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Bone And Infections

Chen Liu, Man Han, Lei Zhao, Mengjie Zhu, Qinzhu Xu, Ying Song, Hui Wang
OBJECTIVE: This research aimed to explore the significance of low activity of ADAMTS-13 in acute myeloid leukemia (AML) after bone morrow transplantation (BMT), and to evaluate the disease progress and prognosis of the patients with low or normal activity of ADAMTS-13 after BMT. METHODS: 46 AML patients were included in our research. ADAMTS-13 activity was measured before BMT. Their medical indicators were recorded one month after BMT. All the patients were followed up and their disease progression was evaluated afterwards...
October 16, 2018: Hematology (Amsterdam, Netherlands)
Deepak Bushan Raina, Irfan Qayoom, David Larsson, Ming Hao Zheng, Ashok Kumar, Hanna Isaksson, Lars Lidgren, Magnus Tägil
A metaphyseal bone defect due to infection, tumor or fracture leads to loss of cancellous and cortical bone. An animal model separating the cancellous and cortical healing was used with a combination of a macroporous gelatin-calcium sulphate-hydroxyapatite (Gel-CaS-HA) biomaterial as a cancellous defect filler, and a thin collagen membrane (CM) guiding cortical bone regeneration. The membrane was immobilized with bone morphogenic protein-2 (rhBMP-2) to enhance the osteoinductive properties. The Gel-CaS-HA cancellous defect filler contained both rhBMP-2 and a bisphosphonate, (zoledronate = ZA) to prevent premature callus resorption induced by the pro-osteoclast effect of rhBMP-2 alone...
October 4, 2018: Biomaterials
Michael Kim, Ilya Rybkin, Harrison Smith, Jared Cooper, Michael Tobias
BACKGROUND: Hydrocephalus is an international disease process that is commonly treated surgically with a ventriculoperitoneal shunt. This device may be prone to malfunction, most commonly from obstruction, disconnection, or infection. CASE DESCRIPTION: A 35-year-old female with hydrocephalus and a ventriculoperitoneal shunt presented with altered mental status and imaging concerning for a shunt malfunction. Intraoperatively, she was found to have bone growing over and compressing the proximal occluder of the shunt valve, causing a mechanical obstruction...
October 12, 2018: World Neurosurgery
Shahryar Ahmadi, Thomas M Lawrence, Shawn Sahota, Cathy D Schleck, William S Harmsen, Robert H Cofield, John W Sperling
Background: The purpose of this study was to evaluate the value of perioperative tests for the diagnosis of infection in revision shoulder arthroplasty. Methods: A retrospective analysis was performed on 537 shoulder arthroplasties (429 patients) that underwent revision shoulder arthroplasty at our institution. Periprosthetic tissue cultures were positive in 169/537 surgeries. Results: White-blood cell count (WBC) was elevated in 3.8% revision arthroplasties...
September 2018: Archives of Bone and Joint Surgery
Aurélie Baldolli, Claire Daurel, Renaud Verdon, Arnaud de La Blanchardière
BACKGROUND: Mycobacterium avium complex (MAC) infection is often disseminated and mainly involves lymph nodes, spleen, liver or bone marrow. Peritonitis due to MAC infection (PMAC) is a very uncommon manifestation. METHODS: In this report, after describing the case of the only PMAC infection in our 10-year retrospective study, which occurred in an AIDS patient who was non-adherent to highly active antiretroviral therapy (HAART), we performed a systematic literature review of documented bacteriological PMAC...
October 14, 2018: Infectious Diseases
Kira Behrens, Warren S Alexander
Platelets are anuclear blood cells required for haemostasis and are implicated in other processes including inflammation and metastasis. Platelets are produced by megakaryocytes, specialized cells that are themselves generated by a process of controlled differentiation and maturation of bone-marrow stem and progenitor cells. This process of megakaryopoiesis involves the coordinated interplay of transcription factor-controlled cellular programming with extra-cellular cues produced locally in supporting niches or as circulating factors...
October 15, 2018: Growth Factors
B Palla-Rubio, N Araújo-Gomes, M Fernández-Gutiérrez, L Rojo, J Suay, M Gurruchaga, I Goñi
To avoid dental implant-related infections and to promote the osseointegration of titanium implants, the application of silicon and chitosan containing coatings is proposed. Silicon is a well-known osteogenic element and chitosan was selected to confer the antibacterial properties. The synthesis of hybrid silica-chitosan coatings using the sol-gel process is presented and the characterization using 29 Si-NMR to verify the correct formation of the network is discussed. The 13 C NMR spectroscopy was used to confirm the covalent union between chitosan and the silicon network...
