Read by QxMD icon Read

diagnostic or prognostic meta analysis

Xiong-Gang Yang, Deng-Xing Lun, Yong-Cheng Hu, Yong-Heng Liu, Feng Wang, Jiang-Tao Feng, Kun-Chi Hua, Li Yang, Hao Zhang, Ming-You Xu, Hao-Ran Zhang
BACKGROUND: Cancer patients' survival time has obviously improved, with the development of systemic treatment techniques. However, the probability of metastases to the vertebrae has also been increased which makes some adverse effects on patients' quality of life. The prediction of survival plays a key role in choosing therapeutic modality, and Tokuhashi Score was established as one of the most commonly used predictive systems for spinal metastases. Thus, this study was conducted to identify the prognostic effect of factors involved in revised Tokuhashi Score (RTS)...
December 13, 2018: BMC Cancer
Xiangwei Zhang, Yuanzhu Jiang, Yang Wang, Zhaoyang Wang, Linping Zhao, Xianbiao Xue, Shaowei Sang, Lin Zhang
BACKGROUND: The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in esophageal cancer (EC) remains controversial. METHODS: The aim of this study was to evaluate the association between NLR and oncologic outcome of EC patients through a meta-analysis. A systematic search was performed in PubMed, Web of Science and Embase for relevant studies. Meta-analysis was performed using hazard ratio (HR) and95% confidence interval (CI) as effect measures. RESULTS: Finally, 33 articles with 11,039patients were included in our study...
December 2018: Medicine (Baltimore)
Chao Ma, Xing-Guo Nie, Yan-Li Wang, Da-Peng Wu, Qiu-Dong Liang
BACKGROUND: Plasmacytoma variant translocation 1 (PVT1) is reported to be dysregulated in various cancers. Therefore, this meta-analysis was performed to clarify its utility as a prognosis marker in malignant tumors. METHODS: Electronic databases, including PubMed, OVID, Cochrane Library, and Web of Science databases, were retrieved from inception to December 16, 2017. Typically, hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated, so as to explore the relationship between PVT1 expression and patient survival...
December 2018: Medicine (Baltimore)
Wei Jiang, Lijin Zhang, Bin Wu, Zhenlei Zha, Hu Zhao, Yuan Jun, Yuefang Jiang
OBJECTIVE: Numerous studies have shown that lymphovascular invasion (LVI) is linked to biochemical recurrence (BCR) in prostate cancer (PCa) patients following radical prostatectomy (RP). However, the actual clinicopathological impacts of LVI remain unclear. Thus, we performed a meta-analysis to evaluate the pathologic and prognostic impacts of LVI in PCa patients. METHODS: Following the guidance of the PRISMA statement, relevant studies were collected systematically from the PubMed, EMBASE, and Web of Science databases to identify relevant studies published before June 2018...
December 2018: Medicine (Baltimore)
Kezhong Tang, Yanmo Liu, Linping Dong, Bo Zhang, Lantian Wang, Jian Chen, Guofeng Chen, Zhe Tang
The objectives of this systematic review and pooled analysis were to examine long-term survival, morbidity, and mortality following thermal ablation of gastric cancer hepatic metastases and to identify prognostic factors that improve survival.Patients with hepatic metastases from gastric cancer are traditionally treated with palliative chemotherapy. Surgical resection is an alternative treatment of hepatic metastases. Whether patients can obtain benefit from thermal ablation of hepatic metastases is still controversial...
December 2018: Medicine (Baltimore)
Yiqi Liu, Ping Li, Liang Liu, Yilian Zhang
BACKGROUND: Drug-induced liver injury (DILI) is a potentially severe adverse drug reaction especially in susceptible patients. But there are no sensitive or specific parameters to detecting DILI. The specific expression of miR-122 in the liver has been a hotspot in the evaluation of hepatic toxicity due to its high stability and sensitivity. METHODS: We performed a systematic literature review through July 31, 2017 to identify studies which evolved DILI patients testing miR-122 without limiting a certain drug...
December 2018: Medicine (Baltimore)
Banghyun Lee, Kidong Kim, Youngmi Park, Myong Cheol Lim, Robert E Bristow
BACKGROUND: In cervical cancer, the impact of hospital volume of laparoscopic radical hysterectomy (LRH) has not been investigated systematically as in ovarian cancer.The aim of this study was to investigate the impact of hospital care volume of LRH on treatment outcomes of patients with cervical cancer. METHODS: The PubMed, Embase, and Cochrane Library databases were searched with the terms "cervical cancer," "radical hysterectomy," and "laparoscopy...
