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Osteosarcopenia

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https://www.readbyqxmd.com/read/30513557/effects-of-resistance-exercise-on-bone-health
#1
REVIEW
A Ram Hong, Sang Wan Kim
The prevalence of chronic diseases including osteoporosis and sarcopenia increases as the population ages. Osteoporosis and sarcopenia are commonly associated with genetics, mechanical factors, and hormonal factors and primarily associated with aging. Many older populations, particularly those with frailty, are likely to have concurrent osteoporosis and sarcopenia, further increasing their risk of disease-related complications. Because bones and muscles are closely interconnected by anatomy, metabolic profile, and chemical components, a diagnosis should be considered for both sarcopenia and osteoporosis, which may be treated with optimal therapeutic interventions eliciting pleiotropic effects on both bones and muscles...
December 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30487671/relationship-between-osteosarcopenic-obesity-and-dietary-inflammatory-index-in-postmenopausal-korean-women-2009-to-2011-korea-national-health-and-nutrition-examination-surveys
#2
Susan Park, Woori Na, Cheongmin Sohn
Osteosarcopenic obesity syndrome is a condition including osteopenia, sarcopenia and obesity. A pro-inflammatory dietary pattern has been reported to be associated with obesity and osteoporosis. However, studies on the association of dietary inflammatory index with osteosarcopenic obesity syndrome in the Korean population are lacking. The aim of this study was to analyze the relationship between dietary inflammatory index and osteosarcopenic obesity syndrome among Korean postmenopausal women. We analyzed the 2009-2011 Korea National Health and Nutrition Examination Survey, consisting of 1,344 postmenopausal women aged 50 years or older...
November 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30471719/-osteosarcopenia-a-narrative-review
#3
REVIEW
Bernardo Cedeno-Veloz, Pedro López-Dóriga Bonnardeauxa, Gustavo Duque
Osteosarcopenia is a phenotype resulting from the combination of sarcopenia and low bone mineral density. Based on the relationship between bone and muscle, this phenotype is associated with a higher risk of falls, fractures, dependence, and health care costs than its individual components. Given its characteristics, it can be considered as a new geriatric syndrome. Therefore, understanding its pathophysiology and diagnosis, as well as its non-pharmacological and pharmacological management is a task of great importance...
November 21, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/30425007/assessment-of-bone-and-muscle-measurements-by-peripheral-quantitative-computed-tomography-in-geriatric-patients
#4
M Drey, M Henkel, S Petermeise, S Weiß, U Ferrari, M Rottenkolber, R Schmidmaier
The loss of bone and muscle mass increases the risk of osteoporotic fractures. Dual energy X-ray absorptiometry (DXA) loses sensitivity in older age. The purpose of this study was to evaluate bone and muscle measurements of peripheral quantitative computed tomography (pQCT) in a geriatric cohort with osteoporosis. Bone mineral density and muscle area of 168 patients aged 65 years and older (76.3 ± 6.5) were measured with pQCT at distal forearm additionally to an osteoporosis assessment consisting of anamnesis, blood test and DXA of lumbar spine and hip...
October 12, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/30402799/is-there-a-definition-of-low-lean-mass-that-captures-the-associated-low-bone-mineral-density-a-cross-sectional-study-of-80-men-with-hip-fracture
#5
Marco Di Monaco, Carlotta Castiglioni, Edoardo Milano, Giuseppe Massazza
BACKGROUND AND AIMS: Subjects with osteosarcopenia, the concurrent presence of sarcopenia and osteoporosis, have prognostic disadvantages and can benefit from treatments targeted at both the conditions. Our aim was to elucidate whether the available definitions of low appendicular lean mass (aLM) capture or not the men with associated low bone mineral density (BMD) following a hip fracture. METHODS: 80 men admitted to our rehabilitation hospital underwent a dual-energy X-ray absorptiometry scan 19...
December 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/30149984/body-composition-igf1-status-and-physical-functionality-in-nonagenarians-implications-for-osteosarcopenia
#6
Eleonora Poggiogalle, Katie E Cherry, L Joseph Su, Sangkyu Kim, Leann Myers, David A Welsh, S Michal Jazwinski, Eric Ravussin
OBJECTIVES: Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old. SETTING AND PARTICIPANTS: Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included. MEASURES: The definition of sarcopenia was based on appendicular lean mass (ALM)...
August 24, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/30032209/does-combined-osteopenia-osteoporosis-and-sarcopenia-confer-greater-risk-of-falls-and-fracture-than-either-condition-alone-in-older-men-the-concord-health-and-ageing-in-men-project
#7
David Scott, Markus Seibel, Robert Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Louise M Waite, Vasant Hirani
Background: It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so called "osteosarcopenia") are at greater risk of falls and fractures than those with either condition alone. Methods: 1,575 community-dwelling men aged ≥70 years had appendicular lean mass, total hip and lumbar spine bone mineral density (BMD) determined by dual-energy X-ray absorptiometry, and completed hand grip strength and gait speed tests. Osteopenia/osteoporosis was defined as a T-score at any site ≤-1...