January 1, 2019: Carbohydrate Polymers
Barbara J Boucher
Vitamin D deficiency is common, world-wide, but vitamin D repletion throughout life, and into older age, has accepted health benefits for bone. Many mechanisms through which vitamin D also benefits soft tissues are understood, and clinical evidence of such benefits is now accumulating, especially following re-analyses of trial data, which are revealing previously missed health benefits with correction of deficiency. Areas covered: The sources of vitamin D, its activation, mechanistic effects; problems of trials of supplementation for reducing health risks, the benefits shown for mortality, cardiovascular disease, infection and cancer; the global problem of vitamin D deficiency; age-related reductions in vitamin D efficacy, and currently recommended intakes...
October 5, 2018: Expert Review of Endocrinology & Metabolism
Romain Guery, Anoosha Habibi, Jean-Benoît Arlet, François Lionnet, Victoire de Lastours, Jean-Winoc Decousser, Jean-Luc Mainardi, Keyvan Razazi, Laurence Baranes, Pablo Bartolucci, Bertrand Godeau, Fréderic Galacteros, Marc Michel, Matthieu Mahevas
BACKGROUND: Non-typhoidal salmonellosis (NTS) often occurs in children with sickle-cell disease (SCD) and remains a significant cause of mortality in developing countries. However, there is lack of reports on the clinical presentation, outcome and complications of NTS in adults with SCD. METHODS: We performed a chart review between 2006 and 2016 of adults SCD diagnosed with NTS in 3 referral centers monitoring approximately 3500 SCD adults. RESULTS: Twenty-three episodes of NTS were diagnosed among 22 SCD adults...
October 14, 2018: Infectious Diseases
Aylin Oral, Bülent Yazıcı, Cenk Eraslan, Zeynep Burak
Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
Dehui Zeng, Pingbo Yao, Hong Zhao
Abundant evidence indicted that P2X7 receptor show a essential role in human health and some human diseases including hypertension, atherosclerosis, pulmonary inflammation, tuberculosis infection, psychiatric disorders, and cancer. P2X7 receptor also has an important role in some central nervous system diseases such as neurodegenerative disorders. Recently, more research suggested that P2X7 receptor also plays a crucial role in bone and joint diseases. But the effect of P2X7 receptor on skeletal and joint diseases has not been systematically reviewed...
October 14, 2018: Journal of Cellular Physiology
Allan Bybeck Nielsen, Ulrikka Nygaard, Thomas Hoffmann, Kim Kristensen
No abstract text is available yet for this article.
October 13, 2018: Archives of Disease in Childhood
Giulia Franzoni, Silvia Dei Giudici, Annalisa Oggiano
African swine fever (ASF) is a devastating viral disease of domestic pigs and wild boar for which there is no vaccine available. The aetiological agent ASF virus (ASFV) has a predilection for cells of the myeloid lineage. Macrophages provide a first line defence against pathogens and are the main target of ASFV, thus several studies analysed their response to infection in terms of cytokine/chemokine expression and modulation of functionality. These studies have typically used macrophages differentiated in vitro from blood or bone marrow progenitors and few studies have focused on responses of polarized macrophages (M1, M2) or functional macrophage subsets isolated from different tissues...
October 11, 2018: Virus Research
Siddhant K Mehta, Wood W Dale, Michael D Dedwylder, Patrick F Bergin, Clay A Spitler
PURPOSE: The purpose of this study is to evaluate the incidence of neurovascular injuries, compartment syndrome, early postoperative infection as well as the injury factors predictive of neurovascular injury following ballistic fractures of the radius and ulna. METHODS: A retrospective review was performed to identify all ballistic fractures of the radius and ulna in skeletally mature patients over a 5-year period at a single level-1 trauma center. Chart and radiographic review was performed to identify patient and injury demographics, associated neurologic or vascular injuries, and fracture characteristics...