December 2018: Medicine (Baltimore)
Yuanxiu Leng, Qing Luo, Xumei Chen, Fang Chen, Xue Wang, Yana Pan
BACKGROUND: An increasing number of studies have recently highlighted the role of zinc finger antisense 1(ZFAS1) as a prognostic marker in cancers. However, these results remain controversial. Hence, a meta-analysis was conducted to further investigate the effects of ZFAS1 expression on clinicopathological features and survival outcomes. METHOD: All eligible studies were searched from PubMed, Embase, Web of Science, and the Cochrane Library. All included articles evaluated the relationship between the expression levels of ZFAS1 and survival, or the range of pathological features in cancer patients...
December 2018: Medicine (Baltimore)
Dabiao Liu, Xuesong Liu
AIM: To make an accurate estimation of the association of ERCC1 and ERCC2 polymorphisms with osteosarcoma (OS) prognosis in Chinese population. METHODS: Total 7 qualified studies with 1404 osteosarcoma patients were included. Odds ratios (OR) with 95% CIs were pooled for the survival rate in different osteosarcoma patients with ERCC1 and ERCC2 genetic polymorphisms. The heterogeneity was assessed by I test. Potential publication bias was assessed by Begg funnel plot and Egger linear regression test...
December 2018: Medicine (Baltimore)
Junwu Duan, Linlin Pan, Ming Yang
BACKGROUND: Preoperative neutrophil-lymphocyte ratio (NLR) and derived NLR (dNLR) have been suggested to be correlated with the prognosis of patients with breast cancer (BC). However, the results still remain controversial. Therefore, this study was to further evaluate the prognostic potential of preoperative NLR and dNLR for BC patients using a meta-analysis. METHODS: Relevant articles were sought in PubMed and Cochrane Library databases up to September 2018. The associations between preoperative NLR/dNLR and overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) were assessed by the STATA software with the results presented as pooled hazard ratio (HR) with 95% confidence interval (CI)...
December 2018: Medicine (Baltimore)
Qinghua Liu, Jian Cheng, Jingjing Li, Xiang Gao, Hongbo Li
BACKGROUND: Contrast-enhanced ultrasound (CEUS) is a non-invasive method that has been used in the diagnosis of several diseases. Recently, CEUS has been used in the differentiation of benign and malignant thyroid nodules. However, the performance of CEUS in thyroid nodules has not been studied clearly. METHODS: The databases of Pubmed, Embase, Cochrane library and the unpublished studies were systematically searched for candidate inclusions, with the use of CEUS in differentiating the benign and malignant thyroid nodules...
December 2018: Medicine (Baltimore)
Xinwei Zou, Yi Zhang, Lin Zhang, Jiaxi Li, Chenjie Zhu, Qiuhong Cheng, Jinhua Zhou, Youguo Chen
BACKGROUND: Murine double minute 2 homolog (MDM2) plays an important role in the downregulation of P53 tumor suppressor gene. MDM2 inhibits P53 transcriptional activity and thereby results in accelerated tumor formation. Overexpression of MDM2 has been found in several cancer types including endometrial cancer. SNP309 is located in the promoter region of MDM2 and contributes to the overexpression of MDM2. The association between MDM2 SNP309 polymorphism and endometrial cancer risk has been investigated in several studies; however, the conclusion remains controversial...
December 2018: Medicine (Baltimore)
(no author information available yet)
OBJECTIVEPediatric high-grade gliomas (pHGGs), including diffuse intrinsic pontine glioma, present a prognostic challenge given their lethality and rarity. A substitution mutation of lysine for methionine at position 27 in histone H3 (H3K27M) has been shown to be highly specific to these tumors. Data are accumulating regarding the poor outcomes of patients with these tumors; however, the quantification of pooled outcomes has yet to be done, which could assist in prioritizing management. The aim of this study was to quantitatively pool data in the current literature on the H3K27M mutation as an independent prognostic factor in pHGG...
November 1, 2018: Journal of Neurosurgery. Pediatrics
Michael E Chua, Jonathan S Mendoza, Jessica M Ming, Jun S Dy, Odina Gomez
PURPOSE: To assess the diagnostic accuracy and safety of contrast-enhanced voiding urosonogram using second-generation contrast with harmonic imaging (CEVUS-HI) in detecting vesicoureteral reflux (VUR) among children. METHODS: A systematic literature search was performed in March 2018. Relevant comparative studies from Medline, EMBASE, World of Science, Scopus, CENTRAL, WHO trial registry and were identified and appraised using QUADAS-2. Diagnostic accuracy parameters were determined using VCUG as the reference standard...