July 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/30003169/the-impact-of-probiotics-administration-on-glycemic-control-body-composition-gut-microbiome-mitochondria-and-other-hormonal-signals-in-adolescents-with-prediabetes-a-randomized-controlled-trial-study-protocol
#8
Charikleia Stefanaki, Flora Bacopoulou, Athanasios Michos
Background: Recent studies have demonstrated that a significant proportion of adolescents exhibit abdominal obesity in early-middle adolescence, and impaired glucose metabolism. Dysregulation of glucose metabolism is aggravated by the existing osteosarcopenia not only in obese but also in overweight youth. Biochemical inflammation, derived from glucose metabolism dysregulation, in combination with increased stress levels lead to the accumulation of reactive oxygen species, also known as ROS, which seem to afflict the integrity of the gastrointestinal wall, gut mucosa, and commensal, intestinal gut microflora...
September 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29903644/high-parathyroid-hormone-levels-are-associated-with-osteosarcopenia-in-older-individuals-with-a-history-of-falling
#9
Pushpa Suriyaarachchi, Fernando Gomez, Carmen L Curcio, Derek Boersma, Lavanya Murthy, Vivian Grill, Gustavo Duque
OBJECTIVES: The combination of osteopenia/osteoporosis and sarcopenia (osteosarcopenia) defines a diagnostic subset of individuals at higher risk of falls, fractures and institutionalization. In this study we aimed to assess the potential role of high serum levels of parathyroid hormone (PTH) in osteosarcopenia. We hypothesized that a high PTH level is one of the major determinants of this syndrome. STUDY DESIGN: Cross-sectional study in 400 subjects (mean age = 79, 65% women) assessed between 2009 and 2014 at the Falls and Fractures Clinic, Nepean Hospital (Penrith, Australia)...
July 2018: Maturitas
https://www.readbyqxmd.com/read/29858868/chronic-stress-and-body-composition-disorders-implications-for-health-and-disease
#10
REVIEW
Charikleia Stefanaki, Panagiota Pervanidou, Dario Boschiero, George P Chrousos
Recent studies have suggested that body composition is key to health and disease. First, fat tissue is a complex, essential, and highly active metabolic and endocrine organ that responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine, metabolic, and immune functions. Second, skeletal muscle mass is an important predictor of health in adult life, while severe mass loss has been associated with the frailty of old age...
March 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29727228/osteosarcopenia
#11
James Paintin, Cyrus Cooper, Elaine Dennison
Osteosarcopenia is a newly described syndrome that describes the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. Osteoporosis, a condition of low bone mass and micro-architectural deterioration of bone, and sarcopenia, the loss of muscle mass, strength and function, often co-exist in a frail subset of the elderly population, leading to significantly worsened outcomes than seen in either condition alone. These include a greater risk of falls, fractures and institutionalization, and significant socioeconomic costs...
May 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29564300/review-of-epidemiology-diagnosis-and-treatment-of-osteosarcopenia-in-korea
#12
REVIEW
Jun-Il Yoo, Yong-Chan Ha
Sarcopenia was listed in the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) as M62.84, on October 1, 2016. Sarcopenia is primarily associated with metabolic diseases, such as diabetes, obesity, and cachexia, as well as chronic renal failure, congestive heart failure, and chronic obstructive pulmonary disease. Sarcopenia is also significantly associated with osteoporosis in elderly populations and the combined disease is defined as osteosarcopenia. Several studies have confirmed that sarcopenia and osteoporosis (osteosarcopenia) share common risk factors and biological pathways...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29541625/diagnostic-imaging-of-osteoporosis-and-sarcopenia-a-narrative-review
#13
REVIEW
Carmelo Messina, Gabriele Maffi, Jacopo Antonino Vitale, Fabio Massimo Ulivieri, Giuseppe Guglielmi, Luca Maria Sconfienza
Osteoporosis and sarcopenia represent two major health problems with an increasing prevalence in the elderly population. The correlation between these diseases has been widely reported, leading to the development of the term "osteosarcopenia" to diagnose those patients suffering from both diseases. Several imaging methods for the diagnosis and management of osteoporosis exist, with dual-energy X-ray absorptiometry (DXA) being the most commonly used for measuring bone mineral density (BMD). Imaging technique other than DXA is represented by conventional radiography, computed tomography (CT) and ultrasound (US)...
February 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29318794/osteosarcopenia-in-patients-with-hip-fracture-is-related-with-high-mortality
#14
Jun Il Yoo, Hyunho Kim, Yong Chan Ha, Hyuck Bin Kwon, Kyung Hoi Koo
BACKGROUND: This study evaluated the prevalence of osteosarcopenia, as well as the relationship between one-year mortality and osteosarcopenia, as defined by criteria of the Asian Working Group on Sarcopenia in patients age 60 or older with hip fracture. METHODS: A total of 324 patients age 60 years or older with hip fracture were enrolled in this retrospective observational study. The main outcome measure was the prevalence of osteosarcopenia, as well as the relationship between osteosarcopenia and 1-year mortality...