October 6, 2018: Injury
Fricia Marco, Nicolosi Federico, Ganau Mario, Cebula Helene, Todeschi Julien, Santin Marie des Neiges, Nannavecchia Benny, Morselli Carlotta, Chibbaro Salvatore
BACKGROUND: Despite the mixed evidence regarding the effect of decompressive craniectomy in terms of outcome, a tremendous increase in related papers has been observed in the last years. Cranioplasty plays a key role in restoring function and anatomy of the cranial vault. Considering that cranioplasty is not exempt from risks, the identification of the safest technique becomes crucial to achieve better patients' recovery. Porous hydroxyapatite (PHA) has received growing attention for its potential in bony integration...
October 10, 2018: World Neurosurgery
Eriko Ishihara, Masahiro Toda, Ryota Sasao, Hiroyuki Ozawa, Shin Saito, Kaoru Ogawa, Kazunari Yoshida
BACKGROUND: Visual field deterioration caused by secondary empty sella after cabergoline therapy for prolactinoma is a rare event. Chiasmapexy is performed to treat empty sella syndrome. Although various materials have been used for the elevation of the optic chasm, the most appropriate material remains to be established. Here, we describe the efficiency of chiasmapexy for empty sella syndrome following dopamine agonist treatment and the utility of septal cartilage and sphenoidal sinus bone as materials for chiasmapexy...
October 10, 2018: World Neurosurgery
Hong Zhu, Zeng Wang, Zhen Dong, Cong Wang, Quan Cao, Fan Fan, Jingjing Zhao, Xiangwei Liu, Meng Yuan, Xiaolei Sun, Xiuhua Peng, Yunzeng Zou, Jingmin Zhou, Junbo Ge, Xiaohui Zhou, Yingmei Zhang
Previous evidence has indicated a beneficial role for aldehyde dehydrogenase 2 (ALDH2) in suppressing atherosclerotic plaque progression and instability. However, the underlying mechanism remains somewhat elusive. This study was designed to examine the effect of ALDH2 deficiency on cholesterol diet-induced atherosclerotic plaque progression and plaque vulnerability in atherosclerosis-prone ApoE knockout (ApoE-/- ) mice with a focus on foam cell formation in macrophages and senescence of vascular smooth muscle cells (VSMCs)...
October 10, 2018: Biochimica et biophysica acta. Molecular basis of disease
Seonghwan Byun, Ji Ye Lee, Bo Gyung Kim, Hyun Sook Hong
RATIONALE: Acute unilateral audiovestibulopathy is a common neurotological syndrome. Differential diagnoses of acute unilateral audiovestibulopathy include viral infection, vascular insults, and tumors. Regarding vascular causes, ischemic stroke in the anterior inferior cerebellar artery (AICA) territory is known to be the leading cause of acute audiovestibular loss. Previous reports of AICA infarction with audiovestibulopathy failed to demonstrate magnetic resonance imaging (MRI)-positive vestibulocochlear infarctions...
October 2018: Medicine (Baltimore)
Xinhua Yin, Liang Yan, Ming Yang, Shichang Liu, Baorong He, Zhongkai Liu, Dingjun Hao
The study aims to evaluate the clinical efficacy of bilateral costotransverse debridement, transpedicular fixation, fusion, and local continuous chemotherapy in 20 patients of contiguous multisegmental thoracic spinal tuberculosis (CMTSTB). We analyzed 20 patients with contiguous thoracic spinal tuberculosis (TB) who underwent surgery via bilateral costotransverse debridement, fusion, posterior instrumentation, and postural drainage with local continuous chemotherapy. The clinical outcomes were evaluated in terms of kyphotic angle, bone fusion, neurologic status, erythrocyte sedimentation rate (ESR), and intraoperative and postoperative complications...
October 2018: Medicine (Baltimore)
Anthony J Slate, David Wickens, Joels Wilson-Nieuwenhuis, Nina Dempsey-Hibbert, Glen West, Peter Kelly, Joanna Verran, Craig E Banks, Kathryn A Whitehead
External bone fixation devices provide support and rehabilitation for severely damaged/broken bones, however, this invasive procedure is prone to infection. Zirconium nitride/silver (Ti-ZrN/Ag) coatings were characterised for surface topography, chemical composition, physicochemistry and antimicrobial efficacy (against Staphylococcus aureus and Staphylococcus epidermidis), in the presence of a blood conditioning film. The conditioning film altered the width of the microtopography of the surfaces however, the depth of the features remained relatively constant...
September 26, 2018: Colloids and Surfaces. B, Biointerfaces
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