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https://www.readbyqxmd.com/read/30513228/preoperative-endoscopic-clipping-for-rectal-tumor-localization-in-laparoscopic-anterior-resection
#1
Jong Hee Hyun, Kyung Su Han, Byung Chang Kim, Chang Won Hong, Jae Hwan Oh, Sung Chan Park, Min Jung Kim, Dae Kyung Sohn
BACKGROUND: Increasing the number of rectal tumors undergoing preoperative chemoradiotherapy or endoscopic resection has increased the importance of accurate tumor localization. This study describes the preoperative endoscopic clipping method for the localization of rectal tumors and evaluated the feasibility of this technique. MATERIAL AND METHODS: A total of 109 patients underwent preoperative endoscopic clipping to localize non-palpable rectal adenocarcinomas, which were located within 10 cm from the anal verge...
December 4, 2018: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/30505815/prospective-performance-of-the-prostate-health-index-in-prostate-cancer-detection-in-the-first-prostate-biopsy-of-men-with-a-total-prostatic-specific-antigen-of-4-10-ng-ml-and-negative-digital-rectal-examination
#2
Supon Sriplakich, Bannakij Lojanapiwat, Wilaiwan Chongruksut, Siwat Phuriyaphan, Pruit Kitirattakarn, Jakrit Jun-Ou, Akara Amantakul
Background: The disadvantage of using total serum prostatic specific antigen (PSA) test for detection of prostate cancer is that it has a low specificity. The low specificity of total PSA (tPSA) test leads to unnecessary prostate biopsies. In this prospective study, we assessed the serum tPSA, free PSA, p2PSA, and the Prostate Health Index (PHI) in the detection of prostate cancer in men with a tPSA of 4-10 ng/mL and a negative digital rectal examination (DRE). Materials and methods: 101 male outpatients with a serum PSA of 4-10 ng/mL and nonsuspicious DRE for prostate cancer who underwent first transrectal ultrasound with a prostate biopsy were recruited...
December 2018: Prostate International
https://www.readbyqxmd.com/read/30483762/microrna-30e-inhibits-adhesion-migration-invasion-and-cell-cycle-progression-of-prostate-cancer-cells-via-inhibition-of-the-activation-of-the-mapk-signaling-pathway-by-downregulating-chrm3
#3
Xin-Min Zheng, Peng Zhang, Man-Hua Liu, Ping Chen, Wei-Bing Zhang
Prostate cancer (PCa) testing is currently based on measurement of serum prostate‑specific antigen levels and digital rectal examination, which are limited by a low predictive value and the adverse effects associated with overdiagnosis and overtreatment. Recent studies have reported that the abnormal expression of microRNAs (miRNAs) is associated with the mechanism underlying the development of PCa. Thus, the aim of the present study was to investigate the effects of miR‑30e and its target gene, M3 muscarinic acetylcholine receptor (CHRM3), on the adhesion, migration, invasion and cell cycle distribution of PCa cells via the mitogen‑activated protein kinase (MAPK) signaling pathway...
November 26, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30458966/-prostate-cancer-screening-reasons-of-controversy
#4
Gauthier Delporte, Arnauld Villers, Nicolas Penel
We propose herein a short synthesis of evidence leading to deny organized screening of prostate cancer using PSA plus or minus rectal digital examination. Nevertheless, many scientific societies support opportunistic screening on basis of shared decision. Today, numerous proposals had been made to reduce the overdiagnosis and overtreatreatment.
