In this study, we hypothesized that low lamin A expression is also associated with frailty in humans. We aimed to develop a non-invasive method to quantify lamin A expression in epithelial and circulating osteoprogenitor (COP) cells, and to determine the relationship between lamin A expression and frailty in older individuals. COP cells and buccal swabs were obtained from 66 subjects (median age 74; 60% female; 26 non-frail, 23 pre-frail, and 17 frail) participating at the Nepean Osteoporosis and Frailty (NOF) Study...
February 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29101922/osteosarcopenia-a-new-geriatric-syndrome
#11
Ebrahim Bani Hassan, Gustavo Duque
BACKGROUND: Longevity, the increase in the ageing population and a lifestyle of minimal physical activity come with a hefty price. Consequently, two diseases are increasingly becoming a concern for the welfare of patients and the health industry: osteoporosis and sarcopenia. These conditions are usually interrelated through several mechanisms and metabolic pathways, and comprise a syndrome called osteosarcopenia. OBJECTIVE: As patients with osteosarcopenia represent an important subset of frail individuals at higher risk of institutionalisation, falls and fractures, the aim of this review is to further familiarise general practitioners with osteosarcopenia as a new geriatric syndrome that requires early diagnosis and effective therapeutic interventions...
November 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28806178/vitamin-d-and-osteosarcopenia-an-update-from-epidemiological-studies
#12
Olivier Bruyère, Etienne Cavalier, Jean-Yves Reginster
PURPOSE OF REVIEW: The review summarizes recent epidemiological studies that examined the relationship between osteoporosis and sarcopenia to assess the impact of vitamin D status or supplementation on health outcomes related to these two medical conditions. RECENT FINDINGS: Osteoporosis and sarcopenia are major public health problems, but whether these two diseases should be considered alone or combined into a single condition is not clear. No consensual definition of osteosarcopenia is largely accepted...
November 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28742506/bioimpedance-analysis-vs-dexa-as-a-screening-tool-for-osteosarcopenia-in-lean-overweight-and-obese-caucasian-postmenopausal-females
#13
Melpomeni Peppa, Charikleia Stefanaki, Athanasios Papaefstathiou, Dario Boschiero, George Dimitriadis, George P Chrousos
BACKGROUND-OBJECTIVES: We aimed at evaluating the efficiency of a newly developed, advanced Bioimpedance Analysis (BIA-ACC®) device as a screening tool for determining the degree of obesity and osteosarcopenia in postmenopausal women with normal or decreased bone density determined by Dual-Energy X-Ray absorptiometry (DEXA) in a representative sample of Greek postmenopausal women. METHODS: This is a single-gate cross-sectional study of body composition measured by BIA-ACC® and DEXA...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28733716/osteosarcopenia-where-bone-muscle-and-fat-collide
#14
REVIEW
H P Hirschfeld, R Kinsella, G Duque
As the world's population ages, the prevalence of chronic diseases increases. Sarcopenia and osteoporosis are two conditions that are associated with aging, with similar risk factors that include genetics, endocrine function, and mechanical factors. Additionally, bone and muscle closely interact with each other not only anatomically, but also chemically and metabolically. Fat infiltration, a phenomenon observed in age-related bone and muscle loss, is highly prevalent and more severe in sarcopenic and osteoporotic subjects...
October 2017: Osteoporosis International
https://www.readbyqxmd.com/read/27622887/androgens-have-antiresorptive-effects-on-trabecular-disuse-osteopenia-independent-from-muscle-atrophy
#15
Michaël R Laurent, Ferran Jardí, Vanessa Dubois, Dieter Schollaert, Rougin Khalil, Evelien Gielen, Geert Carmeliet, Frank Claessens, Dirk Vanderschueren
Aging hypogonadal men are at increased risk of osteoporosis and sarcopenia. Testosterone is a potentially appealing strategy to prevent simultaneous bone and muscle loss. The androgen receptor (AR) mediates antiresorptive effects on trabecular bone via osteoblast-lineage cells, as well as muscle-anabolic actions. Sex steroids also modify the skeletal response to mechanical loading. However, it is unclear whether the effects of androgens on bone remain effective independent of mechanical stimulation or rather require indirect androgen effects via muscle...
December 2016: Bone
https://www.readbyqxmd.com/read/27434725/healthy-overweight-obese-youth-early-osteosarcopenic-obesity-features
#16
Charikleia Stefanaki, Melpomeni Peppa, Dario Boschiero, George P Chrousos
BACKGROUND: Osteosarcopenic obesity was recently described as a variant phenotype of obesity, mainly observed in old age. This nested case-control study was performed to detect the differences in body composition between young, healthy overweight/obese and healthy lean populations of both genders. Our null hypothesis was that except for the fat mass, there would be absence of body composition differences, namely skeletal muscle and bone masses, between the groups. METHODS: We used an advanced bio-impedance device to determine the body composition and measured circulating CRP (hsCRP) and diurnal salivary cortisol concentrations, as indices of inflammation and chronic stress, respectively...
September 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26563287/osteosarcopenia-is-more-than-sarcopenia-and-osteopenia-alone
#17
RANDOMIZED CONTROLLED TRIAL
Michael Drey, Cornel C Sieber, Thomas Bertsch, Jürgen M Bauer, Ralf Schmidmaier
BACKGROUND: Sarcopenia and osteopenia/osteoporosis show a high prevalence in old age and incur a high risk for falls, fractures, and further functional decline. Physical performance and bone metabolism in patients suffering from the so-called osteosarcopenia-the combination of sarcopenia and osteopenia-are currently still unknown. AIMS: This study investigates physical performance and bone metabolism in osteosarcopenic, prefrail, community-dwelling older adults...
October 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/26506009/muscle-bone-interactions-from-experimental-models-to-the-clinic-a-critical-update
#18
REVIEW
Michaël R Laurent, Vanessa Dubois, Frank Claessens, Sabine M P Verschueren, Dirk Vanderschueren, Evelien Gielen, Ferran Jardí
Bone is a biomechanical tissue shaped by forces from muscles and gravitation. Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco-osteoporosis) is seen in ageing, numerous clinical situations including after stroke or paralysis, in neuromuscular dystrophies, glucocorticoid excess, or in association with vitamin D, growth hormone/insulin like growth factor or sex steroid deficiency, as well as in spaceflight. Physical exercise may be beneficial in these situations, but further work is still needed to translate acceptable and effective biomechanical interventions like vibration therapy from animal models to humans...
September 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/25512216/phenotype-of-osteosarcopenia-in-older-individuals-with-a-history-of-falling
#19
COMPARATIVE STUDY
Ya Ruth Huo, Pushpa Suriyaarachchi, Fernando Gomez, Carmen L Curcio, Derek Boersma, Susan W Muir, Manuel Montero-Odasso, Piumali Gunawardene, Oddom Demontiero, Gustavo Duque
OBJECTIVES: In older persons, the combination of osteopenia/osteoporosis and sarcopenia has been proposed as a subset of frailer individuals at higher risk of institutionalization, falls, and fractures. However, the particular clinical, biochemical, and functional characteristics of the osteosarcopenic (OS) patients remain unknown. In this study, we used a clinical definition of osteosarcopenia aiming to determine the clinical, functional, and biochemical features that are unique to these patients within a population of older people who fall...
April 2015: Journal of the American Medical Directors Association
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