January 22, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29203402/lamin-a-expression-in-circulating-osteoprogenitors-as-a-potential-biomarker-for-frailty-the-nepean-osteoporosis-and-frailty-nof-study
#15
Ahmed Al Saedi, Piumali Gunawardene, Sandra Bermeo, Sara Vogrin, Derek Boersma, Steven Phu, Lakshman Singh, Pushpa Suriyaarachchi, Gustavo Duque
Lamin A is a protein of the nuclear lamina. Low levels of lamin A expression are associated with osteosarcopenia in mice. In this study, we hypothesized that low lamin A expression is also associated with frailty in humans. We aimed to develop a non-invasive method to quantify lamin A expression in epithelial and circulating osteoprogenitor (COP) cells, and to determine the relationship between lamin A expression and frailty in older individuals. COP cells and buccal swabs were obtained from 66 subjects (median age 74; 60% female; 26 non-frail, 23 pre-frail, and 17 frail) participating at the Nepean Osteoporosis and Frailty (NOF) Study...
February 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29101922/osteosarcopenia-a-new-geriatric-syndrome
#16
Ebrahim Bani Hassan, Gustavo Duque
BACKGROUND: Longevity, the increase in the ageing population and a lifestyle of minimal physical activity come with a hefty price. Consequently, two diseases are increasingly becoming a concern for the welfare of patients and the health industry: osteoporosis and sarcopenia. These conditions are usually interrelated through several mechanisms and metabolic pathways, and comprise a syndrome called osteosarcopenia. OBJECTIVE: As patients with osteosarcopenia represent an important subset of frail individuals at higher risk of institutionalisation, falls and fractures, the aim of this review is to further familiarise general practitioners with osteosarcopenia as a new geriatric syndrome that requires early diagnosis and effective therapeutic interventions...
November 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28806178/vitamin-d-and-osteosarcopenia-an-update-from-epidemiological-studies
#17
Olivier Bruyère, Etienne Cavalier, Jean-Yves Reginster
PURPOSE OF REVIEW: The review summarizes recent epidemiological studies that examined the relationship between osteoporosis and sarcopenia to assess the impact of vitamin D status or supplementation on health outcomes related to these two medical conditions. RECENT FINDINGS: Osteoporosis and sarcopenia are major public health problems, but whether these two diseases should be considered alone or combined into a single condition is not clear. No consensual definition of osteosarcopenia is largely accepted...
November 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28742506/bioimpedance-analysis-vs-dexa-as-a-screening-tool-for-osteosarcopenia-in-lean-overweight-and-obese-caucasian-postmenopausal-females
#18
Melpomeni Peppa, Charikleia Stefanaki, Athanasios Papaefstathiou, Dario Boschiero, George Dimitriadis, George P Chrousos
BACKGROUND-OBJECTIVES: We aimed at evaluating the efficiency of a newly developed, advanced Bioimpedance Analysis (BIA-ACC®) device as a screening tool for determining the degree of obesity and osteosarcopenia in postmenopausal women with normal or decreased bone density determined by Dual-Energy X-Ray absorptiometry (DEXA) in a representative sample of Greek postmenopausal women. METHODS: This is a single-gate cross-sectional study of body composition measured by BIA-ACC® and DEXA...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28733716/osteosarcopenia-where-bone-muscle-and-fat-collide
#19
REVIEW
H P Hirschfeld, R Kinsella, G Duque
As the world's population ages, the prevalence of chronic diseases increases. Sarcopenia and osteoporosis are two conditions that are associated with aging, with similar risk factors that include genetics, endocrine function, and mechanical factors. Additionally, bone and muscle closely interact with each other not only anatomically, but also chemically and metabolically. Fat infiltration, a phenomenon observed in age-related bone and muscle loss, is highly prevalent and more severe in sarcopenic and osteoporotic subjects...
October 2017: Osteoporosis International
https://www.readbyqxmd.com/read/27622887/androgens-have-antiresorptive-effects-on-trabecular-disuse-osteopenia-independent-from-muscle-atrophy
#20
Michaël R Laurent, Ferran Jardí, Vanessa Dubois, Dieter Schollaert, Rougin Khalil, Evelien Gielen, Geert Carmeliet, Frank Claessens, Dirk Vanderschueren
Aging hypogonadal men are at increased risk of osteoporosis and sarcopenia. Testosterone is a potentially appealing strategy to prevent simultaneous bone and muscle loss. The androgen receptor (AR) mediates antiresorptive effects on trabecular bone via osteoblast-lineage cells, as well as muscle-anabolic actions. Sex steroids also modify the skeletal response to mechanical loading. However, it is unclear whether the effects of androgens on bone remain effective independent of mechanical stimulation or rather require indirect androgen effects via muscle...
December 2016: Bone
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