November 17, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/30457246/diagnostic-value-of-cognitive-registration-multiparametric-magnetic-resonance-guided-biopsy-for-the-detection-of-prostate-cancer-after-initial-negative-biopsy
#5
Igor Tomašković, Ivan Pezelj, Karolina Bolanča Čulo, Luka Novosel, Sven Nikles, Miroslav Tomić, Ante Reljić, Josip Katušić, Matej Knežević, Matea Pirša, Božo Kruslin, Monika Ulamec, Boris Ružić
The aim of this prospective clinical study was to determine the detection rate of prostate cancers by multiparametric magnetic resonance and transrectal ultrasound (mpMRI-TRUS) cognitive fusion biopsies in patients with a previously negative TRUS-guided biopsy. Between 1 October 2016 and 1 July 2017, in 101 consecutive patients with elevated antigen (PSA) and/or positive digital rectal examination and after a negative first TRUS biopsy, a second, repeated prostate biopsy was performed. In 24 patients, cognitive fusion mpMRI-TRUS biopsy of the prostate with 8-10 system cores and 1-3 target biopsies was performed, in line with the European Association of Urology guidelines...
October 2018: Acta Clinica Croatica
https://www.readbyqxmd.com/read/30446447/free-hand-transperineal-prostate-biopsy-provides-acceptable-cancer-detection-and-minimizes-risk-of-infection-evolving-experience-with-a-10-sector-template
#6
Benjamin T Ristau, Matthew Allaway, Demetri Cendo, John Hart, Jason Riley, Vasil Parousis, Peter C Albertsen
INTRODUCTION AND OBJECTIVES: Free-hand transperineal prostate (fTP-Bx) biopsy offers an alternative to transrectal prostate biopsy (TRUS-Bx) in the diagnosis of prostate cancer. Our objectives were to determine whether fTP-Bx achieves cancer detection rates comparable to historic TRUS-Bx cohorts; to determine infectious and other complications associated with fTP-B; and to propose a standardized fTP-Bx template. PATIENTS AND METHODS: We present a single institution, retrospective review of fTP-Bx in 1,000 men with elevated prostate-specific antigen, abnormal digital rectal examination, or on an active surveillance protocol...
November 13, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/30430015/prognostic-and-predictive-value-of-interstitial-cells-of-cajal-populations-following-stapled-transanal-rectal-resection-starr-in-patients-with-obstructed-defecation-syndrome
#7
Hong-Cheng Lin, Hua-Xian Chen, Liang Huang, Ya-Xi Zhu, Qian Zhou, Juan Li, Yu-Jie Xu, Dong-Lin Ren, Jian-Ping Wang
Objective: The present study was designed to evaluate the functional outcome of stapled transanal rectal resection (STARR) and to examine the relationship between the population density of the interstitial cells of Cajal (ICC) and the efficacy of the STARR operation in the management of obstructed defecation syndrome (ODS) patients. Methods: Full-thickness rectal samples were obtained from 50 ODS patients who underwent STARR. Samples were analysed using ICC immunohistochemistry...
November 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/30426077/does-prostate-median-lobe-really-matter-for-greenlight-hps-laser-photovaporization-of-the-prostate
#8
Yohan Bodokh, Patrick Julien Treacy, Laetitia Imbert de la Phalecque, Matthieu Durand
Background: Benign prostatic hyperplasia (BPH) is a common pathology in elderly patients, inducing lower urinary tract symptoms. The treatment of BPH is first a medical option, then a surgical treatment, either by endoscopy or open surgery. We here report a case of GreenLight HPS™ laser photovaporization (PV) with an impaired maintenance of median lobe postoperatively, unimportant on functional results. Case Presentation: A 68-year-old man presented with lower urinary tract symptoms in the last 2 years, treated first by medicine with good response...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/30396635/a-multicentre-evaluation-of-the-role-of-the-prostate-health-index-phi-in-regions-with-differing-prevalence-of-prostate-cancer-adjustment-of-phi-reference-ranges-is-needed-for-european-and-asian-settings
#9
Peter K-F Chiu, Chi-Fai Ng, Axel Semjonow, Yao Zhu, Sébastien Vincendeau, Alain Houlgatte, Massimo Lazzeri, Giorgio Guazzoni, Carsten Stephan, Alexander Haese, Ilse Bruijne, Jeremy Yuen-Chun Teoh, Chi Ho Leung, Paola Casale, Chih Hung Chiang, Lincoln Guan-Lim Tan, Edmund Chiong, Chao Yuan Huang, Hsi Chin Wu, Daan Nieboer, Ding-Wei Ye, Chris H Bangma, Monique J Roobol
Asians have a lower incidence of prostate cancer (PC). We compared the performance of the Prostate Health Index (PHI) for 2488 men in different ethnic groups (1688 Asian and 800 European men from 9 sites) with PSA 2-20ng/ml and PHI test and transrectal ultrasound-guided biopsy results available. Of these, 1652 men had PSA 2-10ng/ml and a normal digital rectal examination and underwent initial biopsy. The proportions of PC (Gleason ≥6) and higher-grade PC (HGPC, Gleason ≥7) across different PHI ranges were compared...
