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https://www.readbyqxmd.com/read/30326213/in-silico-approaches-for-screening-molecular-targets-in-candida-albicans-a-proteomic-insight-into-drug-discovery-and-development
#1
REVIEW
Diego Romário Silva, Janaína de Cássia Orlandi Sardi, Irlan Almeida Freires, Andréa Cristina Barbosa Silva, Pedro Luiz Rosalen
Candida species are opportunistic pathogens which can cause conditions ranging from simple mucocutaneous infections to fungemia and death in immunosuppressed and hospitalized patients. Candida albicans is considered to be the species mostly associated with fungal infections in humans and, therefore, the mostly studied yeast. This microorganism has survival and virulence factors which, allied to a decreased host immunity response, make infection more difficult to control. Today, the current limited antifungal arsenal and a dramatic increase in fungal resistance have driven the need for the synthesis of drugs with novel mechanisms of action...
October 13, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30318079/back-and-forth-between-cancer-treatment-and-cancer-control-programs-insights-from-the-cuban-experience
#2
REVIEW
Agustin Lage, Teresa Romero
Cancer control is a wider concept than oncology, and includes comprehensive actions for prevention, early diagnosis, treatment, services organization, and education, aiming to modify hard indicators such as incidence, mortality rates, and survival at a population scale. Based on these concepts, organized national cancer programs appeared in several countries in the second half of the 20th century. But at the same time, scientific efforts began to modify the landscape of cancer control. Evidence of mortality reductions began to appear, cancer-driving mutations became measurable, many novel drugs were registered, the methodology of clinical trials spread through health systems, targeted drugs and immunotherapy entered into the mainstream of therapeutics, and treatment goals started to shift from cure to chronic control...
January 2018: Seminars in Oncology
https://www.readbyqxmd.com/read/30308694/pharmacological-properties-of-geraniol-a-review
#3
Yu Lei, Peng Fu, Xie Jun, Peng Cheng
Geraniol is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants including Cinnamomum tenuipilum, Valeriana officinalis , and several other plants. The limited source of geraniol from plant isolation cannot fulfill the great demand from the flavor and fragrance industries, which require maximizing geraniol production through biotechnology processes. The diverse activities of geraniol suggested that geraniol could treat various diseases as a promising drug candidate. In order to evaluate the potential of geraniol applied in a clinical trial, this review aims at providing a comprehensive summary of the pharmacological effects of geraniol...
October 11, 2018: Planta Medica
https://www.readbyqxmd.com/read/30307447/new-biotechnological-treatments-for-lipid-disorders
#4
Natalia Valencia-Enciso, Carlos O Mendivil
Disorders of lipid and lipoprotein metabolism play a central role in the pathogenesis of atherosclerotic cardiovascular diseases (CVDs). Despite the widespread use of efficacious lipid-modifying therapies, the residual risk of CVD remains unacceptably high. The purpose of this manuscript is to review the application of new technologies in the treatment of lipid disorders. New therapies work mostly at the gene expression level and are, therefore, different from traditional small-molecule drugs that work mainly by inhibiting already synthesized proteins...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/30302980/biologics-and-public-health-prospects-and-challenges
#5
Olasupo Owoeye, Oluwabusayo Owoeye
Biotechnology has been used by humankind for thousands of years and it remains a very important part of human medicine. Biotechnology is particularly relevant to the creation of new medicines and vaccines. Biotechnology drugs or biologics are becoming increasingly popular in the life sciences sector. Biologics were estimated to account for US$289 billion pharmaceutical sales in 2014 and are projected to reach US$445 billion in 2019. It is also anticipated that biologics' share of global prescription and over-the-counter pharmaceutical sales will rise to 26% by 2019...
October 2018: Journal of Law and Medicine
https://www.readbyqxmd.com/read/30301514/effect-of-dsdna-on-the-assembly-pathway-and-mechanical-strength-of-sv40-vp1-virus-like-particles
#6
Mariska G M van Rosmalen, Chenglei Li, Adam Zlotnick, Gijs J L Wuite, Wouter H Roos
Simian virus 40 (SV40) is a possible vehicle for targeted drug delivery systems because of its low immunogenicity, high infectivity, and high transfection efficiency. To use SV40 for biotechnology applications, more information is needed on its assembly process to efficiently incorporate foreign materials and to tune the mechanical properties of the structure. We use atomic force microscopy to determine the effect of double-stranded DNA packaging, buffer conditions, and incubation time on the morphology and strength of virus-like particles (VLPs) composed of SV40 VP1 pentamers...
