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https://www.readbyqxmd.com/read/30108537/eye-closure-enhances-creative-performance-on-divergent-and-convergent-creativity-tasks
#1
Simone M Ritter, Jens Abbing, Hein T van Schie
In today's world of rapid changes and increasing complexity, understanding and enhancing creativity is of critical importance. Studies investigating EEG correlates of creativity linked power in the alpha frequency band to creativity, and alpha-power has been interpreted as reflecting attention on internal mental representations and inhibition of external sensory input. Thus far, however, there is no direct evidence for the idea that internally directed attention facilitates creativity. The aim of the current study was to experimentally investigate the relationship between eye-closure-a simple and effective means to stimulate internally directed attention-and creativity...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30108139/prostaglandin-f2%C3%AE-promotes-embryo-implantation-and-development-in-the-pig
#2
Piotr Kaczyński, Monika Baryla, Ewelina Goryszewska, Stefan Bauersachs, Agnieszka WacŁawik
Successful establishment and development of pregnancy requires proper communication between developing conceptuses and the maternal reproductive tract. Prostaglandins are key players involved in the regulation of reproductive processes in mammals including pigs. Due to its luteolytic action, prostaglandin F2-alpha (PGF2α) is mainly considered as an undesirable factor during early pregnancy. However, its content in the uterine lumen is elevated in pigs and other mammals. Recently, we reported an important role of PGF2α in the endometrium during early pregnancy in the pig...
August 14, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30104552/effects-of-rhizome-extract-of-dioscorea-batatas-and-its-active-compound-allantoin-on-the-regulation-of-myoblast-differentiation-and-mitochondrial-biogenesis-in-c2c12-myotubes
#3
Junnan Ma, Seok Yong Kang, Xianglong Meng, An Na Kang, Jong Hun Park, Yong-Ki Park, Hyo Won Jung
With the aging process, a loss of skeletal muscle mass and dysfunction related to metabolic syndrome is observed in older people. Yams are commonly use in functional foods and medications with various effects. The present study was conducted to investigate the effects of rhizome extract of Dioscorea batatas (Dioscoreae Rhizoma, Chinese yam) and its bioactive compound, allantoin, on myoblast differentiation and mitochondrial biogenesis in skeletal muscle cells. Yams were extracted in water and allantoin was analyzed by high performance liquid chromatography (HPLC)...
August 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30102876/measuring-early-childhood-development-in-brazil-validation-of-the-caregiver-reported-early-development-instruments-credi
#4
Elisa Rachel Pisani Altafim, Dana Charles McCoy, Alexandra Brentani, Ana Maria de Ulhôa Escobar, Sandra J F E Grisi, Günther Fink
OBJECTIVE: The present study aims to analyze the psychometric properties and general validity of the Caregiver Reported Early Development Instruments (CREDI) short form for the population-level assessment of early childhood development for Brazilian children under age 3. METHOD: The study analyzed the acceptability, test-retest reliability, internal consistency and discriminant validity of the CREDI short-form tool. The study also analyzed the concurrent validity of the CREDI with a direct observational measure (Inter-American Development Bank's Regional Project on Child Development Indicators; PRIDI)...
August 10, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/30099676/rutin-protects-against-lipopolysaccharide-induced-mastitis-by-inhibiting-the-activation-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-and-attenuating-endoplasmic-reticulum-stress
#5
Siyi Su, Xiaoyu Li, Siting Li, Pengfei Ming, Yingying Huang, Yanli Dong, Hongyan Ding, Shibin Feng, Jinchun Li, Xichun Wang, Yu Li, Jinjie Wu
Rutin, found widely in traditional Chinese medicine materials, is used to treat eye swelling and pain, hypertension, and hyperlipidemia. In the present study, a mouse mastitis model induced by lipopolysaccharide (LPS) was established to explore rutin's inhibitory mechanism on mastitis via nuclear factor kappa B (NF-κB) inflammatory signaling and the relationship between NF-κB signaling and endoplasmic reticulum (ER) stress. Mice were divided into six groups: Control group, LPS model group, LPS + rutin (25, 50, and 100 mg/kg) and LPS + dexamethasone (DEX) group...