November 2, 2018: European Urology
https://www.readbyqxmd.com/read/30386737/development-and-internal-validation-of-novel-nomograms-based-on-benign-prostatic-obstruction-related-parameters-to-predict-the-risk-of-prostate-cancer-at-first-prostate-biopsy
#10
Luigi Cormio, Luca Cindolo, Francesco Troiano, Michele Marchioni, Giuseppe Di Fino, Vito Mancini, Ugo Falagario, Oscar Selvaggio, Francesca Sanguedolce, Francesca Fortunato, Luigi Schips, Giuseppe Carrieri
The present study aimed to determine the ability of novel nomograms based onto readily-available clinical parameters, like those related to benign prostatic obstruction (BPO), in predicting the outcome of first prostate biopsy (PBx). To do so, we analyzed our Internal Review Board-approved prospectively-maintained PBx database. Patients with PSA>20 ng/ml were excluded because of their high risk of harboring prostate cancer (PCa). A total of 2577 were found to be eligible for study analyses. The ability of age, PSA, digital rectal examination (DRE), prostate volume (PVol), post-void residual urinary volume (PVR), and peak flow rate (PFR) in predicting PCa and clinically-significant PCa (CSPCa)was tested by univariable and multivariable logistic regression analysis...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30386098/extragastrointestinal-stromal-tumor-of-prostate
#11
Sarah A Almagharbi, Yara A Fayoumi, Taha A Abdel-Meguid, Ahmed Abdelsalam, Rana Y Bokhary, Raed A Azhar
Gastrointestinal stromal tumors (GISTs) that originate outside the GI tract are extremely uncommon. In this case report, we describe a GIST of primary origin in the prostate gland of an 84-year-old male who presented with severe urinary retention at King Abdulaziz University Hospital in Saudi Arabia. Diagnosis was based on patient history, radiological studies, pathologic findings, and immunohistochemical data. Digital rectal examination revealed a hugely enlarged prostate encroaching upon the rectal lumen with a smooth and firm surface...
October 2018: Urology Annals
https://www.readbyqxmd.com/read/30374650/delta-radiomics-for-rectal-cancer-response-prediction-with-hybrid-0-35-t-magnetic-resonance-guided-radiotherapy-mrgrt-a-hypothesis-generating-study-for-an-innovative-personalized-medicine-approach
#12
Luca Boldrini, Davide Cusumano, Giuditta Chiloiro, Calogero Casà, Carlotta Masciocchi, Jacopo Lenkowicz, Francesco Cellini, Nicola Dinapoli, Luigi Azario, Stefania Teodoli, Maria Antonietta Gambacorta, Marco De Spirito, Vincenzo Valentini
The aim of this study was to evaluate the variation of radiomics features, defined as "delta radiomics", in patients undergoing neoadjuvant radiochemotherapy (RCT) for rectal cancer treated with hybrid magnetic resonance (MR)-guided radiotherapy (MRgRT). The delta radiomics features were then correlated with clinical complete response (cCR) outcome, to investigate their predictive power. A total of 16 patients were enrolled, and 5 patients (31%) showed cCR at restaging examinations. T2*/T1 MR images acquired with a hybrid 0...