September 13, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/30282983/cpp-ts-a-new-intracellular-calcium-channel-modulator-and-a-promising-tool-for-drug-delivery-in-cancer-cells
#7
Bárbara Bruna Ribeiro de Oliveira-Mendes, Carolina Campolina Rebello Horta, Anderson Oliveira do Carmo, Gabriela Lago Biscoto, Douglas Ferreira Sales-Medina, Hortênsia Gomes Leal, Pedro Ferreira Pinto Brandão-Dias, Sued Eustáquio Mendes Miranda, Carla Jeane Aguiar, Valbert Nascimento Cardoso, André Luis Branco de Barros, Carlos Chávez-Olortégui, M Fátima Leite, Evanguedes Kalapothakis
Scorpion sting envenoming impacts millions of people worldwide, with cardiac effects being one of the main causes of death on victims. Here we describe the first Ca2+ channel toxin present in Tityus serrulatus (Ts) venom, a cell penetrating peptide (CPP) named CPP-Ts. We show that CPP-Ts increases intracellular Ca2+ release through the activation of nuclear InsP3R of cardiomyocytes, thereby causing an increase in the contraction frequency of these cells. Besides proposing a novel subfamily of Ca2+ active toxins, we investigated its potential use as a drug delivery system targeting cancer cell nucleus using CPP-Ts's nuclear-targeting property...
October 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30273387/first-evidence-of-halomicronema-metazoicum-cyanobacteria-free-living-on-posidonia-oceanica-leaves
#8
Nadia Ruocco, Mirko Mutalipassi, Antonino Pollio, Susan Costantini, Maria Costantini, Valerio Zupo
Cyanobacteria contribute to the ecology of various marine environments, also for their symbioses, since some of them are common hosts of sponges and ascidians. They are also emerging as an important source of novel bioactive secondary metabolites in pharmacological (as anticancer drugs) and biotechnological applications. In the present work we isolated a cyanobacteria in a free-living state from leaves of the seagrass Posidonia oceanica leaves. This newly collected strain was then cultivated under two laboratory conditions, and then characterized by combining morphological observation and molecular studies based on 16S rRNA gene sequences analysis...
2018: PloS One
https://www.readbyqxmd.com/read/30267812/phyto-mirnas-based-regulation-of-metabolites-biosynthesis-in-medicinal-plants
#9
REVIEW
M Sabzehzari, M R Naghavi
Medicinal plants, are known to produce a wide range of plant secondary metabolites (PSMs) applied as insecticides, drugs, dyes and toxins in agriculture, medicine, industry and bio-warfare plus bio-terrorism, respectively. However, production of PSMs is usually in small quantities, so we need to find novel ways to increase both quantity and quality of them. Fortunately, biotechnology suggests several options through which secondary metabolism in plants can be engineered in innovative ways to: 1) over-produce the useful metabolites, 2) down-produce the toxic metabolites, 3) produce the new metabolites...
September 26, 2018: Gene
https://www.readbyqxmd.com/read/30266595/synaggreg-a-multifunctional-high-throughput-technology-for-precision-study-of-amyloid-aggregation-and-systematic-discovery-of-synergistic-inhibitor-compounds
#10
Hubert Aviolat, Yves Nominé, Sophie Gioria, Anna Bonhoure, David Hoffmann, Christine Ruhlmann, Hélène Nierengarten, Frank Ruffenach, Pascal Villa, Yvon Trottier, Fabrice A C Klein
Numerous proteins can coalesce into amyloid self-assemblies, which are responsible for a class of diseases called amyloidoses, but which can also fulfill important biological functions and are of great interest for biotechnology. Amyloid aggregation is a complex multi-step process, poorly prone to detailed structural studies. Therefore, small molecules interacting with amyloids are often used as tools to probe the amyloid aggregation pathway, and in some cases to treat amyloidoses as they prevent pathogenic protein aggregation...