August 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/30098513/marital-distress-depression-and-a-leaky-gut-translocation-of-bacterial-endotoxin-as-a-pathway-to-inflammation
#6
Janice K Kiecolt-Glaser, Stephanie J Wilson, Michael L Bailey, Rebecca Andridge, Juan Peng, Lisa M Jaremka, Christopher P Fagundes, William B Malarkey, Bryon Laskowski, Martha A Belury
BACKGROUND: Marital distress and depression work in tandem to escalate risks for inflammation-related disorders. Translocation of bacterial endotoxin (lipopolysaccharide, LPS) from the gut microbiota to blood circulation stimulates systemic inflammatory responses. METHODS: To investigate increased gut permeability (a "leaky gut") as one potential mechanistic pathway from marital distress and depression to heightened inflammation, this secondary analysis of a double-blind, randomized crossover study examined serial assessments of two endotoxin biomarkers, LPS-binding protein (LBP) and soluble CD14 (sCD14), as well as C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) during two separate 9...
August 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/30097271/irhom2-promotes-atherosclerosis-through-macrophage-inflammation-and-induction-of-oxidative-stress
#7
Cheng Chaohui, Huang Wei, Wen Hongfeng, Zhang Yueliang, Peng Xiaoqin, Zhou Pingli, Ai Zhibing
Atherosclerosis is a complex chronic inflammatory disease that is characterized by the formation of lipid-rich plaques on the inner walls of the arteries. Inactive rhomboid protein 2 (iRhom2) was recently determined as a necessary regulator for the shedding of tumor necrosis factor-alpha (TNF-α) in immune cells. In the present study, we aimed to explore the effects of iRhom2 on the inflammatory response and oxidative stress induced by low-density lipoprotein (ox-LDL) in RAW264.7 and THP-1-derived macrophages...
August 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30096164/small-rnas-detected-in-exosomes-derived-from-the-mh7a-synovial-fibroblast-cell-line-with-tnf-%C3%AE-stimulation
#8
Yosuke Takamura, Wataru Aoki, Atsushi Satomura, Seiji Shibasaki, Mitsuyoshi Ueda
Rheumatoid arthritis (RA) is an autoimmune disease that causes the chronic inflammation of the joints. Intercellular communication containing synovial fibroblasts seems to play a major role in RA pathogenesis. In this study, to better understand intercellular communication related to RA pathogenesis, we identified exosomal microRNAs (miRNAs) derived from synovial fibroblasts. Exosomes were collected from an RA synovial fibroblast (RASF) cell line, namely, MH7A, with or without stimulation by tumor necrosis factor alpha (TNF-α)...
2018: PloS One
https://www.readbyqxmd.com/read/30094405/a-survey-of-molecular-heterogeneity-in-hepatocellular-carcinoma
#9
Juan Jovel, Zhen Lin, Sandra O'keefe, Steven Willows, Weiwei Wang, Guangzhi Zhang, Jordan Patterson, Carlos Moctezuma-Velázquez, David J Kelvin, Gane Ka-Shu Wong, Andrew L Mason
Understanding the heterogeneity of dysregulated pathways associated with the development of hepatocellular carcinoma (HCC) may provide prognostic and therapeutic avenues for disease management. As HCC involves a complex process of genetic and epigenetic modifications, we evaluated expression of both polyadenylated transcripts and microRNAs from HCC and liver samples derived from two cohorts of patients undergoing either partial hepatic resection or liver transplantation. Copy number variants were inferred from whole genome low-pass sequencing data, and a set of 56 cancer-related genes were screened using an oncology panel assay...
August 2018: Hepatology Communications
https://www.readbyqxmd.com/read/30092845/cytokine-profiling-in-active-and-quiescent-sle-reveals-distinct-patient-subpopulations
#10
John A Reynolds, Eoghan M McCarthy, Sahena Haque, Pintip Ngamjanyaporn, Jamie C Sergeant, Elaine Lee, Eileen Lee, Stephen A Kilfeather, Ben Parker, Ian N Bruce
BACKGROUND: Patients with SLE display marked clinical and immunlogical heterogeneity. The purpose of the study was to investigate patterns of serum cytokines in patients with active and stable systemic lupus erythematosus (SLE) and to determine how they relate to clinical phenotype. METHODS: Serum levels of 10 cytokines were measured retrospectively in a cohort of patients with SLE and in healthy controls using a high-sensitivity multiplex bead array. Disease activity was determined using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and British Isles Lupus Assessment Group (BILAG-2004) indices...