October 29, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/30374274/clinical-considerations-for-intravesical-prostatic-protrusion-in-the-evaluation-and-management-of-bladder-outlet-obstruction-secondary-to-benign-prostatic-hyperplasia
#13
REVIEW
Jason Gandhi, Steven J Weissbart, Albert N Kim, Gunjan Joshi, Steven A Kaplan, Sardar Ali Khan
Background: Intravesical prostatic protrusion (IPP) is a manifestation of benign prostatic hyperplasia marked by overgrowth of the prostatic median lobe into the bladder, producing bladder outlet obstruction and related storage and voiding symptoms. Methods: A MEDLINE® database search of the current literature was guided using combination of "prostate" with the following terms: intravesical prostatic protrusion, bladder trabeculation, bladder outlet obstruction, lower urinary tract symptoms, alpha blockers, transrectal ultrasonography, and prostatectomy...
October 2018: Current Urology
https://www.readbyqxmd.com/read/30361408/prostate-cancer-diagnostic-pathway-is-a-one-stop-cognitive-mri-targeted-biopsy-service-a-realistic-goal-in-everyday-practice-a-pilot-cohort-in-a-tertiary-referral-centre-in-the-uk
#14
Edward James Bass, Alex Freeman, Charles Jameson, Shonit Punwani, Caroline M Moore, Manit Arya, Mark Emberton, Hashim Uddin Ahmed
OBJECTIVES: To evaluate the feasibility of a novel multiparametric MRI (mpMRI) and cognitive fusion transperineal targeted biopsy (MRTB) led prostate cancer (PCa) diagnostic service with regard to cancer detection and reducing time to diagnosis and treatment. DESIGN: Consecutive men being investigated for possible PCa under the UK 2-week wait guidelines. SETTING: Tertiary referral centre for PCa in the UK. PARTICIPANTS: Men referred with a raised prostate-specific antigen (PSA) or abnormal digital rectal examination between February 2015 and March 2016 under the UK 2-week rule guideline...
October 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/30343993/mobile-phone-apps-for-the-prediction-of-prostate-cancer-external-validation-of-the-coral-and-rotterdam-apps
#15
Cosimo De Nunzio, Riccardo Lombardo, Giorgia Tema, Fabiana Cancrini, Giorgio Ivan Russo, Rodrigo Chacon, Eduard Garcia-Cruz, Maria Jose Ribal, Giuseppe Morgia, Antonio Alcaraz, Andrea Tubaro
OBJECTIVE: To analyze the performance of two mobile phone apps-the Rotterdam prostate cancer risk app and the Coral app-in a cohort of patients undergoing prostate biopsies. METHODS: A consecutive series of men undergoing prostate biopsies were enrolled in two centers. Indications for prostate biopsy included abnormal prostate-specific antigen levels (PSA >4 ng/mL) and/or an abnormal digital rectal examination (DRE). Prostate cancer risk and high-grade prostate cancer risk were assessed using the Rotterdam prostate cancer risk app (iOS) and the Coral app (iOS)...
October 16, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30337786/brachial-plexopathy-in-carcinoma-of-the-prostate-an-uncommon-presentation-of-a-common-malignancy
#16
C Danny Darlington
Neurological presentation is rare in carcinoma prostate. Brachial plexopathy as the only manifestation of carcinoma prostate is very rare and has not been previously reported. We report an 88-year-old man who presented with new-onset paralysis of the right hand. Digital rectal examination revealed a hard, enlarged prostate and biopsy revealed adenocarcinoma of the prostate with a Gleason score of 7 (4 + 3) with perineural invasion. Computed tomography of the neck showed osteoblastic secondaries involving C6, C7, and T1 vertebrae with a paravertebral soft-tissue mass involving the right foramina of C6, C7, and T1 vertebra...