September 25, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/30262109/biotechnological-applications-of-bioactive-peptides-from-marine-sources
#11
Daniela Giordano, Maria Costantini, Daniela Coppola, Chiara Lauritano, Laura Núñez Pons, Nadia Ruocco, Guido di Prisco, Adrianna Ianora, Cinzia Verde
This review is an overview on marine bioactive peptides with promising activities for the development of alternative drugs to fight human pathologies. In particular, we focus on potentially prolific producers of peptides in microorganisms, including sponge-associated bacteria and marine photoautotrophs such as microalgae and cyanobacteria. Microorganisms are still poorly explored for drug discovery, even if they are highly metabolically plastic and potentially amenable to culturing. This offers the possibility of obtaining a continuous source of bioactive compounds to satisfy the challenging demands of pharmaceutical industries...
2018: Advances in Microbial Physiology
https://www.readbyqxmd.com/read/30260637/confinement-facilitated-protein-stabilization-as-investigated-by-small-angle-neutron-scattering
#12
Justin Siefker, Ralf Biehl, Margarita Kruteva, Artem Feoktystov, Marc-Olivier Coppens
While mesoporous silicas have been shown to be a compelling candidate for drug delivery and the implementation of biotechnological applications requiring protein confinement and immobilization, the understanding of protein behavior upon physical adsorption into silica pores is limited. Many indirect methods are available to assess general adsorbed protein stability, such as Fourier-transform infrared spectroscopy and activity assays. However, the limitation of these methods is that spatial protein arrangement within the pores cannot be assessed...
October 2, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30257346/bovine-serum-albumin-nanoparticles-induce-histopathological-changes-and-inflammatory-cell-recruitment-in-the-skin-of-treated-mice
#13
Natalia Ingrid Oliveira da Silva, Ezequiel Aparecido Salvador, Isabella Rodrigues Franco, Gabriel Augusto Pires de Souza, Stella Maria de Souza Morais, Raissa Prado Rocha, Rômulo Dias Novaes, Patrícia Paiva Corsetti, Luiz Cosme Cotta Malaquias, Luiz Felipe Leomil Coelho
Albumin is a natural, biocompatible, biodegradable and nontoxic polymer and due to these features, nanoparticles made of albumin are a good system for drug or antigen delivery. Polymeric nanoparticles are being widely explored as new vaccines platforms due to the capacity of those nanoparticles to prime the immune system by providing sustained release of the antigen after injection. Biodegradable nanoparticles associated with proteins represent a promising method for in vivo delivery of vaccines. In our previous studies, bovine serum albumin nanoparticles (BSA-NPs) were identified as a promising system for in vivo delivery of microbial antigens...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30255754/the-place-for-enzymes-and-biologically-active-peptides-from-marine-organisms-for-application-in-industrial-and-pharmaceutical-biotechnology
#14
Jean-Etienne Rl Morlighem, Gandhi Radis-Baptista
Since the beginning of written history, diverse texts have reported the use of enzymatic preparations in food processing and have described the medicinal properties of crude and fractionated venoms to treat various diseases and injuries. With the biochemical characterization of enzymes from distinct sources and bioactive polypeptides from animal venoms, the last sixty years have testified the advent of industrial enzymology and protein therapeutics, which are currently applicable in a wide variety of industrial processes, household products, and pharmaceuticals...