August 9, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/30091957/validation-of-oral-health-impact-profile-14-and-its-association-with-hypossialia-in-a-sj%C3%A3-gren-syndrome-portuguese-population
#11
João Amaral, Catarina Sanches, Duarte Marques, José Vaz Patto, Filipe Barcelos, António Mata
AIMS: The objective of this study was to perform the Portuguese transcultural adaptation of the original Brazilian version of the Oral Health Impact Profile-14 (OHIP-14) while evaluating the association between hyposalivation and quality of life in a Sjögren´s Syndrome population. METHODS: The original Brazilian version of the Oral Health Impact Profile-14 was culturally adapted following the guidelines for cross-cultural adaptation of health-related quality of life measures...
April 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/30088950/making-ivf-more-effective-through-the-evolution-of-prediction-models-is-prognosis-the-missing-piece-of-the-puzzle
#12
Mara Simopoulou, Konstantinos Sfakianoudis, Nikolaos Antoniou, Evangelos Maziotis, Anna Rapani, Panagiotis Bakas, George Anifandis, Theodoros Kalampokas, Stamatis Bolaris, Agni Pantou, Konstantinos Pantos, Michael Koutsilieris
Assisted reproductive technology has evolved tremendously since the emergence of in vitro fertilization (IVF). In the course of the recent decade, there have been significant efforts in order to minimize multiple gestations, while improving percentages of singleton pregnancies and offering individualized services in IVF, in line with the trend of personalized medicine. Patients as well as clinicians and the entire IVF team benefit majorly from 'knowing what to expect' from an IVF cycle. Hereby, the question that has emerged is to what extent prognosis could facilitate toward the achievement of the above goal...
August 8, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/30088541/saquinavir-plus-methylprednisolone-ameliorates-experimental-acute-lung-injury
#13
Guanghua Zhang, Xue Zhang, Haidi Huang, Yunxia Ji, Defang Li, Wanglin Jiang
Glucocorticoid insensitivity is an important barrier to the treatment of several inflammatory diseases, including acute lung injury (ALI). Saquinavir (SQV) is an inhibitor of the human immunodeficiency virus protease, and the therapeutic effects of SQV in ALI accompanied with glucocorticoid insensitivity have not been previously investigated. In this study, the effects of SQV on lipopolysaccharide (LPS)-mediated injury in human pulmonary microvascular endothelial cells (HPMECs), human type I alveolar epithelial cells (AT I), and alveolar macrophages were determined...
August 6, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30086435/potential-cause-effect-relationship-between-insulin-autoimmune-syndrome-and-alpha-lipoic-acid-two-case-reports
#14
Simona Moffa, Ilaria Improta, Sandro Rocchetti, Teresa Mezza, Andrea Giaccari
OBJECTIVES: Insulin autoimmune syndrome (IAS) or Hirata disease is a rare cause of autoimmune hypoglycemia with apparent high insulin levels and anti-insulin autoantibodies and was first described by Hirata in Japan in 1970. IAS cases are usually related to exposure to sulfhydryl-containing drugs, which stimulate the production of insulin autoantibodies. Among sulfhydryl-containing compounds, alpha lipoic acid (ALA) has recently emerged as a cause of IAS. After the first observations of ALA-induced IAS were reported in Japan in 2006, an increasing number of cases related to ALA administration have been described...
May 25, 2018: Nutrition
https://www.readbyqxmd.com/read/30082522/follistatin-like-1-promotes-bleomycin-induced-pulmonary-fibrosis-through-the-transforming-growth-factor-beta-1-mitogen-activated-protein-kinase-signaling-pathway
#15
Yan-Kun Jin, Xiao-He Li, Wang Wang, Jie Liu, Wei Zhang, Yin-Shan Fang, Zhi-Fei Zhang, Hua-Ping Dai, Wen Ning, Chen Wang
Background: Follistatin-like 1 (FSTL1) is a novel profibrogenic factor that induces pulmonary fibrosis (PF) through the transforming growth factor-beta 1 (TGF-β1)/Smad signaling. Little is known about its effects on PF through the non-Smad signaling, like the mitogen-activated protein kinase (MAPK) pathway. Therefore, this study aimed to investigate the role of FSTL1 in PF through the MAPK signaling pathway and its mechanisms in lung fibrogenesis. Methods: PF was induced in Fstl1+/- and wild-type (WT) C57BL/6 mice with bleomycin...