October 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/30317850/incidental-18-f-fdg-uptake-of-the-pubic-ramus-and-abdominal-muscles-due-to-athletic-pubalgia-during-acute-prostatitis
#17
Olivier Rager, Marlise Picarra, Emmanouil Astrinakis, Valentina Garibotto, Gaël Amzalag
A 23-year-old African native male patient presented with fever, lumbalgia and dysuria after returning from a trip to Togo. His physical examination revealed pain over the pubic symphysis and rectal tenderness on digital exam. The C-reactive protein (CRP) level was elevated along with positive blood and urinary cultures for methicillin-resistant Staphylococcus aureus . An magnetic resonance imaging that has been performed to rule out arthritis/osteomyelitis in the pubis revealed edema of the symphysis. An 18 F-FDG positron emission tomography/computed tomography supported the diagnosis of prostate infection and showed a focal uptake of the pubic symphysis, with diffuse hyper-metabolism of the insertions of the rectus abdominis and longus adductor muscles, corresponding to athletic pubalgia...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/30305152/advanced-colorectal-carcinoma-with-testicular-metastasis-in-an-adolescent-a-case-report
#18
Adarsh Pratap Singh, Amit Kumar, Anita Dhar, Shipra Agarwal, Sudhir Bhimaniya
BACKGROUND: Colorectal carcinoma in the pediatric age group is rare and tends to be very aggressive and present late, due to which it has a very poor prognosis. It may present with distant metastasis; however, metastasis to the testes is very rare and signifies an advanced stage of the disease. Surgery is the only effective modality to cure patients with localized colorectal carcinomas. However, statistics show a higher incidence of unresectable disease and a higher metastasis rate in childhood colorectal carcinomas...
October 11, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30300002/improving-diagnosis-of-primary-prostate-cancer-with-combined-68-ga-prostate-specific-membrane-antigen-hbed-cc-simultaneous-pet-and-multiparametric-mri-and-clinical-parameters
#19
Amarnath Jena, Rajesh Taneja, Sangeeta Taneja, Aru Singh, Venkatesh Kumar, Anshuman Agarwal, Narasimhan Subramanian
OBJECTIVE: The current study was designed to test the diagnostic performance of 68 Ga-prostate-specific membrane antigen (PSMA) PET and multiparametric MRI along with clinical parameters in the characterization of prostatic lesions. MATERIALS AND METHODS: Eighty-two men with 63 malignant and 21 benign histologically proven prostate lesions who underwent complete clinical workup were included in this retrospective study. All patients underwent simultaneous whole-body 68 Ga-PSMA PET/MRI with dedicated multiparametric MRI...
December 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/30294801/rna-based-markers-in-biopsy-cores-with-atypical-small-acinar-proliferation-predictive-effect-of-t2e-fusion-positivity-and-mmp-2-upregulation-for-a-subsequent-prostate-cancer-diagnosis
#20
I Ezgi Eryilmaz, Berna Aytac Vuruskan, Onur Kaygısız, Unal Egeli, Berrin Tunca, Yakup Kordan, Gulsah Cecener
BACKGROUND: Atypical small acinar proliferation (ASAP) is a precursor lesion of prostate cancer (PC), and PC develops from this suspicious focus or an unsampled malignant gland nearby. However, PC-related molecular alterations that could guide the timing of repeat biopsies and help monitor PC risk in ASAP-diagnosed patients have not been investigated. The purpose of this study was to first investigate the expression of seven different PC-related RNAs that included serine 2 (TMPRSS2): erythroblastosis virus E26 oncogene homolog (ERG) gene (TMPRSS2-ERG, T2E) fusion, alpha-methylacyl-CoA racemase (AMACR), kallikrein related peptidase 3 (KLK3), androgen receptor (AR), prostate cancer specific antigen 3 (PCA3), and matrix metalloproteinases (MMP)-2 and 9...
October 7, 2018: Prostate
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