September 26, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/30250310/sugerencias-en-torno-a-medicamentos-de-efectividad-demostrada-sin-inter%C3%A3-s-comercial-para-la-industria-farmac%C3%A3-utica
#15
Manuel De la Llata, José Hálabe, Ricardo Plancarte, Oscar Arrieta, Rubén Burgos, Carlos Campillo, Miguel Ángel Celis, Judith Domínguez, Sergio Islas, Luis Jasso, Alberto Lifshitz, Mucio Moreno, Alejandro Reyes, Guillermo Ruiz-Argüelles, Antonio Soda, Emma Verástegui, Julio Sotelo
Varios medicamentos de adecuada eficacia han sido retirados del mercado por razones financieras, ya sea por su reducido precio (la patente ha expirado) o porque han sido sustituidos por nuevos fármacos (con patentes vigentes); otros tantos no han sido desarrollados porque las enfermedades contra las que van dirigidos no son económicamente promisorias debido al tipo de población que las padece (estratos económicamente marginados o sin significación numérica). Deberán establecerse lineamientos e incentivos para la industria farmacéutica y de biotecnología...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/30249983/applications-of-magnetotactic-bacteria-magnetosomes-and-magnetosome-crystals-in-biotechnology-and-nanotechnology-mini-review
#16
REVIEW
Gabriele Vargas, Jefferson Cypriano, Tarcisio Correa, Pedro Leão, Dennis A Bazylinski, Fernanda Abreu
Magnetotactic bacteria (MTB) biomineralize magnetosomes, which are defined as intracellular nanocrystals of the magnetic minerals magnetite (Fe₃O₄) or greigite (Fe₃S₄) enveloped by a phospholipid bilayer membrane. The synthesis of magnetosomes is controlled by a specific set of genes that encode proteins, some of which are exclusively found in the magnetosome membrane in the cell. Over the past several decades, interest in nanoscale technology (nanotechnology) and biotechnology has increased significantly due to the development and establishment of new commercial, medical and scientific processes and applications that utilize nanomaterials, some of which are biologically derived...
September 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30244279/bioproduction-purification-and-application-of-polysialic-acid
#17
REVIEW
Jianrong Wu, Xiaobei Zhan, Liming Liu, Xiaole Xia
Polysialic acid (PSA) is a negatively charged linear homopolymer linked by N-acetylneuraminic acid and widely present in vertebrates and some pathogens. PSA, commonly found on cell surfaces as glycoproteins and glycolipids, plays important roles in intercellular adhesion, cell migration, and formation and remodeling of the neural system by regulating the adhesive property of nerve cell adhesion molecules. PSA with a molecular weight that can reach as high as 260 kDa also belongs to the group II capsule polysaccharide of neonatal meningitis-causing Escherichia coli K1...
September 22, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/30242687/high-throughput-transfection-of-hek293-cells-for-transient-protein-production
#18
Tia A Arena, Peter D Harms, Athena W Wong
Transient transfection of mammalian cells is used in the biotechnology industry to quickly supply recombinant protein for research and large molecule drug development. Here, we describe a method for high throughput transient transfection of Human Embryonic Kidney 293 (HEK293) cells in 30 mL tubespins using polyethylenimine (PEI) as a transfection reagent. An automated liquid handler can be used to perform pipetting steps for transfecting batches of 96 tubespins, and septa in the tubespin caps allow for rapid processing without decapping...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30241924/the-current-scientific-and-regulatory-landscape-in-advancing-integrated-continuous-biopharmaceutical-manufacturing
#19
REVIEW
Adam C Fisher, Mark-Henry Kamga, Cyrus Agarabi, Kurt Brorson, Sau L Lee, Seongkyu Yoon
There is a trend across the pharmaceutical sector toward process intensification and continuous manufacturing to produce small-molecule drugs or biotechnology products. For biotechnology products, advancing the manufacturing technology behind upstream and downstream processes has the potential to reduce product shortages and variability, allow for production flexibility, simplify scale-up procedures, improve product quality, reduce facility footprints, increase productivity, and reduce production costs. On the upstream side of biotechnology manufacturing, continuous perfusion cell cultures are fairly well established...
September 18, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/30240152/protein-nanotherapeutics-as-an-emerging-modality-for-cancer-therapy
#20
REVIEW
Liang Cheng, Liang Yang, Fenghua Meng, Zhiyuan Zhong
Protein drugs are a unique and versatile class of biotherapeutics that have not only high biological activity but also superb specificity. This rapidly evolving biotechnology has rendered it possible to produce various proteins in a large scale and reproducible way. Many proteins have demonstrated striking anticancer activities and have emerged as advanced alternatives to cytotoxic chemotherapeutic agents for cancer therapy. The clinical translation of anticancer proteins with intracellular targets is, nevertheless, severely hindered by their fast degradation in vivo, poor cell penetration, and inefficient intracellular transportation...
September 21, 2018: Advanced Healthcare Materials
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