August 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/30081092/the-tgf%C3%AE-erk-pathway-contributes-to-notch3-upregulation-in-the-renal-tubular-epithelial-cells-of-patients-with-obstructive-nephropathy
#16
Mei Huang, Jin Zhang, Hui Xu, Ting Ding, Damu Tang, Qiongjing Yuan, Lijian Tao, Zunlong Ye
Renal interstitial fibrosis is a common renal injury resulted from a variety of chronic kidney conditions and an array of factors. We report here that Notch3 is a potential contributor. In comparison to 6 healthy individuals, a robust elevation of Notch3 expression was observed in the renal tubular epithelial cells of 18 patients with obstructive nephropathy. In a rat unilateral ureteral obstruction (UUO) model which mimics the human disease, Notch3 upregulation closely followed the course of renal injury, renal fibrosis, TGFβ expression, and alpha-smooth muscle actin (α-SMA) expression, suggesting a role of Notch3 in promoting tubulointerstitial fibrosis...
August 3, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/30081007/tumor-necrosis-factor-alpha-suppresses-the-invasion-of-htr-8-svneo-trophoblast-cells-through-microrna-145-5p-mediated-downregulation-of-cyr61
#17
Zhengfang Wen, Yue Chen, Yu Long, Jian Yu, Mujun Li
Deficiency in trophoblast invasion is causally linked to the pathogenesis of preeclampsia. Tumor necrosis factor-alpha (TNF-α) shows the ability to suppress the invasiveness of trophoblasts, while cysteine-rich 61 (Cyr61) exerts an opposite function in trophoblast invasion. This study was designed to check the hypothesis that cysteine-rich 61 (Cyr61) may be involved in the anti-invasive activity of TNF-α in trophoblasts. To this end, we examined the effect of TNF-α treatment on Cyr61 expression in HTR-8/SVneo trophoblast cells and investigated the mechanism for the regulation of Cyr61 by TNF-α...
August 3, 2018: Life Sciences
https://www.readbyqxmd.com/read/30080894/processed-eggshell-membrane-powder-regulates-cellular-functions-and-increase-mmp-activity-important-in-early-wound-healing-processes
#18
Tram T Vuong, Sissel B Rønning, Tamer A E Ahmed, Kristiane Brathagen, Vibeke Høst, Maxwell T Hincke, Henri-Pierre Suso, Mona E Pedersen
Avian eggshell membrane (ESM) is a natural biomaterial that has been used as an alternative natural bandage to cure wounds, and is available in large quantities from egg industries. We have previously demonstrated that processed eggshell membrane powder (PEP), aiming to be used in a low cost wound healing product, possesses anti-inflammatory properties. In this study, we further investigated effects of PEP on MMP activities in vitro (a dermal fibroblast cell culture system) and in vivo (a mouse skin wound healing model)...
2018: PloS One
https://www.readbyqxmd.com/read/30079052/genome-wide-association-study-in-vestibular-neuritis-involvement-of-the-host-factor-for-hsv-1-replication
#19
Dan Rujescu, Annette M Hartmann, Ina Giegling, Bettina Konte, Marko Herrling, Susanne Himmelein, Michael Strupp
Objective: In order to identify genetic variants associated with vestibular neuritis, a common cause of peripheral vertigo with a potential causative link to the reactivation of herpes simplex type 1 (HSV-1), we conducted a genome-wide association study. Methods: Association was assessed using approximately 8 million variants. 131 patients with vestibular neuritis and 2,609 controls of European ancestry were included. Results: Genome-wide associations with vestibular neuritis were detected in 4 regions containing protein coding genes assignable to two functional groups: virus hypothesis and insulin metabolism...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30079045/focusing-attention-on-muscle-exertion-increases-eeg-coherence-in-an-endurance-cycling-task
#20
Selenia di Fronso, Gabriella Tamburro, Claudio Robazza, Laura Bortoli, Silvia Comani, Maurizio Bertollo
The aim of this study was to examine EEG coherence before, during, and after time to exhaustion (TTE) trials in an endurance cycling task, as well as the effect of effort level and attentional focus (i.e., functional external, functional internal, and dysfunctional internal associative strategies-leading to Type 1, Type 2, and Type 3 performances) on brain functional connectivity. Eleven college-aged participants performed the TTE test on a cycle-ergometer with simultaneous EEG and rate of perceived exertion (RPE) monitoring...
2018: Frontiers in Psychology
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