December 12, 2018: World Journal of Urology
Isabelle Finke, Gundula Behrens, Linda Weisser, Hermann Brenner, Lina Jansen
Background: The impact of socioeconomic differences on cancer survival has been investigated for several cancer types showing lower cancer survival in patients from lower socioeconomic groups. However, little is known about the relation between the strength of association and the level of adjustment and level of aggregation of the socioeconomic status measure. Here, we conduct the first systematic review and meta-analysis on the association of individual and area-based measures of socioeconomic status with lung cancer survival...
2018: Frontiers in Oncology
Jing Geng, Jun Tang
The present study evaluated the diagnostic value of contrast-enhanced ultrasound (CEUS) in endometrial carcinoma (EC). Articles published until 31 January 2017 were retrieved from PubMed, EMBASE, Elsevier, Springer and Google scholar, with the following inclusion criteria: i) The accuracy (sensitivity and specificity) of CEUS in the diagnosis of EC was evaluated; ii) a gold standard was adopted to treat and confirm EC, including surgery, histopathology and appropriate follow-up (as included in the meta-analysis); iii) the data allowed for construction of a 2×2 table of positives, false-positives, negatives and false-negatives...
December 2018: Experimental and Therapeutic Medicine
Peng Xu, Lulu Lyu, Muhammad Umair Sami, Xin Lu, Haitao Ge, Yutao Rong, Chunfeng Hu, Kai Xu
In recent years, the role of magnetic resonance angiography (MRA) in the diagnosis of Budd-Chiari Syndrome (BCS) has been the focus of various clinical studies. The purpose of the present study was to perform a meta-analysis of the diagnostic performance of MRA in patients with BCS by using digital subtraction angiography as a reference method. The search strategy for relevant research articles was based on the Cochrane Handbook for Systematic Reviews, and literature databases (including PubMed, Medline and China National Knowledge Infrastructure) and reference lists of retrieved studies published from 2000 to 2016 were searched...
December 2018: Experimental and Therapeutic Medicine
Anine P Skibsted, Moshgan Amiri, Patrick M Fisher, Annette Sidaros, Melita Cacic Hribljan, Vibeke Andrée Larsen, Joan Lilja S Højgaard, Miki Nikolic, John Hauerberg, Martin E Fabricius, Gitte Moos Knudsen, Kirsten Møller, Daniel Kondziella
Aims and Objectives: To facilitate individualized assessment of unresponsive patients in the intensive care unit for signs of preserved consciousness after acute brain injury. Background: Physicians and neuroscientists are increasingly recognizing a disturbing dilemma: Brain-injured patients who appear entirely unresponsive at the bedside may show signs of covert consciousness when examined by functional MRI (fMRI) or electroencephalography (EEG). According to a recent meta-analysis, roughly 15% of behaviorally unresponsive brain-injured patients can participate in mental tasks by modifying their brain activity during EEG- or fMRI-based paradigms, suggesting that they are conscious and misdiagnosed...
2018: Frontiers in Neurology
Eduardo Angeli Malavolta, Jorge Henrique Assunção, Mauro Emilio Conforto Gracitelli, Talitha Koo Yen, Marcelo Bordalo-Rodrigues, Arnaldo Amado Ferreira Neto
INTRODUCTION: The accuracy of MRI for subscapularis tear is lower than that of overall rotator cuff tears. Until now, no systematic reviews and meta-analysis have been conducted to compile these data. The purpose of this study was to determine, through a systematic review and meta-analysis, the diagnostic accuracy of MRI in the detection of subscapularis tendon tears. MATERIALS AND METHODS: A systematic review of PubMed, EMBASE, and MEDLINE databases up to April 2017 was performed...
December 11, 2018: Archives of Orthopaedic and Trauma Surgery
Gang Hu, Qin Liu, Jian-Ying Ma, Cheng-Yuan Liu
Introduction: Pretreatment platelet-to-lymphocyte ratio (PLR) has been considered a prognostic factor in various cancers. However, the application of PLR in the assessment of patients with cholangiocarcinoma remains controversial. This study aimed to evaluate the prognostic value of pretreatment PLR in cholangiocarcinoma. Methods: A systematic search was performed in MEDLINE, EMBASE, and Cochrane Library to identify studies assessing the prognostic significance of the pretreatment PLR in cholangiocarcinoma...
2018: BioMed Research International
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"